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Characters from the 2001 film Osmosis Jones.

For characters introduced in Ozzy & Drix, go here.

All spoilers are unmarked. Read on at your own discretion.

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Main characters

    Osmosis "Ozzy" Jones 
https://static.tvtropes.org/pmwiki/pub/images/char_36701_606.jpg
"Next time, I'll be the bad cop."
Voiced by: Chris Rock (movie) Phil LaMarr (TV series)

A hot-headed, impulsive white blood cell whose recklessness has put him in the police department's bad books, Ozzy finds himself having to save Frank's life when his body is invaded by the deadly virus Thrax.


  • All of the Other Reindeer: Most of his fellow officers mock him for trying to catch criminals alone, not to mention the infamous incident that caused Frank to puke on Shane's teacher.
  • Be Careful What You Wish For: When Phlegmming chews him out for blowing up the Zit, he wishes that cells would think about the dangers in Frank rather than the trip to Buffalo, New York. Phlegmming responds with his thought on the matter: firing Ozzy himself.
  • Blue Is Heroic: Even though he's a white blood cell, his color is a light shade of blue.
  • Cheshire Cat Grin: He sports one of these big, wide smiles every now and again.
  • Cool Car: Had his cop car customized.
  • Cool Shades: Occasionally wears a pair of black sunglasses.
  • Cowboy Cop: Constantly ignores orders and goes rogue on the belief he can catch criminals by himself, to the point where he causes more problems for Frank than he solves.
  • Determinator: Chases down Thrax outside Frank's body.
    Thrax: You just don't know when to quit, do ya, Jones?
  • Dogged Nice Guy: Niceness downplayed. He has a little trouble winning Leah Estrogen's affections. He does at the end, though.
  • Drives Like Crazy: To call him a reckless driver is an understatement.
  • Goofy Print Underwear: An X-ray scan when he goes to pick up Drix shows that he's wearing these.
  • Grin of Audacity: He usually smiles in the face of danger to show that everything is going to be okay.
  • Guttural Growler: With Chris Rock's coarse, raspy voice, this is a given.
  • The Hero: What did you expect after reading the title of the movie?
  • I Did What I Had to Do: Ozzy had to eject a dangerous virus via vomit from Frank after the latter ate some raw oysters. He saved Frank's life in the process, but at the expense of his reputation and position.
  • Idiot Hero: Osmosis, fast-talking aside, is not quite as bright as Drixenol.
  • In-Series Nickname: He's always known by "Ozzy".
  • Jerk with a Heart of Gold: He's an egotistical Cowboy Cop, for sure, but he ultimately works for the best interest of his city.
  • Large Ham: What else would one expect from Chris Rock?
  • Master of Disguise: He can use his shape-shifting abilities to make himself utterly unrecognizable, other than his color. Heck, he can even make it look as though he has only one eye!
  • Red Oni, Blue Oni: The red to Drix's blue.
  • Rubber Man: Do you see results in that? He is a white blood cell.
  • Sensitive Guy and Manly Man: The Manly Man to Drix's Sensitive Guy.
  • Sesquipedalian Smith: He's an expert in osmosis, for crying out loud!
  • Shapeshifter Showdown: What saves him against Thrax.
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    Drixenol "Drix" Koldreliff 
https://static.tvtropes.org/pmwiki/pub/images/drix_9360.jpeg
"Special Agent Drixobenzometaphedrimine... Drixenol! The brand that eases your coughs and sneezes."
Voiced by: David Hyde Pierce (movie) Jeff Bennett (TV series)

A sugar pill taken to control a case of throat inflammation, Drix partners with Ozzy to resolve the Thrax crisis.


Movie characters

    Thrax 
https://static.tvtropes.org/pmwiki/pub/images/thrax_7616.png
"Careful. I'm contagious."

