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Characters / Osmosis Jones

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    Osmosis "Ozzy" Jones
Voiced by: Chris Rock

A hot-headed, impulsive white blood cell whose recklessness has put him in the police department's bad books, Ozzy finds himself having to save Frank's life when his body is invaded by the deadly virus Thrax.

  • All of the Other Reindeer: Most of his fellow officers mock him for trying to catch criminals alone, not to mention the infamous incident that caused Frank to puke on Shane's teacher.
  • Blue Is Heroic: Even though he's a white blood cell, his color is a light shade of blue.
  • Cassandra Truth: When Jones discovers Thrax's plan to kill Frank, no one takes him seriously, seeing his and Drix's "popping a pimple without a permit" as a bigger deal, and a testimony to Ozzy's frivolous behavior.
  • Cheshire Cat Grin: He sports one of these every now and again.
  • Cool Car: Had his cop car customized.
  • Cool Shades: Occasionally wears a pair of black sunglasses.
  • Cowboy Cop: Constantly ignores orders and goes rogue on the belief he can catch criminals by himself, to the point where he causes more problems for Frank than he solves.
  • Determinator: Chases down Thrax outside Frank's body.
    Thrax: You just don't know when to quit, do ya, Jones?
  • Dogged Nice Guy: Niceness downplayed. He has a little trouble winning Leah Estrogen's affections. He does at the end, though.
  • Drives Like Crazy: To call him a reckless driver is an understatement.
  • Goofy Print Underwear: An X-ray scan when he goes to pick up Drix shows that he's wearing these.
  • Guttural Growler: With Chris Rock's raspy voice, this is a given.
  • The Hero: What did you expect after reading the title of the movie?
  • Heroic BSoD: He falls into one after he is fired from the force by Mayor Phleggming.
  • I Did What I Had to Do: Ozzy had to eject a dangerous virus via vomit from Frank after the latter ate some raw oysters. He saved Frank's life in the process, but at the expense of his reputation and position.
  • In-Series Nickname: He's always known by "Ozzy".
  • Jerk with a Heart of Gold: He's an egotistical Cowboy Cop, for sure, but he ultimately works in the best interest of his city.
  • Large Ham: What else would one expect from Chris Rock?
  • Master of Disguise: He can use his shape-shifting abilities to make himself utterly unrecognizable, other than his color. Heck, he can even make it look as though he has only one eye!
  • Nice Job Breaking It, Hero!: He did the right thing causing Frank to vomit, thereby saving him from a contaminated oyster, but it caused Frank to lose his job and the respect of the local community, and got Ozzy suspended for "use of unnecessary force".
  • Now or Never Kiss: Gives one to Leah before he has himself shot out of Frank's body to stop Thrax.
  • Official Couple: With Leah at the movie's end.
  • Protagonist Title: For the film. In the animated series he shares the title with Drix.
  • Red Oni, Blue Oni: The red to Drix's blue.
  • Sensitive Guy and Manly Man: The Manly Man to Drix's Sensitive Guy.
  • Sesquipedalian Smith: He's an expert in osmosis, for crying out loud!
  • Shapeshifter Showdown: What saves him against Thrax.

    Drixenol "Drix" Koldreliff
Voiced by: David Hyde Pierce

A sugar pill taken to control a case of throat inflammation, Drix partners with Ozzy to resolve the Thrax crisis.

  • Arm Cannon: He utilizes his icy painkilling abilities by shooting blasts of frigid air from a cannon replacing his arm.
  • The Big Guy: He's much taller and wider than Ozzy.
  • By-the-Book Cop: Part of what makes him different from Osmosis — he's a stickler for procedure, which requires the two of them to adjust their technique. Once this is accomplished, they make a surprisingly good team.
  • Captain Ersatz: Drix bears a strong resemblance to Iron Man.
  • Deadpan Snarker: He always seizes a chance to make a dry quip at Ozzy's Cowboy Cop tendencies.
  • Despair Event Horizon: He almost flushes himself out of Frank's organism via the bladder, before Ozzy talks him out of it, and informs him Thrax is still at large.
  • Deuteragonist: As Ozzy's partner in both the film and the spinoff series, Drix is pratically the second main character.
  • Genius Bruiser: An imposing, powerful, but also book-smart cold pill.
  • An Ice Person: His painkilling abilities are portrayed as this.
  • In-Series Nickname: "Drix" is this, short for Drixenol (or Drixobenzometaphedramine).
  • The Lancer: To Ozzy.
  • Motor Mouth: His introduction is delivered very quickly, in the manner of the narration that follows most medicine commercials.
  • Nice Guy: Cordial, friendly and helpful.
  • Only Known by Their Nickname: Nobody refers to him by his full name in the film, other than himself in his introduction.
  • Red Is Heroic: His main colors are red and yellow.
  • Red Oni, Blue Oni: The blue to Ozzy's red, ironically.
  • Sensitive Guy and Manly Man: The Sensitive Guy to Ozzy's Manly Man.
  • Sesquipedalian Loquaciousness: He is very eloquent.
  • Slasher Smile: When pretending to be crazy to extract information from a flu vaccine. Complete with an evil giggle!
  • The Smart Guy: He certainly acts smarter than Osmosis, at least. To be fair, he is intelligent and educated, Ozzy just has more experience, and Drix listens to him when it is prudent to do so.
  • Straight Man and Wise Guy: The straight man to Ozzy's wise guy.

