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Main cast
Garfield
"Big fat hairy deal."
- Voiced by: Frank Welker; Wataru Takagi (Japanese)
The fat orange cat himself.
- Big Eater: Naturally. Rare is the episode that goes by where he doesn’t eat mass amounts of food or think about eating.
- Buffoonish Tomcat: He’s just as slapstick-prone as everyone else in the show, and tends to show a goofier side depending on what the episode calls for.
- Cats Are Lazy: It wouldn’t be Garfield if he wasn’t the epitome of this trope.
- Cats Are Snarkers: He wouldn't be Garfield if he didn't make snide remarks every now and then.
- Deadpan Snarker: Easily the most sarcastic character in the show, often making quips at the expense of his supporting cast.
- Fat Bastard: On his worse days, he can be a complete jerk without showing his more heroic qualities.
- Hypocrite: Occasionally shows a distaste for bullies even though he often bullies Odie, Jon, and Nermal, among others.
- Jerk with a Heart of Gold: He's lazy and tends to be mean, but he will do the right thing when needed. the gold part of the trope is especially prominent in this show compared to the comic strip and previous show.
- Unsympathetic Comedy Protagonist: Has shades of this, being a Jerk with a Heart of Gold who’s constantly put through slapstick antics.
Odie
"WOOF! WOOF!"
- Voiced by: Gregg Berger
A dim-witted canine who is both Garfield's main victim and closest friend.
- Adaptational Intelligence: While he’s still fairly dumb, he’s relatively smarter than his comics counterpart, showing an observant side to his personality.
- Butt-Monkey: Tends to be on the receiving end of Garfield's abuse.
- Cloud Cuckoolander: He's a bit... odd. For example, he fell in love with a grooming brush.
- Heroic Dog: A dog and the nicest of the main trio.
- Nice Guy: He's a light-hearted dog and good friend to Garfield.
Jon
"I could do a comic about a cat who eats lasagna and sleeps all day! And a puppy with a long tongue that fetches sticks all the time!"
- Voiced by: Wally Wingert; Toshihiko Seki (Japanese)
Garfield's often hapless owner.
- Adaptational Intelligence: Normally a goof and doofus in the comics, he's more intelligent here and catches onto Garfield's antics quicker.
- Adaptational Jerkass: Some episodes see him act like more of a jerk than his comics counterpart, often in the form of applying harsher punishments to Garfield’s misbehavior and punishing the generally better-behaved Odie alongside him.
- Birthday Episode: "Delicious Donut Day" takes place on his birthday and has him trying to keep Garfield from eating the box of Darcie's Donuts delivered to him by Herman Post. Garfield ends up eating them all, but only because Squeak informed him that everyone Jon knew had mailed boxes of Darcie's Donuts to him.
- Butt-Monkey: It's not as bad as in the comics, but he still has some pretty bad luck.
- Jerkass Ball: While his anger at Garfield's misbehavior is understandable, he occasionally goes too far when enacting punishment, often into Kick the Dog territory (e.g. threatening to let Garfield starve if he touches Liz's birthday lasagna in "Curse of the Were-Dog").
- Nice Guy: While he still grabs the Jerkass Ball often, for the most part he's a good-natured guy.
- Official Couple: With Liz, like in the comics.
Nermal
"Hiya, Garfield!"
- Voiced by: Jason Marsden; Hideto Nitta (Japanese)
An obnoxious kitten who fancies himself the cutest in the world.
- Adaptational Jerkass: While he wasn't a saint in the comics or the old show, his jerkass side is more prominent here.
- Asshole Victim: He’s just as prone to Garfield’s torment as the rest of the cast, but it’s often justified given his own jerkass behavior.
- Attention Whore: If he's not goading Garfield to see how irresistibly cute he is, he's heading out into town solely to have people praise his looks.
- Berserk Button: Don't call him mangy.
- Bitch in Sheep's Clothing: He uses his cuteness to get away with several instances of jerkish behavior.
- Cute Kitten: Naturally. People will stop in the streets to fawn over how cute he is.
- Jerkass: He openly mocks Garfield for not being as cute as him, and can be quite cruel towards him otherwise. In addition, he's a self-absorbed Narcissist who only cares about looking nice.
- Jerkass Has a Point: When Garfield asks why he and Odie won't share the food they were given for caroling with him in "Christmas Capers", Nermal replies by pointing out that Garfield never shared any of his food with them, so they don’t see why they have to share with Garfield. Garfield concedes that Nermal is right.
