Popuko is pissed off. A man nearby later states when she is hungry, she goes all "Poptepipic" and needs a Snickers. However, Popuko runs over the guy with a car before he could even finish his sentence.
The Bob Epic Team version of the "Are you mad" strip has Popuko then beating the crap out of Pipimi after she has stated she is not mad from two punches, then going to a factory as she's turned into pickled radishes. She's still not mad.
In the end of the "POP TEAM STORY" skit, one of the villains later has a fidget spinner on their middle finger for no reason whatsoever.
The adaptation of the Lemon skit takes a sharp swerve. Instead of Popuko licking a lemon before Pipimi plays a guitar song, the skit is instead portrayed as a Yakuza drama with the lemon licking replacing them swearing an oath with drinks in jail.
Also during this skit, Pipimi decides to sever ties with the Yakuza group she's in because they've lost their way and started committing YouTube crimes.
Popuko and Pipimi, fused together, attack King Records and question if they're mad during their defeat. They scream that they aren't as they explode.
Edo Era Pop Team
The OP for the first half of the episode is another OP featuring the cast of Hoshiiro Girldrop. As for the second half, the OP starts as the same Hoshiiro Girldrop, only for it to get hijacked by the cast of Bob Epic Team.
The fact that the anime made its American television premiere on, of all places, [adult swim]'s Toonami, an action animation block that usually doesn't air non-action shows. To say it took everyone by surprise would be an understatement.