Movie characters


A deadly and highly dangerous virus who entered Frank's body when the latter ate a boiled egg he found on the ground, Thrax aims to kill each new host he enters faster than the previous one, wanting to be known in medical textbooks as one of the most deadly diseases in history.

  • Ass Kicking Equals Authority: He gets the bacterias to accept him as their new leader after single-handedly killing their prior boss Scabies.
  • Ax-Crazy: When it comes to Thrax and his desire to get in the medical books he will pile up as many bodies as he can, and he will do it all with a gleeful and wicked smile on his face.
  • Bad Boss: He kills all his remaining underlings when one of them suggests waiting for some days in incubation before striking, which would've derailed Thrax's plot to kill Frank within 48 hours.
  • Badass Boast: When Scabies mocked Thrax, saying he thinks himself the Ebola Virus.
    Thrax: "Ebola"? Let me tell you a little something about Ebola, baby. Ebola is a case of dandruff compared to me!
  • Badass Longcoat: One that he can use as a glider at that.
  • Berserk Button:
    Scabies: Look who thinks he's the Ebola virus! (laughs)
    Thrax: ..."Ebola"? Let me tell you a little something about Ebola, baby: Ebola is a case of dandruff compared to me!
  • Big Bad: His plans to cause an infection of historical proportions are the reason why Frank is in danger.
  • Big "NO!": He does this when Ozzy tricks him into getting his claw lodged in a fake eyelash that is about to fall.
  • Bond Villain Stupidity: Rather than using his One-Hit Kill claw on a dazed Ozzy during the final battle, he decides to strangle him using his DNA Chain. This costs him big when Frank's daughter blinks: he loses his grip on the chain, and when he decides to actually use the aforementioned Touch of Death, Ozzy manages to dodge it (by forming a hole in his torso around it) and get Thrax stuck, sealing the virus's fate.
  • Cold Ham: Usually he keeps his voice very light and low, but he is also capable of letting real loose when excited, or angry, as shown above.
  • Cool Shades: He owns a pair of these, and wears them frequently.
  • Deadpan Snarker: He tends to make dry comments on the somewhat low quality of Frank's criminal underworld.
  • Diseased Name: And a Punny Name at that, as his name is a play on the bacterial disease anthrax. This is a bit odd, however, considering that he's a virus and not a bacterium. It's possible that his name is purely for aesthetic.
  • Disney Villain Death: Double-Subverted. He falls, but that doesn't kill him — it's what he falls into that does. And we get to see it.
  • Establishing Character Moment: The first thing he does upon being introduced is to casually murder two harmless workers, at least one in an incredibly gruesome way. He then proceeds to burn their entire boat by merely scratching its surface with his index finger claw while he is walking.
  • Evil Is Bigger: Downplayed. He towers over every germ and cell we see, and only Drix is larger than he is.
  • Evil Is Burning Hot: Thrax's immolating Touch of Death takes the form of one of his talons (the one on his left index finger) glowing red hot. His plan to kill Frank involves sabotaging his hypothalamus, which is the gland responsible (among other things) for regulating body temperature. Once Thrax steals an important component of the hypothalamus, the temperature skyrockets and deadly fires start breaking out across the city.
    Thrax: Think I'll turn up the heat in here!
  • Evil Sounds Deep: Courtesy of Laurence Fishburne, who is a baritone. His voice is considerably deeper than the raspy tenor of Osmosis Jones.
  • Expy: Given his color scheme and extremely short action timespan, he's one of Edgar Allan Poe's Red Death from "The Masque of the Red Death". This is given a nod via a witness calling him "La Muerte Roja".
  • Fame Through Infamy: He hopes that his murders will get him a chapter dedicated to him in the medical textbooks.
  • Family-Unfriendly Death:
    • His Touch of Death has pretty gruesome results, and one of the first things he does is inflict this on an innocent cell. Said victim proceeds to boil alive from the inside out.
    • Fittingly, this ends up being Thrax's own fate; he falls into a beaker of rubbing alcohol and is completely dissolved.
