Jo, in the episode "Double Standard," beating Harrison Andrews with a shoe after he tries to rape her.
Blair trying to punch Harrison Andrews after she finds out he tried to rape Jo.
Doubles as a Funny Moment because Blair, in an attempt to dress more like the tough girl Harrison apparently favors, is in a biker get-up straight out of The Wild One.
When Jeri gets asked out on a date by Mr. Palmer, the hot French professor, Blair thinks he's only doing it because he feels sorry for her. After being out with him all night, Jeri sets the record straight.
Blair: I just don't want you letting him take advantage of you because you feel grateful to him.
Jeri: Grateful?! I don't have to feel grateful that he asked me out! He's lucky I went!
There's also the implication that Jeri lost her virginity well before any of the girls, with her making clear to Blair that this was not her first date. "I've had. . . experiences with guys."
One exchange between Jo and a guy that almost got into a fight with her:
Tough Guy: You're lucky you're a girl.
Jo: So are you.
In the reunion special, Blair manages to make a limousine wheel spin as she drives it. As anyone who drives (or has driven) a limousine will know, this is a notoriously hard feat to do.
Mild, Meta example. When Lisa Whelchel declined to take part in a "Losing her virginity" storyline due to her religious beliefs, the show dared to shift that storyline to Natalie, portraying a woman who was not rail-thin as both desirable, and sexually confident.