- DuckTales (1987):
Scrooge: I may be a city slicker, but we'll have a hot time in the old town tonight!
- Scrooge's chili, in "Ducks of the West". It turns everybody who eats it (aside from Scrooge) into a Fire-Breathing Diner. Scrooge's unintentional victims then head to a nearby horse trough to cool out their mouths.
Big Time Beagle: Ma's homemade chili. The most corrosive substance known to man.
- Ma Beagle's homemade chili in "The Masked Mallard". The Beagles use it to melt glass and (attempt) to steal a diamond.
- The Diablo Sauce in Kim Possible, which Ron uses packets of for hand warmers at one point. They're spicy enough to fry a robot's circuits.
- Fire Salt in Steven Universe. Consuming a full bottle turns anyone into a Fire-Breathing Diner. As in actually breathing fire and setting things around him ablaze.
- The Merciless Hot Pepper of Quetzalsacatenango, also known as the Guatemalan Insanity Pepper from The Simpsons. They're "grown deep in the jungle primeval by the inmates of a Guatemalan insane asylum." Homer has to lacquer his mouth and esophagus in order to eat one, and is still driven temporarily insane by its spiciness.
- Hermes from Futurama, in the episode "The Six Million Dollar Mon", spilled a drop of sauce from his wife's spicy curried goat, and it ate its way through the dining-room table, the floor, two other residences underneath, and on down to Robot Hell, where it scalded the Robot Devil. Hermes himself thought it needed more hot sauce.
- Beavis and Butt-Head: The Missing Episode "Down Mexico Way" has our Anti Heroes decide to try the local cuisine. While waiting, they torment a dog by force-feeding it the bottle of "Killer Hot Sauce" on their table. This pisses off the Mexican cook, who reaches for the "Mexican Death Sauce" (which is in a bottle with smoke coming out of it) and puts it on their tacos. Cue Fire-Breathing Diner. (This scene even provides the page image for that trope.)
- On SpongeBob SquarePants, Sandy threatens SpongeBob with a single drop of hot sauce to the tongue. A drop of hot sauce that talks."By the powers of naughtiness, I command this particular drop of hot sauce to be really, really hot!"
- After SpongeBob surrenders, she casually starts gulping the stuff down like it was lemonade.
- In "Bubble Troubles", SpongeBob and Patrick decide to substitute their bubble soap with hot sauce, creating spicy bubbles that burn anything on contact. This becomes a problem when they destroy the oxygen tanks to Sandy's treedome, requiring them to find her a new source of oxygen as she becomes increasingly delirious.
- In "Bunny Hunt", SpongeBob covers his furniture in hot sauce so the sea bunny he took in will stop chewing on it, but it ends up making the furniture even more appealing and turns the sea bunny into a Fire-Breathing Diner that nearly destroys SpongeBob's Mermaid Man and Barnacle Boy comic collection.
- A staple for food-related pranks in Looney Tunes cartoons; often the effect can be done with plain old Tabasco sauce.
- As very spicy mustard (which features a different chemical than capsaicin to produce its spice) used to be much more common, some older works feature this instead of the modern hot sauce. Tom and Jerry features this in several episodes.
- You can get very hot mustard as a condiment at your average Chinese take-out restaurant. WARNING: Do NOT eat more than a light glaze of this stuff on your food - unless you have a cold and you really want to clear out your sinuses.
- Very hot mustard is also commonly found in Russian cuisine. In Russia, you can buy this stuff in quite large jars cheaply.
- In Avatar: The Last Airbender, Fire Nation fire flakes turn out to be, well, hot, as Sokka finds out the hard way. Doesn't stop him from taking a liking to them, though. Meanwhile, Mai can munch them down like popcorn!
- In My Little Pony: Friendship Is Magic, Pinkie Pie apparently loves this. She likes to put it on cupcakes. Her brand is so hot that, when Twilight Sparkle accidentally drank some, her tail and mane caught on fire and she let out the classic "train whistle" steam clouds out her ears.
