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Arch Enemy / Anime & Manga

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Oh believe me, this is just Monday for these two.
  • Light and L from Death Note are each other's archenemies, foils, and near intellectual equals.
    • Near is Mello's Arch Enemy even though they're theoretically on the same side.
  • Baikinman from Soreike! Anpanman is Anpanman's Arch Enemy, who was born to fight Anpanman. However, Anpanman treats him as friendly as anyone else as long as he isn't causing trouble.
  • In Shakugan no Shana, Wilhelmina Carmel explicitly refer to Sabrac, The Destructive Blade, as her nemesis.
  • Seto Kaiba in Yu-Gi-Oh! might qualify, though he could also be considered a rival to Yugi. He even invokes this trope in the abridged series:
    Kaiba: After all, he's my arch rival. The Sherlock Holmes to my Moriarty, the Kaneda to my Tetsuo, the Speed Racer to my Racer X. I could go on but I won't.
  • Higurashi: When They Cry has Furude Rika and Miyo Takano, who have been at each others' throats for 200 years due to a Groundhog Day Stable Time Loop. Takano invariably kills Rika, at which point Hanyuu pushes the Reset Button, and it gets more personal for poor Rika, who is completely conscious of the time loop. Rika only finds out Takano is her Arch Enemy in the second-to-last loop, and Takano is never aware of the loop..
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  • In Umineko: When They Cry, both Battler and Beatrice, as well as Bernkastel and Lambdadelta have reached this point with each other. Subverted; Battler and Beato end up married while Bern and Lamb are working together.
  • Spike in Cowboy Bebop has Evil Counterpart Vicious. He also has Lord Error-Prone Andy, who is a mockery of this trope, being a one-shot foil who's a near perfect expression of Spike's id despite the latter's constant protests to the contrary.
  • Negi Springfield in Mahou Sensei Negima! has Fate (no, not that Fate), who seems to go out of his way to make personal attacks on Negi's friends.
    • Setsuna has her own Arch Enemy in the psychotic Tsukuyomi.
    • From the sequel UQ Holder!, Touta Konoe has one in Tena "Cutlass" Vita, who, like him, is a clone of Negi from a failed experiment to replicate Negi and Asuna Kagurazaka's powers. She has a loathing for immortal beings (and anyone who leads a "privileged" life) in general but has a particular ax to grind against Tota for his optimism and, like Fate above, carries out especially vicious attacks on Touta and his friends. Also similarly to the Negi-Fate dynamic, Cutlass' curb-stomping of Touta is part of what motivates him to get stronger. It finally culminates in Cutlass orchestrating an elaborate terrorist attack to force a Sadistic Choice on Touta to psychologically break him, a plot that ends with Yukihime killing her.
  • Zero and Suzaku in Code Geass, though it's another case of moral ambiguity/ideological antagonism. They eventually get over their issues and honestly work together.
    • For Lelouch himself, both Charles and Schneizel follow this straight. And maddeningly enough, he has the misfortune to get sold out to both to them after they've already caused him enough grief for several lifetimes.
  • In Naruto it's a little hard to decide, but mostly earlier friends turn into enemies, such as Orochimaru and Jiraiya, Kakashi and Obito, or even Naruto and Sasuke (though, the latter is in a quite difficult situation). Sasuke also considered Itachi his arch-nemesis for a long time until learning the truth behind the latter's killing of the Itachi clan, leading to the former turning his ire to Naruto and the Hidden Leaf Village, especially Danzo Shimura, who ordered the massacre in the first place. The Hidden Leaf 11 as a whole consider Sasuke to be their nemesis. Tobi and the Akatsuki to Naruto and his allies is perhaps the primary one. Pain and Konan to Jiraya, their former sensei. After Jiraya's death, Naruto devoloped a vendetta against Pain. Zetsu to both the Senju and Uchiha clans, having caused and manipulated the conflict between them for centuries. Deidara to Gaara, who sacrificed himself (temporarily) to save his village from Deidara. Kisame Hoshigaki to Might Guy, although Guy keeps forgetting him, and Killer Bee, whom Kisame tried to capture. Hidan and Kakazu to Shikamaru Nara, Choji Akimichi, and Ino Yamanaka, because Hidan killed their msensei, Asuma. Sasori to Sakura Haruno, Kankuro, and Chiyo.
