Protagonists: Chris Redfield | Leon S. Kennedy
Series canon: Resident Evil | Resident Evil 2 | Resident Evil 3: Nemesis | Code Veronica | Resident Evil 0 | Resident Evil 4 | Degeneration | Resident Evil 5 | Revelations | Damnation | Resident Evil 6 | Revelations 2 | Resident Evil 7: Biohazard | Vendetta
Spin-offs: Gun Survivor/DeadAim | Outbreak | The Umbrella Chronicles | The Darkside Chronicles | Operation Raccoon City
Other media: The Marhawa Desire | Heavenly Island
Voiced by Patrick Seitz
- "All for Umbrella!"
A former Soviet colonel, Sergei Vladimir is Umbrella's chief of security, and following the company's collapse, its acting CEO. As Spencer's right-hand man, Sergei is privy to most of the company's secrets, and specializes in keeping them that way. Characterized by his Undying Loyalty, he has a strong rivalry with the treacherous Albert Wesker. He is the main antagonist of Resident Evil: The Umbrella Chronicles.
- Ax-Crazy: Lampshaded by other Umbrella personnel and Chris. Sergei partly acknowledges his insanity and simply states the people that go down in history as "heroes" are never stable.
- Badass Longcoat: His greatcoat is very badass.
- Big Bad: Of The Umbrella Chronicles (unless you wanna give that role to Wesker).
- Cleanup Crew: Controls the Umbrella Biohazard Countermeasure Service and Monitors, who both specialise in cleaning up/hiding the evidence of Umbrella's screw-ups.
- Colonel Kilgore: Demonstrated by how he greeted Chris and Jill on their arrival at the testing area for T.A.L.O.S. development.
- Dirty Commies: If his constantly addressing you as "Comrade" is any tipoff.
- He was a former Soviet military officer. Obviously, the collapse of the Soviet Union left him without a job until Spencer hired him.
- Dragon-in-Chief: Spencer's still nominally in control of the organisation, but Sergei is the one who is actually running the show.
- Empowered Badass Normal: He was elite Russian military long before he became Umbrella's first Tyrant.
- Eviler Than Thou: With Wesker, to see who will control Umbrella's future.
- Final Boss: Of The Umbrella Chronicle (specifically the Dark Legacy secret chapter), following his mutation into some sort of hideous Tyrant.
- The Unfought: From an in-game perspective; the player gets to face him as Wesker, but the heroes never do.
- Foil: To Wesker. They're both mutant gunmen entrusted to do Ozwell Spencer's bidding, but Sergei remains The Dragon to Wesker's Chronic Backstabbing Disorder-afflicted Wild Card. He'd be Wesker's Evil Counterpart if the latter weren't already a Villain Protagonist.
- They also acted as Psycho Prototypes to Spencer's plans. Wesker was a Psycho Prototype (or at the very least the sole surviving byproduct besides Alex Wesker) for the Wesker Children Project, a project dedicated to using the Progenitor Virus to transform people into super human, whereas Sergei was the Psycho Prototype to the Tyrant Super Soldier line.
- Former Regime Personnel: Recruited by Umbrella following the collapse of the USSR.
- Genius Bruiser: Sergei's far from stupid; in fact, the entire T.A.L.O.S. design was his idea.
- Handicapped Badass: Blind in one eye, due to action in Afghanistan. It doesn't slow him down much.
- The Heavy: In The Umbrella Chronicles, where almost every major event is determined by his actions. More broadly, he fills this role to Ozwell Spencer. Spencer's the mastermind, but his age and crippling leave him reliant on Sergei to do just about everything for him. Actually justified; see Undying Loyalty below.
- Large Ham: As bad as Wesker. Leads to Ham-to-Ham Combat.
- Humanoid Abomination: His horrific form after going One-Winged Angel to battle Wesker can best be described as just short of Eldritch Abomination
- Laughing Mad: In his mutated form while fighting Wesker.
- Licking the Blade: Repeatedly cuts himself with his double-edged knife, before licking up the blood.
- Lightning Bruiser: In the same vein as Wesker.
- The Man Behind the Man: To many of the events in Resident Evil 2 and Resident Evil 3: Nemesis, as well as much of The Umbrella Chronicles.
- Obviously Evil: So, the huge Russian guy in the greatcoat with the booming voice is evil, huh? Who'd'a thunk it?
- One-Winged Angel: Transforms himself into an utterly hideous monstrosity during his confrontation with Wesker.
- Psycho Prototype: You know those Tyrant B.O.W? Well, they were made from his genetic template, meaning that he's the first Tyrant. And boy, is he insane.
- Psycho Supporter: Sergei is, like most Umbrella personnel, highly unstable. His loyalty towards Spencer stems from this.
- That, as well as basically his even being granted a job after he lost his from the collapse of the Soviet Union.
- Renegade Russian: The note towards Nikolai a.k.a Silver Fox indicated that he planned to revive the Soviet Union.