- However, not even Pinkie can handle the spiciness of liquid rainbow* . She turns different colors and breathes a small gout of flame before going weak on her knees and running off, presumably to get something to abate the taste. Keep in mind that this is a character that eats pastries with hot sauce. However, nowhere in the series is liquid rainbow used as a spice. If it's spicier than actual hot sauce, that's probably for the best.
- In the Rocko's Modern Life episode "Flu-In-U-Enza," the Enchanted Upchucks prepare a spicy concoction for Rocko to help him get better. It works.
- In the Hey Arnold! episode "On the Lam", Harold, Stinky, and Sid launch a rocket filled with vinegar, baking soda, and Stinky's bottle of Louisiana Hot Sauce, which they believed to blow up an old police station with, when it was really demolished by Ernie.
- The "Honor Thy Ed" episode of Ed, Edd n Eddy starts with the Eds having set up a taco stand selling "tacos" made of paper plates, grass, and shredded crayons. After Ed, Extreme Omnivore he is, eats several crayons thinking they are flavors, Edd humors him and takes a bite of one. He is disgusted and needs water, but the closest thing is Eddy's Brother's Armenian Secret Hot Sauce. He guzzles part of it and seems unfazed at first. Ed also consumes some. Eddy thinks the sauce didn't work and also eats some. It's at that moment the effect takes hold, however. We see a Discretion Shot from down the street as a tower of flame erupts from the stand and the Eds sticking their mouths on a sprinkler.
- "Grandpappy's Texas Tin-Horn Sizzlin' Salsa Sauce" in Xiaolin Showdown. Two bottles of it turn Dojo, a dragon who can normally only breath soot clouds, into a volcano.
- Chowder gets a whole episode based around this, considering it's a cartoon about food. The episode (aptly named "the Fire Breather") introduces the rarest and hottest peppers in the world, the Dancing Diablos. Peppers so hot that it turns your stomach into a furnace and makes you breath fire every time you open your mouth. Guess who decides to eat all of them?Mung Dall: Chowder! Look what you did! Now the animators have to draw all this fire!
- Garfield had Grandma's sausage gravy in A Garfield Christmas. It started out as Mom's normal gravy, but Grandma snuck in and added chili powder while whispering about how her gravy won first prize at the fair three years in a row while Mom's didn't even place. A bit later, Garfield comes in and gets some on his finger, then licks it. Cue the fire breath a second later, and then Garfield going "Perfect!".
- In Garfield and Friends, we see him using this on a horse named Certain Death.
- Regular Show: When Mordecai and Rigby try to pass off an unconscious Benson as awake, they get him involved in a spicy food contest with a guy. Benson comes to just as the guy prepares a concoction he calls "Mississippi Queen", so he has Mordecai and Rigby drink it as well. The "Mississippi Queen" is made of Kimchi, Pasta Sauce, Sashimi, Chuco, Soy Sauce, whole Clam shells, Shrimp, Mayo, and Hot Chili Peppers poured into a huge glass and served with a little cocktail umbrella. At first, they feel nothing, but suddenly start hallucinating while the song of the same name plays and wake up the next morning in the park.
- Another episode had Skips go looking for some hot wings to uphold a tradition in their family before they get married (in this case, his cousin, Quips, was tying the knot). But because of National Wing Day, all the shops are sold out, save for one in a bayou that'll only hand over their wings if said person can complete their challenge of eating some very spicy wings. So spicy that they have a wall of people who died trying to finish it. Skips has to undergo a Battle in the Center of the Mind while doing the challenge in which he literally fights the wings as he's eating them. The sauce consists of mutated ghost peppers, hot magma extract and black widow venom! The wings are literally on fire when they're served, the sauce burns right through both the plate and the table and they throw away the blue cheese dressing before the challenge begins.
- Taz-Mania: In "Francis Takes a Stand", Francis switches Taz's lemonade recipe with a recipe for a Blazing Inferno Hellfire Sauce. Naturally, Francis ends up drinking more of the stuff than Taz does.