- Jerk with a Heart of Gold: He may be an egotistical jerk, but when push comes to shove, he's one of the good guys.
- Karma Houdini: In “King Nermal”, he manages to get away with faking an injury and making Garfield and Odie look bad. Fortunately this isn't the case in all his other appearances.
- Small Name, Big Ego: He proudly brags about being the "World's Cutest Cat" in his appearances, and takes it poorly if he’s upstaged.
Liz
"Oh, Jon. You're so wonderful."
- Voiced by: Julie Payne
Jon's loving girlfriend and a veterinarian.
- Adaptational Nice Guy: While her comic strip counterpart took a while to warm up to Jon, here she’s nice and dating him from the start. Justified, given that the cartoon was meant to match the then-current status quo.
- Deadpan Snarker: Toned down heavily, but still can pop up regularly.
- Forced Transformation: Is turned into a mouse for much of "Every Witch Way".
- Official Couple: With Jon, as in the comics.
Arlene
"The guy I want has to be one-of-a-kind, with a great sense of humor."
- Voiced by: Audrey Wasilewski
A kind yet snarky pink cat, and Garfield's love interest.
- Advertised Extra: She appears in the title sequence with the other main characters, but doesn't appear nearly as often as the others in the show itself.
- Morality Pet: She tends to bring out Garfield's better side.
- Satellite Love Interest: Usually only really exists to be a potential love interest for Garfield.
Allies
Vito Cappelletti
"Let Vito show you how pizza should be made!"
- Voiced by: Jason Marsden
Owner of Vito's Pizzeria, Garfield's favorite pizzeria.
- Depending on the Writer: In some episodes, he dislikes Garfield due to his gluttony; in others, he's grateful towards him (usually after he defends his restaurant).
- In the Blood: The "Lasagna Tree" special shows that cooking runs in the family, as his mother's lasagna recipe is about the only thing that can match his cooking.
- Supreme Chef: He's the local owner of an Italian restaurant/pizzeria and generally acknowledged as one of the best cooks in the show.
Eddie Gourmand
"Now that the lasagna's ready, we can go to work on our lovely caesar salad!"
- Voiced by: Frank Welker
A pompous but jolly TV food critic and cook.
- Big Fun: What he usually is: a large, jovial man who loves eating.
- Caustic Critic: While he isn't normally this, he briefly becomes one in "Inside Eddie Gourmand", prompting an investigation from Garfield.
- Depending on the Writer: Whether he's Big Fun or a Fat Bastard tends to depend on what the episode's plot requires.
- Hypocritical Humor: In the "Mean Machine" special, he encounters his own robot double and derides him for being obese and having poor taste in fashion.
- Meaningful Name: His surname is Gourmand and he's a food critic.
Drusilla and Minerva
"We wanna play with the kitty cat!"
- Voiced by: Laura Summer
Jon's hyperactive twin cousins.
- Audience Surrogate: In "Long Lost Lyman", they serve as this, with Jon telling them (and by extension the viewer) what happened to Lyman.
- Bratty Half-Pint: They're not intentionally bratty, but they still act like this on occasion.
- Genki Girls: A pair of overzealous young girls
- Girlish Pigtails: Both have their hair in pigtails.
- Identical Twin ID Tag: Drusilla has red glasses, a striped sweater, and no bangs; Minerva has green glasses, a flower-patterned sweater, and bangs.
- Identical Twin Mistake: Other characters, including themselves, have difficulty telling the twins apart.
- Single-Minded Twins: They're always in agreement with each other.
Squeak
- Voiced by: Gregg Berger
A mouse who is a good friend of Garfield.
- Nice Mice: He's a mouse and a frequent ally of Garfield.
- Odd Friendship: He, a mouse, is friends with Garfield, a cat. It certainly helps that Garfield doesn't eat mice.
- Seers: One episode sees him supposedly develop the ability to see the future. In actuality, he's just watching a rerun of the episode he's currently in.
Harry
"Whatever you say, Garfield."
- Voiced by: Gregg Berger
A scraggly and selfish alley cat. He and Garfield are technically friends, but they are often in conflict.
- Curb-Stomp Battle: He handily defeats Garfield in a straight fight in "The Bluebird Of Happiness", not helped by Garfield being out of shape (which he points out).