A deadly and highly dangerous virus who entered Frank's body when the latter ate a contaminated boiled egg from being in the mouth of a zoo monkey, which was then dropped to the ground. Thrax aims to kill each new host he enters faster than the previous one, wanting to be known in medical textbooks as one of the most deadly diseases in history.


  • Ambition Is Evil: He wishes to be remembered as the most dangerous virus in human history and earning a place in medical books. To reach his goal he infected and killed numerous innocent people and after doing the same thing to Frank he plans to beat his record by killing his little daughter.
  • Asskicking Equals Authority: He gets the bacteria to accept him as their new leader after single-handedly killing their prior boss, Scabies.
  • Ax-Crazy: When it comes to Thrax and his desire to get in the medical books he will pile up as many bodies as he can, and he will do it all with a gleefully wicked smile on his face.
  • Bad Boss: He kills both of his remaining underlings when one of them suggests waiting for some days in incubation before striking, which would've derailed Thrax's plot to kill Frank within 48 hours.
  • Badass Boast: When Scabies mocked Thrax, saying he thinks himself the Ebola Virus.
    Scabies: Look who thinks he's the Ebola virus! (laughs)
    Thrax: "Ebola"? Let me tell you a little something about Ebola, baby. Ebola is a case of dandruff compared to me!
  • Badass Longcoat: One that he can use as a glider at that.
  • Berserk Button:
  • Big Bad: His plans to cause an infection of historical proportions are the reason why Frank is in danger.
  • Big "NO!": He yells this when Ozzy tricks him into getting his claw lodged in a fake eyelash that is about to fall.
  • Bond Villain Stupidity: Rather than using his One-Hit Kill claw on a dazed Ozzy during the final battle, he decides to strangle him using his DNA Chain. This costs him big when Frank's daughter blinks: he loses his grip on the chain, and when he decides to actually use the aforementioned Touch of Death, Ozzy manages to dodge it (by forming a hole in his torso around it) and get Thrax stuck, sealing the virus's fate.
  • Cold Ham: Usually he keeps his voice very light and low, but he is also capable of letting real loose when excited, or angry, as shown above.
  • Cool Shades: He owns a pair of glasses and wears them frequently.
  • Creepy Souvenir: He always keeps a chain made of DNA of his previous victims.
  • Deadpan Snarker: He tends to make dry comments about things he finds off, most notably on the somewhat low quality of Frank's criminal underworld, as well as his memories.
  • Diseased Name: And a Punny Name at that, as his name is a play on the bacterial disease anthrax. This is a bit odd, however, considering that he's a virus and not a bacterium. It's possible that his name is purely for aesthetic.
  • Disney Villain Death: DoubleSubverted. He falls, but the fall doesn't kill him — it's what he falls into that does. And we get to see it.
  • Evil Is Bigger: Downplayed. He towers over every germ and cell we see, and only Drix is larger than he is.
  • Evil Is Burning Hot: Thrax's immolating Touch of Death takes the form of one of his talons (the one on his left index finger) glowing red hot. His plan to kill Frank involves sabotaging his hypothalamus, which is the gland responsible (among other things) for regulating body temperature. Once Thrax steals an important component of the hypothalamus, the temperature skyrockets and deadly fires start breaking out across the city.
    Thrax: Think I'll turn up the heat in here!
  • Evil Sounds Deep: Courtesy of Laurence Fishburne, who is a baritone. His voice is considerably deeper than the raspy tenor of Osmosis Jones.
  • Expy: Given his color scheme and extremely short action timespan, he's one of Edgar Allan Poe's Red Death from "The Masque of the Red Death". This is given a nod via a witness calling him "La Muerte Roja".
  • Fame Through Infamy: He hopes that his murders will get him a chapter dedicated to him in the medical textbooks.
  • Family-Unfriendly Death:
    • His Touch of Death has pretty gruesome results, and one of the first things he does is inflict this on an innocent cell. Said victim proceeds to boil alive from the inside out.
