- In the Episode 'The Crime Machine', Holmes freaked out when Watson got shot in the leg. In the Canon story, "The Three Garridebs", Watson was shot in the leg and Holmes freaked out there. So, it was really a case of deja'vu for him.
- The reference to Moriarty being a Star Trek fan makes a lot more sense when one remembers in the original canon, he was an astrophysicist. And considering Moriarty "guest starred" on Star Trek: The Next Generation, here he's just returning the "favor", as it were.
- Of course Sherlock Holmes and Moriarty are right at home in the 22nd Century: part of Moriarty's reasons for villainy in canon is that he's such a brilliant mind that people of his time literally couldn't comprehend his work, and Sherlock is in the same tier of intelligence as him. Both were centuries ahead of their time, so it makes sense they're right at home.
- Fridge Horror: As pointed out in his profile, the proportion of Tennyson's chair to the rest of his body and the fact that we never see him out of it could very well indicate he doesn't have legs. What in the world caused that?
Fridge / Sherlock Holmes in the 22nd Century