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8!Per wiki policy, Administrivia/SpoilersOff applies here and all spoilers are unmarked. Administrivia/YouHaveBeenWarned.
9[[quoteright:119:https://static.tvtropes.org/pmwiki/pub/images/i_found_pills.png]]
10[[caption-width-right:119:[[LargeHam I FOUND PILLS!]]]]
11
12* ''VideoGame/TheBindingOfIsaac'', of all games, has one where in one of the endings, Isaac picks up a fetus in a jar...and is shown wearing a Dr. Fetus Costume.
13** And then it plays the {{Sting}} from ''Super VideoGame/MeatBoy''.
14* Unlocking a treasure chest, only to find another treasure chest inside it. It appears Edmund likes to toy with expectations.
15** Or unlocking a treasure chest, finding another treasure chest in it, and then ''finding another treasure chest in that.''
16*** Not as funny when they're gold chests, as you end up wasting two or three keys, or might not even be able to open all of them (unless you're holding the paper clip trinket).
17* [[ToiletHumor Number]] [[UrineTrouble One]]. The look on Isaac's face as he chooses to [[http://images1.wikia.nocookie.net/__cb20130124121929/bindingofisaac/images/3/37/Number_One_Isaac.png pee on everything]] is just priceless.
18** Even better, beating Mega Satan with this power up. Enjoy killing '''Mega Satan''' by peeing onto his face! Doubles as a [[SugarWiki/MomentOfAwesome Crowning Moment of Awesome]], obviously.
19* Isaac can wear his mother's brassiere or her menstrual pad as items. Doing so causes the enemies to freeze or back away, respectively. Presumably, they're {{Squick}}ed out by the sight of it!
20** Segmented enemies like Larry Jr. will even fall apart when they try to flee. They are so disgusted that it breaks the laws of physics.
21* When you meet Greed in a hidden room, you can immediately leave through the hole you made without having to defeat him. Hi, Greed. Bye, Greed. If you have X-ray glasses, you can even use his room as a shortcut, running past him without ever engaging him.
22** Greed got wise to this, and, as such, it no longer works in ''Rebirth'': the entrances to the rooms around the hidden room get blocked until you defeat him.
23* The beggar that runs the shell game in the arcade is a jerk. Giving you a giant grin as he takes all your money without giving you the items you want? Seeing the slot machine throw a troll bomb at him is just too hilarious a karma to be true.
24** There are times where beggars will unveil a troll bomb ''[[TooDumbToLive right next to themselves.]]''
25** Similarly, sometimes the Beggar "rewards" you with a troll bomb. His eagerness to kill himself makes whatever money you wasted on him worth it.
26* In ''Wrath of the Lamb'', getting the Speed Ball item (a syringe with white fluid in it) gives Isaac [[OpenTheIris very large, dilated eyes]] and [[http://bindingofisaac.wikia.com/wiki/Speed_Ball a little smile]]. It looks incredibly goofy (though less so once you see [[http://images4.wikia.nocookie.net/__cb20120529091414/bindingofisaac/images/7/77/Speedback.png the bloody syringe]] sticking out the back of his head).
27* The glitches in this game can sometimes cause [[https://www.youtube.com/watch?v=DY_aTu0mUWQ&t=11m40s hilarious reactions]] from players. Especially since, given the tone of the game and previous games by Edmund [=McMillen=], it's difficult to tell if some of them are actually glitches.
28* One of the random effects of pills is "I Found Pills" with the description "...and ate them." This pill also causes Isaac to get a silly, derped look on his face and make a faint "duuur" noise when you take it.
29** Even funnier is the Horse Pill version of "I Found Pills": When Isaac takes it, he gets a face that seems to look like he's doing an exaggerated impression of an ''actual'' horse (this is the current page image). If the face wasn't funny enough, the voice clip for this pill has the narrator shouting in a [[LargeHam hammy]] voice, "I FOUND PILLS!"
30* Another effect of the pills is the "Puberty" pill, which causes Isaac to grow a few scraggly hairs on the top of his head. Then you realize, those are ''pubes'' growing on his head...
