Spoilers for all works set prior to Avengers: Infinity War and Avengers: Endgame are unmarked.
This category is only for enchanced individuals who don't fit in other categories due to their status as wildcards and/or fluid affiliations.
Chan Ho Yin / Scorch
Species: Enhanced human
Portrayed By: Louis Ozawa Changchien
Appearances: Agents of S.H.I.E.L.D. (appears in Episode 5: "Girl in the Flower Dress")
A pyrokinetic street magician on S.H.I.E.L.D.'s watchlist. He is recruited by the organization behind Centipede in the hopes that they can use him to stabilize their serum.
- Canon Foreigner: Chan Ho Yin isn't a character from the comics, though his codename is borrowed from a couple other D-list pyrokinetics. His ethnicity, as well as being "kind of a tool," also recalls Sunfire from the X-Men comics.
- Code Name: Scorch, given to him by the people of Project Centipede to play to his ego.
- Comic-Book Movies Don't Use Codenames: A major plot point is the aversion of this. The assignment of a codename to Chan helps him embrace the idea that he must have gotten his powers for a reason and that he's someone special and powerful for them. When he refers to himself as Scorch, Coulson treats the information that "they gave him a name" as an Oh, Crap! and realizes how seriously he's taking things.
- Foil: Of a sort to Mike. Both began gaining superpowers, both were approached by the Centipede project, and both were frustrated by their inability to make their lives work despite their powers. However, the big difference is that Mike thought more about helping his son survive than doing great things with his powers, and eventually realized that he could be a hero with some direction. Chan just wanted to be seen, and it led to his Sanity Slippage.
- I Love Nuclear Power: It's theorized his powers come from living near a nuclear plant that caught fire. However, it's noted that no one else in the vicinity received powers of any sort, so in the end the source is unknown.
- Jerkass: He first demonstrates his powers by scaring a couple who weren't impressed with his magic tricks. His S.H.I.E.L.D. file describes him as "kind of a tool."
- Not Using the "Z" Word: His debut was before Disney/MCU had the rights to X-Men, but it is likely he'd be referred to as a mutant. The Agents even theorize that exposure to nuclear radiation may have caused his powers, which was one of the reasons often given for Mutants developing mutations.
- Playing with Fire: His power is generating fire from his hands.
- Pyromaniac: After his Sanity Slippage he's a mad man with fire powers.
- Required Secondary Powers: His blood platelets make him immune to being burned by his own powers. Once they're extracted, he ends up scorching himself each time he lights up.
- Riddle for the Ages: It is never ultimately explained how he first acquired his fire powers.
- Roaring Rampage of Revenge: After being given a taste of the Centipede serum then being betrayed by Raina. As soon as he gets free, he starts attacking everyone.
- Strapped to an Operating Table: Happens to him during Debbie's experiments: "This isn't testing, this is torture!"
- Street Performer: What he did for a living is magic tricks on street corners.
- Super-Power Meltdown: He's given an overdose of Extremis when it's clear they can't talk him down.
- That Man Is Dead: Once he embraces his codename, he says that only "Scorch" lives.
Portrayed By: Robert Baker
Appearances: Agents of S.H.I.E.L.D. (appears in Episode 9: "Repairs")
A technician who was seemingly killed in a laboratory accident; in reality, he's somehow caught between two worlds, and is stalking Hannah Hutchins.
- Anti-Villain: Tobias is not trying to hurt Hannah, he's trying to protect her. It's not very comforting, but it's a far cry from the killer or demon everyone originally thought him to be.
- The Atoner: He's trying to make up for his mistakes.
- Expy: While teleporting is a fairly common power, doing so by traveling through a Hell-dimension in a puff of smoke is unique to the X-Men's Nightcrawler. There's also the fact that both characters are very religious.
- Extradimensional Shortcut: When he teleports, he travels between Earth and another realm he thinks is Hell.
- Manchild: He causes problems so Hannah will pay him attention; like the boy in the sandbox that tugs on a girl's pigtails.
