- Its True (1998) as Jenna
- 8 Simple Rules (2003) as Jenny
- Buffy the Vampire Slayer (2003) as Colleen
- The O.C. (2003 — 2007) as Summer Roberts
- That '70s Show (2004) as Christy
- Chuck (2007) as Lou Palone
- How I Met Your Mother (2010 — 2014) as Cindy
- Hart of Dixie (2011 — 2015) as Dr. Zoe Hart
- Gossip Girl (2012) As Herself
- Drunk History (2016) as Constance Kopp
- Nashville (2017) as Alyssa Greene
- Take Two (2018) as Sam Swift
- Drunk History (2019) as Helen Callaghan
- Actor Allusion: In the first few minutes of Hart of Dixie, Zoe says Summer Roberts trademark "ew".
- Romance on the Set: With Adam Brody on The O.C. and with Hayden Christensen on Jumper.
- Star-Making Role: Her role as Summer Roberts in The O.C..
- Written-In Infirmity: Bilson was pregnant during season 4 of Hart of Dixie. Her character Zoe gets a plot where discovers that she's pregnant.
- Hide Your Pregnancy: However, as Bilson was farther along in her pregnancy it still lead to some obvious attempts to mask how far along she is. Mostly she's simply shot from the shoulders up, but there are also quite a few scenes with her conspicuously covered by a blanket.