- Grossology: Pink-Eye attempts to torture Lance Boil by force-feeding 10 bottles of this stuff. It fails because Boil has replaced his stomach with an artificial digestive system.
- Storm Hawks gives us Skyside Shanty's signature extra potent, quadruple malt vinegar.Junko: Kinda sour, but I like it.Finn: What a shock.
- The super-hot chili peppers that prove to to be the best defence against the mutant raccoons in the Camp Lakebottom episode "High Plains Garbage Eater".
- In The Smurfs episode "Gingerbread Smurfs", Brainy has Clumsy add volcanic lava juice to his recipe for making gingerbread cookies to make them really spicy. It is so powerful that it blows up the kitchen when it is added.
- In an episode of Goof Troop, Pete tried to prank Goofy with the spiciest sandwich EVER. He loaded it up with normal hot sauce and spicy ingredients, and added a drop of Hellfire Sauce that made the sandwich boil. Goofy ate it without flinching and asked for some hot sauce. Pete, in a state of shocked fury, took a big bite of the sandwich, turned red, ran outside and drank his entire swimming pool.
- In one episode of Batman: The Animated Series, a goofy villain calling himself the "Condiment King" dealt with someone who tried to stop him by squirting him in the mouth with a packet of hot sauce.
- In the "Too Young" episode of Adventure Time, Princess Bubblegum accidentally invents a Blazing Inferno Hellfire Sauce while trying to create a new bath product.
- In the Mixels Moon Madness special, Rokit's hot sauce causes a Nixel to go up in a mushroom cloud when Rokit offers the sauce to him, then it comes back down after a few seconds. When Rokit eats the sauce, his head flies off.
- One episode of Adventures of Sonic the Hedgehog had Scratch and Grounder attempt to capture the blue blur by setting up a fake chili dog stand. Sonic disguises himself as a "chili dog inspector" and critiques Grounder's chili for not being spicy enough. He "helps" Grounder by giving him a can of "Very Hot Chili" to add to the mix and then tricks Grounder into eating a hot dog covered with said chili, causing the latter to explode like a rocket. Sonic then proceeds to serve two dogs (with regular chili) for himself and Tails.
- Subverted in the Rugrats episode "Dummi Bear Dinner Disaster." One of the various ways that Angelica tries to ruin a dinner between Susie's dad and his boss so Susie wouldn't have to move away to a new house was by spiking the main course with "Volcano Brand" hot sauce. This plan backfires when it turns out that the boss loves spicy food and applauds the cooking as delicious.
- SWAT Kats: The Radical Squadron T-Bone and Razor start an episode off by having a hot pepper eating contest which gets called off when an emergency comes in with Razor pocketing one of pepper when T-Bone wasn't looking and claiming he ate it. It comes in handy later when dealing with Dark Kat's forces and one tries to jump on Razor. To which he gets it off him by squirting some of the pepper juice in it's face.
- In one episode of Be Cool, Scooby-Doo!, Shaggy and Scooby try a hot sauce called "The Grimm Repepper" which is so hot that the waiter has to hold it with a pair of tongs and it burns Shaggy's finger when he tries to touch it. When the duo actually do taste it, it burns up Scooby's eyebrows and causes Shaggy's eye juices to boil.
- In the Pucca short "Ring Ring's Party Favours", rather than feeding it to anyone, Ring Ring attempts to sabotage Pucca's party by pouring a drop of hot sauce on the floor, which then spreads and heats up the vicinity for the partygoers, but she just ends up creating a Dance Sensation.
- The title character in Who Framed Roger Rabbit is forced to drink this in the Show Within a Show Somethins Cookin. After a tea kettle gets stuck on his head Roger has an entire bottle of Acme Chili Sauce Extra Hot poured directly into his mouth, the contents are so hot they heat up the tea kettle until it is bright red with steam coming out of it and his overalls. Eventually Roger explodes out of the kettle like a rocket in flames across the kitchen head first into an ironing board.
Blazing Inferno Hellfire Sauce / Didn't Think This Through