  • Faux Affably Evil: He likes to hum "Fever" by Peggy Lee and presents himself as charismatic, but this barely hides the monster he is.
  • Finger Poke of Doom: Quite literally with his first victim. "Ow."
  • Glory Hound: Thrax is like a serial killer who's trying to become famous in the most brutal fashion.
  • Horrifying the Horror: Played for Laughs. As part of a funny moment, he's visibly disturbed upon seeing some of Frank's nightmares and bad memories.
    Thrax: (after escaping from the room) Phew! This cat was sick before I even got here...
  • Karmic Death: He gets burned and dissolved after falling into a beaker of rubbing alcohol.
  • Knight of Cerebus: Were you expecting a movie about Chris Rock as a blood cell to have a virus in the form of a serial killer?
  • Lack of Empathy: He makes everyone around him (both humans and the organisms inhabiting them) suffer without any qualms.
  • Leitmotif: "Fever" by Peggy Lee, though it's invoked because he's always humming it. The title alone suits him.
  • Monstrous Germs: He is a red-skinned humanoid with tentacle-like dreadlocks and a large burning claw on one of his hands.
  • Names to Run Away from Really Fast: Thrax, meant to evoke anthrax.
  • Nice Job Fixing It, Villain!: In the final battle with Ozzy, he uses the black chain holding the hypothalamus chromosome to try and choke him. But then Shane blinks, separating the two with the chain still around Ozzy's neck. His final attack failing thanks to Ozzy's morphing abilities seals the deal.
  • Omnicidal Maniac: Thrax's plans involve killing people, causing the civilizations of cells in their bodies to die. The loss of life is apocalyptic at the cellular level, with an implied decimation among humans (since Thrax wants his own chapter in the medical books, he'd likely seek to become an epidemic, which would entail massive loss of life).
  • The Perfectionist: Thrax wants to kill Frank in record time with hopes of getting his own chapter in the medical books.
  • Playing with Fire: His fingernail claw burns whatever he scratches into a melting, burning lava mess.
  • Red and Black and Evil All Over: Red-skinned, dressed in black, and definitely evil.
  • Sadist: He revels in the pain he causes and enjoys seeing his victims' suffering.
  • Scary Black Man: Invoked by Laurence Fishburne.
  • Serial Killer: He keeps DNA beads stolen from each of his victims as trophies and reminisces about them.
  • A Sinister Clue: Only a given, since that's the hand he uses to kill all his victims and spread his infection.
  • Sinister Shades: Aside from making Thrax look cool, they also highlight his overall Lack of Empathy.
  • Slasher Smile: He sports quite a few throughout the movie, the most notable one being when he threatens to kill Frank's daughter.
  • The Sociopath: He'll kill as many people as it takes to get into the medical books.
  • Too Spicy for Yog-Sothoth: Finds Frank’s sub conscious dreams a bit too much to handle.
    Thrax: “Phew! This cat was sick before I even got here...”
  • Touch of Death: His left index finger causes any organic matter it touches to combust or explode.
  • Vile Villain, Saccharine Show: And how. Apart from the serial killer overtones, there's his meeting with the group of germs in the Zit. With his plan to organize coordinated assaults with the intention of causing widespread death and destruction, also spreading fear and intimidation outside Frank. Thrax comes across as a leader of a terrorist group planning an attack. It's jarring how such a vicious, murderous, monstrous villain managed to stick in an otherwise light-hearted comedy.
  • Villainous Cheekbones: Thrax's cheekbones are so pointy they look sharp, and he his clearly evil.
  • Would Harm a Senior: He boasts that he killed an old man in 72 hours.
  • Would Hurt a Child: Aside from threatening to have poor Shane join both of her parents in death after having her father die right before her eyes, Thrax previously killed another girl who didn't like to wash her hands.

    Mayor Phlegmming
Voiced by: William Shatner

The short-sighted and self-serving mayor of the City of Frank, whose poor decisions and attempts to secure his own position led to Frank's deteriorating health and both began and exacerbated the virus outbreak.

