- The adventure game Lost Eden features two main human characters — Adam and Eve, living in a world where dinosaurs rule over humans. At the end of the game, it is revealed the dinosaurs will go extinct and Adam and Eve will lead humans into an age where they are the dominant species.
- Downplayed in Halo: When the Forerunners were forced to fire the Halos and wipe out all sentient life in the galaxy in order to stop the Flood, they stored as many specimens from different species as they could on the Ark, a giant installation located far away from the Halos' effects. After the Halos had fired, these specimens were sent back to repopulate their various homeworlds.
- In Duke Nukem: Land of the Babes, the invading aliens kill all the men, and La Résistance calls up Duke from their past to help. The ending shows a clear Adam and Eve Plot, although in this case it's more an "Adam and Eve-land" Plot.
- The good ending of Odin Sphere. After The End of the World as We Know It, Oswald and Gwendolyn are the only two humans left alive and presumably, the ones who repopulate the devastated planet. Well, Velvet and Cornelius survived it too, but they're not exactly human anymore (unless you get the Golden Ending).
- Referenced in Half-Life 2 (one of the episodes, anyway) where the well-intentioned Dr. Kleiner mentions on the monitors previously used for Breencasts (and which are therefore presumably scattered strategically worldwide) that since the Combine suppression field that had been inhibiting pregnancies was now gone, that those so inclined might as well set about replenishing the human population. Alyx incredulously asks the question that was likely in every player's head at that moment: "Did he just tell everyone to... get busy?"
- Shin Megami Tensei I. There's a possibility that the characters actually are Reincarnations of Adam and Eve. At least, Lillth thinks so.
- Shin Megami Tensei II's neutral ending has the Heroine say this is what they need to do as they walk off into the sunset.
- Shadow of the Colossus The bridge to the Shrine of Worship is destroyed as Lord Emon and his men escape. That just leaves Mono and Wander to repopulate the Cursed Land.
- Parodied in Left 4 Dead:Zoey: Wait, that makes me the last woman on earth... Shit.
- And in the sequel, when Rochelle dies:Nick: There goes repopulating the earth.
- And in the sequel, when Rochelle dies:
- Radiant Silvergun where at the end it turns out that the first humans on Earth are the clones of last humans on Earth who were sent back in time for Reset Button.
- Averted in Mass Effect: The last hundred or so surviving Protheans were put into stasis, but the genocide of the Protheans by the Reapers lasted centuries. In order to conserve energy, Vigil, the pseudo-AI watching over them, had to initiate a contingency program that would shut down stasis pods one-by-one, starting from the lowest ranking individuals upwards. By the time the genocide ended centuries later, only the top dozen Protheans remained, which, as Vigil pointed out, was far too few to repopulate the species.
- Mass Effect 3 has the appropriately named Eve, the sole female krogan who has been cured of the genophage thanks to Maelon's experiments in Mass Effect 2. This makes her the prime candidate for starting the krogan's repopulation efforts.
- In Mass Effect 3 if you sided with Wrex and released the cure for the Genophage, he is considered a Prime male for breeding with the females of his species.
- Subverted in Fallout 3: The Overseer of Vault 101 refuses to let anyone out of the Vault because he thinks it's the last settlement of humans uncorrupted by the chaos outside, but it's possible to convince him otherwise by pointing out that the Vault doesn't have enough genetic diversity to survive.
- Assassin's Creed II shows a different interpretation of Adam and Eve. In the games' story, humanity originally began as a slave race created by a highly evolved and technologically advanced (possibly alien) race. If you find all the glyphs and unlock the hidden video, you see a 20 second clip of Adam and Eve parkouring their way through a factory and escaping. If you look above in the Mythology section you'll see this is closer to the Summarian Adam and Eve than the Biblical one.
- Actually, they led a human revolt against the "gods" with the help of a Piece of Eden.
- The Excuse Plot of Volfied ends with this.
- In Chaos Rings and its prequel Chaos Rings Ω the entire purpose of the Ark is to set one up using the best possible Battle Couple to breed humans capable of defeating an Eldritch Abomination. However, the genetic problems with this trope are addressed in the first game: in Ayuta's story, there's a bit where it's claimed that the First Couples are dropped off at an era with plenty of other humans for breeding.
- The Legend of Zelda: Skyward Sword ends with Link and Zelda, rather than returning to Skyloft, deciding to remain in what would eventually become Hyrule. While it's probably safe to assume they won't be the only ones to repopulate the surface (the cloud barrier between it and Skyloft has disappeared, making it possible for anyone to come), the Adam and Eve symbolism is still very apparent.
- After you clear the first Act of each area in ActRaiser, the Master creates a temple and two people, a man and a woman, to lead the local civilization, for the most part these two people are the ones who specifically address you when you listen to the peoples' prayers.
- Xenoblade Chronicles X: The Orphe are reduced to a mere five individuals by the time humanity rescues them from the Ganglion. Fortunately, due to Orphe reproducing via "fission" rather than sex, there isn't any danger of inbreeding. Unfortunately, they require a specific chemical (senirapa water) to use as a catalyst for their reproduction, and they only have a few cups of it left. Once they find a way to produce more, their population grows extremely rapidly.
- Briefly played for laughs in Fate/Grand Order's first Summer event. After being transported to an uninhabited tropical island for a rare vacation from saving the world, your Yandere Servant Kiyohime demands to "become Adam and Eve" with you. Even if you're an Eve yourself, from which Scathach says that runes can "take care" of that.
- In Chapter 5 of Danganronpa V3: Killing Harmony, it is revealed that after the events of Danganronpa 3, civilization started to recover, but then the Earth got struck by meteorites that carried a deadly disease. In response, Makoto Naegi, now headmaster of Hope's Peak Academy, gathered up talented individuals who were immune to the disease (although Kaito Momota apparently was infected), and put them into a spaceship bound for another planet so that the students could repopulate humanity on a habitable world. In the final trial, however, this turns out to be a lie, as part of the storyline for the fifty-third season of Danganronpa.
- The Shofixti from Star Control II are at one point reduced to two males and about half a dozen females. If you can get the two groups together, you'll have a fully viable species in a few months or so.
Adam And Eve Plot / Video Games