    • The Second Tsuchikage and Second Mizukage had a long-standing grudge, which eventually led to their final battle where both perished.
    • Madara Uchiha to everyone. Literally speaking, everything that went wrong in the 'verse that would eventually lead to the plot can be blamed on him. The fact that his ultimate goal is to destroy free will is what causes the entire ninja world, who has been in almost a constant state of war for the last century, to unite and stand against him, speaks volumes about what kind of man Madara Uchiha is. Madara himself considers Hashirama Senju and Tobirama Senju to be his archenemies. In fact his rivalry with Hashirama is so fierce, Madara has a near orgasm of excitement when he senses the first Hokage on the battlefield. On the other hand, Tobirama killed Madara's brother Izuna, prompting Madara to unnecessarily throw an extra receiver onto him once he got a chance.
    • Gaara's was his father, at least until he died. Ironically, Gaara wasn't the one who killed him (though, there is no doubt he probably wished he was at the time) — Orochimaru was. By the time they finally had their fight (via Edo Tensei), Gaara had already forgiven him.
    • Kurama, the Nine-Tails, considers Minato Namikaze to be his nemesis because Minato sealed him away. Though he is later forgiving.
    • Kaguya Otsuksuki to her two children, Hagoromo and Hamura.
    • Naruto and Sasuke's conflict escalated to where when Sasuke attempted to become Shadow Dictator of the world, he said the only one standing in his way was Naruto. Not just because he's the only one to match him in absurd power by this power, but also because he is still his best friend and views that attachment as a burden. The bitterness finally ends with Naruto beating sense into Sasuke into one final fight.
  • In Detective Conan Shinichi's rival might be considered Kaito Kid, wherefore his nemesis is 'the organization' with his most present member Gin.
  • Char Aznable and Amuro Ray are perhaps the most iconic throughout the Gundam fandom. What started out as a professional military rivalry, later turned deeply personal after the death of Char's assistant Lahlah Sune, whom both men loved, when she attempted to intervene in a battle between the two of them. In the end their rivalry leads to a Mutual Kill in Mobile Suit Gundam: Char's Counterattack.
    • Zeta Gundam: While Paptimus Scirocco might be the Big Bad and Yazan Gable the resident Hero Killer, it's Titans' Ace Pilot and former Jerk Jock Jerid Messa who is protagonist Kamille Bidan's archetypal archnemesis. The two of them essentially go back and forth on killing one another's friends and loved ones (Jerid kills Kamille's mother, girlfriend, and one of his friends; Kamille Jerid's crush, his Big Brother Mentor, his girlfriend, and a truckload of his subordinates), until the rivalry turns deeply personal. By the end all that Jerid in particular is living for is his dream of seeing Kamille's head on a pike.
    • Judau Ashta and Haman Khan from Gundam ZZ play the trope rather differently from the usual Gundam rivalry. Haman is in love with Judau, who kind of reciprocates, but Haman's philosophy of life is completely irreconcilable with Judau's idealism. Mutual attraction and a Newtype connection between the two, rather than hatred, is what makes their opposition into a personal feud, to the point that when they go looking for a duel, the reaction of their respective crews is to Leave the Two Lovebirds Alone.
      • Contrasting them is the equally twisted relationship between Roux Louka, Judau's right-hand girl, and Haman's treacherous subordinate Glemmy Toto. From shortly after his first appearance, Glemmy becomes obsessed with Roux, stalking her wherever she goes, and doing his best to gain control over her, while Roux alternately manipulates and defies him, using him for information one moment, then trying to kill him the next. Glemmy, in return, begins to subvert Roux's expectations, using her attempts at manipulating him in order to gain advantage over her crewmates. In the end, it's Roux who kills Glemmy, who accepts it with grace.
