Fans! adjusted the Federal Bureau of Investigation into the Fantasmagorical Investigation Bureau, or FIB.
EVIL stands for the Elite Villains Institute of Learning. It also features such organizations ass ASS (Academic Superiority Society) and FOWL (Future Opressors of the World at Large).
The secret anti-alien organization in It's Walky! is called SEMME... which does stand for something, but the author has yet to reveal what. It's pronounced like "semi", creating useful pun fuel. In one strip, part of the E on their building is blown off, prompting Walky to start calling the organization "SEMMF".
I'd think there'd be more pun fuel if it were pronounced how it looks.
The author once claimed to have forgotten what SEMME stood for (having invented it in his childhood).
The KA Mics had the Semi-Mystical Otherworldy Gates or S.M.O.G. Nothing deep about the name though, the author took the acronym from a running gag he was part of on one of Nitcentral's humor threads.
Mr. Mighty in Everyday Heroes is a member of The Society of Amazing, Valiant, and Extrememly Unselfish Superheroes ... S.A.V.E.U.S.
According to the cast page, Mr. Mighty has previously worked for the Team Hoping to Uphold Decency (THUD), the White House Advanced Personnel Protective Office (WHAPPO), the American-Mexican International Group Of Superheroes (AMIGOS), and the Group Of Official Do-Gooders United In Suppressing Evil (GOOD GUISE.).
The villains have their own group, the Mid-Western Alliance of Hired Assassins, Henchmen, Anarchists, Highly Anti-social Hackers, And Hideous Abominations (MWAHAHAHAHAHA).
A straighter example is this strip, where Douglas Hofstadter's autobiography reads, "I'm So Meta, Even This Acronym".
The Perpetual Aquarium had the fish take the Comprehesive Assessment and Report of Progress, or CARP. This was lampshaded when one of the fish comments that basing a year's progress isn't CARP, it's C——, and, when interrupted, comments that he likes anagrams.
The name was suggested by a reader after the writer decided he had to call it something so he might as well call it DAVE.
The Trustworthy Room test from Tower of God requires to gather rooms and teammates, though with a high risk of losing ones room. So Ja Wangnan and Nia decide to do it the gentlemanly way: Operation S.I.R., Stay In the Room.
Irregular Webcomic! has the Secret Action Squadron Team of Cryptid Hunters. There's also Russian double agent Valentina Irina Ranevskaya Galina Ivana Natalya Iriyushka Anastasia Sonyechka Marinochka Ineslenka Tatyana Hvorostovskaya. As you might expect, she's usually referred to by her alias, Virginia Smith. If you wonder where she got that alias, read her name again.
In the Jet DreamRemix Comic, the T-Girls represent NATO's Joint Elite Team, Division of Raiding-Expert Aeronautical Maidens (J.E.T. D.R.E.A.M., or usually just "Jet Dream.") Their "little sister" team is Junior Echelon, Teen T-Girls, Elle-Boys, and Esprit-Girls (Natural!), or J.E.T. T.E.E.N. Both organizations must deal with the sinister schemes of Zoned Extortion and Removal, Occidental (Z.E.R.O.).
Erfworld has Lord Stanley the Tool's elite hobgobwin knights, the Knights In Stanley's Service. They are, of course, a reference to the band KISS; their "war paint" is the makeup KISS wears onstage, and their name is a reference to the old moral panic-driven legend that KISS stood for "Knights In Satan's Service" (which it didn't).
The GIGAHERTZ, or Gizmonic Institute Graphical Automated Hyper-Enhancement of Reality through Teleportation and, uh... Zoom, from The Way of the Metagamer.
Responded to with the Clayton Forrester Volumetrically Displayed Entertainment and World-Taking Over Device, or, uh... CFVDEWTOD (khfhvhdootodd?) for short.
Precocious has Time Advancement Device Associated With ARelative Position. T.A.D.A.W.A.R.P.
A comic-within-the-comic has Max worry about girls giving him gifts with C.O.O.T.E.E.S, Camera-Outfitted Observational Trackers, Embedded Espionage Systems.note those last two words were cut off in the comic and are only known through Word of God
And then later, when Caliborn takes over the narritive and is retelling the story, he can't remember the name of Dave's planet, and so invents his own. What does he call it? Land of Someone's Handicraft I Took (LOSHIT).
The kids' chumhandles are TentacleTherapist, TurntechGodhead, GardenGnostic, and (formerly) GhostyTrickster. This is also the case with several of the trolls' nicknames. This remains post-Scratch, with the handles being GutsyGumshoe, TipsyGnostalgic, TimaeusTestified, and GolgothasTerror.
Not to mention the exiles, who have each got several titles all making the same two-word acronym.
The Crossover Wars had their DRACO (Dimensional Reality Arcane Crossover Organizer)
Violet: And you're U.N.I.T.Y. Unity: Yep! Violet: The Upgradeable Necrotic Independent... what? Unity: We don't talk about my acronym. Violet: Sorry, did I touch a nerve? Unity: Well, you know. People died and stuff. Violet: People died... because of your acronym. Unity: The committee meetings, man! It was law of the jungle!
In a later arc, we meet G.O.D.O.T., an AI whose primary function is a military-grade backronym generator. It turns out G.O.D.O.T. went mad trying to work out what U.N.I.T.Y. could stand for, which is presumably the point at which people died.
It turns out that Unity came up with her own acronym, which pissed off Godot to no end. It's something Sweetheart said: "Unity's Nice, I Tell You."
Dork Tower also has the group Matt started called Gamers For Personal Hygiene. At first Igor questions this acronym since "it doesn't spell anything," but then a very smelly geek walks by and he makes the sound effect "GFPH!"
From the eyetree quest storyline, there are the two Bradicor males Really Old Dude, or Rod, and Very Old Guy, or Vog, both of whom are millions of years old.
Lt. Flinders and Enesby were ordered to come up with a manual of operations for the Toughs to standardize actions. This strip shows the results: Toughs Handbrain Of Operations: Senior Officers, or THOOSO; Toughs Handbrain Of Operations: Platoon Officers, or THOOPO; Toughs Handbrain Of Operations: Grunts, or THUG (treating the double O as a U, not letting language stand in the way of a memorable acronym); and the master volume that combines the previous volumes into one work: Toughs Handbrain Of Operations: Master.
Enesby: THOOM, if you will. Comodore Tagon: Well played. I think we all will.
Clockwork: Mercia Fortress's Robot Buddy prototype is called Mercian Artificial Intelligence: Labour (Build 0), shortening conveniently to MAILO, pronounced like "Milo".
In Hoofstuck, Rainbow Dash gets the Land Of Youth And Longing.
In the Narbonic Sunday strips, there was a competition to give MIT Student Dave Barker a new title, now that he had graduated and become a transport planner. The winner was Newly Educated Master of Expressways, Sideroads and Innercity Streets. Or "Helen's NEMESIS" for short.
In Skyvein, VISN is one of the many acronyms (short for the Visual Information and Surveillance Network).
The Petri Dish has the cyborgs BOB (Brains On Board) and Irene (Intelligence Relays Enhanced with Neural Encoding). There's also an organization whose initials spell FART.
Ennui GO!: Key Manati's space program is called the Aeronautical Society for Science and Space EXploration.