Having done little animation, Loomis only voiced small roles in the As Told by Ginger TV series for Klasky-Csupo, the Star Wars: Rebellion CD Rom game for LucasArts, Detective Barbie, and Crayon Shin chan, In 2010, he landed the role of Tony Stark/Iron Man for Marvel Animation in The Avengers: Earth's Mightiest Heroes! on Disney XD. Prior to that year, he voiced Iron Man in the video game tie-in to Iron Man 2 and reprised his role in Marvel vs. Capcom 3 (as well as Marvel Vs Capcom: Infinite). As a result from his great performances as the character in the popular Marvel adaptation as well as some video games, fans generally consider him to be the definitive voice actor for the Golden Avenger (aside from perhaps Robert Hays, who voiced Shellhead in the 90s Marvel cartoons).
- Tony Stark/Iron Man in the Iron Man 2 video game tie-in, The Avengers: Earth's Mightiest Heroes, Marvel vs. Capcom 3, and Marvel Vs Capcom: Infinite.
- Additional Roles in As Told by Ginger, Star Wars: Rebellion, Crayon Shin chan, commercials that are for McDonald's, Carl's, HP, On Star, Toyota, Panda Express, and the Coca Cola company.