- Foil: He's essentially Garfield with several of his morals removed.
- Jerk with a Heart of Gold: Harry is a bit rude and rough around the edges, but can still be a good friend of Garfield's when necessary, such as warning him about Angel in "Little Angel".
- Paper-Thin Disguise: His disguise as "Kittykins" consists of nothing but him wearing an orange wig, yet Garfield is unable to see through it until the reveal.
- With Friends Like These...: He constantly acts like a jerk, but is considered a friend of Garfield regardless.
Nimbus
"I forgot. They have gravity on this planet. Let's see what's around here."
- Voiced by: Frank Welker ("Freaky Monday")
A friendly but incredibly incompetent visitor from another planet.
- Alien Arts Are Appreciated: He loves Earth's marshmallows.
- Little Green Men: The kind of alien he is.
- Nice Job Breaking It, Hero: He tries to be helpful, but his help often leads to trouble for Garfield and Odie.
Mrs. Ester Cauldron
"The strongest magic doesn't come from the wand, but from the heart."
- Voiced by: June Foray
A kindly old lady and veteran witch.
- Cain and Abel: The Abel to Varicella's Cain.
- Cool Old Lady: She's a witch and often an ally to Garfield.
- Dark Is Not Evil: While she dresses up in dark clothes and practices witchcraft, she's one of the nicest characters on the show.
- Laser-Guided Amnesia: Inflicts this on other characters in some episodes, usually making them forget that witches are real.
- Really 700 Years Old: A throwaway line reveals she's about 300 years old.
- Witch Classic: She looks like your stereotypical elderly witch.
Winona Cauldron
"I will find someone someday, won't I?"
- Voiced by: Laraine Newman
Mrs. Cauldron's niece. While relatively nice, she has a tendency to go overboard whenever she gets a crush on someone.
- Abhorrent Admirer: To Jon and, later, to Doc Boy.
- Badass Teacher: Has become a teacher in the "Bewitched" special, and is a fairly skilled witch on top of that.
- Character Catchphrase: "For sure."
- Dark Is Not Evil: She wears dark clothes and skull earrings, but tends to be a Jerk with a Heart of Gold at her worst.
- Hot Witch: A pretty blonde witch.
- In Love with Love: Her crushes on the Arbuckle brothers seem to stem from her desire to have a boyfriend at all.
- Jerk with a Heart of Gold: Obsessive crushes aside, she’s a fairly nice woman.
- Meaningful Name: "Winona" means "firstborn daughter" and she's the elder of the Cauldron nieces.
- Purple Is Powerful: A beautiful, powerful witch in a purple long-sleeved shirt.
- Shout-Out: Her hairstyle makes her resemble Sabrina the Teenage Witch.
- Team Mom: Acts as a mother figure to Abigail in the "Bewitched" special, and supports her younger cousin the most.
- Took a Level in Badass: She's become a full-fledged witch in "Bewitched" special, with the power boost to go with it.
- Took a Level in Kindness: She loses several of her negative traits in the "Bewitched" series.
Abigail
"I did it! I cast an important spell, and it seems to be working!"
- Voiced by: Laraine Newman
Another niece of Mrs. Cauldron, a mischievous but kind-hearted witch in training who develops a close bond with Garfield.
- Badass Adorable: Young and cute, but still able to hold her own in combat.
- Cute Witch: An adorable young witch-in-training.
- Friendless Background: Most of her peers at witch school bully her.
- Hair of Gold, Heart of Gold: A blond-haired Nice Girl and the main heroine of "Bewitched".
- Pink Means Feminine: Her clothes in the human world are primarily pink.
Angie
"The animals around here are mostly endangered; species that could become extinct if they aren't allowed to breed."
- Voiced by: Misty Lee
A tour guide with a love of animals. She used to work for Dirk Dinkum, but quit due to his cruel nature; the two of them frequently oppose each other now.
- All Love Is Unrequited: Her second appearance all but states she has a bit of a crush on Jon, but he's already dating Liz. She accepts it without much fuss, telling Liz she's a lucky woman.
- Foil: To Dirk Dinkum; he's the money-hungry poacher to her kind-hearted Friend to All Living Things. Naturally, they tend to clash with each other.
- Hair of Gold, Heart of Gold: She's got blonde hair and is a kind character overall.
