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Danny McNamara (portrayed by Matt Barr)
A former FBI agent turned antiquities expert who is once again called back to action to find Cleopatra before Farouk finds it first.
- Badass Bookworm: He's a ridiculously well-educated and well-read lawyer who's well-versed in arts and antiquities but he prefers using his knowledge to be a rough-and-tumble investigator and adventurer.
- Berserk Button: It turns out he has one when criminals insist they arent rats... because he turned his father in to stop a murder, and his dads refusal to testify himself is why hes still in jail.
- Chronic Hero Syndrome: Danny can't seem to help from doing the right thing. Jay describes him as someone who "has to save beautiful, broken things."
- I Am Not My Father: Danny deliberately structured his life to make it nothing like that of his father Patrick, a corrupt cop who went to jail for an art heist.
- I Did What I Had to Do: Turns out the reason why Reese became the closest thing he has to a father figure instead of his actual dad is because Danny turned in his father when his dad was about to kill someone to cover up a theft. Dad eventually agreed he made the right decision.
- Informed Flaw: He dresses quite nicely but Lexi considers his day-to-day style to be a little scruffy.
- The Paragon
- Pop-Cultured Badass: In comparison to Lexi, he cant help but gleefully spout quotes and references whenever they would apply.
Lexi Vaziri (portrayed by Sofia Pernas)
A master thief & con-woman who teams up with Danny to find Cleopatra, and also to avenge her father's death at the hands of Farouk.
- Action Girl
- Big Eater: She's constantly eating and other characters, particularly Chuck, complain about how she clears out their refrigerators.
- Classy Cat-Burglar: She's a high-end thief who uses her looks and charms to steal from extremely wealthy people while dressed to the nines.
- In the Blood: Turns out her mother was an Action Girl as well... and a member of the Brotherhood and Fabis partner.
- Loveable Rogue: But of course!
- Pop-Cultural Osmosis Failure: Completely misses most of Dannys references. Even when visiting Casablanca, she has to look up clips of the film to get some of them.
- Secret Legacy: Eventually, Danny figures out from an inscription in the Brotherhoods crypt that Lexi descends from someone important to the plot: Cleopatra and Antony.
- You Killed My Father: Farouk blew him up with a bomb right after Danny had set him up in Witness Protection. Lexis response to finding out that Farouk is still alive is to pursue him for free with Danny.
Gwen Karlsson (portrayed by Katia Winter)
An Interpol agent assigned to Farouk's case.
- Action Girl
- Inspector Javert: A mild version - shes arrested most of the heroes at various times while rigidly ahdering to proper procedure and the law. She lightens up, though.
- Teeth-Clenched Teamwork: A comedic example when she partners up with Lexi to infiltrate Italian Police Headquarters, and is clearly irritated and uncomfortable with Lexis exuberance.
Aiden Shaw (portrayed by Michael James Shaw)
An arms dealer with ties to Farouk who reluctantly assists Danny and Lexi.
- Accent Relapse: Played with, in that Shaw loves to maintain his Fake Brit accent with just about everyone, but often drops it around Danny and Lexi.
- Fake Brit
- Loveable Rogue: What he eventually morphs into as he starts to become somewhat more dependable as an ally to the heroes and starts making himself somewhat more useful.
Simon Hardwick (portrayed by James Callis)
Dr. Ana Castillo
Ana Castillo (portrayed by Alicia Coppola)
Father Chuck Donnelly
Chuck Donnelly (portrayed by Mark Gagliardi)
Danny's old friend working as the foreign ministry at Vatican.
Captain Bruno Fabi
Bruno Fabi (portrayed by Antonio Cupo)
A Carabinieri TPC officer assissting Agent Gwen Karlsson in investigating Farouk, but he is secretly a member of The Brotherhood Of Serapis.
Karim Farouk (portrayed by Oded Fehr)
A seemingly-deceased terrorist leader from Egypt who seeks to weaponize Antony & Cleopatra. He is later revealed to be a legitimate son of Jacob "Jay" Reece III.