- Played with in El Goonish Shive: Outside of being written by Dan Shive, the title is meaningless. However, long after it started, there was a gag strip with a single panel featuring a goon — and this was said to completely justify the title, even though he has never appeared again and most probably never will.
- Dominic Deegan: Oracle For Hire ...until the end of the first year. And then again. And then stopped again.
- Chainmail Bikini — Sapphire was the only character in the entire comic to ever wear a Chainmail Bikini, and she got killed off halfway through.
- Bob and George averted the trope when the originally planned comic failed and the Mega Man sprite comic, originally used simply for filler, proved more popular by merging portions of the Bob and George plot, including characters, with the Mega Man sprite comic. Bob and George were even given Plot Armor as long as they were in the title, which lead to a joke of a character "dying" thus leading to his name being removed from the title.
In fact, Bob and George is a very interesting example. The Mega Man sprite comic originally had no mention of the title characters at all; according to the author's notes for the first few hundred comics, he hadn't planned on making Bob and George characters at all once the strips became 100% Mega Man sprite comics. But he realized that he already had a developing fanbase and it was too late to change the comic title, and he didn't want to keep a title that was irrelevant to the story, so he added Bob and George, completely changing the story. So he tried so hard to avert this trope that he ended up drastically changing his comic and adding in two characters that ended up being way more important than Mega Man.
- 8-Bit Theater was originally going to feature several video game parodies, an idea abandoned by Clevinger when the Final Fantasy comic became popular; hence the title, which seems to suggest more 8-bit stories that were never made (and never will be). The trope was, however, slightly averted by the brief side comic “Field of Battle” (included in the 8-Bit archives here), which features the sprite comic style but is otherwise unconnected to 8-Bit Theater.
- MS Paint Adventures: Only the first panel of the first adventure is done in MS Paint. The rest are done in Photoshop and Flash.Andrew Hussie: I am so good, I can emulate pressure sensitivity with MS Paint.
- Thoroughly zig-zagged by Homestuck, that being both a title reflecting the state of the protagonists at the beginning and a reference to Earthbound, as the protagonists are very often stuck in places which could be considered home, but not always.
- The Sluggy part of Sluggy Freelance never meant anything, but the Freelance used to refer to Torg's job as a freelance web guy. Now he works for an advertising firm. What the title actually meant is a bit of a Running Gag during Fourth-Wall-Breaking fillers strips. It is finally given meaning when it's revealed that Bun-bun used to be a god named Sluggy, but he declared, after a near-apocalypse, that he was going freelance.
- The Whiteboard. Although the comic started as doodles on a whiteboard, it stopped after only "strips", there was one later on to celebrate a holiday, and lastly 5 more celebrating the comic's 15th anniversary, for a grand total of eleven — less than 5 permille note of the now 2500+ strip archive.
- Polk Out, where polking out (Named after James K. Polk) is a phrase the Polkster coined to refer to pulling out when the job is done. This was to refer to the rotating comics which have long since stopped doing any rotating. It just might apply again in the near future.
- Hey guys, remember when Lilformers was actually about Transformers?
- What exactly is all over the house in All Over The House?
- Christian Weston Chandler's Sonichu comic is named for a Sonic/Pikachu hybrid that the creator made. Said character was Demoted to Extra in the third issue. However, considering how Sonichu is also the name of the species he's part of, it's not that much of an artifact considering the Spotlight-Stealing Squad has the ability to morph into a Sonichu.
- Jix is named for a character, but several story arcs have nothing to do with her. Often times, her human friend Lauren takes over the story. This trope is sometimes lampshaded by the characters knowing Jix's change to her any of her other personalities isn't permanent because of the name of the comic, thus breaking the fourth wall.
- American Gothic Daily. It was, initially, but Schedule Slip set in. Sometimes it isn't even quarterly.
- When it first started in 2007, This Is Not Fiction was titled after the main character's favourite novel. But in the 2010 rewrite, the book makes but one brief appearance and is never named, making the title rather mysterious to new readers.
- Irregular Webcomic! was originally intended to be a fun side project for the creator that he would update simply whenever he got the time. It went on to become one of the most consistently regular webcomics of all time, until its end in 2011... upon which it was still regularly updated every day with longer scientific/mathematic posts on Sundays and reruns with new commentary of old strips other days. And then regular, though less frequent, comic updates returned in 2015. It's only "irregular" in the sense that it has numerous mostly-separate storylines with no concrete swapping schedule.
- Inverted in Coach Random. The character in the title shows up in the penultimate official strip. This was lampshaded.
- Oglaf appeared in exactly two early comics of the strip that bears his name.
- Looking for Group was originally conceived as a World of Warcraft parody, and the name was fitting. But over time, the series began moving away from Warcraft by parodying other fantasy franchises and developing its own universe. Nowadays, the strip is more of a Dramedy, and parody gags of any kind are few and far between.
- Girls with Slingshots: The two main characters are still female, but the Slingshots in question are drinks. The Slingshot is the specialty beverage of a drag bar where Jamie and Hazel went once, and had one Slingshot each. Neither the bar nor the beverage has been mentioned since. Actually, the title was originally conceived when the comic was going to be a comedic "superheroes" story, with Jamie and Hazel wielding slingshots as their heroic weapons.
- Deathbulge used to be about the misadventures of the eponymous metal band, before eventually drifting into a more surreal, disconnected joke of the week format.
Artifact Title / Web Comics