- Take a sip every time Spidey freeze-frames to tell you something you already know.
- 2 sips if it's that Phil Coulson is his principal or if it's that the Green Goblin is Harry's father.
- Take a shot every time Spidey uses the phrase "my best friend's dad" when talking about Norman.
- Take 2 shots if he mentions that he has "the latest S.H.I.E.L.D. tech".
- Take a sip every time Green Goblin says a stock villain line.
- Take a full glass if Iron Fist says something zen-like.
- Take a sip whenever Jameson starts trash-talking Spider-Man with no real reason or justification. Small sips, or you'll die.
- Take a shot whenever Captain America does something awesome.
- Take half a shot when Spidey gets Good Angel, Bad Angel.
- Finish your drink whenever it should be obvious to Spidey that Norman Osborn is after him.
- Take a sip whenever Agent Venom and Rhino are at each other's throats.
- Take two sips if it's Agent Venom and the Scarlet Spider.
- Take a sip whenever the Scarlet Spider says 'punk'.
- Take a sip whenever Doc Ock is trying to do mad science involving Spidey, Venom, or the Green Goblin.
- Take another if he describes whatever abomination he's dreaming up of as beautiful in any sense.
- Drink the rest of your friend's drink if he died of alcohol poisoning while playing this game.
Drinking Game / Ultimate Spider-Man