- Psychopathic Manchild: Tobias clearly never learned that when someone upsets your crush, you don't blow up their gas station or try to run them over.
- Stalker with a Crush: To Hannah, both less disturbing than normal (he's just a normal guy who didn't know how to talk to the girl he likes) and more (he sabotaged a particle accelerator). Skye notes that he's acting like a kid with a crush.
- Stealth Hi/Bye: He pulls it a lot with the teleporting power and everything. Then May pulls it on him, disappearing in the space of a half-second black out right as he's about to whack her with a wrench.
- Talking the Monster to Death: May confronts Tobias, and convinces him to stop "protecting" Hannah for her own sake, since his current actions are only dragging her to hell with him. He realizes this, and lets himself slip through.
- Teleporter Accident: The rough theory goes that the scientists running the particle accelerator were trying to recreate the rifts from Thor: The Dark World. Then Tobias came in and sabotaged a minor part, which snowballed into a detonation that trapped him between two worlds. He's able to move between them, but is slowly losing himself to the other one.
- Teleport Spam: He makes good use of being stuck between worlds, such as disappearing to dodge attacks, enter locked rooms, and so forth.
- Too Dumb to Live: He repeatedly sabotaged a particle accelerator in order to get Hanna's attention.
- Wrench Whack: He is lugging around a pipe wrench, which he was carrying during the accident. This serves as the first hint that there's more to the accident than first appears; a pipe wrench is not the proper tool to be tightening bolts with.
Species: Enhanced human
Portrayed By: Dylan Minette
Appearances: Agents of S.H.I.E.L.D. (appears in Episode 12: "Seeds", Episode 25: "Making Friends and Influencing People")
- "I want to be left alone but you people won't stop coming after me. So I'm done hiding. It's time HYDRA learn once and for all I'm not interested. I'm not afraid. I'm pissed off. And every HYDRA agent they send is going to feel it."
An introverted genius at the S.H.I.E.L.D. Sci-Tech academy who gets involved in a series of attacks involving devices that are able to freeze people solid.
- Abusive Parents: His parents didn't even realize how smart he was because they ignored him so much. When S.H.I.E.L.D. told his father that Donnie was gifted, his father replied "In what?"
- Adaptation Species Change: He's Inhuman in the comics. Ironically, the Inhumans have yet to be introduced in the series when he appeared.
- Adaptational Heroism: It's Adaptational Anti-Villainy in his case. He still ends up as a bad guy, but is given a sympathetic backstory. It's also made abundantly clear that he never intended for his actions to hurt anyone, at least at first, and he also never served HYDRA willingly; when he, as Blizzard, is acting of his own free will, it's actually against HYDRA. The only reason why S.H.I.E.L.D. put him down at the end of "Making Friends and Influencing People" is so HYDRA won't be able to use him again.
- Age Lift: His comics counterpart is an adult criminal-for-hire.
- He wasn't interested in Ian Quinn's money. He was just having fun building something with Seth.
- In his second appearance, he isn't even antagonistic toward S.H.I.E.L.D. at all until Bakshi triggers the mental conditioning HYDRA put him through.
- Berserk Button: Don't even pretend to be HYDRA.
- Brainwashed and Crazy: He was brainwashed by HYDRA sometime during season 1. His programing is re-activated during "Making Friends and Influencing People".
- The Bus Came Back: He resurfaces in the Season 2 episode "Making Friends and Influencing People".
- Comic-Book Movies Don't Use Codenames: Played with. He is never called as Blizzard, his comics counterpart's alias. But the project to analyze his gifted power is indeed called as "Project: Blizzard" at HYDRA.
- Empowered Badass Normal: While never badass in the "combat-capable" sense, his debut episode makes it clear he has borderline superhuman engineering abilities, rivaling those of Fitz (who is nearly a decade his senior and with more experience). After the accident at the end of his debut episode he gains a Touch of Death power via cryokinesis.
- Friendless Background: Bonds with Fitz over this and their love of engineering. He had no friends in his hometown, and even at S.H.I.E.L.D Academy, he's a loner.
