- In the episode "Invention Convention", when Brackenreid is going to the dentist, actually physically being coerced by his wife of all things, Crabtree comes by, gives him the report of the status of the case, then runs off with the apple Brackenreid was gonna have as a reward. Later comes the Call-Back from Brackenreid as he thanks Crabtree for him giving the report and running away from the dentist. Especially funny because he'd been expecting Constable Higgins, who he'd bribed/ordered to call him away due to a made-up emergency and get him out of having his tooth pulled.
- In the episode "Who Killed the Electric Carriage?", Inspector Brackenreid finds out that his wife (who's been giving him a hard time about his drinking) and other ladies from bloody Temperance League participate in bloody gambling, so he orders Constable Crabtree to arrest everybody in the bloody den. The following exchange has perfect comedic timing and is complete with hilariously ominous music.Constable Crabtree: Sir? What? Even your wife?Inspector Brackenreid: Especially the wife!
- Inspector Brackenreid comments on one boy's poetry in his letters, and casually asks Murdoch whether he ever wrote something like that. Murdoch says that he's not much of a poet, but he recalls composing and being proud of a rhyming couplet when he was a young boy... on their family dog. Inspector's face goes from mildly amused expression to an extremely excited one, and then he just gets visibly disappointed. Murdoch's one-liner after the beat is priceless: "He was a very well-behaved dog."
- Murdoch is explaining to constable Crabtree that he's using a liquid, testing whether there is blood on a bullet. If there is, the haemoglobin will cause the reaction. George nods and just repeats that yes, haemo-GOBLIN will do that. Oh, George...
- Murdoch nearly drowns in a room on a boat that is slowly filling up with water. He is saved by Dr. Ogden after she and Brackenreid drag him out of the water. The first thing he says? "I lost my hat."
- In the epilogue of "Murdochophobia", Crabtree is delighted when a previously-thought-dead spider that he grew a liking to throughout the episode, comes back to life. Brackenreid proceeds to drop off some papers for Crabtree to go through. Right on the spider.
- In the episode "The Knockdown", the scene with the ferret as a bloodhound, especially when the ferret climbed up Murdoch's trouser leg.
- In the 7th season episode with the tunneling thieves, Crabtree assures a somewhat exasperated Murdoch that he knows "there are no vampires....in North America"
- "The Filmed Adventures of Detective William Murdoch":
- William and Julia have dinner with the actors playing them. William's actor envisions William all wrong ("but how does it affect you?"), while Julia's actress complains that William and Julia's friendship is not exciting enough for a "modern woman." Julia remarks that an actually modern woman shouldn't be defined by her relationship to a man.
- The male actor's assumption that William must surely be haunted and angst-ridden about the ugly events his work exposes him to is also funny on a meta level, as it can be taken as a dis on film's (and television's) overuse of the Defective Detective trope. This, in an episode that loves mocking cheesy film tropes.
- At the end of the episode "Bloodlust" Julia has a rather steamy fantasy moment about William, which is then interrupted by Darcy, her husband to be entering the scene who asks her "Have you given it to the detective yet?" (Referring to the wedding invitation), much to her initial confusion.
- The entirety of "The Keystone Constables", though special mention should go to the ending, wherein Murdoch sets up Julia with a handmade whoopee cushion.
- In "The Curse of Beaton Manor" Murdoch goes to discuss a case with Julia and she complains that she hasn't even had her tea yet but allows him to draw her into a discussion about using puffer fish poison to fake your death. Julia comments that using it would probably result in brain damage because "The brain requires a constant flow of oxygen..or tea!"
- In "Marked Twain", Crabtree convinces Higgins to interview a suspect ten miles out of town, a task the recently superior Higgins wanted to delegate to Crabtree, by hinting that he can console himself by gazing at an attractive woman who lives nearby, to visitor Mark Twain's amusement.Mark Twain: Too bad you don't need a fence painted.
- In season 10, after a successful flight in a gliding suit, Murdoch exclaims repeatedly to James Pendrick, "I FLEW!", with a goofy grin on his face.
- In "Brother's Keeper," Murdoch has Higgins help him reenact a suspect's account of a struggle over a gun. Higgins does... and knees Murdoch in the groin, which did not happen in the account. He flung up his hands in triumph and had a big grin on his face. When called on it, Higgins pointed out that the two men in question were fighting over a gun, and one of them would have tried the move. Brackenreid, much to his own surprise, acknowledges that Higgins is right.
- Murdoch building, in essence, a steampunk roomba in "Operation: Murder". He's pleased to see it works...until it turns and chases him.
- "The Final Curtain" may be one long episode of funny:
- Almost every scene of the investigation occurring on the stage is presented as if it were a play, with sheer Ham-to-Ham Combat as all of the characters even The Stoic Murdoch present their lines as over the top and dramatically as possible.
- The revelation that one suspect could not have had an altercation with the victim before their murder where Watts and Murdoch thought he was...because John Brackenreid was having a tryst with the victim a married woman at that particular time and place. While Murdoch hams it up on the stage presenting his theory in front of the others, John quietly whispers the truth to Watts, who interrupts Murdoch and relays it as well, leading Murdoch to backtrack on the theory. An impatient Brackenreid demands they explain why they've ruled out the suspect, and Watts and Murdoch each wordlessly argue with each other over who is going to tell him. When the beans are spilled John is embarrassed, Brackenreid seems absurdly pleased, and Mrs. Brackenreid faints and spends the rest of the episode in denial.
- And the snickering between the two Brackenreids during the double entendre-riddled conversation between John, Brackenreid, and Murdoch that follows, over the fact that the victim's husband had not even consummated the marriage leading to the hookup. It's capped up with the two sharing a guffaw when a comment is made about the husband not being able to load the bullet which killed the victim into the prop gun.
- When the older male lead of the play hamfistedly hits on Margaret, watch John's face as he eats his dinner with a "seriously WTF" face
- In "Murdoch on the Corner" Crabtree notes that after finding out about the Serial Killer the neighbourhood seems a lot more ominous, cue a montage of the characters around the square looking ominous and brandishing weapons...and the Pizza Pie guy offering a pizza in the same creepy tone.
- At the end of "24 Hours till Doomsday" Terrence Meyers seemingly dies by accidentally locking himself in James Pendricks experimental rocket and launching it, in "From Murdoch to Eternity" it turns out he survived the crash and was worshipped as a god by a tribe in Borneo for a while.
- In "Murdoch Escape Room", Crabtree comes up with a theory about who has trapped them in the titular escape room: In the future, James Gillies' preserved brain was transplanted to another person, that person became Gillies, then built a time machine to go back in time and torment Murdoch.Brackenreid: Do you ever have a day off, Crabtree?!
Crabtree: Alright. Well, if we make it out of here, at the very least, we're getting rid of that brain.
- The Newsomes outdo themselves in sheer buffoonery in "Dominion of New South Mimico": When the city committee won't let him build a dock for his yacht, Rupert legally declares the estate its own sovereign nation. There's a flag, official language, heads of state and everything. As Watts puts it, the whole thing is "the manifestation of a lunatic's untethered vanity".
Funny / Murdoch Mysteries