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7->'''Salt:''' Shouldn't we contact the command center, let them know we have the antiserum?\
8'''Daniels:''' They don't care; they wanna bury the town.\
9'''Salt:''' Ah, this is crazy.\
10'''Daniels:''' They want their weapon.\
11'''Salt:''' They're gonna kill all those people?\
12'''Daniels:''' Right, they want their weapon.\
13'''Salt:''' They're gonna sit there, and watch all those innocent people die?!\
14'''Daniels:''' Yes, they want their weapon!
15-->-- ''Film/{{Outbreak}}''
16
17Just like GeneticEngineeringIsTheNewNuke, Biological/Chemical outbreaks are the new NukeEm.
18
19So why choose this above DeusExNukina? Several reasons. While nuclear weapons are highly destructive and devastating to an enemy, a [[WorldWarIII nuclear war]] would probably cause more problems than it solved (perpetual winter, radiation, etc.), and thanks to the UsefulNotes/ColdWar, the general public is ''very'' familiar with the theoretical effects of a nuclear war. On the other hand, [[PhlebotinumDuJour biological weapons are so variable that they can basically do whatever the plot requires.]]
20
21So, if the heroes are experiencing their DarkestHour, and the end looms near, this is a simple and effective way to tiptoe around a situation where OnlyTheAuthorCanSaveThemNow. Likewise, if you want to demonstrate how depraved your villain is, you can certainly show victims of ThePlague dying in slow and horrible ways and punctuate it with mounds of burning bodies.
22
23It can go by many names: [[TheVirus The "Virus"]], The "Plague", The "Cure", The "Cleansing", etc., but it fits the same criteria:
24
25# It targets only living things. Infrastructure and biospheres are left untouched.
26# It will completely destroy the enemy ranks, or at least decimate them to the point that they are not a significant threat.
27# It can be spread across the entire kingdom, continent, planet, universe, etc.
28# It has a half-life long enough or communicability rapid enough that it's nigh impossible to escape.
29# (Optional) It will target the enemy and ''only'' the enemy, leaving the deploying army free from consequence.
30
31When used by the good guys at the climax, rarely do the negative affects get addressed. In RealLife, viruses are well known to mutate into nastier and unpredictable forms. A virus that once spread slowly and was cured easily could potentially mutate into a rapid pandemic. If it was bacteria/fungi, that stuff can survive outside of a living host and contaminate all sorts of things. If it was some sort of nerve agent, the issue of tainting water supplies or tainting landscape is glossed over.[[note]]Admittedly, this is mostly TruthInTelevision, as most nerve agents are unstable in aqueous environments and hydrolyze easily.[[/note]] And even if humans are immune from the weapon used, it usually conveniently leaves other terrestrial lifeforms and ecosystems intact. This may be justified if it's an AlienInvasion, and NoBiochemicalBarriers is averted.
32
33SisterTrope to DeusExNukina. May lead to a ZombieApocalypse, [[GeneticAbomination horrific mutants]] or simply an AfterTheEnd scenario.
34
35Usually used in a GuiltFreeExterminationWar. SubTrope of FinalSolution (that trope doesn't specify ''how'' it gets carried out).
36'''As an EndingTrope, BEWARE OF SPOILERS!'''
37----
38!!Examples:
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40[[foldercontrol]]
41
42[[folder:Comic Books]]
43* In ''ComicBook/TheLeagueOfExtraordinaryGentlemen'', it is revealed that [[Literature/TheWarOfTheWorlds1898 the bacteria which killed the Martians]] was in fact a hybrid of Anthrax and Streptococcus developed by [[Literature/TheIslandOfDoctorMoreau Dr. Moreau]] while working for the British Military.
44[[/folder]]
45
46[[folder:Fan Works]]
47* {{Averted|Trope}} in ''Fanfic/{{Origins}}'', since the salarian STG's attempts to develop one to fight off an AlienInvasion repeatedly fail to produce anything that would be viable against the enemy [[spoiler:(though given that enemy is the Flood, this makes sense)]].
48[[/folder]]
49
50[[folder:Film]]
51* The crux of ''Film/BladeTrinity'' is the use of a virus that will kill all vampires everywhere, seemingly instantaneously.
52* ''Film/{{Outbreak}}'': General [=McClintock=] believes that weaponized Motaba will solve enough problems in wartime to merit killing off an American town and keeping it a secret.
53* ''Film/ThePuppetMasters'': The alien slugs are vulnerable to encephalitis[[note]]inflammation of the brain[[/note]] -- being almost all brain, they are ''far'' more vulnerable to it than humans are. After the disease is unleashed, a military man in the area admits that he and his men are "sick as hell" but are now free.
