Elizabeth has gained critical acclaim for her versatile performances in a wide variety of different roles, playing anything from sadistic paedophiles to fierce action girls to psychologically complex piano teachers and everything in-between.
- 1998: Gia as Linda
- 2000: Frequency as Julia 'Jules' Sullivan
- 2000: Nurse Betty as Chloe Jensen
- 2002: The Santa Clause as Mrs. Claus / Carol Newman
- 2006: Running Scared as Edele Hansel
- 2016: The Purge: Election Year as Senator Charlene Roan
- 1996: The Sentinel as Wendy Hawthorne
- 1996: JAG as Lt. Sandra Gilbert
- 2000-2001: ER as Dr. Kim Legaspi
- 2001: The Beast as Alice Allenby
- 2001: Spin City as Nancy Wheeler
- 2003: Law & Order: Special Victims Unit as Andrea Brown
- 2003: CSI: Crime Scene Investigation as Melissa Winters
- 2004: Everwood as Sara Beck
- 2004: Boston Legal as Christine Pauley
- 2004: House as Sister Mary Augustine
- 2006-2010: Lost as Dr. Juliet Burke
- 2009-2011: V (2009) as Erica Evans
- 2011 Law & Order: Special Victims Unit as June Frye
- 2012-2014: Revolution as Rachel Matheson
- 2014: Once Upon a Time as Ingrid the Snow Queen
- 2016: Dead of Summer as Deb Carpenter
- 2018: The Expanse as Rev. Dr. Annushka "Anna" Volovodov
Elizabeth Mitchell exhibits these tropes:
- Fascinating Eyebrow: She has a very expressive eyebrow twitch.
- Ms. Fanservice: In Hollywood Palms, Gia, and Once Upon a Time.
- Statuesque Stunner: Is 5'9".