The main male character. Makoto was a normal 12-year-old boy until something awful happened one night that would shape his life forever.
- Affectionate Nickname: Junko calls him "Sweetheart".
- Used to Be a Sweet Kid: However Komaru's death changed that.
- Well-Intentioned Extremist: Let's the world be destroyed. So he and Kyoko could rebuild the world through brainwashing and create their utopia.
- Would Hit a Girl: He kills Komaru accidentally.
The main female character. Kyoko was a 12-year-old girl who was training to be a detective. She was scouting the streets looking for a serial killer when she meets Makoto.
- Affectionate Nickname: Junko calls her "Babe".
- Well-Intentioned Extremist: Let's the world be destroyed. So she and Makoto could rebuild the world through brainwashing and create their utopia.
The leader of the Ultimate Despair. Who has a keen interest in Makoto and Kyoko
- Character Development: Junko becomes nicer as her friendship with Makoto and Kyoko grows.
- Forceful Kiss: Does this to Makoto and Kyoko when the couple agree to Junko's plan
- Honorary Aunt: Becomes this to Makoto and Kyoko's child in the spinoff.
Mukuro is the older twin sister of Junko. She obeys Junko's orders without question.
- Abusive Parents: Is this to Kyoko when she steps out of line.