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1[[quoteright:222:https://static.tvtropes.org/pmwiki/pub/images/grey_matter_mcmillen_4967.png]]
2[[caption-width-right:222: It's grey indeed.]]
3
4->''Reality is the #1 cause of insanity among those who are in contact with it.''
5
6The first video game from Team Meat (Creator/EdmundMcMillen and Tommy Refenes) of ''Super VideoGame/MeatBoy'' fame, Grey Matter is a 2008 UsefulNotes/AdobeFlash game billed as an "anti-shooter", due to its inversion of CollisionDamage - the enemies do the shooting, and it's your job to ram into ''them''. The theme and general aesthetic of the game is mental illness- you play as a little black dot, representing medicine, and must destroy monsters representing mental illness- [[ExcusePlot but that's really just there]] to compliment the [[BulletHell craziness of the gameplay]].
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8The original can be found [[http://www.newgrounds.com/portal/view/467236 here]]. A slightly updated version was also released as part of [=McMillen's=] Basement Collection.
9
10----
11!!This game provides examples of:
12* BigBad: Mortem Obire, the game's boss, is the last opponent and seems to be the source of the illnesses plaguing the brain.
13* BossRush: An odd example; Boss Mode only has one boss, Mortem Obire, but the game tracks the time it takes you to beat it, and gives you 100 lives to do so with. Since it makes you do it with minimal upgrades, you'll need a fair number of them.
14* BulletHell: Not only do the enemies shoot bullets at you, but you actually need to [[CollisionDamage run into them]] to hurt them, necessitating you getting close to them. [[FinalBoss Mortem Obire]] in particular shoots hordes of bullets, especially on Expert mode.
15* CollisionDamage: Notably inflicted by the player rather than the enemies, and this is your method of attack.
16* EnergyWeapon: Both the final boss, Mortem Obire, and some late-game enemies use these.
17* EvilIsVisceral: The enemies all consist of brains and pieces of bone.
18* FlashStep: One type of enemy will avoid you this way. The most reliable way to kill them is to back them into a wall.
19* PuzzleBoss: Mortem Obire's body is protected by a
20* RuleOfThree: Defeating three of the same enemy type in a row will increase your chain multiplier and unleash a trinity attack, which is a triangle with vertices at the three enemies' death positions. Doing this is actually necessary to beat Mortem Obire, who cannot be hurt any other way.

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