He first appeared in The Many Loves of Dobie Gillis and became a noted character actor in the 1960s. He soon got a lead role in My Favorite Martian, which lasted for over 100 episodes before it was cancelled for budgetary reasons.
After a few years and more character appearances while turning down the male lead in That Girl, Bixby eventually got the lead in The Courtship of Eddie's Father, which got him an Emmy nomination. After that, he starred in the short-lived The Magician in 1973 before he got the role that would prove to be his greatest.
That, of course, was as Dr. David Banner in The Incredible Hulk. He was initially reluctant to take a "comic book role", but soon came around after reading the script. That role made him a late 1970s/early 1980s pop culture icon who helped define the tragedy and soul of the superhero ever since.
After that series ended, he later acted in the short-lived sitcom Goodnight Beantown, hosted the Nickelodeon biography series Against the Odds, and directed episodes of Wizards and Warriors and Sledge Hammer! before returning to the Hulk in three TV movies.
Bixby died of cancer in 1993 at age 59.