She married Dave Franco in 2017.
- Scream 4 (2011) as Rebecca Walters
- The Five-Year Engagement (2012) as Suzie Barnes-Eilhauer
- Save The Date (2012) as Beth
- The Kings of Summer (2013) as Heather
- The LEGO Movie (2014) as Unikitty
- Sleeping With Other People (2015) as Lanie
- Get Hard (2015) as Alissa
- Get a Job (2016) as Tanya Sellers
- The Disaster Artist (2017) as Amber
- The Little Hours (2017) as Alessandra
- The Post (2017) as Lally Graham
- Weathering With You(2019) as Natsumi (NYAV Post dub)
- Horse Girl (2020) as Sarah note
- The Rental (2020) as Michelle
- Promising Young Woman (2020) as Madison
- Happiest Season (2020) as Sloane
- Hannah Montana (2006) as Nina (episode: "It's My Party and I'll Lie If I Want To")
- Mad Men (200715) as Gertrude "Trudy" Campbell (36 episodes)
- Community (200915) as Annie Edison (110 episodes)
- NTSF:SD:SUV:: (2012) as Joanie (episode: "Sabbath-tage")
- Bojack Horseman (201420) as Diane Nguyen / Additional Voices (77 episodes)
- Dr. Ken (2017) as Herself (episode: "Ken's Big Audition")
- GLOW (201720) as Ruth Wilder / "Zoya the Destroya" (30 episodes) note
- Drunk History (2019) as Thea Spyer (episode: "Love")
- Rick and Morty (2021) as Planetina (episode: "A Rickconvenient Mort")
- Star Wars: Visions (2021) as Am
- Marvel's 616 (2020) - episode: "Spotlight"
- Adaptational Nationality: In the ITV miniseries Doctor Thorne, set and filmed in England, she plays an American - who in the original book is Australian.
- The Cutie: A common role for her, although often with a bit of a dark side.
- Hidden Depths: She can freestyle rap. Really well.
- Ms. Fanservice: In Community. Also wound up featuring in many photospreads, and starred in an online series called Hot Sluts. Post-Community, Brie has taken a number of sexually provocative film roles in movies such as Get Hard and Sleeping with Other People, both of which feature Brie in sexy lingerie. This is extended even further in GLOW (2017), which features her in nudity and sex scenes.
- Inverted in Horse Girl, where she has a prominent Fan Disservice scene. Despite being fully nude, she has on a massive furry merkin, is in the middle of a retail store and is practically catatonic from a mental breakdown.