When Peter (after throwing a football which dented one of the goalposts) is asked if he wants to play football, his response is "Too dangerous". On the base of things, it sounds sarcastic, especially since the trailers show this scene right at the end, after various clips of Spider-Man in peril. But Peter's right. Football is too dangerous for him to play because he has super strength and could easily injure the other players without trying, as evidenced by the newly dented goalpost.
Judging by how nice Flash was being to Peter at the end of the movie, it seems like his humiliation on the basketball court might not have been the pointless vengeance Uncle Ben saw it as. Perhaps getting A Taste of Their Own Medicine helped shape the boy for the better.
Considering that he seemed to know how it feels to lose a loved one, as well as how it feels better to lash out at someone, there may be more at play.
At the same time, it did show that Flash was not a sadistic Jerk Jock that most would come to expect.
The police arrive very quickly when Peter begins to rough up the car thief. Then we learn later from Captain Stacy that the thief was a mule the police were conducting a sting on so he could lead them to the ringleaders of a larger operation.
For that matter, the fact that the car thief had this complicated electronic lock pick instead of say, a coathanger, should have indicated something about whatever resources he had.
Like back in Spider-Man 2, we have a mad scientist using his newfound powers on the people who cut his funding (though this also happened in Fantastic Four) and Peter using his brains to win over a scientist who turns into the Big Bad.
Some people on WMG wonder why Manhattan has so many cranes. But if Marvel hadn't been pressed for time, OsCorp would've cameoed in The Avengers, meaning they would be in the same continuity. And, more importantly, there's nothing saying they still aren't. New York has so many cranes because they're still making repairs after the Incident.
The finale has something that can best be described as a "Chekhov's Disarming". During his run to the tower, Peter seals his bullet wound with webbing. Once he reaches the tower, the Lizard crushes his webshooters, meaning he can't use them to seal up Captain Stacy's impalement wounds later on.
Another reason for destroying the webshooters was so that at the critical moment when Peter goes over the side of the building, it is the bad guy (in an act of redemption) that is his only hope of rescue.
Some viewers complained about Peter's name being on the back of his camera when he tried to take pictures of the Lizard in the sewer (which lead to the Lizard learning his identity), as he shouldn't have done something so dumb. But remember in some of the comics (at least the Ultimate ones) and other media that Spidey gets cocky sometimes. Considering that he was playing games on his phone while waiting for the Lizard to show up, really lax for someone waiting for a dangerous monster, it probably never crossed his mind that something would go wrong.
The bridge scene is pivotal for many reasons to be sure. But also consider that Ben was a draftsman of bridges; while a bridge is certainly an easy way to have lots of tension combined with innocent bystanders, it's perhaps one of the symbols that strikes Peter to turn from vigilante into hero because he's reminded of Ben in that moment.
The bridge scene, and the fact that it leads to Jack's father arranging for all the cranes to provide Spidey with easy points to swing from to get to Oscorp can also be read as the good counterpoint to the moral lesson of what happened to Ben; in an act of spite, without consideration of the consequences, Peter does nothing to stop the thief from robbing the store, only for him to then go on to murder Ben, on the Bridge Spidey chooses to save a child over pursuing a monster, and in the process gaining the gratitude of a man who, unbeknownst to Peter, would end up in a position to assist him in getting to Oscorp.
When Peter informs Captain Stacy of the Lizard's real identity and George asks for info on it, nothing ever became of it. In the sequel, it's shown that whenever something bad happens at Oscorp, the board of directors immediately start covering stuff up. Considering Curtis Connors was just fired from Oscorp a few days ago and a giant, rampant lizard is on the loose, it's likely that Oscorp wanted to cover up any association with him, which is why Captain Stacy couldn't find anything. It's probably also why he believed Spider-Man so easily in the climax; he personally knew Curtis was a good and brilliant man, having little to no info come up has got to ring some alarm bells for him.
The ending where Peter implies he's going to break his promise to George Stacy and date Gwen. While it was cute in the movie itself, if the movies follow the comics then Gwen will eventually die after being a hostage in a Spider-Man fight. If Peter would've kept his promise, Gwen would likely live.note Confirmed as of the sequel, as Gwen was about to permanently leave Peter's life by going to Oxford, and him insisting on following her is what ultimately got her killed.
Gwen is on her way to the airport near the climax. It's after she talks with Peter that Max attacks the grid and they go save the city.
Watching Peter so recklessly toss Gwen out a window and then stop her fall by webbing her shows how little he knows at the moment about how fragile her body is. This comes back to bite him...
It worked with a small kid, how would he know?
To be fair with the kid, Spider-Man caught the kid by the chest. Also, the kid was essentially motionless and vertical while Gwen was caught by the leg and both prone and in active free fall. Maaaaajor difference.
This ended up being a cross-series foreshadowing, as Gwen does indeed die when Peter tries to save her in this fashion after she falls down a clock tower.
On the bridge, there's a brief moment where Peter contemplates continuing his fight with the Lizard after Crane-Dad shouts for someone to help save his son. If Peter had gone after the Lizard instead of helping the kid, he would've stopped the second half of the movie from happening and saved Captain Stacy's life, since the Lizard formula's starting to wear off and turn Connors back to normal at the time. But, the kid would have died in the meantime, and Spider-Man would be branded a menace who left a child to die since he'd rather continue fighting. Plus, since Peter had just told Gwen that he's Spider-Man, it'd more than likely destroy their budding relationship and she could've easily told her father who Spider-Man was out of sheer disgust over Peter letting a kid die.
That's only if people knew that that had happened. Even with the kid's father knowing Spider-Man saved him, the police apparently hadn't heard about it. They didn't know what Spider-Man was doing other than being there. Unless Peter felt the need to tell everyone (which, guilt-ridden, he might), no one's would realize he literally chose to stop the bad guy over saving a kid. Jack would just be a kid who died in the accident.
