Young Justice (2010) made many such changes, some of them highly controversial.
- One controversial change to Superman was that, instead of instantly embracing his clone, Superboy, he went through a (thankfully rather Downplayed) version of That Thing Is Not My Child! and only came around to being his fatherly/Big Brother Mentor at the end of the first season.
- Impulse is still Fun Personified, but he's nowhere near as loopy and easily distracted as his comic counterpart, and at least some of his cheerfulness is an act to hide his plans to Set Right What Once Went Wrong, also getting serious and questioning fellow time travelers Chameleon Boy and Saturn Girl when they come to him for their own need to fix time.
- Miss Martian, who was introduced to the comics as an Expy of the Supergirl, is much more angsty about being a White Martian. She also uses her powers more questionably than her comic version, though this mainly applies to her personality in season 2, as she undergoes significant Character Development in that season to stop abusing her powers. However, she is missing her Superpowered Evil Side from the comics.
- Cheshire is a cynical but sympathetic Anti-Villain who genuinely loves her sister Artemis and Roy, while in the comics she's The Sociopath and manipulated Roy for her own purposes. This is more similar to her early personality.
- Similarly, Black Manta is a Noble Demon, while his comic counterpart is a Psycho for Hire.
- As part of being an Expy of David Xanatos, Lex Luthor is much calmer and less vindictive, being genuinely Affably Evil without any of the rage Beneath the Mask that comics Luthor is known for, at least for the first two seasons, where he reverted to his more typical personality in season 3.
- Red Tornado is much less snarky than he was in the Young Justice comics, though his personality here fits his depictions elsewhere.
- Billy Hayes, aka Harm, is slightly less of The Sociopath here, as his sister is his Morality Chain in this version. A chain he cut himself, but still. Also, he's a Third-Person Person and refers to everyone except his sister as "it".
- Superboy is much more serious and gloomy than he was during his Young Justice days, though this is partly due to the show being based on that series In Name Only.