    • In G Gundam the Canadian fighter Andrew Graham considers the Russian Fighter Argo Gulski his nemesis because he blames him for his wife's death. Also Domo Kasshu's and Master Asia's difficult relationship might be some kind of arch nemesis.
    • In Gundam Wing Zechs spends too much time on the good side to be this for Heero despite their constant battles, but Wufei definitely has one in Treize Kushrenada.
    • Rau Le Creuset of Gundam SEED is the Arch Enemy of Earth Forces' Ace Pilot Mu La Flaga. Their rivalry goes back to early in the war, and is extremely personal, even before The Reveal that Le Creuset is a dying clone of La Flaga's father. Early in-show, the Le Creuset team, and especially Athrun Zala are set up as the Archenemies of the Archangel, and Kira Yamato in particular. By the end they have pulled a Heel–Face Turn and Le Creuset takes their position as Kira' Arch Enemy.
    • In Gundam SEED Destiny Shinn Asuka and Rey Za Burrel both consider Kira Yamato to be their Arch-Nemesis, although Kira doesn't necessarily agree. An interesting case in that the arch enemies never so much as knew each other by name, only by the machines that they piloted (and in Shinn's case, recognizing Kira's fighting style after they each got a Mid-Season Upgrade).
    • In Gundam 00 Graham Acre considers Setsuna F. Seiei and his Gundam Exia his arch nemesis for their crimes (though he calls it a special kind of love...) But he's really more The Rival in that regard. A better fit for Setsuna's archnemesis is psychopathic Blood Knight Ali Al-Saachez for destroying not just his life, but also killing off Lockon Stratos' family as well.
    • In Gundam AGE Decil Galette is Flit Asuno's Arch Enemy starting late in Season 1 and continuing into Season 2. Flit might hate all of the Vagan with a passion, but it takes Decil's return to send him into a murderous enough rage that he sorties himself, while Decil is living for revenge after Flit humiliated him in Season 1's climax.
  • Gauron and Sousuke in Full Metal Panic!!. The feeling tends to be a lot more one-sided on Gauron's part, as he makes it his personal mission to put himself in a position where he can constantly antagonize Sousuke. It's so bad, it's to the point where it's suggested that he actually stalks and watches Sousuke, and purposefully chooses missions that would put him at odds with Sousuke, allowing them to meet again. Sousuke, on the other hand, finds Gauron insanely annoying, and would really love nothing more than for the guy to just go die somewhere and leave him alone.
  • Red and Giovanni in Pokémon Adventures are the most important. Also, Yellow and Lance, with a dash of Evil Counterpart for good measure. The only reason Petrel managed to get the drop on Lance in the HGSS arc is because he took the appearance of the person who disturbs Lance the most — Yellow.
  • Pokémon has several examples:
    • The original enmity was between Ash and Gary, with Gary rubbing his superiority in Ash's nose and Ash going crazy as he tried to catch up. They eventually buried the hatchet when they finally battled at the Johto League. Although Ash beat Gary, Defeat Means Friendship and they became friendly rivals afterward.
    • Ash later developed a more bitter rivalry with Paul over their methods of training Pokemon. A combination of Break the Haughty on Paul's part and Ash eventually beating him in the Sinnoh League again led them to bury the hatchet, and while they didn't exactly become friends afterward, they did develop a new respect for one another.
    • Galactic Commander Saturn's Toxicroak to Brock's Croagunk.
    • Mewtwo with Giovanni, made even more awesome as they stood facing each other amongst the flaming ruins of the Team Rocket lab. Though Mewtwo considers Mew his greatest enemy as he was cloned from it, though it's purely one sided as Mew has the intellect of a toddler.
    • Team Rocket's Meowth feels this way towards every Persian he comes across.
    • Misty had special enmity with Jessie as the respective female of their trios, Jessie especially hated Misty calling her old. Though Misty is no longer present in the later sagas, Jessie does't show the same hatred towards other girls in Ash's party.
    • In both the games and the anime, Groudon and Kyogre are this to each other.