    • Fittingly, this ends up being Thrax's own fate; he falls into a beaker of rubbing alcohol and is completely dissolved.
  • Faux Affably Evil: He likes to hum "Fever" by Peggy Lee and presents himself as charismatic, but this barely hides the monster he is.
  • Finger Poke of Doom: Quite literally with his first victim. "Ow."
  • Glory Hound: Thrax is like a serial killer who's trying to become famous in the most brutal fashion.
  • Horrifying the Horror: Played for Laughs. As part of a funny moment, he's visibly disturbed upon seeing some of Frank's nightmares and bad memories.
    Thrax: (after escaping from the room) Phew! This cat was sick before I even got here...
  • It's All About Me: Given that he's single-mindedly concerned with racking up as many victims as possible in the shortest possible time, it's no surprise that Thrax is a profound egoist.
  • Knight of Cerebus: Were you expecting a movie about Chris Rock as a blood cell to have a virus in the form of a serial killer?
  • Lack of Empathy: He makes everyone around him (both humans and the organisms inhabiting them) suffer without any qualms whatsoever.
  • Leitmotif: "Fever" by Peggy Lee, though it's invoked because he's always humming it. The title alone suits him.
  • A Molten Date with Death: How Thrax meets his end: after Ozzy traps him in a false eyelash that falls into a glass of rubbing alcohol, he's completely liquefied by it once he surfaces.
  • Monstrous Germs: He is a red-skinned humanoid with tentacle-like dreadlocks and a large burning claw on one of his hands.
  • Names to Run Away from Really Fast: Thrax, meant to evoke anthrax.
  • Omnicidal Maniac: Thrax's plans involve killing people, causing the civilizations of cells in their bodies to die. The loss of life is apocalyptic at the cellular level, with an implied decimation among humans (since Thrax wants his own chapter in the medical books, he'd likely seek to become an epidemic, which would entail massive loss of life).
  • The Perfectionist: Thrax wants to kill Frank in record time with hopes of getting his own chapter in the medical books.
  • Playing with Fire: His fingernail claw burns whatever he scratches into a melting, burning lava mess.
  • Red and Black and Evil All Over: Red-skinned, dressed in black, and ''definitely'' evil.
  • Sadist: He revels in the pain he causes and enjoys seeing his victims' suffering.
  • Scary Black Man: Invoked by Laurence Fishburne.
  • Serial Killer: He keeps DNA beads stolen from each of his victims as trophies and reminisces about them.
  • A Sinister Clue: Only a given, since that's the hand he uses to kill all his victims and spread his infection.
  • Sinister Shades: Aside from making Thrax look cool, they also highlight his overall Lack of Empathy.
  • Slasher Smile: He sports quite a few throughout the movie, the most notable one being when he threatens to kill Frank's daughter.
  • Terrorist Without A Cause: He's disturbingly similar to a modern day terrorist who commits acts of mass murdering just to make himself famous.
  • The Sociopath: He'll kill as many people as it takes to get into the medical books.
  • Too Spicy for Yog-Sothoth: Finds Frank’s subconscious dreams a bit too much to handle and runs away from them in mild horror.
  • Touch of Death: His left index finger causes any organic matter it touches to combust or explode.
  • Vile Villain, Saccharine Show: And how. Apart from the serial killer overtones, there's his meeting with the group of germs in the Zit. With his plan to organize coordinated assaults with the intention of causing widespread death and destruction, also spreading fear and intimidation outside Frank. Thrax comes across as a leader of a terrorist group planning an attack. It's jarring how such a most evil, murderous, vicious, sadistic, monstrous villain managed to stick in an otherwise light-hearted comedy.
  • Villainous Cheekbones: Thrax's cheekbones are so pointy they look sharp, and he his clearly evil.
  • Would Harm a Senior: He boasts that he killed an old man in 72 hours.
  • Would Hurt a Child: Aside from threatening to have poor Shane join both of her parents in death after having her father die right before her eyes, Thrax previously killed another girl who didn't like to wash her hands.