- Nature Lover: She spends most of her time outdoors, researching and protecting various endangered animals.
Mary Margaret
- Voiced by: Candi Milo
Squeak's talkative niece who has an interest in Portugal.
- Accessory-Wearing Cartoon Animal: She wears a pair of pink glasses and a blue bow atop her head.
- Badass Adorable: Despite only being a tiny mouse, she still manages to hold her own against Bruno when he tries to eat her.
- Motor Mouth: She speaks quite quickly.
- Pint-Sized Powerhouse: She may be small, but she is still strong enough to throw around a cat that's many times her size. Just ask Bruno.
Recurring antagonists
The Space Lasagna
"We will find that orange creature, and we will destroy him!"
Invading aliens who bear a striking resemblance to Earth lasagna.
- Alien Invasion: Their goal is to invade and conquer Earth.
- Aliens of London: They have Italian accents, to go with their resemblance to an Italian food.
- Arch-Enemy: They see Garfield as theirs, given that he eats lasagna on a regular basis.
- Evil Sounds Deep: Spumoni has an extremely deep voice, which leads to Vocal Dissonance when he uses his natural voice in his "cute kitten" disguise.
- Heel–Race Turn: After Spumoni takes over, the entire species presumably gives up conquering Earth, given that we only see them again in a What If? episode.
- Large and in Charge: Their former leader, King Parma, is the tallest of all of them.
- Ridiculously Cute Critter: In "Cuter Than Cute", they send Spumoni down to Earth in the form of a kitten cuter than Nermal to learn Garfield's weaknesses. Spumoni ends up liking the attention so much he pulls a Heel–Face Turn.
Aunt Ivy
"Hmph. I see this dump hasn't changed one bit."
- Voiced by: Laraine Newman
Jon's extremely overbearing aunt.
- Control Freak: When she arrives at the Arbuckle home, she rules it with an iron fist.
- Evil Aunt: She's less outright evil and more of a Jerkass, but she's Jon's aunt and she frequently serves as an antagonist.
- Fat Bastard: She's noticeably overweight and is a recurring antagonist.
- Jerkass: Even Nermal and Squeak, a self-proclaimed pest, can't stand to be around her. The only people she doesn't act like a jerkass to are Drusilla and Minerva.
- Pet the Dog:
- She treats Drusilla and Minerva (and in "Everything's Relative", her twin sister and other nieces) better than any other member of her family.
- In "Delicious Donut Day", she is one of the people mentioned to have mailed Jon Arbuckle a box of Darcie's Donuts for his birthday.
- Why Did It Have to Be Snakes?: The one thing she hates most in the world is mice.
Mama Meany
"I never give anyone their money back, and you know why? Because people are stupid. They never catch on that the stuff I sell is garbage!"
- Voiced by: Gregg Berger
The greedy owner of a pizza place. As his food tastes terrible, he usually resorts to underhanded tactics to make money.
- Corrupt Corporate Executive: He partakes in several shady business deals in the name of getting more money.
- Engineered Public Confession: The "Lasagna Tree" special ends with Garfield using Eddie Gourmand's robotic cameraman to ruin Mama Meany's business by recording Meany gloating about making his fortune by selling horrible and cheaply-manufactured food as well as calling his customers idiots for continuing to fall for his scam. The recording ends up being broadcasted worldwide, resulting in the public turning against Mama Meany and his restaurants going out of business.
- Eye-Obscuring Hat: He wears a cowboy hat that covers up his eyes.
- Fat Bastard: Overweight and a recurring antagonist.
- Lethal Chef: Most of the food he sells qualifies as barely edible at best, which means he often relies on bribing his customers with coupons and deals.
- Names to Run Away from Really Fast: His name is Mama Meany, and he's just as corrupt as that implies.
- One Bad Mother: Yeah, he's a man who goes by Mama Meany, and he's more Meany than Mama.
- The Rival: To Vito when it comes to pizza-making.
- Villainous Gold Tooth: He is the greedy, crooked owner of a pizza place and a recurring antagonist. He has a golden tooth.
Nathan
"Puppy! You're gonna help me with my new science experiment!"
- Voiced by: Melissa Disney (Season 1), Grey Griffin (Season 2 onward)
A brilliant but maniacal boy inventor who wants to conquer the world.
- Bitch in Sheep's Clothing: Odie goes to him initially because he seems nicer than Garfield, but he soon reveals his true colors.