  • Ranma of Ranma ½ had Happosai (outright stated to be Ranma's Arch Enemy in the datebook)
  • Harima the delinquent in School Rumble had Hanai the class president. Harima's love rival is Karasuma. Eri & Yakumo too.
  • Makoto and Jinnai in El-Hazard: The Magnificent World.
  • Bleach:
    • Yamamoto's seems to be Yhwach. Notably, Yhwach is the only enemy that Yamamoto doesn't call "child", and he immediately unleashes his incredibly destructive Bankai as soon as he shows up. The feeling is mutual - they've been at it for at least a millenium and it's pretty obvious that they really hate each other.
      • Yhwach could also be considered one to Ichigo.
    • Nel and Nnoitra have incompatible philosophies. She believes in never fighting without reason and avoiding it if possible, he believes fighting itself is a reason to fight. He hates women, especially women in positions of authority over him, as Nel used to be and Harribel is. Nel dismisses his philosophy and refuses to see him as a warrior. As a result, she feels he needs to be watched over to prevent himself from getting into more trouble than he can handle. Eventually, he rips off her fraccions' masks, smashes her mask and throws her out of Las Noches.
  • Kimblee to Scar in Fullmetal Alchemist, as well as Hohenheim to Father. Wrath also becomes this to both Greed and Scar.
  • GUN×SWORD - Justifying the Designated Girl Fight, Carmen 99 and Fasalina are arch enemies. Fasalina is responsible for destroying Carmen's hometown, causing the death of Carmen's best friend from childhood, and Carmen ends up blamed for Fasalina's actions and shunned and exiled from her town.
  • Johann vs Tenma in Monster, but Nina wants in on it for a good reason.
  • Griffith to Guts in Berserk by holy Jesus god though they were (as is often the case) once bosom buddies. Even more so in the case of Griffith who had suspect feelings towards Guts, feelings which drove Griffith off the deep end when Guts defeated him and left the Hawks. Guts himself only has postive feelings towards Griffith... until Griffith sacrificed all of his comrades to The Godhand and ascended into demonic godhood himself, with his very first act as a demon god being to rape Casca (Guts's girlfriend) while he was held down and forced to watch. And if that wasn't horrific enough, Guts and Casca's unborn baby was mutilated and changed as a result of the violation, and Casca herself went mad as a result of the ordeal. Needless to say, Guts hates Griffith more than anything on Earth and plans to kill him as painfully as possible. Griffith claims after returning to the mortal realm that he doesn't care for Guts anymore but his own beating heart says otherwise.
    • Skull Knight also has one in Void, the leader of the Godhand. Especially considering the first thing he does when seeing him is try to kill him and carries a sword designed to fight Void's dimensional powers, it's implied a similar history to Guts and Griffith.
    • Zodd considers the Skull Knight his, although Skully doesn't seem to take their rivalry quite as personally, considering him a Worthy Opponent and only shows irritation at Zodd challenging him when he is busy with other matters.
  • Neo Saiba to Taichi Yagami in Digimon V-Tamer 01.
  • Kyubey to Akemi Homura in Puella Magi Madoka Magica. There are some parallels to Takano Miyo and Furude Rika from Higurashi: When They Cry.
    • In fact, as of Rebellion thier relationship somewhat resembles Lambdadelta and Bernkastel respectively from the sequel.
  • Black★Rock Shooter: The eponymous character versus Dead Master. Ultimately Defied in the anime thanks to Power of Love.
  • InuYasha and his friends have Naraku.
  • In Durarara!!, while almost anyone can set off Shizuo's Hair-Trigger Temper, just seeing Izaya (and sometimes just hearing his name) is enough to send Shizuo into a homicidal rage. Meanwhile, Izaya screws around with everyone's lives, but that's just because he likes seeing how they'll react; Shizuo's the only person in the world he actually hates.
    • He also despises Anri and doesn't see her as human at all (Izaya "loves" human beings and has a very twisted way of showing it). The hate is mutual for Anri as well, due to how Izaya manipulates and torments Mikado and Masaomi.