54* Failed spectacularly in ''Film/{{Serenity}}''. The Alliance introduced the Pax, a chemical agent of their design, into the atmosphere of the planet of Miranda, designed to make the populace docile and well-behaved, to suppress any and all aggression (and thus resistance). The Pax worked ''[[GoneHorriblyRight too]]'' well: most of the population of Miranda became so apathetic that they just laid down and died. A small percentage of the population [[GoneHorriblyWrong had the exact opposite reaction to the Pax]] -- they became [[HatePlague hyper-violent and very aggressive]], becoming the Reavers.
55* [[ZigZaggingTrope Zig-zagged]] in ''Film/TheWarOfTheWorlds1953'', which maintains the ending of [[Literature/TheWarOfTheWorlds1898 the original story]], but before the natural bacteria of Earth do the job, the military and the scientists propose to use bio-warfare (out of desperation, because [[NukeEm nuking the machines]] doesn't work and the only option left is to try and see if it's possible to kill the Martians themselves). Unfortunately, the mobilization of the Martians towards L.A. means that the university the scientists are in needs to be evacuated, and [[ApocalypseAnarchy the trucks that carry the equipment are stolen by desperate Angelenos who smash it all to make room]] (in the words of ScienceHero protagonist Dr. Clayton Forrester: "they sliced their own throats!").
56[[/folder]]
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58[[folder:Literature]]
59* ''Literature/{{Animorphs}}'':
60** {{Subverted|Trope}}: the Andalites ''tried'' to do this to prevent the Yeerks from enslaving the Hork-Bajir race (by way of a virus that only affected the Hork-Bajir), but eventually failed.
61** Later, there is an attempt to use a virus to kill off the Yeerks, but because there was a possibility that it would mutate to infect their host species (such as humans) the Animorphs stopped it.
62* In ''Auf zwei Planeten'' (''On Two Planets'') by Creator/KurdLasswitz, which was published a year before ''Literature/TheWarOfTheWorlds1898'', Oß, the leader of the Antibat faction in Martian politics, wants to retaliate against the rebellion of Earth against the Martian "protectorate" by introducing the dreaded Martian disease Gragra there. However, when this morally abhorrent plan becomes known to the public, he is resoundingly defeated in the elections, enabling a peace treaty between Mars and Earth to be concluded.
63* ''Literature/TheBerenstainBears'': Suggested in the climax of the Big Chapter Book ''And the Great Ant Attack''. According to Dr. Smythe-Jones, hybrid species catch certain diseases easier than normal species, and she suspects that's what happened to the super-ants when they suddenly start dropping dead -- their mixed DNA made them more vulnerable to some natural illness. It also saves the bears from resorting to spraying a super variety of DDT, which could have caused even greater environmental damage by killing good insects as well as bad.
64* Creator/RobertRankin trumps Creator/HGWells in his Victorian {{Steampunk}} novel ''The Educated Ape''. Literature/{{The War of the Worlds|1898}} is referenced as having just been won, as per book, by the Martians not having thought to inoculate against Earth's diseases. But the devious Winston Churchill (in life a fervent nationalist who seriously considered the eugenic sterilization of genetically [[https://en.wikiquote.org/wiki/Winston_Churchill "degenerate Britons"]]) sent some of the captured Martian spacecraft back to them, loaded with volunteer crews of terminally ill humans, with every contagious disease known to Man. A Mars cleansed of its higher life forms is then open to colonization from the British Empire...
65* In ''Literature/LastAndFirstMen'', the millennia-long war between the Second Men and the Martians (sentient clouds of bacteria) is brought to an end using a designer virus. Unfortunately, it's too late for the Second Men at that point but they are succeeded by the Third Men.
66* In Edward Willett's ''Marseguro'', a colony of genetically engineered humans called "Selkies" is invaded by the religious fanatics who rule the rest of human space. The Selkies unleash a plague designed not to harm them and vaccinate the baseline human colonists. The invaders die but the baseline who drew them there in the first place was vaccinated and an unknowing carrier, and he made it back to Earth where it kills a large chunk of the planet. The sequel ''Terra Insegura'' covers a Selkie mission to bring the vaccine to Earth.