- Child Prodigy: A young genius constantly creating new inventions.
- Enfant Terrible: He's just a kid, yet he's evil and desires to conquer the world.
- Evil Genius: Loves creating inventions to torment others.
- Mad Scientist: He uses his genius to create nefarious inventions and he wishes to take over the world.
- Suspiciously Similar Substitute: Is basically Roscoe from from the Garfield and Friends episode "Brain Boy", but even meaner.
Doctor Whipple
"After several hours of my training, you'll be a tame, docile cat like Kittykins here!"
- Voiced by: Stan Freberg
An unpleasant psychologist who is often in conflict with Garfield and Jon.
- Bad People Abuse Animals: He's not nice to the animals under his care.
- Depending on the Writer: Sometimes he's portrayed as a good guy; sometimes he's an antagonist.
- Psycho Psychologist: A psychologist and a recurring antagonist.
Anthony Allwork
"I'm a lawyer, Arbuckle. It's my job to sue people."
- Voiced by: Jack Riley
A corrupt lawyer who causes trouble with his various get-rich-quick schemes.
- Alliterative Name: Anthony Allwork.
- Amoral Attorney: He's a lawyer in his first appearance.
- Corrupt Corporate Executive: He takes control of the weather so he can sell season-appropriate items at exorbitant prices, for starters.
- Frivolous Lawsuit: His debut episode has him obsessed with suing other people, even going so far as to plan on suing his cousin and his own mother.
- Meaningful Name: His last name is Allwork, and he's a Corrupt Corporate Executive.
- Parental Neglect: He's neglectful of his son Jack.
- Pet the Dog: As neglectful as he is of Jack, he does try to make him happy when he can.
The Dogcatchers
- Voiced by: Jason Marsden (Pete), Wally Wingert (Al)
A group of dogcatchers who frequently go after the neighborhood's stray animals, including Garfield and Odie.
- Bad Boss: Mr. Cannell, who frequently threatens to fire Pete and Al over their mistakes.
- Diabolical Dog Catcher: They're a group of dog catchers who frequently serve as antagonists.
- Fat and Skinny: Al is the Fat, Pete is the Skinny.
- George Jetson Job Security: Mr. Cannell frequently fires Pete and Al for their incompetence, but they're always seen back on the job by their next appearance.
- Pounds Are Animal Prisons: Literally, in this case — any pet that breaks the law will end up hunted by these guys and tossed in the pound for their crimes.
Hercules
- Voiced by: Jason Marsden
A tiny yet aggressive chihuahua who lives next door to Garfield.
- The Bully: Often bullies other pets as well as humans, his favorite tactic being stealing their things.
- I Just Want to Have Friends: "Desperately Seeking Pooky" reveals that he's actually pretty lonely and desires friends, but his aggressive personality drives people away.
- Mister Muffykins: He's a small dog who also happens to be a bully and thief.
Minor/one-shot antagonists
Neferkitty
- Voiced by: Susan Silo
The high priestess of a cat-populated alternate dimension who seeks to rule over humanity.
- Be Careful What You Wish For: In her first appearance, she desires to escape her dimension. She gets what she wants, only to lose the power she had and get stuck with the embarrassing name Fuzzbutton.
- Embarrassing Nickname: Liz's niece gives her the name "Fuzzbutton" after adopting her, something she greatly resents.
- The Prophecy: She and the rest of her people believe in a prophecy that they'll gain their freedom when a cat and dog that match Garfield and Odie's descriptions come to their dimension. Her next appearance reveals that it technically came true: by trapping Neferkitty in his dimension, Garfield freed the other cats from her tyrannical rule.
- Taken for Granite: In her second appearance, she tries to use a magical artifact to turn every human on the planet into stone.
- Take Over the World: Her main goal is to invade Garfield's dimension and take it over.
Angel
- Voiced by: Gregg Berger
A white cat that looks like an innocent kitten, but is anything but.
- Bitch in Sheep's Clothing: He acts like an innocent kitten, but is actually quite cruel.
- The Fake Cutie: He plays up his cuteness to get away with numerous crimes.
- Older Than They Look: Apparently, he shaves his fur to keep himself looking like a kitten; in actuality, he's older than Garfield.
Dirk Dinkum
"If anybody's gonna find the Zabadu and get rich and famous off of it, it's gonna be Dirk Dinkum!"