  • In Soul Eater, Medusa is the Arch Enemy of Maka, on Maka's part due to Medusa's connection to the black blood and Crona, and on Medusa's side thanks to Maka's Soul Perception. Asura is this Lord Death and his DWMA Students, Staff, and many of their allies, including The Heroine Maka and her friends.
  • Alucard and Alexander Anderson from Hellsing. Both regard the other as a Worthy Opponent.
    • The two organizations they work for, Hellsing and Iscariot respectively, are arch enemies and rivals.
  • In Hunter x Hunter, Hisoka is the closest thing Gon has to one. He has an unnerving obssession with Gon and anticipates the day he "ripens to his full potential" just so he can have the chance to fight and possibly kill him, and Gon also had a desire to fight Hisoka earlier in the series for hurting his pride. Neferpitou becomes this to Gon during the Chimera Ants arc, after murdering Kite and using his corpse as a training dummy for other Chimera Ants.
    • Chrollo Lucifer is Kurapika's Arch Enemy, due to being the leader of the group responsible for slaughtering his entire clan.
    • The one person Killua hates and fears more than anyone else is his own older brother Illumi. Illumi is psychotically devoted to Killua and has done some truly awful things to him and to others because of it.
  • In Jojos Bizarre Adventure, Dio Brando is this to Jonathan Joestar in Part I and arguably to the Joestar bloodline for the rest of the series. Even after he is permanently slain in Part III, the mess he left behind causes trouble for Jonathan's descendants.
  • One Piece: While for the most part subverted due to the Arc Villain formula, there have been exceptions.
    • Nami to Arlong, and it's incredibly justified as Arlong is the one who invaded her hometown, enslaved her people and killed her adoptive mother right in front of her. Arlong then kept Nami captive in his fortress and forced her to create maps for him, which he could use in his world conquest. But the sickest part is Arlong bears no ill will to Nami and sees her a invaluable tool in his schemes and forgives her even when she attempts to assassinate him multiple time, only making sure she can't ever escape from him. Arlong used her loved ones as hostages, so she couldn't be truly free. It's due to the four boys (Luffy, Zoro, Usopp and Sanji) fighting Arlong for her and especially Luffy wrecking Arlong Park as a whole, that Nami is so close to the four of them. Nami truly believes they can beat anyone, and says so to Vivi when faced against Crododile (a warlord of the sea).
      • It's due to Arlong, that Nami is so reluctant to go Fishman island, and has a lot reason to hate Jimbei (as Sanji pointed out) since he's the one who released Arlong upon her home sea. But Nami forgives Jimbei and holds no grudge against the Fishman race as a whole (only Arlong), finally understand why Fishman hates humans.
    • Vivi, who's practically an angel, hates Crocodile with such a passion that he was the only person she has ever expressed the desire to kill. Then again, he's more than earned her hatred, and that of all of Alabasta for that matter.
      • Luffy, who may be one of the most forgiving people in the series, has aided several of his enemies, including Buggy and Mr. 3, but immediately had his live-and-let-live tendencies shut down the very moment he met Crocodile again while in Impel Down. Luffy would have never let him out of his cell had it not been for Ivankov.
      • Crocodile himself has or had one in Whitebeard.
    • Robin utterly hates Spandam, for trying to kill her friends, abusing her all the way to Gates of Justice. But most importantly due to Spandam being the son of Spandine- the man who ordered her home island to be destroyed and her mother and friends massacred. This is why the first thing Robin does after being unchained is to slap Spandam a thousand times and later snap his spine to interrupt his hate rant.