67* This nearly backfires in ''Literature/NewJediOrder''. The virus in question, Alpha Red, is specifically designed to target [[ScaryDogmaticAliens Yuuzhan Vong life-forms]] (and ''only'' Yuuzhan Vong life-forms). The Jedi oppose it for idealistic reasons (as not all the Yuuzhan Vong were evil, and they believed the race as a whole could likely be redeemed--and if that were ''not'' the case, they would not be a party to genocide), but the final novel (''The Unifying Force'') adds several pragmatic considerations to the question (which had, to some extent, been brought up before, but in that novel they go from theoretical to ''actual''). On a planet the virus was tested on, the virus also affected a native form of life, proving the virus could mutate to infect other lifeforms. Worse, [[spoiler:an infected ship escaped, letting the Yuuzhan Vong know about the threat... and ''even worse'', Alpha Red was a threat to the living world Zonama Sekot, which was an offspring of the primordial homeworld of the Yuuzhan Vong. The last part of the novel includes the Yuuzhan Vong trying to crash that infected ship on the living planet, and the heroes attempting to stop it]].
68* This plan works at the end of ''Literature/ThePuppetMasters''. The [[PuppeteerParasite parasitic mind-controlling slugs]] are vulnerable to a Venusian disease called Nine-day Fever, which is deliberately spread among them to cut back on their numbers and try to save humanity as a free race- the fever is dangerous to humans, too.
69* In Creator/JackLondon's story "The Unparalleled Invasion", what prevents the YellowPeril from taking over the world is the bombardment of Chinese cities with glass tubes containing "every virulent form of infectious death," which exterminates the Chinese population in six weeks.
70* In ''Literature/TheWarOfTheWorlds1898'', Earth's bacteria do in the aliens. This is kept in most adaptations, from [[Radio/TheWarOfTheWorlds1938 radio]] to [[Film/TheWarOfTheWorlds1953 the 1953 movie]]. {{Subverted|Trope}} at first in the [[Series/WarOfTheWorlds1988 1980s TV show]], which just has the aliens in hibernation. Later, one of the characters develops a bacterium to kill off the aliens for good. The in-universe justification is that the Martians have evolved to the point that they no longer have immune systems and are unprepared for Earth's microorganisms.
71[[/folder]]
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73[[folder:Live-Action TV]]
74* ''Series/The100'': The Grounders send Murphy back to the 100 after infecting him with a virus that will render his people feverish and weak by the time the Grounders invade two days later. It doesn't quite work, but only through quick thinking on the 100's part.
75* An erstwhile Alliance officer in ''Series/{{Firefly}}'' made his fortune using biological weapons to depopulate communities, then he looted their untouched valuables. [[spoiler:This was a lie, but it was certainly a plausible one.]]
76* An arc in ''Series/StargateAtlantis'' involves an attempt to develop a virus that would turn Wraiths into humans. They never manage to make its effects permanent or figure out an effective delivery mechanism, but their first test subject, "Michael", becomes a major recurring villain. Never really exploited is the fact that even when it's only temporary in effect, it still renders them amnesiacs with no ability to operate their own ships' biotechnology until the virus wears off.
77* ''Series/StargateSG1'': The episodes "[[Recap/StargateSG1S4E162010 2010]]" and "[[Recap/StargateSG1S5E102001 2001]]" feature an alien race named the Aschen, who conquer worlds by supposedly being nice and friendly and handing out life extending drugs... that sterilize most of the population, letting the Aschen move in and take over after nearly everyone on the target planet has died out. The Aschen also offered Earth a bacterium that could be engineered to wipe out the Gou'ld, and tried to use it on Earth when their "sterility drug" plan was uncovered.
78* ''Series/StarTrekDeepSpaceNine'': In "[[Recap/StarTrekDeepSpaceNineS01E05Babel Babel]]", the station is infected with a mysterious plague where victims develop aphasia before taking a turn for the worse. It turns out that the plague was caused by a bio-engineered virus created Bajoran resistance scientists to attack Cardassians and the computer program to replicate the virus was smuggled on board Deep Space Nine by members of the resistance. Chief O'Brien inadvertently activates the program while repairing the replicator systems and causes the virus to spread through the station. Naturally O'Brien is the [[ButtMonkey first]] to come down with the disease and comes closest to dying. While the doctor who created the virus is long dead, his assistant is still alive and able to develop a cure in time to save the station.
79* In the 7th season of ''Series/{{Supernatural}}'', the Leviathans plant a special chemical in fast food that makes the bodies of humans who eat it deadly to all other [[ToServeMan anthrophagic]] monster species.
80* In ''Series/{{V 1983}}'', the human resistance develops a "Red Dust" that only kills the aliens, driving them off the planet. When the aliens return for the later TV series, the Dust can't be used again because long term studies have shown that any greater concentration in the atmosphere would damage the ecosystem.
