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Love & Other Drugs is a 2010 Sex Comedy movie directed by Edward Zwick, starring Jake Gyllenhaal and Anne Hathaway.

Jamie Randall (Gyllenhaal) is a Viagra salesman who falls in love with Maggie Murdock (Hathaway), a young woman who suffers from Parkinson's Disease; they start a relationship based on sex but end up actually falling in love with each other, to their mutual chagrin. A minor subplot involves Jamie's fat, nerdy brother Josh (Josh Gad), who gets kicked out of the house by his lover and moves in with Jamie, disrupting his intimate life. Hilarity Ensues.

The film is probably best known for its Playing Against Type role for Hathaway, star of such Girl Next Door roles as The Princess Diaries movies, and for the amount of nudity and sex scenes it contains, to the point it can almost be considered Porn with Plot.

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This film provides examples of:

  • Bittersweet Ending: Sure, Jake and Maggie end up together, but they're both very much aware that she will eventually lose all physical and mental coordination.
  • Bowdlerise: The Spanish subtitles are hilarious because they have all the swear words censored... in a film with graphic sex scenes. It seems talking about sex is bad, but not showing sex.
  • The Charmer: Jamie even lampshades it, delightfully enough.
    Jamie: You're gonna like me eventually. Everyone does.
  • Defrosting Ice Queen: Subverted. Jamie eventually does convince Maggie to be his girlfriend, but she doesn't change her behavior until the very end.
  • Diagnosis from Dr. Badass: Trey tells Jamie EXACTLY what type of pain he's delivering.
  • Does Not Like Shoes: Maggie has a habit of walking around barefoot in her studio and likes getting her feet dirty.
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  • Dramatic Irony: Jamie works as a Drug Rep for Pfizer, the creator of Viagra, and he soon begins successfully selling the drug. Later on, he engages in a threesome at a party, taking Viagra to stimulate himself; he ends up having a negative reaction to the drug, which leaves him with a painfully erect and extremely sore penis, forcing him to go to the hospital. Yes, it turns out that the sex obsessed Viagra salesmen can't take Viagra himself.
  • Fanservice: Both leads spend about half the movie butt naked.
  • Friendly Tickle Torture: Jamie attacks Maggie with tickles during a scene on the couch. Like pretty much everything else they do in the movie, it ends with them having sex.
  • The Film of the Book: It's loosely based on the 2005 non-fiction book Hard Sell: The Evolution of a Viagra Salesman.
  • Girl-on-Girl Is Hot: And also shameless.
  • Good-Times Montage
  • Good People Have Good Sex: Despite how sex-obsessed the characters are, nothing kinkier than oral is even discussed.
  • Hot And Cold: Maggie is a classic case.
  • Ill Girl: Maggie is suffering from the onset of Parkinson's Disease and trying to avoid falling apart.
  • The Immodest Orgasm: Many.
  • Interchangeable Asian Cultures: One character makes a terrible, "sexy" pun about her friend's race as a lead-up to a threesome. "She's Thai, and I'm Thai-curious." Which is made worse by the fact that the girl is blatantly Filipino.
  • Jerk with a Heart of Gold: Jamie is this, though it takes a while for even him to realize it. Maggie can be something of a bitch, too.
  • Lady Killer In Love: This is what the movie is about, and what makes it sweet.
  • The Loins Sleep Tonight: It's about a Viagra salesman.
  • Modesty Bedsheet: Averted. Jamie and Maggie have a ton of sex but don’t bother to cover up. When, in a moment of brief shyness, she pulls her sheet up to her collarbone, Jamie gets off the bed and it uncovers her boob and she doesn’t bother to cover it up again.
  • Oscar Bait: A rare example of one that doubles as a Sex Comedy.
  • Present-Day Past: There's the introduction of Viagra and Prozac, and there's the bit with '90s ghetto blasters at the start. Nothing else sets this is '96. One character justifies being addicted to Internet porn by saying "Isn't everybody?" No, not in '96 they weren't. Not even in '97. Seriously, cast your mind back to how much porn there was on the Internet when the first Grand Theft Auto came out. There's even a scene Josh compares Jamie's penis to the Eye of Sauron, back before there was a common consensus on what that actually looked like, it being 5 years before The Lord of the Rings was a movie. Not to mention in the beginning of the film, there's Flat-screen LCD TV's in the background.
  • Product Placement: For Pfizer and their products (mostly Viagra), but its somewhat subverted in that the entire company comes off looking like a bunch of douchebags.
    • And lots of Bud and Bud Light abound.
  • Race for Your Love
  • Sex Montage: Natch.
  • A Threesome Is Hot: Said threesome.
  • Ugly Guy, Hot Wife: Josh and whatsername.
  • Unsympathetic Comedy Protagonist: The men in this film are jerks. Gyllenhaal's redeemed by The Power of Love.
  • What Happened to the Mouse?: A homeless man keeps showing up to take the Prozac Jamie dumps in the trash and once makes an offhand comment that he has a job interview later before scampering off with the drugs. We had seen him take the drugs repeatedly, but the relevance of this fact is never addressed so the "job interview" comment is borderline Big-Lipped Alligator Moment.
    • It's a joke. He's been taking the Prozac and he got his life in order.

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