- Voiced by: Fred Tatasciore
A proud and selfish hunter with a love of money and a lack of empathy towards any living creature.
- Alliterative Name: Dirk Dinkum.
- Arc Villain: He is the antagonist of the "Long Lost Lyman" and "Lion Queen" specials.
- Bad Boss: He constantly mistreats his assistant Buckley, constantly blaming him for all his problems and eventually firing him in "The Lion Queen". This comes back to bite him later; Buckley ends up retaliating by trying to upstage Dinkum in front of his employer.
- The Bogan: He's Australian and far from being a good person.
- Card-Carrying Jerkass: He's outright proud to be a mean and repugnant jerk.
- Egomaniac Hunter: He's a hunter who especially likes hunting rare and exotic animals, targeting the Zabadu in the "Long Lost Lyman" special and the Manzian White Lion in "The Lion Queen" special.
- Evil Cannot Comprehend Good: He has no idea why Angie quit working for him and guesses it's because he didn't pay her enough, even after she directly states it was because of how he treated animals.
- Exit, Pursued by a Bear: His debut ends with him being chased away by the Zabadu.
- Foil: To Angie; she's the kind-hearted Friend to All Living Things to his money-hungry poacher. Naturally, they tend to clash with each other.
- For the Evulz: His whole motivation for being evil is simply because he likes being evil. His Villain Song "Bad Boy" is about how much he loves trolling other people.
- Hated by All: He is loathed by everyone he comes across for his behavior and he is more than proud of the fact.
- Karmic Butt-Monkey: In both of his appearances, he ultimately faces defeat by the very animals he terrorises; his debut has him and Buckley being chased away by the Zabadu, and "The Lion Queen" has an entire zoo give him what for, finishing in him and Buckley being stuck inside a hippo before being hauled away by the police.
- Mean Boss: He treats his lackey Buckley like trash.
- Never My Fault: If something goes wrong, he'll blame it on Buckley, even if it was the direct result of him ignoring Buckley's advice.
- Only in It for the Money: While he's proud to be a jerk overall, pretty much all of his schemes on the show are motivated by a desire to get money.
- Pet the Dog: "Delicious Donut Day" mentions him as one of the people who mailed a box of Darcie's Donuts to Jon Arbuckle for his birthday.
- Villain Song: He sings "Bad Boy" in "The Lion Queen" special, where he gloats about what a horrible person he is.
Buckley
- Voiced by: Gregg Berger
Dirk Dinkum's much-abused underling.
- Butt-Monkey: He's constantly mistreated and blamed for everything by Dinkum.
- The Dog Bites Back: In "The Lion Queen", after being fired by Dinkum, Buckley gets his revenge by bringing in another Manzian white lion to upstage Dinkum in front of his employer.
- Nice Job Fixing It, Villain: His The Dog Bites Back moment ends up reuniting Tania with her mate, giving her the motivation needed to fight back against her captors.
Bella Bellissima
- Voiced by: Laraine Newman
A vain opera singer who desires nothing more than fame.
- Arc Villain: Of the "Little Trouble in Big China" four-parter.
- Berserk Button: Never tell her that she can't sing.
- Hollywood Tone-Deaf: While she believes herself to be a great opera singer, her singing ends up causing pain to all that hear it.
- It's All About Me: Her grand plan is to build an opera house shaped like her face that only she can perform in.
- Right-Hand Cat: She owns two Siamese cats named Siam and Tyham; they're the only things she shows affection for besides herself.
Varicella
"Thanks for doing the hard work for me. Now all I need is the Lilith Wand, and the world is MINE!"
Click to see her after her heel-face turn
- Voiced by: Rose Marie
A literally heartless old witch who wants to turn all humans into frogs.
- Arc Villain: She is the central villain of the "Bewitched" multi-parter.
- Cain and Abel: The Cain to Mrs. Cauldron's Abel, as she is her evil sister.
- Connected All Along: Near the end of the special she appears in, it’s revealed that she is Mrs. Cauldron's sister and therefore Abigail and Winona's other aunt.
- Dark Is Evil: She exemplifies the trope of being as evil as one is hideous, in contrast to the other witches.
- Evil Aunt: To Abigail and Winona, as the revelation of her being Mrs. Cauldron's sister makes her their aunt, too.
- Good Costume Switch: Upon reforming, she switches from red and black clothing to a light blue ensemble.