81[[/folder]]
82
83[[folder:Mythology and Religion]]
84* ''Literature/TheBible'': {{God}} has done this a few times, like in the Ten Plagues of Egypt, which turned the water to blood, unleashed frogs, lice and flies upon the land, pestilence upon livestock, hail and fire, boils, darkness, and the deaths of the firstborn sons of Egypt.
85[[/folder]]
86
87[[folder:Tabletop Games]]
88* ''TabletopGame/BattleTech'' has the [[https://www.sarna.net/wiki/Redburn_Virus Redburn Virus]], the influenza strain from hell engineered by the Word of Blake. It isn't curable and has fatality rates of 30 per 100,000 and higher. Originally, it was non-contagious, but at least one variant strain has mutated. The rest of the Inner Sphere is horrified, as ''any'' biological weapons, including ''tear gas'', are [[EveryoneHasStandards supposed to be banned]].
89* ''TabletopGame/Warhammer40000'': [[http://wh40k.lexicanum.com/wiki/Virus_bombing Virus bombing]] is one of the ways Exterminatus (destroying a planet that has succumbed to TheCorruption or cannot be saved) can be carried out. As it destroys all life (and eventually, the ''atmosphere''), its use is rather limited. Now they've found out that using them strengthens [[{{Plaguemaster}} Nurgle, the Chaos god of disease]]...
90[[/folder]]
91
92[[folder:Video Games]]
93* In ''VideoGame/{{Crysis}} 2'', the Ceph are the ones trying to do this against humanity by using massive spires that release a spore that targets human DNA. Throughout most of the game, [[VoiceWithAnInternetConnection Jacob Hargreave]] is directing you to interface with these spires, allowing the spores to infect the Nanosuit. It turns out that the Nanosuit is capable of "reprogramming" the genetic code of the spores so that they will instead destroy Ceph DNA instead of human, and the final mission involves you jumping into a massive stream of the spores in the largest spire in New York City to wipe out all Ceph presence in NYC.
94* ''VideoGame/FinalFantasyXIV'': In the ''Stormblood'' story, we're introduced to the Black Rose, a chemical agent that "stops the flow of aether" in any living being's body, resulting in instant death. It was developed by the Garlean Empire for use during an invasion of Eorzea. The weapon is so potent that even several of the most prominent antagonists in the Empire [[EvenEvilHasStandards are appalled by its use]]. The Black Rose becomes a major plot element in [[spoiler:''Shadowbringers'', which reveals that in a BadFuture where the weapon was used, it went out of the Empire's control and spread across the entire world. So many people died from it that civilization and law completely collapsed, with the world being thrown back into a barbaric age of blood and tribalism. Even the [[PlayerCharacter Warrior of Light]] and his TrueCompanions were killed by the Black Rose, killing everyone who might have even had a chance of restoring order]].
95* In ''VideoGame/GalacticCivilizations II: Dark Avatar'', the Korath use "spore" ships that wipe out all life on a planet and leave the remainder a toxic world, which they can colonize.
96* An eleventh-hour cure is used in ''VideoGame/GearsOfWar'' to destroy both the Locust and the Lambent.
97* The original ''Franchise/{{Halo}}'' trilogy can be loosely interpreted to end this way. The eponymous Halos are installations which can wipe out all life within a certain radius, meant to "starve" [[TheVirus the Flood]]; they aren't biological weapons themselves, but they're clearly built to target certain forms of life (plants and most animals are left untouched, but anything sapient is toast). [[spoiler:The Chief fires one at the end of ''VideoGame/Halo3'' to wipe out the Flood infecting the Ark.]]
98* ''VideoGame/MetalGearSolidVThePhantomPain'' has the Vocal Cord Parasites, a bioweapon developed by XOF. When the Parasites infect someone, they lie dormant until exposed to the specific soundwaves created by speaking in a specific language, after which they attack the victim's lungs and drive them into a zombie-like state of dementia as a means of spreading to new hosts. It is described as "a weapon to surpass Metal Gear", and a strain of the parasite attuned to the English language is a key component in Skull Face's plans to conquer the world by robbing the world of its most commonly-used language.
99* In the Destroy ending of ''VideoGame/MassEffect3'', the trope is {{inverted|Trope}}, with the final weapon destroying all ''synthetic'' life, including the friendly ones, and leaving the organic life alone.