- The Rival: To Wesker.
- Super Soldier: He's actually the prototype to the Tyrant enemies. You can pretty much guess what that means...
- The Spymaster: Almost all of Umbrella's behind the scenes actions are run by this man.
- Undying Loyalty: To Umbrella as a whole, and Spencer in particular. It stems from their giving him a place after the collapse of his homeland.
Voiced by Tara Platt
- "I am Red Queen. My primary objective is the management and protection of Umbrella assets."
A highly advanced and self-aware computer A.I. designed to protect and oversee Umbrella assets. The main part of the system existed in U.M.F.-013, which was transferred to Caucasus Laboratory during Raccoon City Destruction Incident. Later on the A.I. was connected to T.A.L.O.S. to control the B.O.W.
- A.I. Is a Crapshoot: Though she never gets a chance, her objectives are to protect Umbrella assets, protect Umbrella officers, and a third she doesn't get a chance to say, in that order. All she gets to do on-screen is lock Wesker out of the system.
- Canon Immigrant: Until her appearance in this game, she was exclusively a film-verse character.
- In the Rebirth secret chapter, before Red Queen introduced itself to Wesker, the computer screen briefly shown that there was another computer system besides Red Queen, which was called...White Queen. However the name was never mentioned again in the series, so we'd never know what it was used for.
- Master Computer: The Red Queen served as the guardian for all data files accumulated by Umbrella's many branches and divisions across the world. Every single bit of bio-weapon research, every dirty secret, she held custodianship of it all. That's why Wesker seeks her out so he can found Tricell, anonymously sending copies of incriminating data from her files to the US government to get Umbrella closed whilst exploiting the bio-weapon data to help develop Tricell into Umbrella's replacement.
- Names Given to Computers: Ostensibly a type VI, though "Red Queen" is possibly a shout-out to the Red Queen Hypothesis note .
A specially re-engineered derivation of the T-103 Tyrant line designed by Umbrella for Sergei. Only two of them are known to exist and serve as the colonel's bodyguards.
- Body Guarding A Badass: The Ivans seen in the game are bodyguards for Sergei Vladimir, whose genetic compatibility with the T-Virus allows him to dose himself to go One-Winged Angel, becoming more deadly than either of his subordinates.
- Curb-Stomp Battle: The many zombie dogs outside the Spencer Mansion in the events of the first game are the reason the protagonists cannot run out of the estate. One Ivan single-handedly kills all of them to clear path for Sergei.
- It Can Think: The smartest Tyrant model ever produced behind T-A.L.O.S. (which was being aided by the Red Queen), being able to easily pass off as human.
- One-Winged Angel: Subverted, surprisingly. Perhaps intentional in an attempt to make them pass off more as human beings, it seemingly can't mutate after sustaining grievous injuries.
- Super Soldier: In a way, the Ivans are the most marketable of all the Tyrant variations, since they can so easily pass as just ordinary humans.
Biologically engineered by the Umbrella Corporation to be the ultimate Bio Organic Weapon. It is an unholy fusion of highly advanced computer-controlled powered assault armor and a Tyrant, the model T-011.
- BFG: Brandishes a giant multiple rocket launcher on its right shoulder, which it was given to counteract its previous weakness to aerial attack vehicles.
- Cyborg: What separates it from its organic, inferior brethren; it's outfitted with surgically-integrated armor and chips in its brain and nervous system that give it a wireless link to an Artificial Intelligence in a super-computer, which makes it smarter, faster, and more controllable than any previous Tyrant model.
- Fricking Laser Beams: Once it goes One-Winged Angel, the T-A.L.O.S. sports a set of four thin tentacles on its back that it uses to blast cutting lasers at Chris and Jill.
- Lightning Bruiser: The fastest and strongest Tyrant of them all.
- Super Intelligence: Due to its cybernetic link to the Red Queen AI, this Tyrant is much smarter than any human.
- One-Winged Angel: Once it takes enough damage, it undergoes this, though nowhere near as violently as other Tyrants. It abandons its legs, with its spinal column ripping free to attach itself to a computer terminal like an umbilical cable, its upper torso bloats to several times its previous size, its left hand unsheathes massive curling claws, its right arm and hand swells and distorts to become symmetrical with the left arm, its helmet bursts away to reveal a Lamprey Mouth, and it develops a small set of tentacles tipped with laser beam projectors.
- The Right Hand of Doom: Left hand, really. In its default form, its left arm is massively oversized and ends in a primitive, four-fingered hand that it uses to brace itself like an ape, whilst its right arm is human-like. When it goes One-Winged Angel, the right arm swells and elongates to match its left.
- Super Soldier: In theory, at least, the T-A.L.O.S. is the ultimate pinnacle of Tyrant evolution, compensating for all of the flaws established from past models ranging from the T-002 through Mr. X and Nemesis and beyond.