Having done little animation, Loomis only voiced small roles in the As Told by Ginger TV series for Klasky-Csupo, the Star Wars: Rebellion CD Rom game for LucasArts, Detective Barbie, and Crayon Shin-chan, In 2010, he landed the role of Tony Stark/Iron Man for Marvel Animation in The Avengers: Earth's Mightiest Heroes on Disney XD. Prior to that year, he voiced Iron Man in the video game tie-in to Iron Man 2 and reprised his role in Marvel vs. Capcom 3 (as well as Marvel vs. Capcom: Infinite). As a result from his great performances as the character in the popular Marvel adaptation as well as some video games, fans generally consider him to be the definitive voice actor for Iron Man (aside from perhaps Robert Hays, who voiced the character in the 90s Marvel cartoons).
- Tony Stark/Iron Man in the Iron Man 2 video game tie-in, The Avengers: Earth's Mightiest Heroes, Marvel vs. Capcom 3, Marvel vs. Capcom: Infinite, and Marvel Ultimate Alliance 3: The Black Order.
- Additional Roles in As Told by Ginger, Star Wars: Rebellion, Crayon Shin-chan, commercials that are for McDonald's, Carl's, HP, On Star, Toyota, Panda Express, and the Coca Cola company.