A local bad boy and one of the first characters to encounter the Blob. He and Meg are also the first to find out where the blob came from.
- All Guys Want Cheerleaders: Double Subverted. He doesn't show much interest in Meg at first, but they end up together by the end of the movie, although it's relatively subtle.
- Anti-Hero: A delinquent to be sure, but he helps save the day in the end and is a good person deep down.
- Badass Biker: He rides motorcycles and is able to fight trained soldiers hand to hand and helps defeat the Blob.
- Battle Couple: With Megan, who helps him fight and subdue the blob in the climax
- Deadpan Snarker: Half of his lines are sarcastic quips.
- Hero with Bad Publicity: Starts out as this, being considered a delinquent and punk.
- Jerk with a Heart of Gold: For all that he claims not to care about anyone in Arborville but himself, he sure shows concern for them when the chips are down, for the old homeless man in particular. He also returns to rescue Meg and Kevin in the sewer and even helps out one of Meddows' soldiers.
- Mexican Standoff: Between him, Meddows, the military and local police.
Paul's (and later Brian's) girlfriend. She and Paul were on a date when the blob first crashed in. After Paul is killed, she and Brian try to find out where the Blob came from. She ends up having to save her brother when the blob attacks the local movie theater.
- Big Sister Instinct: She risks everything to save Kevin (and to a lesser extent his friend Eddie).
- Took a Level in Badass: At the beginning of the film she was your average teenage cheerleader who was scared of what's going on, by the climax, she is fighting the Blob with a fire extinguisher.
Paul is a popular jock who was on a date with his girlfriend Meg, when the Blob first shows up. Before long, he and Meg come across Brian and an old man who was attacked by the blob. Not long after that, he is killed by the blob in the hospital.
- The Ace: Everyone in town seems to like him, not only because he is an incredible football player, but a total Nice Guy.
- Cruel and Unusual Death: Not that the other deaths by the Blob weren't horrific, but the later victims at least died quickly. Paul and the hobo's deaths were slow and lingering.
- Decoy Protagonist: The film's opening credits are spent showing him winning a football game with Meg cheering him on. Next twenty minutes are about his date with Meg, then he gets snacked on by the blob.
- Lovable Jock: He's not your typical football player stereotype, making his gruesome death especially horrifying.
- Nice Guy: A helpful, all-around decent guy. The reason he gets killed is because he decided to stay with the homeless man at the hospital.
- Sacrificial Lion: The film starts out focusing on him, before he gets eaten by the Blob, showing that Anyone Can Die.
Dr. Christopher Meddows
A scientist who leading a military investigation on the town. He claims to be investigating the blob and it's attacks and has put the town on quarantine. Turns out he and his men created the blob as part of a germ warfare experiment. The quarantine was just part of his plan to get the town killed by the creature.
- Adaptation Name Change: His name is given as "Dr. Bruno Trimble" in the Novelization.
- Asshole Victim: Come on, he deserved it, not matter how he tried to justify his sacrificing the entire town to capture the blob.
- Bad Boss: In addition to be willing to sacrifice the town, he sees Colonel Hargis and his men as disposable too. When one of Hargis' soldiers is stuck in the sewer with Meg and Brian, Meddows makes a point of sealing all three of them inside with the blob despite Hargis' objections.
- Bald of Evil: He doesn't have a hair on his head.
- Big Bad: Is the human antagonist and mastermind behind the mindless Blob's rampage.
- Faux Affably Evil: He's helpful and friendly to Meg and Bryan when they first meet him — then he turn out to be ok with sacrificing an entire town to test the Blob.
- Gone Horribly Right: Considers the Blob to be this, as it is a much more dangerous weapon than a manufactured bacteria.
- Hoist by His Own Petard: He gets eaten by his own creation by the end.
- Knight Templar: Meddows is convinced that the Blob will help the U.S. win the Cold War and help the U.S. in the long run. Very patriotic, until you realize he will kill literally anyone who gets in his way, and dismisses the town of Arborville as acceptable losses.
- Just Think of the Potential: His original plan was to create a germ warfare weapon. He didn't intend for it to mutate into a flesh eating monster, but he is nonetheless pleased by the result.
- The Sociopath: Is capable of acting friendly and helpful, but manipulates the town dwellers and even his own men to achieve his goals, even if it means killing them. He also have high opinion about the botched monstrosity he created, comparing it to other scientific discoveries, like the discovery of the atom. Lastly, when things don't go his way, his composure quickly unravels.
- We Have Reserves: One reason who he's fine trapping one of Hargis' guys in the sewer with Meg and Brian.
- Walking Spoiler: Just mentioning that he has something to do with the Blob gives away a lot of information.
Sheriff Herb Geller
The local sheriff who investigates Paul's death.
- Death by Adaptation: Neither of the cops from the original died.
- Dropped a Bridge on Him: Was set up to be a major character, only to get killed off screen by the Blob.
