
LuPone is of Italian descent, is a Julliard grad, and is married to cameraman Matthew Johnston.
Select stage works
- The Robber Bridegroom (1975): Julia
- Edward II (1975): Prince Edward
- Evita (1979): Eva Perón
- Les Misérables (1985): Fantine
- Anything Goes (1987): Reno Sweeney
- Sunset Boulevard (1993): Norma Desmond
- Company (1993, 2018/2020 revival): Host, Joanne
- Sweeney Todd (2000, 2005): Mrs. Lovett
- Gypsy (2008): Rose
- War Paint (2017): Helena Rubenstein
Other media
- Life Goes On (1989-1993): Elizabeth "Libby" Thatcher
- Driving Miss Daisy (1989): Florine Werthan
- Oz (2003): Stella Coffa
- 30 Rock (2009-2012): Sylvia Rossitano
- Steven Universe (2013-present): Yellow Diamond
- American Horror Story: Coven (2013-2014): Joan Ramsey
- Penny Dreadful (2014-2017): Joan Clayton and Dr. Florence Seward
- Cameos as a club singer in Penny Dreadful: City of Angels.
- Vampirina (2017-present): Nanpire
- Pose (2019): Frederica Norman
- Last Christmas (2019): Joyce
- Randy Rainbow: As Herself