- Gadgeteer Genius: Built devices capable of freezing pools and people solid and causing massive superstorms.
- An Ice Person: As a result of his ice machine backfiring on him, he gets cryokinetic powers. He also has the technical skill to make weapons which can copy those abilities as well.
- Intelligence = Isolation: Has trouble interacting with people below a 170 IQ.
- Never Found the Body: According to Skye, his body hasn't been found since she shot him and he fell into the ocean.
- Start of Darkness: In the comics, he's the supervillain Blizzard and indeed, over the course of the episode, he gets his only friend killed and obtains cryokinetic powers. During his first appearance in season 2, he only uses them in self-defense or to spite HYDRA. His only villainous actions are due to brainwashing.
- Teen Genius: Has an IQ of 190 and still in school.
Carl "Crusher" Creel / Absorbing Man
Species: Enhanced human
Portrayed By: Brian Patrick Wade
Appearances: Agents of S.H.I.E.L.D. (first appears in Episode 23: "Shadows") | Daredevil (2015) (mentioned)
A man who worked for HYDRA after having his death faked by Garrett, Carl Creel is a former boxer nicknamed "The Crusher" with the ability to absorb the properties of anything he touches.
- Adaptational Heroism: Though introduced as a villain, it's revealed that he was a brainwashed pawn. By Season 3, he's free of his HYDRA brainwashing and is working for the US government as Talbot's bodyguard. In the comics, though he's sometimes depicted as an Anti-Villain, he's usually a thug who's murdered, raped, and brutalized people in the past with no remorse.
- Alliterative Name: Carl Creel.
- Ambiguous Situation: After his own out-of-control powers cause him to turn to stone, Coulson isn't quite sure he's actually dead or just in a coma of sorts. Season 3 removes the ambiguity by outright showing that he's alive.
- And I Must Scream: Between his encounter with Team Coulson in "Heavy is the Head" and his recruitment as Talbot's bodyguard, this happened to him. He couldn't move or talk because he was trapped in his own stone body. He eventually recovered and spent time in jail once he'd regained consciousness.
- Bald of Evil: Just like in the comics, Creel doesn't have a single hair on his head. He no longer fits this trope in season 3.
- Book Dumb: While he is hardly an Evil Genius, he nonetheless shows a decent amount of strategy in his appearances and uses his powers creatively, such as for stealth, and not just for brute force. Prior to being a supervillain, he also secretly used his powers to cheat his way to a successful boxing career.
- Blood Knight: He enjoys killing just slightly more than he enjoys the sensation of using his powers, and he seems to enjoy the latter quite a bit.
- The Brute: He serves as Whitehall's muscle while under HYDRA's control. He later acts as one to Talbot as a bodyguard. And later for General Hale.
- The Bus Came Back: Freed by Talbot after he is deprogrammed of his HYDRA brainwashing.
- Chrome Champion: When he turns to steel. May and Lincoln exploit this with May grazing him with a steel pipe, turning him into steel, then Lincoln blasting him with his electric powers.
- Death by Irony: The Absorbing Man... Gets absorbed. Specifically, by Graviton.
- Death Faked for You: He was supposed to have been killed, but it turns out HYDRA faked his death while they were still a part of S.H.I.E.L.D. so they could use his talents for themselves.
- Dragon Their Feet: Was brought into HYDRA's employ by Garrett, but doesn't show up until after Garrett has been dispatched.
- Elemental Shapeshifter: He can take on the properties of any material he touches — wood, steel, glass, concrete; you name it. Assuming his powers are as flexible as they are in the comics, this can extend even further.
- Even Evil Has Standards:
- While he has no problem killing targets who are trained professionals, he does seem concerned about the waitress he infects by accident (though that may have been more about losing control of the Artifact than any actual concern) and was reluctant to hurt Raina.
- It eventually turns out despite being a lifelong criminal, he had to be brainwashed into serving HYDRA, and he promptly turns once he's freed from it.
- Forgot About His Powers: Despite being able to turn into any substance he touches, he has a habit of fighting in his normal human form.