31** Taking three Puberty pills gives the "adult" transformation, which is just a free health-up... but also gives Isaac some scraggly facial hair and deeper voice clips. This applies on ''all'' characters, including [[BeardedLady female ones]].
32* Even more amusing pills in the remake. A new pill effect is "R U A Wizard?" This causes Isaac to get a derpy, walleyed look that forces him to shoot his tears diagonally for a short while. The Wiz, a DunceCap, has a similar effect, complete with the same walleyed expression.
33** The fact that the game treats this as a ''positive'' pill effect makes it even funnier.
34* Any of the secret messages from the Fortune Telling machine. Some of these include cryptic nonsense like "[[Franchise/MortalKombat LOOK TO LA LUNA]]" or "[[Film/PeeWeesBigAdventure DON'T LEAVE THE HOUSE TODAY]]". Then there are some that seem to be talking to the player, such as "GO OUTSIDE" or "YOU ARE THROWING YOUR LIFE AWAY". The way the game is just totally fucking with you in this moment is priceless. Oh, the best of all these? "YOU ARE WORSHIPPING A SUN GOD."
35** ''Rebirth'' continues these messages with blatant insults like "YOU WERE BORN WRONG", or [[AscendedMeme "REBIRTH]] [[BlatantLies GOT CANCELED"]].
36** [[https://dl.dropboxusercontent.com/u/41669097/YOU%20ARE%20PLAYING%20IT%20WRONG.png "YOU ARE PLAYING IT WRONG, GIVE ME THE CONTROLLER."]]
37** "WHEN LIFE GIVES YOU LEMONS, [[LuckManipulationMechanic REROLL]]!"
38* Some of the boss enemies make some pretty funny expressions, such as Chub's [[MemeticMutation poker face]] during her intro, War's OhCrap face when he runs out of stamina, Pin's stereotypical frown (it looks exactly like ":c"), or even Loki's expressions of pure glee while he fires his 4-way shots.
39* The fact that of all the Seven Deadly Sins, the only one without a unique sprite is Sloth. Or, in more modern terms, laziness.
40** As another rung to how goofy Sloth is, Edmund would later confirm that the Bob items and transformation are in fact referring to Sloth by his first name. In addition, this mean that Sloth finally gets a unique sprite set due to the Bob transformation... and then he can't be bothered to use it. And on the final rung of these recurring bits of lore, Edmund has also stated that Sloth represents the brother of Isaac's father... [[OverlyPrePreparedGag Meaning that logically]], [[LiteralMetaphor Bob's your uncle]].
41* One of the between-level dreams features Isaac using the toilet... and discovering there's no toilet paper left. His reaction is the typical "No!" reaction used in other dreams, but it seems more like he's going "Curses!" this time around. Don't worry, Isaac, other people can relate.
42** In ''Afterbirth'', one of the new dream transitions is Isaac and his penis falling off. His reaction is what any man's reaction would be if his dick fell off.
43** ''Repentance'' adds a dream where Isaac goes cloud watching. Then he realizes one of the clouds is [[FlippingTheBird flipping him off]].
44** Another ''Repentance'' dream is just Isaac in his usual TroubledFetalPosition. Then the Isaac inside the dream has another dream showing ''another'' Isaac, and ''[[DrosteImage that]]'' [[DrosteImage Isaac has]] ''[[DrosteImage another]]'' [[DrosteImage dream]]...
45* Fighting Wrath, a mini-boss who uses bombs... while you have [[HoistByHisOwnPetard the Remote Detonator on hand]]. Even better if you have Bobby-Bomb on hand, which pretty much means you can sit back and laugh while Wrath gets chased by his own bombs.
46* The fact that you can [[DealWithTheDevil sell your soul...]] [[SoldHisSoulForADonut for a quarter.]]
47** In ''Rebirth'', picking up the Rosary item allows you to potentially sell your soul ''[[{{Irony}} for the Bible.]]''
48* ''Rebirth'' adds an item called [[YouHaveResearchedBreathing "How to Jump"]], its description being "it's time you learned." The animation for jumping is just Isaac's head slapped onto the hopper sprite. It's as ridiculous as it sounds; it must be seen for oneself.