    • Franky also detests Spandam, as Spandam the one who used Franky's battleships against innocent people to frame Franky's company/family. Spandam fueled Franky's hatred further by capturing Tom (Franky's mentor and father figure), and gloating over Tom fallen body. Causing Franky to go nuts and smash Spandam's face with rifle, disfiguring him for life. Spandam soon hated Franky so much he was willingly to screw the rules and "speed up" Franky's execution by hitting him with a speeding train but was unsatisfied that Franky's body was never found, and indecently delighted to find Franky alive so he could enact his revenge. But Franky's contempt for him is stronger, the first thing he does upon seeing Spandam again is to try and bite his head off and swears to smash him into a pulp when he sees Spandam beating on poor Robin. Spandam nearly kills Franky, when the Shipwright burns the blueprints to a ancient weapon- Spandam in a rage kicks Franky off the tower of Justice, Franky finally gets his revenge when face to face with Spandam and wastes no pounding Spandam into the ground with a elephant since Spandam was not taking the hint.
      • It's due to their shared hatred and other connections, that Franky is so close to Robin.
    • Akainu to Luffy and the remnants of the Whitebeard Pirates for killing Ace.
      • Aokiji also has major beef with Akainu, though more from an ideological standpoint. However, their enmity and rivalry did not become so prevalent until Sengoku retired and both competed for the position of Fleet Admiral. Aokiji, normally indifferent, even somewhat adverse to the idea of inheriting such a tedious job, was completely against Akainu becoming Fleet Admiral. This feud between them, the first ever major conflict between admirals, became so heated that it eventually degenerated to a Duel to the Death on the barren island of Punk Hazard, with the winner becoming Fleet Admiral. The victor wound up being Akainu; but for all his ruthlessness, not even he could ignore the decades he and Aokiji served together as comrades and ended up sparing his opponent's life. However, Aokiji despised the idea of serving under his rival so much that he ditched the Marines and gave up his position as an admiral.
    • Blackbeard to the Whitebeard Pirates for betraying them and killing nakama, then orchestrating the Marineford war for his own personal gain, thereby indirectly causing Ace's death, and then personally killing (with the help of his crew) Whitebeard himself.
    • Blackbeard's role in Ace's death has made him Luffy's archenemy as well. Before Ace's death happened, Luffy was shocked to learn that the pirate named Blackbeard, who was responsible for Ace's capture, was actually the seemingly friendly bar patron Luffy met in Jaya who encouraged Luffy to pursue his dreams. Blackbeard rubbed salt into the wound by saying that if Ace hadn't fought him, Blackbeard wound have gone after Luffy instead, provoking Luffy into attacking him until Jimbei reminds him that rescuing Ace is more important. After the Time Skip, Blackbeard further increases Luffy's animosity by making a failed attempt to take Ace's Devil Fruit, and later, by attacking the Revolutionary Army, which is run by Luffy's father, Dragon, and has Luffy's other brother, Sabo, as a member. This is reinforced by the fact that Blackbeard is Luffy's Evil Counterpart and Shadow Archetype, as both of them place a high value of dreams, despite having vastly different morals, and both of them are competing the become King of the Pirates.
    • Trafalgar Law and Donquixote Doflamingo. To the point that Law is willing to do anything to ensure Doflamingo's death, even at the cost of his own life. Doflamingo, after the last two arcs, has come to hate him just as deeply.
      • Doflamingo is also a personal enemy of the Riku royal family, the previous rulers of Dressrosa. Let's put it this way: what Crocodile did to Vivi and Alabasta was nothing compared to what Doflamingo did to the Riku family and Dressrosa as a whole.
      • Though he was unaware of it at the time, Doflamingo's own brother Rocinante (aka Corazon, Law's idol) held great enmity for him for the death of their father, Homing. Doflamingo only found out moments before murdering Rocinante personally, which would earn him Law's hatred. Law would then spend the next thirteen years of his life plotting his revenge.
    • Chapter 764 implies that those bearing the D. initial are this to the World Nobles — to the point that they're nicknamed "God's Natural Enemy". In hindsight, this wasn't really surprising at all, considering how much practically every D. in the series constantly chafed against the World Government and the World Nobles in particular. Law's conflict with Doflamingo just happened to be another example, albeit one we weren't entirely aware of first, while Luffy's actions speak for themselves.
