- Raoul the werewolf in The Bojeffries Saga is somewhat out of touch with reality, for example giving a black workmate white supremacist propaganda because he thought it was too silly to be taken seriously, and failing to notice that all his relatives moved out of their house for years.
- Calvin from Calvin and Hobbes possesses such a runaway imagination — he truly lives in Cloudcuckooland. The very fact that he sees Hobbes as real and everyone else doesn't (which often makes them suspect that Calvin is insane) also establishes him a place in this trope. The very fact that Hobbes thinks Calvin is crazy would fit him into this trope if that didn't. There's also the time where he comes into his class dressed as his superhero alter-ego, Stupendous Man. His classmates' facial expressions are the natural reaction anyone would have toward a Cloudcuckoolander.Ms. Wormwood: Calvin, pay attention!! Now, what state do you live in?
Ms. Wormwood: [sighing] Well, I suppose I can't argue with that...
Calvin: [during the pledge of allegiance on the first day of school] I pledge allegiance to Queen Fragg and her mighty state of Hysteria.
Calvin: You know why birds don't write their memoirs? Because birds don't lead epic lives, that's why! Who'd want to read what a bird does? Nobody, that's who! [beat] This is changing the subject, but have you ever noticed how somebody can say something totally loony and not be aware of it? What are you supposed to do, just let it slide??
- In Curtis, Gunk exhibits various odd behaviors and abilities (explained by the fact that he's from some place called "Flyspeck Island"), as required by the plot.
- The entire Dick Tracy comic, since Max Allan Collins left. Bad guys getting squashed by steamrollers or having their eyes gouged out; businessmen (both good and bad) who dress like playing cards; characters being incinerated in giant fireballs; hillbillies defending themselves with bear traps; and every once in a while, something that seems to make sense. Rarely.
- Jon Arbuckle from Garfield, since the late nineties, has gone from a slightly-dim, arrogant loser to a full-fledged Cloudcuckoolander in some strips, with lines of pure insanity like "I think my feet are jealous of my hands because they get to point at things." This without even getting into the surrealistic brilliance of Garfield Minus Garfield and other projects to improve the strip.
- Gaston Lagaffe: Gaston, who is a clumsy dreamer who is always seen either dozing off or inventing stuff without any regard for the people in his vicinity. Seriously, who would set the entire floor of his apartment underwater just to make his goldfish feel more at home?
- Get Fuzzy: Both Bucky and Satchel occasionally display these tendencies, and many of Bucky's feline visitors really do.
- A few characters from the Ink Pen comic strip is this, the main example being Captain Victorious. Here, for instance. Or here.
- InSecurity has Sedine, a Genki Girl who sees stuff in a not exactly normal light, much to the exasperation of her husband Sam.
- Jommeke: Professor Gobelijn, an Absent-Minded Professor, who is often doing stuff that either brings him or his town in danger, but he always realizes this when its already too late.
- Krazy Kat. S/he thinks that getting bricks thrown at her/his head is a sign of affection.
- Nero: Abraham Tuizentfloot, an insane dwarf who dresses himself up as a 17th century pirate and attacks everybody with his sabre. Despite that he can't even swim! The comic strip in itself is also full of eccentric and insane characters.
- Sally from Peanuts has her moments:Sally: Wake up, Santa Claus came last night and he didn't leave you anything! * Pause* April fool!
Eudora: This is my literature report. The book I chose to read was the TV guide.
- Her friend Eudora even more so:
Charlie Brown: Why can't I have a normal dog like everybody else?
- Lucy in the earlier strips. Notably the Trope Namer for Little Known Facts—she thought, for instance, that birds flew to the moon.
- Peppermint Patty. To name but one example of her weirdness, she thought that Snoopy was an odd-looking little kid for years.
- Ming in Safe Havens, who especially in her high school and college days tended to do some kooky stuff (like, say, do an interpretive dance at her graduation). Fittingly, she majored in film studies. Ironically, she's not even the weirdest member of the cast, considering there's animals turned humans, a mermaid, and two time travelers among them.
- Hillary's classmate Nona from Sally Forth. Tends to take Hillary and Faye's idle Zany Schemeing and run with the idea into surrealism. All in the same tone of voice one would normally use when discussing lunch.
- Suske en Wiske: Lambik is often seen doing stupid and crazy things he didn't actually thought through. In De Stalen Bloempot, for instance, he tries climbing out of a castle by rope. His rope then breaks and he plummits down. Lambik tries to solve this problem philosophically by letting the rope go, thinking this will make him stop falling. This, of course, doesn't work.
- A real cloud cuckoolander is Vader Van Zwollem, a man who is literally insane, and protected and taking care of by his daughter Anne-Marie Van Zwollem.
- Tom Poes: Wammes Waggel, a naïve goose who is so optimistic and carefree that he never realizes any real danger and thinks everything is a joke.
- Transformers: Wings of Honor: Vortex and Metalhawk get this way when sprayed with chemicals which mess with their processors. Sprocket is revealed to be this way after some feedback when he integrated into a ship. Now he believes that non-sentient machines talk to him, and speaks to imaginary friends. It's gotten to the point where in the final issue, he doesn't even know his brother died, and continues to talk to him as if he was still there.
- Urbanus: Everybody in this comic strip is pretty daft, especially Urbanus and César. They often engage in zany schemes that others just go along with.
- Meanwhile, US Acres had Bo Sheep, who showed more tendencies of this in the comics than the Garfield and Friends animated series.
- Pierce from Zits seems to be always doing his own thing, on impulse, with little regard for consequences.