- Good All Along: In "The Inside Man", he's presented as being Talbot's morally-ambiguous bodyguard, and he's seemingly confirmed to still be evil when he knocks Lance out. However, it's later revealed that he only knocked Lance out to protect his cover, and he helps save him, Talbot, Coulson, and the other S.H.I.E.L.D. operatives.
- G-Rated Drug: He enjoys the feeling of absorbing materials, keeping a cabinet full of various things to use at his leisure. HYDRA even pays him with exotic materials.
- HeelFace Turn: The US military has apparently broken him free of his HYDRA brainwashing and he's now working as Talbot's bodyguard. Inverted when he's recruited by General Hale.
- Hero Killer: As Hartley and Idaho found out the hard way.
- The Immune: Possibly due to what happened with him and the Obelisk, Creel's blood can 'vaccinate' an unawakened Inhuman from undergoing Terrigenesis.
- Immune to Bullets: As long as he's absorbed something tough enough. Played with a bit; though the bullets don't stop him, they do knock off several chunks that end up reverting to flesh.
- Mind Control: Implied to have been brainwashed by Whitehall into obeying HYDRA (as Bakshi uses the codephrase "Are you ready to comply?" to calm him down at one point). Later confirmed in his return in Season 3.
- Mundane Utility: Before being discovered, he used his powers to cheat at boxing by turning his fists to steel beneath his gloves for easy knockouts.
- Mythology Gag:
- In his debut appearance, he rips off a ball and chain to fight May with, an iconic weapon of his in the comics.
- Subsequent appearances has Raina offer him a material to absorb with the special property of being capable of absorbing energy itself. This is something he could do on his own in the comics.
- His name is also mentioned in flashbacks in Daredevil (2015) as a boxing rival of 'Battlin' Jack' Murdock, Daredevil's father.
- Not Quite Dead: Coulson is smart enough to know that even if Creel's turned to stone, he could always do that. It's better to keep him secure in case it doesn't stick. It doesn't.
- Offscreen Moment of Awesome: Whatever he did to make Talbot literally trust him with his life must have been spectacular, but we never see it.
- Power Incontinence: Touching the Obelisk, even while made of rubber didn't completely insulate him from its effects and patches of it start spreading across his body. It's mentioned this isn't the first time he's had such problems.
- Sculpted Physique: When he turns into stone or concrete.
- Shapeshifter Swan Song: After being hit with a molecular disruptor by Coulson, he cycles through several of his past materials before turning into inanimate stone.
- Shirtless Scene: He gives one in his trailer, and another while fighting Team Coulson in the warehouse. The latter is justified, since he was using his absorbing powers to camouflage himself (which wouldn't have worked with a powder blue shirt on). It doesn't explain why he's still shirtless walking down the street at the end of the episode.
- Sleeves Are for Wimps: If he's not shirtless, then he's not wearing sleeves either.
- Super Strength: Naturally strong due to his past as a boxer, but his strength increases depending on the material he absorbs. He was able to stop the speeding vehicle carrying Hartley and the Obelisk by absorbing the properties of the asphalt road he was standing on.
- Super Toughness: By absorbing tougher materials, his durability is enhanced, allowing him to shrug off bullets and survive being hit by a car, totaling the car in the process. He's not completely invulnerable, however, as the bullets managed to knock off several chunks which eventually reverted into normal flesh, allowing the team to ID him.
- Taken for Granite: After being defeated he gets stuck in his stone form, but unable to move. With help from Talbot and the government, he recovers.
- This Was His True Form: Not the man himself, but part of him. He's bulletproof during his first encounter with Team Coulson, but they do recover a piece of shrapnel from his then-metallic body after the fight. It reverts back to flesh and blood while Fitz is analyzing it, which makes the team realize that they're dealing with a gifted.
- Unexplained Recovery: He's back for season 3, though it's not explained how he returned to normal.
- Unwitting Instigator of Doom: It was refusing to throw a fight with him that got Jack Murdock killed. His blood looks like it's going to cause this as well. In the right hands, the vaccine that could be created from it can prevent another Bahrain. In the wrong hands, it can prevent any Inhumans from appearing ever again.