    Mayor Phlegmming 
https://static.tvtropes.org/pmwiki/pub/images/char_36705.jpg
Voiced by: William Shatner

The short-sighted and self-serving mayor of the City of Frank, whose poor decisions and attempts to secure his own position led to Frank's deteriorating health and both began and exacerbated the virus outbreak.


  • Fat Idiot: He clearly doesn't see what could happen if he keeps giving Frank junk food instead of healthy food, hence the obesity.
  • Hate Sink: As he is designed to represent and justify Frank's poor health, he inevitably ventures into this. Notably, he abolishes Ozzy from the police force for popping a pimple on Shane's teacher even though it was an emergency situation, fails to acknowledge Thrax as a threat despite the fact that he had killed others in the past (dismissing him as the common cold when he was one of the deadliest viruses ever), and is the only one that doesn't see the problem in giving Frank nothing but junk food (and is oblivious to how it's straining Frank's relationship with Shane).
  • It's All About Me: Even when a threat to the city is imminent, he retains a shockingly solipsistic attitude.
  • Jerkass : He certainly is, especially to Ozzy.
  • Laser-Guided Karma: Abolished Ozzy for having Frank throw up to get out an evil virus. Then at the end when he's been booted out of office, he presses a similar button and winds up flushing himself right out of Frank's own body.
  • Mayor Pain: Though he's not corrupt per se, he's VERY incompetent at his job and cares more about his election than anything else.
  • The Napoleon: Is the shortest of all the adult cell charactersnote  and easily the angriest and most egotistical.
  • Obstructive Bureaucrat: Let's see, he fired Osmosis and gets Drix out of Frank just for popping a pimple without permit (Which is like blowing up a building in the real world) and as mayor control's nearly all of Frank's actions, including his slovenly behavior. Said neglect almost ends up killing the guy and every cell with him.
  • Sleazy Politician: To a tee.
  • Too Dumb to Live: His actions almost get his city destroyed. The end of the film shows he still hasn't learned his lesson about taking warnings seriously when he presses a button under a "Do Not Touch" sign.
  • Underestimating Badassery: Thinks Thrax is no real threat to the city. He's very wrong.

    Leah Estrogen 
https://static.tvtropes.org/pmwiki/pub/images/leah_estrogen.jpg
"Come here, baby. I'm still Jonesin' for a little more Osmosis."
Voiced by: Brandy Norwood
Mayor Phlegmming's secretary and who Ozzy is deeply in love with.
  • Damsel in Distress: Is taken hostage by Thrax, and very nearly killed by him.
  • Graceful Ladies Like Purple: Her suit and even her body are both purple.
  • Impossible Hourglass Figure: Downplayed, but her waist is still tiny compared to her bosom and hips.
  • Jerk with a Heart of Gold: She may be aloof and unpleasant towards Ozzy, but she ultimately turns out to be a very good-hearted character, and even tries to talk some sense into Phlegmming.
  • Non-Mammal Mammaries: Part of being a female human cell.
  • Office Lady: Works as a secretary for Mayor Phlegmming.
  • Official Couple: With Ozzy in the end.
  • Only Sane Woman: In Phleggming's office. She is the only one who tries to talk sense into him, and is brave enough to confront him when his irresponsible ways cross the line.
  • Peek-a-Bangs: Downplayed; one of her bangs falls over her right eye ever so slightly.
  • Sassy Black Woman: Thanks to Brandy.
  • She's Got Legs: That mini-skirt isn't helping the fact that she has long, shapely legs.
  • The Smurfette Principle: Although Leah isn't the only female anthropomorphic cell in Frank's body, she's the only one with Nominal Importance.
  • Tritagonist: To Ozzy and Drix's protagonist and deuteragonist respectively.
  • Tsundere: Type B. Very rough around the edges, but her heart is very much in the right place.
  • Women Are Wiser: Comes into play when she confronts Phleggming about his devil-may-care attitude towards an alert that the hypothalamus is under attack.
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    Police Chief 
Voiced by: Joel Silver
As the name implies, the chief of Frank Police Department who runs who runs a tight ship. He expects nothing but the best from Frank's Finest, but often clashes with Ozzy for disobeying orders.
  • Adipose Rex: He is very corpulent.
  • Benevolent Boss: He expects nothing but the best from his police force, hence why he is upset with Ozzy going over his head. It's also heavily implied that he strongly dislikes Mayor Phlegmming and rightly believes his department's job to keep Frank healthy is becoming harder because of him.
  • Da Chief: Fits this trope to a "T."
  • Everyone Has Standards: He frequently tells off Ozzy for going rogue and causing mayhem, but even he thinks Phlegmming firing Ozzy was a bit excessive.
  • A Father to His Men: Cares deeply about the safety and the performance of all his officers, including Ozzy. Indeed, part of the reason he berates Ozzy a lot is because he genuinely wants him to do better, unlike most of the other police officers and Phlegmming who see him as a laughingstock.
  • Jerk with a Heart of Gold: He may be at odds with Ozzy a lot, but he ultimately trusts him to do what's right.
  • Kicked Upstairs: Does this to Ozzy by assigning him to the throat do deal with a case of pharyngitis, under the condition that he has a partner.
  • Large Ham: "JONES!!! My office!!!"
  • No Name Given: His name is never given in the movie or even promotional material.
  • Reasonable Authority Figure: He's takes Frank's health much more seriously than his boss, and does see some value in keeping Ozzy in the force despite his destructive antics.