- Expy: He resembles Captain Esteridge, another Reasonable Authority Figure police officer who pursues the main character for a crime they did not commit played by Jeffrey DeMunn.
- Nice Guy: He seems to genuinely like Brian despite considering him a "punk," and makes an effort to reign in his more abusive deputy Briggs.
- The Sheriff: Of Arborville.
- Reasonable Authority Figure: While he dislikes Brian, he lets him out of custody when they have no proof that he killed Paul.
- Unresolved Sexual Tension: He has a crush on Fran, and the feeling seems mutual. Sadly, it stays unresolved, since the Blob gets them both.
Reverend Jacob Meeker
The local reverend, who sees the Blob as a sign of the Apocalypse.
- All There in the Manual: His first name is given in the Novelization.
- Driven to Madness: As a result of witnessing the blob's attack on the town and being accidentally burned by a misfired flamethrower.
- FaceHeel Turn: Implied. He was certainly driven mad by the experience, but whether he becomes outright evil is another matter entirely.
- Nice Guy: Seemed to be a stand up guy before the blob's rampage ruined him.
- Sinister Minister: Seems to have become one by the end.
- Well-Intentioned Extremist: Another way of looking at his actions towards the end.
Deputy Bill Briggs
Sheriff Geller's hotheaded deputy.
- Death by Adaptation: Neither of the two cops from the original died.
- Fold-Spindle Mutilation: The Blob bends him in half to pull him through the barricade.
- Irrational Hatred: He believes that Flagg is a violent criminal capable of murder, evidence be damned.
- Jerk with a Heart of Gold: Briggs is hotheaded and unreasonable, but he has the interests of the town at heart and gets along well with Sheriff Geller.
- Reasonable Authority Figure: He becomes this in the end, pitching in to help stop the Blob and protect the townsfolk.
- Redemption Equals Death: Shortly after becoming a Reasonable Authority Figure, the Blob gets him.
Dr. Meddows' second in command.
- A Father to His Men: He is visibly reluctant to carry out Meddows' order to seal one of his men in the sewer with the Blob.
- Better to Die than Be Killed: Before the Blob gets him, he detonates two grenades to avoid being painfully devoured.
- HeelFace Turn: The second Meddows dies, Hargis and his men decide to help the townsfolk kill the Blob.
- Redemption Equals Death: Dies after making a HeelFace Turn.
- Taking You with Me: Attempts this with the grenades on his belt. The Blob is not impressed.
Paul's best friend and fellow jock. It is hard to understand why, exactly, that they're friends, since Paul is a Nice Guy and Scott is a date rapist and all around scumbag.
The owner of the local diner.
- Nice Girl: She is kind to everyone, makes a tired and hungry Flagg a sandwich despite the diner being closed, and gives him and an obviously traumatized Meg pie.
- Unresolved Sexual Tension: Sheriff Geller seems to have a crush on her, and she seems to feel the same. It stays unresolved, since the Blob gets them both.
A local transient with a habit of collecting cans, he has the misfortune of becoming the Blob's first victim.
- Crazy Homeless People: Downplayed. Can Man is definitely eccentric and a little spacey, but isn't violent or delusional.
- Expy: Of the old man from the original.
- The Gadfly: He silently mocks Flagg when he fails in a motorcycle stunt before stealing his beer can.
- The Hermit: He lives out in the woods in a makeshift hut with his pet dog.
- Life-or-Limb Decision: When the still-small Blob engulfs his hand, he tries to chop through his wrist with a hatchet. Subverted when the initial cut only attracts the Blob to engulf his forearm, too.
The owner of the local mechanic shop.
- Back for the Finale: After disappearing from the film after the first act, he shows up at the end helping fight off the Blob.
- Black Dude Dies First: Averted. He survives the Blob's climactic rampage through town, and is last seen helping move the remains to the ice house.
- Cool Bike: He owns a customized motorcycle that he loans to Flagg.
- Chekhov's Gun: His snow maker truck proves crucial in stopping the Blob.
The monster itself.
- Adaptational Villainy: Unlike the Blob from the original movie, which was a Non-Malicious Monster, this version has a sadistic streak.
- Blob Monster: The Trope Namer in all its glory.
- For the Evulz: This thing is at least intelligent enough to be sadistic, which is why it sometimes plays around with it's victims or draws out their deaths for as long as possible. Scott's death at the hands of the Blob should give a little insight. Considering that it played Face Stealer with his girlfriend's hollowed-out corpse when it could have simply broke through and caught them both, all of it most likely was to see the glimpse on his face when it kills him.
- It Can Think: Unlike the previous rendition of the creature, this one has a fiendishly clever mind, which gives it the ability to lay traps, plans, and even on occasions displays a genuine streak of sadism while hunting.
- Kill It with Ice: As always. Freezing it solid is the only known way to stop it.
- Took a Level in Badass: At first it has to ambush its victims because of its small size. Later it just rolls over the victims because it's grown big enough.