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  • Beat whichever plague on Brutal mode. You will be satisfied.
    • Beating it on Mega-Brutal is even more incredible. One wrong step will have the humans hammering away at the cure before you even have a chance of stopping them.
    • Or, for that matter, the Shut Down Everything scenario without special plagues. There is satisfaction to be had when saying "screw you" to the governments on lockdown and killing them anyway.
    • In Cure mode, naming the disease COVID-19 might be a nice little easter egg, until you find that you can actually put a stop to that very strain. Beating that same virus in Mega-Brutal literally means you curbed the COVID-19 against all odds in a world where no one wants to obey lockdowns and restrictions to stop the spread of a deadly pathogen.
  • Unlocking cheat mode. It's very satisfying to have worked so hard figuring out the game, and then being able to just play with its mechanics as you wish.
  • Humanity itself deserves one. Every single person fights to the bitter end to cure the pathogen even when they have organ failure, comas, mental instability, profuse internal bleeding, and are dying by the millions every day.
    • Cure Mode subverts this as you're the only one who is trying to stop an outbreak, and no one else is willing to cooperate with you... at first. If you manage to get the infected states to obey your lockdowns, lower infection rates and treat the infected in the meantime, you will be satisfied that you'll be able to get humanity to side with you until a cure is distributed.
  • As explained on Shown Their Work in the main page, this game managed to impress the U.S. Centers of Disease Control and Prevention. It's a testament to how awesome this game is.
  • The Simian Flu expansion made Plague Inc. into a bit of a licensed game, and they did an incredible job at making the mode faithful to the original films. No Problem with Licensed Games!
    • Simian Flu’s Non-Standard Game Over, The Future is Bright, ends with both humans and intelligent Apes coexisting in peace, ensuring a brighter future for both species as the virus is eradicated.
  • The Ancient Egyptians from the Multiple-Choice Past Necroa virus? The fact it was already in a pyramid and they added warnings of a plague that could destroy humanity means they were fully aware of the virus, what it can do and were able to CONTAIN it. Their method worked until the pyramid was unearthed.
  • Even though it's pretty much required to happen in every game, finally spreading to Greenland or any other island nation with a seaport feels pretty badass.
    • For bonus satisfaction points, if a ship is already en route to Greenland when Greenland closes its port, the ship will still make it there. This can turn what would have been an Unwinnable situation into a moment of triumph as Greenland just barely fails to dodge infection. This also doubles as Developer's Foresight as this can happen with any nation that tries to close its port, but the infection still manages to get there.
    • If you manage to get either Extreme Zoonosis, Extreme Hematophagy or the Fish transmission (only in the Mad Cow Scenario), there's a chance that you'll get a message where your plague will infect a random country, often hitting island nations like Greenland. On casual difficulties, there's a chance for a "spontaneous infection" that will do the same, this time infecting any country despite closing its ports and land borders.
    • Alternatively, you can let them close their ports and then laugh at them as you send a Trojan Plane their way.
  • The vampires of the Shadow Plague basically redefine the term One-Man Army. With blood rage on, a single vampire can murder ALL OF GREENLAND within a few in-game months, presumably one by one. Not to mention they can tear attack drones out of the air! You can single-handedly kill everyone (all 7 billion!) on the planet this way, but the Shadow Virus is just more practical at that point; and even then you can infect millions of people a day with the right upgrades.
    • The templars also get one just for being able to stand up to and possibly destroy such creatures. Along with the WHO, for managing to develop a cure that can be distributed from high-altitude airplanes so the vampire cannot interfere, and lingers long enough in people to poison the bloodsucker to death over the next week, leaving a beast that could kill a country all by itself with nothing left to do but suffer and die.

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