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  • Marceline from Adventure Time was born a half-human, half-demon. She became a vampire at some point during the gap before her debut in the show.
  • The Distant Finale of Aqua Teen Hunger Force revealed that Meatwad had two half-human, half-meatball children with a human woman.
  • Ben 10: Alien Force has Ben training a band of kids with powers similar to his original aliens (or at least he SHOULD be training them, but the animators don't seem to want to have to draw massive amounts of cast members each episode, so the status quo of three is maintained) to fight the alien Big Bad. Interestingly, these kids are all hybrids of aliens of varying species and children of Plumbers (who have all been given badges that act as tracking devices, making them easy to find), which makes you wonder if an interest in alien reproduction is a requirement to join the Plumbers... And the fact that a human shouldn't even be able to touch an alien made of lava can be handwaved with the use of alien technology, should any fan get a case of Fridge Logic.
    • Manny is half-Tetramand (Fourarms' species), Helen is half-Kineceleran (XLR8's species), and Alan is half-Pyronite (Heatblast's species). While Alan can switch between his human and alien forms, Manny and Helen stay looking like Kineceleran and Tetramand. Omniverse retcons this. They weren't born hybrids; they were ordinary human kids who had their DNA mixed with aliens.
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    • Ben and Gwen's grandmother was an Anodite, making them only three quarters human.
      • Ben, Gwen, and her brother Ken are a headache to think about. The Anodite are energy beings, and therefore don't have genetics as such. It's implied that Grandma made a human form. If she made it genetically Terran Human, that means the kids are genetically full human, but still one fourth alien. Yeeeah. However, enough Anodite nature can be handed down for that to be the reason why Gwen can perform magic.
    • Kevin. Until Omniverse retcons that; Osmosians aren't aliens, they're just humans with powers, Kevin's being absorption. Basically, he's just a mutant ...which is what his original creator had planned before the alien retcon! Presumably this means the same project is responsible for Aggregor and his own origin is a false memory, just like Max's memories of Kevin's father. Also, his special ability allowed the conspiracy to create the others. So if a hybrid between a human and a lava alien that a human shouldn't be able to get near, let alone mate with, seems impossible, that's because it is and their original origin is a big fat lie.
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  • Danny Phantom is half ghost. So are Vlad Masters and Danielle Phantom. No breeding between ghosts and humans was involved: the former two were both results of Freak Lab Accidents, and the latter was cloned.
  • DCAU:
    • Two examples in Batman: The Animated Series— Kirk Langstrom and his wife at different times both became Man-Bat, and in the episode "Tyger, Tyger", Catwoman is abducted and transformed into a big cat hybrid to become the mate of a lab-created cat man (who presumably has human DNA and may also qualify for this trope).
    • Rex Stewart aka Warhawk, the son of Green Lantern John Stewart and Hawkgirl Shayera Hol.
      Static: Shayera was one cranky pregnant lady. Although to be fair, if I'd laid an egg that size...
  • In Disenchantment, the protagonist's half-brother Derek is half-Dankmirian, born from King Zog's second marriage to Oona. While she has some Bizarre Alien Biology and her people's typical stoicism, Derek mostly just seems like a normal kid with blue skin.
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  • On an episode of The Fairly Oddparents where Timmy wishes the world were like a comic book, Francis becomes a half bull monster the Bull-E. In another episode, Vicky becomes a harpy.
  • In Futurama, Kif has (accidental) half-(mutant) human/half-Amphibiosan children with Leela. No, Leela didn't get pregnant. Also Amy is considered their "True" mother by Kif's society as to them the origin of the DNA matters little. His people are a single sexed but bi-gendered species able to reproduce via any physical contact with their skin and another source of DNA, even casual contact with a location someone has touched recently (a Toilet Seat is cited, playing off the old joke). However the ablity to do so is brought on only by intense feelings of love, and the person who brought on those feelings is considered the true parent regardless of the origin of the DNA. Leela giving Kif her DNA was accidental, she grabbed his hand during an emergency to save his life after his glove had come off.
  • In Gargoyles, Dr. Savarius tried to create hybrids with the same abilities as gargoyles. To do that, he injected human test subjects with the DNA of jungle cats, bats and electric eels. Later, Thailog has him create Delilah by combining DNA from Demona and Elisa.
    • Averted, however, in a human/gargoyle relationship, which cannot normally produce children. (Note that gargoyles lay eggs.) Word of God does leave some room open for magical and/or scientific advancements in that area, though. Goliath and Elisa apparently adopt a human son at some point, however, as that kid's descendant would have been a main character in a proposed Spin-Off.
    • Fox, on the other hand, is a straight version, with a human father who unwittingly married a Child of Oberon (or ex-wife of Oberon, as the case may be). By extension this makes her son Alexander magical as well.
    • Word of God also says that Oberon himself had at least two children with human women: Merlin and the changeling boy from A Midsummer Night's Dream. Being magical shapeshifters, the Children of Oberon can mate with just about anything. The New Olympians are also descended from the Children's sports with both humans and animals.
  • Irwin from The Grim Adventures of Billy & Mandy may seem like an ordinary Black and Nerdy loser, but later episodes have revealed that his mother was a mummy and his paternal grandfather was Dracula himself. This doesn't become obvious though until the movie Underfist where he gains closer connections to his undead bloodlines.
  • In He-Man and the Masters of the Universe (1983) and She-Ra: Princess of Power, both title characters were half-Eternian and half-Earthling, since Queen Marlena was an astronaut from Earth.