  • The Pretty Cure series has had their share of these:
  • Dragon Ball Z
    • Most of the villains being Arc Villains, the series doesn't have a lot of this, but Frieza is a strong contender for both Goku and Vegeta. Frieza is responsible for the extinction of their species and homeworld, pushed Goku to such a level of Unstoppable Rage when he's normally such a Nice Guy by killing Krillin and kept Vegeta as his servant for years after killing his father. On the flipside, Frieza absolutely despises Goku for humiliating him in their battle on Namek. And it was Trunks, Vegeta's son, that ultimately finishes him off in the following arc. In Resurrection F Frieza outright says that he can't stand to be in an universe where Goku is alive, while in the Dragon Ball Super adaptation of the arc Goku says that any of the excitement and fun he normally experiences when fighting strong opponents is replaced by enmity and disgust when facing Frieza. Given how Frieza is the only villain to make repeated appearances after his first saga, he also qualifies a bit by default. Frieza mainly sees Goku as his nemesis though: During Resurrection F and it's adaptation, he in his own twisted way considers Goku a Worthy Opponent and acknowledges the possibility of Goku defeating him, which is why he bothers coming up with a contingency, whereas the thought of losing to Vegeta never even occurred to him.
    • Frieza comes up in frequent use of main and spinoff games as a major opponent for Goku, and the series desire to repeatedly resurrect him as an obstacle has basically turned him into an Implacable Man unwilling to stop fighting until Goku is dead, even if it is after death. Doesn't help that he has a huge fanbase eager to see him get punched down by Goku again and again.
    • If episode 95 of Super is anything to go by, the mutual emnity and respect between Goku and Frieza is so strong they can communicate telepathically, in the split second they punched eachother in the face.
    • Vegeta and Goku had this relationship for a long time after the former was defeated on Earth. By the end of the series they're relationship evoled into Worthy Opponent.
    • In the original series there is Piccolo, both of them. King Piccolo murdered Krillin and Master Roshi, pushing Goku into a giant Roaring Rampage of Revenge. When King Piccolo was reborn into the current Piccolo, he dedicated his life to killing Goku.
      • Goku and Piccolo remained bitter enemies until Raditz's arrival at the start of Z.
    • Cell to both Gohan and Future Trunks.
      • The Androids from the future would be a better example for Future Trunks, seeing as how they killed almost everyone in his timeline.
    • The Supreme Kai to Babidi and to a lesser extent Majin Buu. The Supreme Kai personally kills Babidi's father and makes it is life mission to stop Buu since Buu killed all his friends and mentors.
    • In Dragonball Super Goku Black has become this due to the fact he's gotten Future Trunks, Vegeta, and Goku to all have a personal vendetta against him. It turns out that Black himself essentially feels that Goku is this to him as he's actually a Kai named Zamasu who stole Goku's Body in another timeline out of spite and envy after he lost to Goku in a sparring match. To be truthful, Goku actually viewed him with curiosity at first, and found him interesting to fight. It's not until Black maliciously reveals that he murdered that alternate universe's Goku, Chi-Chi, and Goten after his body theft and rubs it in Goku's face that Goku starts going after him with intent to kill.
    • Meanwhile Future Trunks despises him because he killed Future Bulma and re-decimated the Future after they just got it back together and dealt with Babidi and Dabura, while Vegeta hates him for the same reason plus the repeated attempts at killing Future Trunks.
  • In Fairy Tail, the demon Deliora ruined Gray's life by wiping out his hometown, killing his parents, and forcing his mentor/surrogate mother Ur to sacrifice herself to defeat him. When Gray encounters Deliora again when the latter is possessing the corpse of Gray's father Silver Fullbuster, Gray loses it.
    • Subverted when it turns out that Silver isn't being possessed by Deliora, he's actually a reanimated corpse, and he just wanted to make Grey angry enough to kill him because he wants him to avenge his death and defeat Tartarus.
    • One can make an argument that Acnologia is the arch-enemy of the Dragon Slayers, seeing as he's the one responsible for the deaths of their adoptive parents. A more concrete example would be Natsu, seeing as Acnologia killed Igneel right in front of him — the rest went out in a more Ascend to a Higher Plane of Existence kind of way.
