The comic was about a voluptuous blonde woman who wasn't very bright and often went on misadventures that resulted in her being disrobed.
Around 2000 and 2001, Dark Horse Comics collected every strip in two volumes.
- All Men Are Perverts: Pretty much every straight man Annie has encountered wanted to jump her bones.
- Black Comedy Rape: Some strips have men (and on one occasion, a woman) attempt to rape Annie and it's played for laughs.
- Continuity Cavalcade: The strip celebrating Annie's 20th anniversary features appearances by many different one-shot and minor characters from previous strips.
- Dumb Blonde: Annie has blonde hair and is often oblivious of how many men see her as a sex object.
- Gone Swimming, Clothes Stolen: In "Jamaica" (originally published in March 1982), Horst the Jock and Macho Mitch steal Annie and Wanda Homefree's swimwear while they're skinny dipping as part of a ploy to get the girls to kiss them naked underwater.
- Innocent Fanservice Girl: The majority of the time, Annie gets naked and is unaware of men leering at her or trying to fondle her.
- No Celebrities Were Harmed: Many minor characters are stand-ins for famous real-life people. Examples include Ralph Raider (a pastiche of Ralph Nader) and Ernest Schpritzwasser (a spoof of Arnold Schwarzenegger).
- Straw Feminist: Annie's friend Wanda Homefree is depicted as the stereotypical misandrist feminist in the strips "Women's Lib" and "This Exploits Women". Bra-burning in particular is satirized by having women denounce brassieres as a tool of chauvinism and not noticing that the men find it more arousing when they go braless.