  • In The Legend of Korra, we find out that spirits can do a version without reproduction. They possess a human, and the human takes on some of the spirit's traits, which remain once the spirit leaves. If the spirit doesn't leave, the human dies. During the Harmonic Convergence, however, a spirit can permanently fuse with a human without hurting them. This is the source of the Avatars: They are humans fused with the light spirit Raava. The (internal) mutations this causes is what allows them to bend all four elements. In the season 2 finale, not only does Unalaq become a Dark Avatar by mirroring the process with Raava's opposite Vaatu, but Raava is ripped from Korra, reduced to her bare essence (destroying the essences of the previous Avatars in the process) and imprisoned within "Unavaatu". However, Korra remains a human/light spirit hybrid, and retains her bending abilities.
  • Robotech naturally picked this up from Super Dimension Fortress Macross, but had notable examples of its own.
    • Komillia Jenius from Macross became Dana Sterling, both in her initial appearances during "The Macross Saga" and in the overwritten Robotech dub of Super Dimension Cavalry Southern Cross, renamed "The Masters Saga". The reason given for her hair changing from blue-green (in the Macross segments) to blonde was the increasing amounts of anti-Zentraedi (and Zentraedi-hybrid, naturally) prejudice in the Armies of the Southern Cross. As a result, Dana dyed her hair to avoid the hassle. As both Southern Cross and "The Masters Saga" had a rather anti-alien, xenophobic military as a major plot point, this Retcon was actually rather well done.
    • Near the end of "The Masters Saga", Dana has a protoculture-induced vision of a sister she's never known, born to her parents after they left Earth on the SDF-3. In the Robotech novel continuity, this character became Aurora Sterling. In the animated continuity, according to Robotech: The Shadow Chronicles, this became hot shot fighter ace Maia Sterling.
    • In the "The Next Generation" saga that made up the last third of Robotech, we were treated to Marlene, an amnesiac young woman who was actually Ariel, the first attempt of the Invid Regis to further evolve her race into human form. Furthermore, the Invid prince Corg and Invid Princess Sera are both Invid-human hybrids, due to the Invid Regis' belief in humanity's evolutionary superiority to her own race's original form.
  • Samurai Jack: The Daughters of Aku are the daughters the human High Priestess and Aku, a Made of Evil Eldritch Abomination.
  • One Halloween episode in The Simpsons revolved around Maggie's real father being an alien.
  • Played for Laughs in the South Park episode "Douche and Turd": Members of PETA are shown to have sex with animals (and, judging by dialogue, are expected to and expected to enjoy it). PETA agents will occasionally conceive a human-animal hybrid; one of them, which seems to be part-duck, begs for passers-by to kill him (which is also played for laughs).
  • Star Wars: The Clone Wars:
    • "The Deserter" involves a Twi'lek woman and her two half-human, half-Twi'lek children as major characters.
    • The Dathomirian species is the result of generations of crossbreeding between the human Nightsisters and the Zabrak Nightbrothers. They're also a case of Bizarre Sexual Dimorphism and Gender Equals Breed, as the Nightsisters look like extremely pale-skinned humans, while the Nightbrothers look like full-blooded Zabraks.
  • Star Wars Rebels has Jacen Syndulla, the son of human Jedi Kanan Jarrus and Twi'lek pilot Hera Syndulla, who was born after his father's death.
  • Steven Universe is a boy with a human father whose mother was one of the Crystal Gems. He looks entirely human, except that he has a gem in his navel which gives him magical powers. This is possible because Gems are shapeshifters, and Word of God is that Steven's mother Rose Quartz (A.K.A. Pink Diamond) grew herself the required sexual organs needed to conceive and carry a child (as Gems have No Biological Sex and do not reproduce naturally). Steven's body clearly contains flesh and blood as opposed to being purely Hard Light like the full Gems, but his Super Toughness, Super Strength, limited shapeshifting ability, and ability to fuse with both pure humans and pure Gems shows his Gem heritage is more pronounced than it appears. Also, literally 50% of him is Rose Quartz, since they can't both exist at the same time; she literally had to give up her physical construct and became half of Steven because her gem was necessary to complete his DNA.
  • Used disgustingly in Superjail!. During the season one finale, the Warden—who has been stuck in an extra-dimensional temporal prison—returns to the titular Superjail to find that the inmates have been forced to rebuild society in his absence. They didn't have any women, so they had to make do with the canary.
    Warden: What has gotten into these inmates?
    Alice: Whole lot of bird dick from the looks of it.
    • Earlier in the same episode, it's revealed that the scientists have been trying (with little success) to make these in an effort to create more docile inmates.
  • In the 2012 incarnation of Teenage Mutant Ninja Turtles April is revealed to be half-human and half-alien.
  • Transformers Animated Sari Sumdac is half human and half Transformer. She's essentially a Maximal with a human as her beast mode.
  • Keith from Voltron: Legendary Defender is revealed to be one of these, with his non-human half being Galra, the alien race Voltron is at war with, though he appears fully human. Naturally, it takes some time for everyone to adjust to this revelation.
    • Lotor and his generals are also half-Galra. It's hinted that all of them, Lotor especially, face severe discrimination because of this.
  • Roxy of Winx Club is a half fairy; Queen Morgana is her mother. Then again, there are no male fairies, so there may not be such thing as a "half fairy".


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