- Visible Invisibility: When he becomes glass, he still has to stand perfectly still to avoid his movements reflecting the light around him.
- What the Hell, Hero?: Expressed to would-be Gilligan Hunter by knocking him out before he can inadvertently blow his cover.
Dr. Samuel Sterns
Portrayed By: Tim Blake Nelson
Appearances: The Incredible Hulk | The Avengers Prelude: Fury's Big Week comics
- "I've always been more curious than cautious, and that's served me pretty well."
A scientist who helps Bruce under the moniker "Mr. Blue". Bruce communicates with him wirelessly while in Brazil in hopes of developing a cure for his condition, but necessary ingredients for the formula require him to return to the United States. There, he discovers that Sterns has more than just curing the Hulk on his mind.
- Aborted Arc: A tie-in comic establishes he was taken into custody by S.H.I.E.L.D. shortly after the events of The Incredible Hulk, but any influence he may have on future Marvel projects is dubious since he otherwise hasn't been mentioned. This also makes it unlikely he's going to become The Leader any time soon.
- Admiring the Abomination: Well, not the actual Abomination, who he's pretty horrified by, but Sterns is in complete awe of Banner as the Hulk, calling it "god-like" and "Olympian", and comparing Bruce to Prometheus giving man fire.
- Adaptational Heroism: Samuel Sterns is an eccentric and careless, but mostly harmless scientist in this movie who tries to cure Banner, while in the comics, he is one of the more diabolical villains in that universe. The comic tie-in shows he eventually turned evil, so it's more like his origin story than a true morality shift.
- Adaptational Intelligence: Instead of working at a nuclear facility as a mentally handicapped janitor, he's already a science genius and university professor.
- Alliterative Name: First and last names starts with S.
- Bunny-Ears Lawyer: He's an odd scientist to be sure.
- Cassandra Truth: When Blonsky demands to have the Hulk's blood and gamma radiation applied to him, Sterns argues against it, claiming that the gamma-blood combined with Blonksky's experimental super-serumed body might turn him into "an abomination". Blonsky doesn't care, and holds Sterns at gunpoint to transform him anyway.
- Code Name: Mr. Blue.
- For Science!: Downplayed. While he is fascinated by Hulk blood he is thrilled by its practical applications.
- Keet: Very hyperactive, especially when it comes to science.
- Morally Ambiguous Doctorate: He wants to cure Banner and find similar cures for diseases but wants to use gamma-irradiated blood to do so which always has unfortunate consequences.
- Motor Mouth: He can get carried away discussing the merits of Hulk blood; the result is a fast-flowing stream of science.
- My Brain Is Big: Caused by Banner's irradiated blood coming in contact with a head wound caused by Abomination.
- Nice Guy: Other than Bruce, he knows how dangerous Hulk blood is better than anyone but instead of treating Bruce like a menace he's 'hail fellow scientist! Well met!'
- We Can Rule Together: To Black Widow when she finds him in Fury's Big Week. She responds by shooting him in the knee and taking him into S.H.I.E.L.D. custody.
- What Happened to the Mouse?: His fate after being taken into S.H.I.E.L.D.'s custody - particularly in the wake of the HYDRA uprising - hasn't been mentioned.
Species: Enhanced Human
Portrayed by: Emma Lahana
Appearances: Cloak and Dagger
Brigid O'Reilly's violent doppelgänger who was created from simultaneous exposure of Darkforce and Lightforce.
- Absurdly Sharp Claws: Sharp enough to slit someone's throat.
- Arrow Catch: In Season 2 Episode 3, she easily catches Tandy's light dagger.
- Colour-Coded for Your Convenience: Brigid wears dark red nail polish while Mayhem wears green.
- Evil Twin: She is not exactly evil, but compared to Brigid, is far more violent and extreme.
- Flash Step: She has a low amount of Super Speed.
- Impersonating the Evil Twin: Inverted case. This happens several times, when Mayhem needs access to police info.