    • Black Mage Zeref and Mavis Vermillion. They were once teacher and student, then (for an all too brief moment) lovers. Now they are sworn enemies, with Zeref vowing to wipe out humanity and Mavis in turn vowing to destroy him. Zeref also seeks to invoke this with his younger brother Natsu — as the strongest of Zeref's demons, E.N.D., he believes Natsu is the only one in the world capable of killing him. Since Zeref is a Death Seeker, he seeks to make Natsu as strong as possible so the latter may kill him, and believes that hating Zeref would provide sufficient motivation. All this being said, the Curse of Contradictions complicates his feelings for both of them. One moment it seems he can't wait to destroy them and bathe in their blood; the next, they are the two most important people in his life, and he can't bear the thought of harming either of them.
  • In Fist of the North Star, main character Kenshiro's arch-nemeses were his adoptive older brothers Jagi and Raoh, who were both bitter over Ken being chosen as the sole successor to Hokuto Shinken over them (and Toki, but he didn't really mind). Even though Raoh was the bigger rival in the story, Jagi gets special mention because he purposefully set out to ruin Ken's life and is personally responsible for the good majority of the plot. In the early part of the series, Shin fufilled this role, as he was the one who took Ken's fiance Yuria away from him and gave him his distinctive seven scars on his chest, though it could be considered subverted in the meta-sense because he was goaded into doing this by Jagi.
  • In My Hero Academia, the arch-enemy of All Might and, by extension, all users of the Quirk One-For-All is a villain known as All-For-One. All For One has the power to steal the Quirks of others and either grant them to whoever he pleases or use them himself in combination. He created One-For-All originally by giving his brother a power stockpiling quirk which combined with the brother's ability to pass down his Quirk to others. All-For-One serves as the Greater-Scope Villain for much of the series, giving orders to the League of Villains until he's forced to act openly. At that point, All Might is the only one capable of standing against him in a battle that manages to cause massive collateral damage after both sides suffered Game Breaking Injuries in their previous encounter. The conflict seems to be ended with All Might's retirement after beating All-For-One.
    • It's heavily implied this will develop for their proteges, The Protagonist Izuku "Deku" Midoriya and Tomura Shiragaki. Izuku is working to become the new Symbol of Peace while Tomura wishes to tear it down for his own order, continuing the work of his mentor, All-For-One.
  • In Fate/stay night [Unlimited Blade Works], Gilgamesh owns every Noble Phantasm in existence and can basically defeat every other servants by using the weapons they're weak against (usually by utilizing the said weapon that has killed the hero historically). Then here comes Archer who is an unknown hero from the future, which means that no weapon is particularly effective against him, is capable of creating imitations of any Noble Phantasm he has seen, allowing him to counter whatever Gilgamesh fires at him and is also capable of creating an infinite amount of swords with Unlimited Blade Works, effectively countering Gilgamesh's Gate of Babylon. While Gilgamesh does own the genuine articles, he didn't bothered to master any particular Noble Phantasm to its fullest potential. Combined with the fact that Archer can create swords much faster than Gilgamesh can bring out new swords from his vault, Archer's existence is literally the perfect counter against him. This makes Archer the natural enemy of Gilgamesh, who loathes him at every given opportunity and is more than happy to see him dead.
    Gilgamesh: The sight of fakes crafted by fakes offends me. Scum. Shams that are naught but copies should be swiftly disposed of like the trash they are.
    • After Shirou realizes that Archer is himself from the future and has the same abilities as he does, he promptly devises a plan in order to defeat Gilgamesh. Naturally, he became Gilgamesh's next arch enemy and Gilgamesh is not happy about it.
      Gilgamesh: Impossible! I'm being forced back? By a fraud like you?
      Shirou: Against any other servant, creating a world like this wouldn't let me hold on my own. Having an infinite number of swords wouldn't let me stand up to a servant who had mastered one! But against you, my swords are ready and waiting, so I'm always one step ahead!

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