Zyzzyx Road is a 2006 American film written, produced and directed by John Penney. It stars Leo Grillo, Katherine Heigl, and Tom Sizemore. The film involves a philandering accountant who goes to Las Vegas on a business trip, where he encounters the seductive Marissa and her jealous ex-boyfriend. The former pair kill and bury the latter along the eponymous Zzyzx Road, a rural road off of Interstate 15 in California's Mojave Desert.
- My Nayme Is: Although the town in the Mojave desert is spelt Zzyzx, the spelling in Zyzzyx Rd is perfectly acceptable. Zyzzyx is also the name of a genus of sand wasp.
- No Pronunciation Guide: The title generally rhymes with Isaacs Road. Unlike most instances of No Pronunciation Guide, there can be variant spellings of Zyzzyx/Zzyzx.