- Improbable Aiming Skills: Mayhem is the part of O'Reilly that can actually aim with the gun, and with frightening precision. Besides trauma, ever since they split, Brigid has been unable to hit her target.
- It's Personal: Her original motivation was to find and kill Connors, who murdered her colleague/boyfriend Fuchs. When she finds Connors, the first thing she tries to do is hang him.
- Literal Split Personality: She is the bad side to Brigid's good.
- Other Me Annoys Me: She hates how weak and pathetic Brigid has acted ever since they were split. Unlike Brigid, who keeps trying to drown her sorrows in alcohol, Mayhem fully intends to act and get her revenge.
- Pet the Dog: She seems to pity Tyrone's former teacher, Father Delgado, and how he has gone back to being The Alcoholic.
- Scarily Competent Tracker: She has Brigid's intellect and is able to track down the girls that were missing for months, despite her limited resources.
- Split-Personality Takeover: Brigid eventually allows her to take over her body.
- Superpowered Evil Side: Mayhem has Super Strength and fingernails sharp enough to easily cut through human skin.
- Vigilante Man: Mayhem doesn't hold too much hope for the law and the judicial system, and she is willing to use torture to get what she wants. Her way to get rid of crime in the city is to kill the criminals instead of getting them into prison.
- Well-Intentioned Extremist: Outside of her intense hatred of her good side, Mayhem still tries to do good things like going after a kidnapping ring that preys on teenage girls. However, her preferred methods are extremely illegal (such as brutally murdering anyone she finds who is involved in the aforementioned kidnapping ring) and make her arguably as bad or worse than the criminals she's targeting.
Dr. Holden Radcliffe
Species: Enhanced human
Portrayed By: John Hannah
Appearances: Agents of S.H.I.E.L.D. (first appears in Episode 62: "The Singularity")
A former GT Agrochemical researcher whose theories and experiments on transhumanism got him fired from the company. He was kidnapped and recruited by Hive in order to recreate the Kree experiment which had created the Inhumans.
- Affably Evil: He is entirely friendly to pretty much everyone (unless he thinks that they're working for HYDRA) and gets on very well with fellow scientists Fitz and Simmons, especially Fitz — as of season 4, the two are frequently sharing beers and discussing science. Really, he's mostly harmless. His only problem is his occasional lack of a moral compass, which doesn't really help matters when he takes one brief glimpse of the text of the evil Darkhold.
- Ain't Too Proud to Beg: Routinely begs for his life whenever he upsets Hive.
- Alas, Poor Villain: Considering he's killed while he's still under Darkhold's corruption, it's hard not to feel a little sorry for him. Doubles for his ultimate death in the Framework, where he is Dying Alone, lamenting how he is glad that he will die now, as he doesn't have his beloved Agnes with him anymore.
- Anti-Villain: During Season 3, all he really wanted was to improve humanity, realizing too late what Hive was really up to. And in Season 4 he gets corrupted by the Darkhold, which warps his view on how to help humanity.
- Arc Villain: Of the LMD pod in Season 4, all in an attempt to gain the Darkhold, and with it, the secret of immortality. Although by the second half of the arc his role is supplanted by Aida as the true villain of the arc.
- Brainwashed and Crazy: Turns out he's under the Darkhold's morality-corrupting control and is using Aida to try to retrieve it.
- Catchphrase: "This was never my intention."
- Character Death: Murdered by Aida in "Self Control" when she thinks his regrets could possibly go too far but she plugs him into the Framework immediately afterward. The death only applies to his physical body.
- Composite Character: He's essentially the Mister Sinister to Hive's Apocalypse, being an Evilutionary Biologist who serves an ancient super powered being. However, personality wise Radcliffe is very different from Sinister. His role as the creator of AIDA is from Tom Thumb.
- Comically Missing the Point: Sometimes the worst thing about Radcliffe is his lack of proper morals. Other times, it's his lack of common sense, usually at Fitz's expense:
- In "Failed Experiments", Hive goes on a speech on how concentrating powers in the hands of a few will result in a war, while his plan to spread the Inhuman gene will avert this. Radcliffe asks if this means they can start the experiment. Hive takes a moment to compose himself before saying yes, implying that this has happened before.
