The comic tells the story of a sarcastic Basset Hound named "Fred". He lives in London with his two owners, a husband and wife duo. It is a slice-of-life comic strip mainly consisting of the whimsical daily life of Fred.
Fred Basset provides examples of:
- Animated Adaptation: In 1976, the strips were adapted into 5-minute animated shorts.
- Comic-Book Time: Fred was born in 1959 and is stil alive after over 50 years.
- Dog Stereotype: Inverted with Fred. He's not the "lazy Basset Hound", the "dumb Basset Hound", or the "affectionate rural Basset Hound". He's decently energetic, is quite sassy and smart, and lives in the suburbs.
- Market-Based Title: It is known by different names in several countries. It's called Lorang in Norway, Wurzel in Germany, Laban in Sweden, and Lillo il Cane Saggio in Italy.
- No Name Given: Fred's owners are unnamed.
- Women Drivers: Several jokes revolve around Fred's female owner being a bad driver.