- SpongeBob SquarePants and Squidward Tentacles. SpongeBob is described as perpetually optimistic, and happy, cares for others, and loves his job whereas Squidward is unhappy, self-absorbent, hates his job, and is a Perpetual Frowner. This is perhaps the reason why Squidward was appointed as the manager over SpongeBob in The Movie, since he was more mature for the job while SpongeBob acts childish despite being a legal adult.
- Patrick Star To SpongeBob SquarePants. They're both ditzy Man Children who share such interests as jellyfishing and bubble blowing, but while SpongeBob is something of a Neat Freak, a Workaholic able to hold down a steady job and often proves to be The Ace at whatever he tries (except driving), Patrick is a Fat Slob, a Lazy Bum who never stays employed for long, and is shown to be so incompetent he can't even sweep or open a jar without outside help, but can drive surprisingly well.
- Mr. Krabs to Squidward Tentacles. While both of them have no tolerance for funny business, have good hearts every now and then in spite of their jerkassery, respond to SpongeBob's childish behavior with sarcasm, and have gone as far as to plot fatal schemes to get him killed, they're different from each other in that:
- Mr. Krabs is considerably armed and served in the Navy, ultimately justifying his power to take down various antagonists.
- Squidward is emotionally sensitive and insecure when in private, becomes timid whenever he suffers a horrible fate, and has become an exploit of Krabs's horrible schemes himself.
- Sandy Cheeks to SpongeBob SquarePants. While both of them are dorky, energetic and eccentric Ridiculously Cute Critters who like karate, their personalities differ in that:
- The Cyclops to Plankton. They both share similar traits, such as being evil, having one eye, and running their respective establishment. The differences being that Plankton is the smallest villain that often gets stepped on by nearly everyone under the sea, while the Cyclops is the largest villain in the movie that can easily step on any sea creature seen so far.
Foil / SpongeBob SquarePants