The Biologic Preservation Organization, a multi-national corporation dedicated to the extermination of sensates.
- Fall From Grace: The organization was originally founded to protect sensates, but turned into one that hunted them down instead. The Old Man of Hoy states that Ruth El-Saadawi would weep if she saw what her life's work has turned into.
- Nebulous Evil Organization: What they have turned into in the present day after 9/11, being a shady organization who hunts sensates.
- They Would Cut You Up: And they would, too. Whispers in particular seems to head BPO's Cutting-Up operations.
The founder of the organization, originally intended to be a place for humans and sensates to pursue mutual good.
- Angsty Surviving Twin: Her twin sister was a sensate who was stoned to death for "witchcraft" after birthing a cluster herself. Ruth created BPO to ensure this sort of thing would never happen again.
- The Ghost: She is never seen in the main story but is a great influence over it, being the founder of BPO.
- Too Good for This Sinful Earth: Consistently portrayed as utterly pure in her intentions, having founded BPO as a sort of Big Good organization for humans and sensates alike.
Richard Wilson Croome
A high-ranking executive in the BPO.
- Friend or Foe: It's hard to tell whether Croome is sincere in what he says to Will or if he is just spinning a yarn because the August 8th cluster has dirt on him. Given his Surprisingly Sudden Death, this question is never definitively answered, but River asserts that he really was pro-sensate.
- Gentleman and a Scholar: He meets Will in an art museum and waxes enthusiastically at length about Rembrandt.
- The Mole: Croome reveals that he is part of a faction within the BPO secretly fighting its current purpose.
- Surprisingly Sudden Death: Just as Croome prepares to make a deal with Will, Whispers uses a lobotomized sensate to stab him repeatedly in the neck.
- You Have Outlived Your Usefulness: A rare non-evil example of this trope, as he does this to Whispers. It doesn't last too long, though.
The man who currently heads BPO, and the overall main antagonist of the show. He is also responsible for the corruption of BPO after 9/11.
- Big Bad: The head of BPO and the one whom Whispers answers to.
- Boom, Headshot!: Jonas kills him remotely by using a prototype of Angelica's technology; a lobotomized sensate shoots him in the head.
- Corrupt Corporate Executive: The Chairman runs a corporation devoted to the extermination of sensates.
- Darth Vader Clone: A high-ranking villain who was horribly burned as a result of a betrayal, so he wears a black bio-mask and uses a voice changer to conceal his identity.
- Establishing Character Moment: His introduction consists into him showing up to face a kidnapped Wolfgang, coldly and calmly referring to sensates as a sickness, before threatening him with a gun and going on a speech about how sapient have been decimating sensates for millennia thanks to their superiority.
- Evil Counterpart: To Ruth El-Saadawi, as he currently heads the BPO and like her is The Ghost but, if his employment of The Sociopath Whispers is any indication, his intentions are anything but benign.
- Evil Old Folks: Old enough to have grey hair, and responsible for the entire corruption of the BPO.
- Facial Horror: He wears a bio-mask to conceal the extensive burn scars that cover his face.
- Fantastic Racism: He is quite openly hateful toward sensates, comparing them to a disease and delivering a speech to Wolfgang about how sapiens are superior.
- The Ghost: In season two, he is never seen in the main story despite his influence constantly hanging overhead. He finally makes an appearance in "Amor Vincit Omnia".
- Malevolent Masked Man: He usually wears a gaz mask covering his face due to the injuries from Angelica bombing a room he was in.
- We Hardly Knew Ye: He only makes two appearances in the finale of the show before being unceremoniously killed off despite being the true Big Bad. Admittedly, what we hear and see about him is enough to make yourself an impression of the kind of man he is.
Members and Associates
A British MP who worked with Ruth El-Saadawi in the past and advocated for inclusive society today. He is murdered by Whispers at the behest of the Chairman.
- Killed Offscreen: At first, anyway. The "mass shooting" where he was killed isn't shown at the time it happens, but is seen later as a recording taken by a bystander.
A professor at the University of Chicago, and a pioneer of the neural graft procedure used to lobotomize sensates.
- Playing with Syringes: Helped Whispers in his experiments on Angelica's subcluster.
The doctor who diagnoses Nomi with a disease that requires a lobotomy.
- Boom, Headshot!: This is how Whispers kills him.
- The Butcher: Right there in his name; "Metzger" is "butcher" in German.
- Even Evil Has Standards: He seems a little put off by Janet Marks' casual abuse of Nomi and transphobic behavior.
- Hidden Depths: He's a fan of Nancy Drew as evidenced by having one of the books in his apartment. Amanita says it's proof that he can't be all bad.
- Hoist by His Own Petard: He's offed by Whispers in the body of a sensate Metzger previously lobotomized.
- Meaningful Name: Metzger is German for "butcher," which is apt considering what he does to sensates.
- Morally Ambiguous Doctorate: He's in league with BPO and is one of the doctors who lobotomize sensates for Whispers to use as People Puppets.
- Oh, Crap!: He has this reaction when he realizes Nomi's just made it clear to Whispers that he's been compromised.
- Pet the Dog: Minor but he does make an effort to refer to Nomi by her preferred name, something even her mother refuses to do.
- Strawman Political: Played for laughs. Amanita believes that a picture of him shaking hands with Dick Cheney means he must be evil.
- You Have Outlived Your Usefulness: Whispers has him killed after Nomi contacts him with Metzger's information.
Ruth El-Saadawi's daughter, and a human working in BPO. She aims to return the organization to its original benevolent goals.