  • Fat Idiot: He clearly doesn't see what could happen if he keeps giving Frank junk food instead of healthy food, hence the obesity.
  • Hate Sink: As he is designed to represent and justify Frank's poor health, he inevitably ventures into this. Notably, he abolishes Ozzy from the police force for popping a pimple on Frank's teacher even though it was an emergency situation, fails to acknowledge Thrax as a threat despite the fact that he had killed others in the past (dismissing him as the common cold when he was one of the deadliest viruses ever), and is the only one that doesn't see the problem in giving Frank nothing but junk food (and is oblivious to how it's straining Frank's relationship with Shane).
  • It's All About Me: Even when a threat to the city is imminent, he retains a shockingly solipsistic attitude.
  • Jerkass : He certainly is, especially to Ozzy.
  • Laser-Guided Karma: Abolished Ozzy for having Frank throw up to get out an evil virus. Then at the end when he's been booted out of office, he presses a similar button and winds up flushing himself right out of Frank's own body.
  • Mayor Pain: Though he's not corrupt per se, he's VERY incompetent at his job and cares more about his election than anything else.
  • My God, What Have I Done?: Doesn't say it but his reaction as the city of Frank burns down around him pretty much has this trope all over it.
  • Obstructive Bureaucrat: Let's see, he fired Osmosis and gets Drix out of Frank just for popping a pimple without permit (Which is like blowing up a building in the real world) and as mayor control's nearly all of Frank's actions, including his slovenly behavior. Said neglect needless to say, almost ends up killing the guy and every cell with him.
  • Sleazy Politician: To a tee.
  • Too Dumb to Live: His actions almost get his city destroyed. The end of the film shows he hasn't learned his lesson about taking warnings seriously when he presses a button under a "Do Not Touch" sign.
  • Underestimating Badassery: Thinks Thrax is no real threat to the city. Needless to say, he's very wrong.

    Leah Estrogen
Voiced by: Brandy Norwood
Mayor Phlegmming's secretary and who Ozzy is deeply in love with.
  • Damsel in Distress: Is taken hostage by Thrax, and very nearly killed by him.
  • Graceful Ladies Like Purple: Her suit and even her body are both purple.
  • Impossible Hourglass Figure: Downplayed, but her waist is still tiny compared to her bosom and hips.
  • Jerk with a Heart of Gold: She may be aloof and unpleasant towards Ozzy, but she ultimately turns out to be a very good-hearted character, and even tries to talk some sense into Phlegmming.
  • Non-Mammal Mammaries: Part of being a female human cell.
  • Now or Never Kiss: Ozzy gives her one before he has himself shot out of Frank's body to stop Thrax.
  • Office Lady: Works as a secretary for Mayor Phlegmming.
  • Official Couple: With Ozzy in the end.
  • Only Sane Woman: In Phleggming's office. She is the only one who tries to talk sense into him, and is brave enough to confront him when his irresponsible ways cross the line.
  • Peek-a-Bangs: Downplayed; one of her bangs falls over her right eye ever so slightly.
  • Sassy Black Woman: Thanks to Brandy.
  • She's Got Legs: That mini-skirt isn't helping the fact that she has long, shapely legs.
  • The Smurfette Principle: Although Leah isn't the only female anthropomorphic cell in Frank's body, she's the only one with Nominal Importance.
  • Tritagonist: To Ozzy and Drix's protagonist and deuteragonist respectively.
  • Tsundere: Type B. Very rough around the edges, but her heart is very much in the right place.
  • Women Are Wiser: Comes into play when she confronts Phleggming about his devil-may-care attitude towards an alert that the hypothalamus is under attack.

    Police Chief 
Voiced by: Joel Silver
As the name implies, the chief of Frank Police Department who runs who runs a tight ship. He expects nothing but the best from Frank's Finest, but often clashes with Ozzy for disobeying orders.
  • Adipose Rex: He is very corpulent.
  • Benevolent Boss: He expects nothing but the best from his police force, hence why he is upset with Ozzy going over his head. It's also heavily implied that he strongly dislikes Mayor Phlegmming and rightly believes his department's job to keep Frank healthy is becoming harder because of him.
  • Da Chief: Fits this trope to a "T."
  • Everyone Has Standards: He frequently tells off Ozzy for going rogue and causing mayhem, but even he thinks Phlegmming firing Ozzy was a bit excessive.
  • A Father to His Men: Cares deeply about the safety and the performance of all his officers, including Ozzy. Indeed, part of the reason he berates Ozzy a lot is because he genuinely wants him to do better, unlike most of the other police officers and Phlegmming who see him as a laughingstock.
  • Jerkass Has a Point: Ozzy's Cowboy Cop approach to curbing crime always seems to make things worse, and the chief frequently calls him out for it.
  • Jerk with a Heart of Gold: He may be at odds with Ozzy a lot, but he ultimately trusts him to do what's right.
  • Kicked Upstairs: Does this to Ozzy by assigning him to the throat do deal with a case of pharyngitis, under the condition that he has a partner.
  • Large Ham: "JONES!!! My office!!!"
  • No Name Given: His name is never given in the movie or even promotional material.
  • Reasonable Authority Figure: He's takes Frank's health much more seriously than his boss, and does see some value in keeping Ozzy in the force despite his destructive antics.
  • What the Hell, Hero?: Frequently berates Ozzy for his Cowboy Cop personality trying to catch criminals.
    Ozzy: "Man, I was right there! I coulda done it—"
    Chief: "Right. 78 trillion cells in the body, all working together, you're the only one who thinks he can do it alone! You ever think that might be your problem, Jones?"