- In "The Ghost", when a dumbstruck Fitz asks "What the hell?" regarding Aida's robot body, Radcliffe assumes that it's over Aida being caught in a loop trying to say hello. Fitz was actually asking where the hell Aida comes from.
- In "Let Me Stand Next To Your Fire", after Fitz mentions how his eyes would bulge when he was frightened, he sees Aida talking with May, and nearly panics. Radcliffe is more interested in seeing that Fitz's eyes actually are bulging.
- In "Broken Promises", Mack describes a missing Aida as a Sex Bot, which Radcliffe takes offense at—he's never had sex with Aida, they're just good friends. Fitz winces over how Radcliffe is making things actually worse.
- Deadpan Snarker: He likes to snark from time to time.Radcliffe: [to Talbot] I can tell by your mustache that you're a man of much importance and not to be trifled with...
- Death Equals Redemption: Literally! After being bumped off by Aida/Madame Hydra, he comes to realize that the Framework has gone too far out of control and, albeit with some coaxing, tells Simmons and Coulson where their friends are being held.
- Disc-One Final Boss: Radcliffe is initially the main villain of the LMD arc as he is the one who programmed Aida to become more ruthless and ultimately steal the Darkhold. However by the halfway point of the arc Aida kills him once she believes that his various regrets could lead towards him deactivating the Framework by which point she becomes the arc's true villain.
- Everyone Has Standards: To Radcliffe, science is meant to improve humanity, not hinder or harm it. He was appalled to learn that HYDRA placed explosives in the Deathlok's ocular enhancements, believing it a horrible misuse of science. When he thinks that Fitz and Simmons are from HYDRA, he orders his security forces to take them away. While working for Hive, Radcliffe makes it pretty clear that he is uncomfortable working on non-volunteers and that his only interest is in advancing the human race. His accidental creation of the Alpha Primitives horrifies him. He also makes it absolutely clear to Aida that he does not approve of her killing Agent Nathanson and attempting to kill Agent May.
- Evil Former Friend: To Fitz after his treachery is revealed. Interestingly, the Radcliffe LMD still indicates that Radcliffe still considers Fitz a friend, though it's fairly one-sided at that point.
- Final Death: After his physical body was killed mid-season to trap his mind in the Framework permanently, his mind is finally deleted along with the rest of the Framework in the Season 4 finale.
- Foil: To Fitz and Simmons, who work selflessly to protect humanity and have lines they will not cross and people they won't work with; Radcliffe is fairly amoral and will work with almost anyone so long as he can advance his transhuman agenda — though he draws the line at HYDRA, and Hive's plan to turn everyone who isn't Inhuman into a swayed Primitive horrifies him.
- For Science!: He willingly works for Hive after being kidnapped due to the opportunity to advance the human race by making everyone an Inhuman. However, he is less than pleased when he realizes Hive is happy with creating the Alpha Primitives instead so that he can have an easy-to-control slave race. Eventually, he's absolutely horrified at everything he's done, but is too afraid of dying to do anything about it.
- Go Mad from the Revelation: He briefly glimpses the Darkhold but refuses to read anymore as he felt his brain was being overloaded. Unfortunately, that brief glimpse corrupted his mind as he wants to uses it to make people immortal, and by "Hot Potato Soup" even he seems to be starting to regret even that brief glimpse. By "BOOM", it gets to the point where he's actively discouraging other people from trying to read it.
- Gone Horribly Right: He is dismayed at the ghoul-like abominations he's created with his experiment, but otherwise it worked exactly as intended. Those exposed to the virus are instantly transformed and enslaved to Hive.
- Hannibal Lecture: After being captured by HYDRA, he's fond of giving personality-probing lines to his captors, particularly the Doctor and his father.
- HeelFace Turn: He develops a friendship with Fitz and Simmons at the end of season 3 and begins working with them regularly. When Simmons has only 24 hours to save May's life in season 4, she makes a bee-line to his house.