    Scabies 
Voiced by: David Ossman

    Bruiser and Joe Cramp 
Voiced by: Rodger Bumpass (Joe Cramp) and Herschel Barber (Bruiser)

    Francis "Frank" DeTorre 
https://static.tvtropes.org/pmwiki/pub/images/435151_frank_detorre.jpg
"99 kinds of wings! 128 different dipping sauces! You love math, crunch the numbers on that - and tell me the possibilities aren't infinite!"
Played by: Bill Murray
The slovernly zookeeper whose body the film takes place. He doesn't have very much regard for hygiene and health despite his daughter's pleas.
  • Bumbling Dad: He means well, and does care about Shane, but he has a major selfish streak. Though this is mostly due to Mayor Phlegmming overriding his body for his own ends.
  • Does This Remind You of Anything?: Its stated that Frank's poor health choices began after the death of wife which is explained as the results of the Mayor Pain in control of his body. From the outside looking, he acts exactly like someone who is eating for comfort while suffering from depression.
  • "Fantastic Voyage" Plot: The plot takes place inside Frank's body
  • Fat Idiot: He ate a lot of junk food after his wife died, but after his near-death experience, he decided to eat healthier.
  • Guys Are Slobs: Played straight and subverted, as in a flashback we hear Shane complain that neither he or Maggie, his wife, take care of themselves very well, Frank just got worse after Maggie died.
  • The Mourning After: Still mourning the loss of his wife, Maggie. Justified, as it seems to be a relatively recent loss.
  • Too Dumb to Live: What kicks off the whole plot as he eats an egg that was inside the mouth of a chimpanzee and got spat out onto the ground. Yeah, that seems safe to eat.

    Shane DeTorre 
Played by: Elena Franklin
  • Broken Bird: Became this for multiple reasons, namely her mother's death, her father vomiting on her teacher and getting fired, a restraining order and a dead end job at the zoo as a result of it and finally, her being ostracized by her peers because of the incident.
  • Children Raise You: Takes care of her dad, because he doesn't take care of himself.
  • Gender-Blender Name: Her first name is predominantly used by boys.
  • Missing Mom: Her mom died of an unspecified illness. Though it's implied she was as unhealthy as Frank has been throughout the movie.
  • Only Sane Woman: Shane often has to be the adult between her and her father.
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