Palicki also has quite a history with comic books adaptations, having been cast as a false Supergirl on Smallville, the villain of a failed Aquaman television pilot at The WB, and NBC's Wonder Woman pilot as the title character. She also showed up in G.I. Joe: Retaliation as Lady Jaye.
She played Barbara "Bobbi" Morse / Mockingbird on Agents of S.H.I.E.L.D. from 2014 to 2016, and plans for a Mockingbird-centric Spin-Off were discussed. Eventually a pilot episode, Marvel's Most Wanted, featuring her character in the lead role, was ordered, but did not develop it as a series.
In addition to her acting career, Palicki co-wrote the comic book No Angel (published by Black Mask Studios) with her brother Eric, and doubles as the visual inspiration for its lead character.
- Smallville (2004) as Kara / Lindsey Harrison
- Supernatural (2005 2009) as Jessica Moore
- Aquaman (2006) as Nadia note
- Friday Night Lights (2006 2011) as Tyra Collette
- Legion (2010) as Charlie
- Lone Star (2010) as Cat Thatcher
- Wonder Woman (2011) as Diana Prince / Wonder Woman note
- Red Dawn (2012) as Toni Walsh
- G.I. Joe: Retaliation (2013) as Lady Jaye
- About a Boy (2014) as Dr. Sam
- John Wick (2014) as Ms. Perkins
- Agents of S.H.I.E.L.D. (2014 2016) as Barbara "Bobbi" Morse / Mockingbird
- The Orville (2017 - ?) as First officer Kelly Grayson
Black Mask Studios:
- No Angel (2016 — 2017)