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  • In the episode "Mayored to the Mob", bodyguard-in-training Homer practices his slow-motion dive. Making it funnier, the instructor is voiced by Mark Hamill (who starred As Himself in the same episode), who should know his Nooooos...
    (Homer gives a running dive with an unenthusiastic Big No)
    Instructor: Well, your dive wasn't bad, but I just didn't believe your 'NOOOOOO'! You gotta sell it! Remember, your 'NOOOOOO' is what gets you your next job! Now drop and give me twenty.
    Homer: NOOOOOOOOOOOO!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!
    Instructor: Better!
  • Used straight in episode "The City of New York vs. Homer Simpson", when Barney discovers he holds the black pickled egg that means he's today's designated driver.
    Barney: (after noticing the others have normal eggs and slowly seeing he got the black one) NOOOOOO! (crushes the egg in his hand and holds his head)
    Homer: (coming up to him) You got the black one.
  • Also used straight by Bart in "Black Widower". While he is initially psyched about going on a field trip to a chocolate factory, he screams this out after realizing that he left his permission slip at home on his bed. This was also midday during a day where everything was going wrong for him.
  • Seymour Skinner releases 4 of them in "Bart's Comet" firstly, when he sees the big skinner balloon for the first time. Secondly, when he discovers that Bart has managed to discover a comet, something Skinner has dreamed of for years, when he briefly left Bart in charge of his telescope whilst trying to capture a less-than-complimentary hot-air-balloon depicting Skinner with a giant rear that Bart earlier released. Then, he realises that in his earlier grief he's released the hot-air-balloon, letting it float free to humiliate him further. Finally, a paperboy drops the morning paper in front of him, with a headline reading "PREZ SEZ: SCHOOL IS FOR LOSERS":
  • Skinner pulls a similar one in season 4's "Duffless", after Bart throws Lisa's giant tomato at his butt while he was bent over tying his shoes. While all the kids (save for Bart and Lisa) were laughing at him, he was left stunned on the ground, likely due to being triggered by his time in the Vietnam War.
  • In season 4's "The Front", when retaking his high school Remedial Science A1 class, Homer lets one out when Principal Dondelinger burns a donut in front of the whole class to show how many calories it has.
  • Done yet again in "Homer and Lisa Exchange Cross Words". Homer makes Lisa so angry that she tells him that she's going to use Marge's maiden name (Bouvier) instead of Simpson. Homer drops to his knees and screams "NOOOOOOOOOOO!" Then another girl walks by and asks if he wants to buy some Band Candy. Homer's reply: "YEEEEEEEEEEEES!"
  • And then there's "Home Sweet Homediddly-Dum-Doodily":
    Ned: Do you reject Satan, and all his empty promises?
    Homer: NOOOOOOOOOOOOOOO!!!!!!! (skin burns on contact with holy water)
  • "Guess Who's Coming to Criticize Dinner?":
    Lisa: Dad, no! [The poisoned eclair] is going to kill you!
    Homer: Eh, I've had a good run. (prepares to take a bite)
    Lisa: No! (thinks) It's low-fat!
    Homer: NNNNNNNNNNNNNNNOOOOOOOOOOOOOOOOOOO! (throws eclair)
  • And parodied yet again in an episode where Grandpa is a Sprawl-Mart greeter, and gets knocked onto an out-of-control shopping buggy.
    Grandpa: NOOOOOOOOOOOOOOOOO— (cut to show that he's headed for a stack of lawn gnomes) —OOOOOOMES!
  • In "Homer's Barbershop Quartet", Chief Wiggum lets out one that gets twisted into a wolf-type howl at the moon.
  • In the beginning of "The Bart Wants What It Wants", Marge threw the Olympic Torch to the Olympic Administrators and the helicopter crashed.
    Administrator 1: Are you okay?
    Administrator 2: Yeah, I'm ok...(looks at extinguished Olympic Torch) NOOOOOOOOO!!!!!!!!!!
  • In "The Simpsons 138th Episode Spectacular", alternate clips are shown including another ending as to who shot Mr. Burns. When he fingers Smithers as the culprit, Smithers gives a big no then adds, "Wait a minute. Yes."
  • Played for Laughs in "Marge Gets a Job". Smithers is finished cleaning the unirals until...
    (Homer bursts in)
    Homer: Oh, man! I really gotta— (unzips fly)
    Smithers: NOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO!!
  • Apu does this when Taking the Bullet for James Woods in "Homer and Apu".
  • In "Sideshow Bob Roberts", Bart learns that his nemesis Sideshow Bob is to be set free from prison leading to Big No. However, he learns this in the middle of class while secretly listening to a radio, prompting a rather bemused response:
    Ms. Krapabbel: ... Well. Despite Bart's objections, the people of South Africa can now vote in free democratic elections.
  • In "Scuse Me While I Miss the Sky", Lisa, who doesn't want the town's lights on at night, lets one out as Mayor Quimby flips the switch turning on every light in town.
  • In "Homer the Vigilante", an angry mob shows up at the Simpsons' door after Homer fails to prevent a notorious cat burglar from stealing a cubic zirconium from the museum, leading to Jimbo losing respect for him.
    Jimbo: You let me down, man! Now I don't believe in nothin' no more! I'm going to law school!
    Homer: NOOOOOOOO!
  • In "Lisa's Date with Density", after she helped Nelson escape from the cops, he looks to see Skinner's reaction as he's cleaning his house after a rancid food attack:
    Nelson: Wait until he sees what I left in his birdbath.
    Skinner: NOOOOOOO!
  • "Treehouse of Horror IX":
    • In "Hell Toupee", Snake is executed and Homer gets his hair for a transplant. However, Snake's hair starts to possess him and uses him to hunt down the people who witnessed his arrest being executed (Apu, Moe, and Bart). He starts with Apu, whom he attacks at the Kwik-E-Mart, and we hear Apu screaming "NOOOOOOO!" when we cut away.
    • In "Terror in Tiny Town" has Scratchy, after being transported from the TV, falling for Snowball II. Marge thinks it's sweet, then she tells him that he'll have to be neutered.
      Scratchy: (while holding his privates) NOOOOOOOOOOO!!!
  • In "Catch 'Em If You Can", when Bart sabotages Homer and Marge's flight to Atlantic City:
    Bart: So, Mom and Dad are going to Atlantic City, but their luggage isn't. And Homer's getting the low-fat meal.
    (cuts to the outside of the plane that Homer and Marge are on)
    Homer: NOOOOOOO!
  • In the Itchy and Scratchy cartoon "Bleeder of the Pack", featured in the episode "C.E.D'oh", Scratchy lets one out when he finds out he's on the same airplane as the Big Bopper, Richie Valens, and Buddy Holly.
  • In "Treehouse of Horror XXIV", during the segment "Oh, the Places You'll D'oh!", Apu lets out a Big No when the Fat in the Hat (Homer) condemns him to a fate worse than death - having to spend time with his wife and eight children.
  • In "Fatzcarraldo", this is Homer's reaction to being told that Krusty Burger has replaced their ketchup with beet aioli as part of their new, healthier menu.

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