100* {{Subverted|Trope}} in ''Franchise/{{Metroid}}''. The Chozo created the eponymous Metroids as a biological weapon to control the rampant Parasite X on planet SR-388, which could have threatened the entire galaxy if left unchecked. Later, other races discovered the Metroid, and the creatures began to spread across the galaxy, proving to be an even worse threat than Parasite X. Then, when Samus eradicated the Metroid, Parasite X came back stronger than ever.
101* ''VideoGame/{{Prototype}}'': The Redlight virus was designed as version 1.0 of all future genetic-triggered viruses. Designed originally to be programmable to target specific ethnic groups it was released into a specially made military town made up of soldiers and their families from varying backgrounds and ethnic groups in order to test it, though we don't know what if any groups the virus was designed to target. Unfortunately, the virus mutated and then made other people mutate into Zombies controlled under a central leader called Elizabeth Greene. Later, Redlight was engineered into a variety of mutagenic viruses made to create anything from super soldiers to corpses.
102* Creating biological weapons, such as viruses and such, forms the entire basis by which the events of ''Franchise/ResidentEvil'' occur, where various MegaCorp factions are in a biological arms race. Naturally, this goes to show why they do not "solve" anything, as the various {{Bioweapon Beast}}s created by these companies are what's putting the world in danger in the first place.
103* In ''VideoGame/{{Resistance}}'', an eleventh-hour cure is used to defeat the Chimaera and end a war that, technically, humanity had already lost years ago.
104* ''VideoGame/{{Skyfall}}'': Following a series of unfortunate political fiascoes, conventional nukes are discredited in favor of biological warheads. This works against the protagonist, as the biological warhead that exploded smack-dab in the middle of the city has mutated any survivors who weren't in a safe room, and the protagonist's safe room is on the penthouse floor of a hotel now filled with feral mutants.
105* ''VideoGame/StarFoxAssault'' concluded with the heroes attacking the Aparoid queen with an electronic virus intended to induce apoptosis in their biological components. However, she is able to suppress it somehow until you finish killing her with conventional weapons.
106* ''VideoGame/SwordOfTheStars'':
107** The Liir rebelled against the Suul'ka by using a bioweapon to wipe them out. Given the species' adeptness with {{Synthetic Plague}}s everyone assumed that the bioweapon was one. This was until the sequel revealed the true nature of the [[SpaceWhale Suul'ka]] and the [[HunterOfHisOwnKind "bioweapon"]] used to destroy them, and that seven of them survived.
108** {{Averted|Trope}} in gameplay; planets hit by Biowar missiles are easily quarantined and it takes multiple warheads to wipe out a planetary population. And after first exposure a faction can research a vaccine to that specific virus.
109* In ''VideoGame/TerraInvicta'', the invading aliens use biological weapons to [[MindControl control humans]] and [[HostileTerraforming xenoform Earth]]. The human factions eventually develop countermeasures to both, and [[spoiler:[[AbsoluteXenophobe Humanity First]] and [[CorruptCorporateExecutive the Initiative]] eventually turn the tables and use biological weapons to exterminate and enslave the aliens, respectively]].
110* In ''VideoGame/TimeCrisis 5'', the BigBad [[spoiler:(Robert Baxter, [[RogueProtagonist previously the protagonist]] of ''Time Crisis II'')]] steals a drug three years ago that turns its victims into mindless zombies, or as [[spoiler:his former comrade Keith Martin]] puts it, makes them incapable of feeling pain or fear. [[spoiler:Robert then reveals that he has a bomb that can be detonated to spread the drug to entire cities, with New York as his first target.]]
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113[[folder:Webcomics]]
114* ''Webcomic/GenocideMan'' takes place after several extremist groups used open-source biotechnology to kill billions. The titular Genocide Project is an international law enforcement agency that uses targeted plagues to wipe out "genetic deviants" and their creators. It later turns out that [[spoiler:the Genocide Project unleashed a gene therapy virus intended to make humanity immune to all the open-source designer plagues out there (but not their own). It killed a billion people]].
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117[[folder:Western Animation]]
118* ''WesternAnimation/CodenameKidsNextDoor'': In "[[Recap/CodenameKidsNextDoorS5E6AOperationVIRUS Operation: V.I.R.U.S.]]", it's revealed that after [[CallBack the teenagers weaponized chickenpox]] the Kids Next Door retaliated by inventing an acne virus, with them unleashing it on Cree's prom in the end.
119* ''WesternAnimation/FamilyGuy:'' Stewie and Bertram end up in a playground war which ends when Bertram infects Stewie's side with chickenpox.
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