Voiced by: David Ossman
  • All There in the Manual: His name was seen in tie-in media.
  • Asshole Victim: Seeing as he was a dirty germ, no tears were shed when Thrax carved him into pieces.
  • Bad Boss: Shows no sympathy for his minion getting injured by Thrax.
  • Big Bad Wannabe: He was, until Thrax killed him.
  • Diseased Name: Scabies is named after the itching condition, but is never shown to cause it besides living in the armpit.
  • Family-Unfriendly Death: He was mutilated by Thrax's index claw, and we get to see him bleed.
  • No Celebrities Were Harmed: Scabies' mannerisms and voice were based on Don Vito Corleone from The Godfather.
  • No Sympathy: Responds to Bruiser getting his arm broken by Thrax by mockingly calling him a "sissy Mary".
  • Starter Villain: Of the film.
  • Too Dumb to Live: Even after being eviscerated by Thrax his disembodied mouth continues to mock him before being sucked down a drain. You'd think he'd have learned something.
  • Underestimating Badassery: Scabies didn't like Thrax's bragging and mockingly asked if he thought he was as dangerous as the Ebola virus. Thrax proceeded to show him why this was a bad idea...

    Bruiser and Joe Cramp 

    Francis "Frank" DeTorre
Played by: Bill Murray
The slovernly zookeeper whose body the film takes place. He doesn't have very much regard for hygiene and health despite his daughter's pleas.
  • Bumbling Dad: He means well, and does care about Shane, but he has a major selfish streak. Though this is mostly due to Mayor Phlegmming overriding his body for his own ends.
  • Children Raise You
  • "Fantastic Voyage" Plot: The plot takes place inside Frank's body
  • Fat Idiot: He ate a lot of junk food after his wife died, but after his near-death experience, he decided to eat healthier.
  • Guys Are Slobs: Played straight and subverted, as in a flashback we hear Shane complain that neither he or Maggie, his wife, take care of themselves very well, Frank just got worse after Maggie died.
  • The Mourning After: Still mourning the loss of his wife, Maggie. Justified, as it seems to be a relatively recent loss.
  • One of the Kids
  • Perma-Stubble
  • Straw Loser
  • Too Dumb to Live: What kicks off the whole plot as he eats an egg that was inside the mouth of a monkey and got spat out onto the ground. Yeah, that seems safe to eat.
  • Vomit Indiscretion Shot: Double Subverted; we don't see it actually happen (although we hear him retching, the focus is on the horrified crowd at the science fair), but we do see a picture of him puking all over Shane's teacher.

    Shane DeTorre 
Played by: Elena Franklin
  • Broken Bird
  • Calling the Old Man Out: Blames Frank and his unhealthy habits for Maggie's untimely death, and calls him out for deciding to take her to a chicken wing Fan Convention instead of the hiking trip she was looking forward to.
  • Children Raise You: Takes care of her dad, because he doesn't take care of himself.
  • Gender-Blender Name: Her first name is predominantly used by boys.
  • Missing Mom: Her mom died of an unspecified illness. Though it's implied she was as unhealthy as Frank has been throughout the movie.
  • My God, What Have I Done?: After Calling the Old Man Out, Shane reconsiders her words when her school bus passes where a classmate points out Frank being loaded into an ambulance surrounded by state police cruisers, and fears her blaming Frank for Maggie's death earlier caused Frank to lose the will to live.
    Osmosis Jones: Just as long as it doesn't hit 108 degrees, or Frank's daughter is an orphan!
    Shane: (upon seeing the ambulance and Frank) Oh my God...STOP THE BUS!!!
  • Only Sane Woman: Shane often has to be the adult between her and her father.
  • Women Are Wiser

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