- Green and Mean: Has green skin and is a Wicked Witch.
- Heel–Face Turn: She ends up redeemed at the end of "Bewitched".
- Near-Villain Victory: She almost succeeds in her scheme to turn all humanity into frogs, but ends up reformed when Abigail uses Mrs. Cauldron's heart amulet to replace the heart she is lacking.
- Red and Black and Evil All Over: She's an evil witch who wears red and black clothes.
- Sealed Evil in a Can: She was sealed in Mrs. Cauldron's spell book for 1,000 years.
- Villain Song: In the last part of the "Bewitched" special, she sings "Varicella Song" during her Near-Villain Victory.
- Wicked Witch: A classic example of a villainous witch until her Heel–Face Turn.
Master Control
"Earth people are already forgetting that they should be in command of their technology, instead of the other way around."
- Voiced by: Mark Hamill
A big and powerful robot who desires to rule the earth.
- Arc Villain: He's the main threat faced in the "Mean Machine" special.
- Cyber Cyclops: He's a one-eyed robot.
- Heel–Face Brainwashing: After his defeat, he ends up being reprogrammed to serve Garfield.
- Knight of Cerebus: In contrast to the rest of the villains in the show, Master Control is played surprisingly straight, with his plan to enslave Earth's inhabitants not really being played for laughs by the characters, and being treated as a serious threat in-universe. The few comedic moments he gets being a result of his abuse on his minion Techno.
- Outside-Genre Foe: Possibly the most outlandish foe Garfield has faced in the franchise even within the already weird series, as his modus operandi, design and plans as a world-conquering alien robot all are closer to those found a sci-fi epic than a comedic episodic cartoon about a lasagna-eating fat cat.
- Villain Song: He gets two:
- In "Robot Rampage", he sings "That Fat Cat", where he expresses how crucial it is to eliminate Garfield for his plan to succeed.
- The final part "The Robot Revolution" has him sing "Alarm Song", where he orders his robot minions to stop Garfield and Odie.
- You Have Failed Me: Downplayed, when Techno fails at catching Garfield one too many times, he sends him to work alongside the rest of the people he's enslaved for no pay.
Metalla
- Voiced by: Susan Silo
One of Master Control's lieutenants, and the more overtly evil of the two.
- Co-Dragons: With Techno, both of them serving as Master Control's main lieutenants.
- Cyber Cyclops: She's a one-eyed robot.
- Fembot: The only notable female robot in the story, she naturally has a far more humanoid and feminine body compared to the others.
- Hartman Hips: She has these to compliment her feminine appearance.
- Heel–Face Brainwashing: Like her boss, she ends up reprogrammed to serve Garfield.
- Male Gaze: We get a lot of shots of her behind throughout the special.
- The Smurfette Principle: Of all the robots in "The Mean Machine", she's the only one definitively confirmed to be female.
Techno
- Voiced by: Jason Marsden
Master Control's other lieutenant, a more cowardly robot
- Butt-Monkey: Takes plenty of abuse from his boss.
- Co-Dragons: With Metalla, both of them serving as Master Control's main lieutenants.
- Heel–Face Brainwashing: Like his boss, he ends up reprogrammed to serve Garfield.
- Irritation Is the Sincerest Form of Flattery: He ocasionally mimics Metalla, which annoys her.
- Oculothorax: His body consists of nothing but an eyeball with six arms attached.
Goliath
Master Control's robot chicken
- Animal Motifs: Chickens, Of course!
- Attack of the 50-Foot Whatever: He's the biggest robot to appear in the special.
- Badass Boast: "You will not interfere! You will be CRUSHED!"
- Final Boss: Of the Mean Machine saga.
- Nice Job Fixing It, Villain: After Garfield launches Blenn's compass in his mouth he short curcuits and wraps himself on the sprocket socket and unplugs it.
Ratzo
"Why settle for scraps when you could have the whole thing? We're rodents! We steal stuff! Let's pillage the fridge and eat everything!"
- Voiced by: Corey Burton
A megalomaniacal rat with big ambitions.
- Arc Villain: He is the main antagonist of the "Rodent Rebellion" four-part special.
- Final Boss: Of the 2008 series as a whole.
- You Dirty Rat!: He's a rat in addition to being a conniving jerk who forms a team of rats and other rodents to steal everything in the city.
