- Any time XR gets blasted into pieces.
- Whenever Buzz shouts his Catch-Phrase, "To Infinity, and Beyond!".
- Make it double if it wasn't Buzz who it, especially Torque and/or his clones.
- Whenever Zurg yells, "CURSE YOU BUZZ LIGHTYEAR!"
- Take a shot any time someone says "Craters".
- Take another shot any time someone exclaims "Sweet Mother of Venus!".
- Whenever Mira ghosts (Except in "Super Nova").
- Whenever Booster mentions anything "Bunzel" related.
For the Advanced/Suicidal Drinker:
- Take a shot any time the show spits in the eye of physics.