In the final story line, we learn that Lord Milligan was specially created to kill Casey and Andy, that he, in fact, has an overriding compulsion to do so. So how did he become friends with Casey in the "Andy woos Jenn" timeline? Because killing each other is the very bedrock of Casey and Andy's friendship!
http://tvtropes.org/pmwiki/pmwiki.php/Fridge/CaseyAndAndy
FollowingFridge / Casey and Andy
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