- The episodes "No Regrets" and "The Return" cement his second one, where he provides everyone on Team Coulson the location to a backdoor out of the Framework.
- Karma Houdini: Somewhat. He helps out S.H.I.E.L.D. in the end, but doesn't seem to face charges for his (at first) willing cooperation with Hive, despite numerous hearings. It's later clarified he was given a pardon, but he's forbidden to conduct experiments without supervision — creating Aida is something that could get him jailed. It goes back and forth over season 4, ending with the corruption of his work, the death of his true love, and his own death, and all of it can be linked back to him.
- Killed Mid-Sentence: As everything in the Framework is being deleted, Radcliffe decides to spend his last moments before he meets the same fate watching the sunset on a beach with a bottle of liquor. He pours himself a glass and raises it for a toast, quoting T. S. Eliot, but is deleted before he can finish his sentence, and the glass he was holding just drops to the ground.
- Like a Son to Me: Radcliffe admits that Fitz had been like the son he never had, and it's implied that Fitz felt the same way. Which makes Radcliffe's betrayal hurt Fitz all the more.
- Mad Scientist: Advancing the transhuman agenda means replacing parts of his own body with what he considers to be superior components from birds or machines and doing the same for others. Personality-wise he's pretty mild.
- The Man Behind the Man: At the end of "Broken Promises", he's revealed to be pulling Aida's strings after duping the others into thinking she rebelled against him.
- MayDecember Romance: He's over twenty years older than Agnes, his lover, going by the ages for their actors.
- The Medic: From time to time, and he tends to be quite good at healing humans, if only because he's willing to come up with solutions that are Crazy Enough to Work.
- My God, What Have I Done?: His reaction upon seeing the Watchdogs transformed into mindless slave creatures. He all but utters the trope by name.
- His breakdown in the Framework!Triskelion's prison "No Regrets" also screams this, after he loses Agnes. This inspires a shred of sympathy from Skye.
- Not in This for Your Revolution: He's largely uninterested in Hive's aims to control the world, save where they intersect with his of improving humanity — when this results in the Primitives, which are as close to an antithesis of his ideas as you can get (they're not evolved humans, really, they're devolved) and Hive is entirely happy with, he's horrified.
- Omni Disciplinary Scientist: Played With. He's a brilliant genetic biologist and cyberneticist, but the practical engineering of a nuclear warhead is beyond him.
- Pet the Dog: He's rather fond of Fitz and Simmons, and in the stinger of Season 3 he expresses sadness at the number of friends they've lost. This inspires his latest project: improving LMDs... which ends up going rather wrong when he's exposed to the corrupting influence of the Darkhold in the next season.
- Plucky Comic Relief: His nonchalance about mad science is played for laughs to various degrees and he makes a great wise guy when paired with Fitz as the straight man.
- Screw This, I'm Outta Here!: After witnessing Hive's horrors, he is all too happy when S.H.I.E.L.D. shows up.
- Transhuman: Not only is he a a member of the transhumanist movement, he is a transhuman, having a hybrid avian eye.Radcliffe: Bird's visual acuity is superior to mammals, I got envious.
- Well-Intentioned Extremist: His intention with the Framework is to end suffering.
Species: Enhanced human
Portrayed By: Camille De Pazzis
Appearances: Agents of S.H.I.E.L.D. (appears in Episode 62: "The Singularity")
A transhumanist follower and assistant of Doctor Holden Radcliffe.
- Girl Friday: She was Radcliffe's assistant before he created and replaced her with Aida.
- Meaningful Name: Anon is the shorter way of saying anonymous, which she is.
- One-Shot Character: Anon only appears in "The Singularity", with her role of follower and assistant to Radcliffe filled out by Aida.
- Suspiciously Similar Substitute: Subverted. She was the assistant to Radcliffe, whom decided to make Aida once he became part of S.H.I.E.L.D.
- Transhuman: She's extensively modified to drastic levels.Mack: [looking at Anon on wide-spectrum bands] Guys, this woman has been heavily modified. In ways you wouldn't even anticipate. Man, I need to get out more.