49* In ''Rebirth'', the "[[TabletopGame/CardsAgainstHumanity A Card Against Humanity]]" card. Its effect is so ridiculous that you can't help but laugh at it. What does it do? [[ToiletHumor It fills each empty space on the room with poop!]] Try using it in a big room or in a boss fight for added hilarity.
50* One secret seed you can input, BASE MENT, gives you a seemingly normal run. Basement I and Basement II are normal, but instead of moving on to Caves I, you go down to Basement III?, which is exactly like Basement I. And then Basement IV?! and Basement V...And then Basement VI and Basement VII. If you have time, you can play the seed for [[https://www.youtube.com/watch?v=ZRJlHZ7DUDM 4 hours!]]
51** If you make it all the way to the thousandth floor, you'll get a special message:
52--->Basement M... [[WhatTheHellPlayer Please Stop.]]
53* Another secret seed, FART SNDS, replaces ''every single sound effect'' with a fart sound.
54* Why does Judas wear a fez? [[https://www.youtube.com/watch?v=gHkb6LDrd70 It's a reference to the Fez creator, Phil Fish, who Edmund McMillen saw as a traitor.]] Clever, and funny.
55** Edmund later revealed that [[LyingCreator he was lying about the fez thing,]] but that doesn't make it any less funny.
56* The red poop dropped by the Carrion Queen will damage any other enemy that touches it. Because of this, during the BossRush, it's possible for some bosses to [[EpicFail die as soon as they enter the room]].
57* Cancer, in real life, is a horrible, life-threatening disease. Cancer in ''The Binding of Isaac'' is probably one of the best trinkets in the game, since it ''significantly'' increases your tear-firing rate, even if you've already hit the cap. The tagline description for it in ''Rebirth'' is even ''"[[ARareSentence Yay, cancer]]!"''
58** Made even better by the fact that you can get rid of it at any time!
59* One way to read Envy having the same attack method as Fistula and Teratoma is that it's a StealthInsult. The joke being, of course, that the dedicated troll amongst the seven sins is functionally identical to a tumor.
60* One ending (ending 11 in ''Rebirth'') has Isaac trying to open up the chest, only for It Lives! to appear, try to growl intimidatingly, and give an incredibly cheeky grin.
61** The very next ending (actually the previous ending in ''Rebirth'') has ??? give Issac a cheeky grin as well. Made even funnier in the original game/''[=WotL=]'', where the Dramatic Chipmunk {{Sting}} plays during this scene.
62** The Greed Mode ending continues this gag. We find out Greed is yet another posthumous Isaac as he gives us this big dumb grin.
63*** ''Afterbirth+'' has the Greedier Mode ending following the above with his head falling off and a literal geyser of spiders erupting from the severed neck. [[GainaxEnding Because why not.]]
64* Several combinations of items can lead to either JustForFun/MadeOfWin or EpicFail situations. [[SecondaryFire Sad Bombs (or Tammy's Head) plus Rubber Cement plus Ipecac equals utter carnage as you try to survive from your own explosive tears.]] [[DelayedExplosion Brimstone (or playing as Azazel) and Anti-Gravity leads to lines of charged beams.]]
65* There's a bonus song on the soundtrack called "He's the Number One." And [[https://www.youtube.com/watch?v=eJ93g4iazVg it's so bizarre it's hilarious.]]
66--> '''He's the number one. God's favorite son. His flowing robes reach down from heaven. His hands will touch you! Build a world around you! The light within his heart is enough to heal us all! He will fill your soul when life takes its toll. Your only goal is to find his kingdom. His love is real! The golden seal! Trust in the book and the bread you took!'''
67** [[https://www.youtube.com/watch?v=RT3laWF0Jx8 Dear Diary]] is even better, which has Isaac rapping about his plight in the most [[BlackComedy twistedly funny]] way imaginable.
68--> "Once I though I had it good, probably Mom misunderstood, when God came down from heaven, and turned the shit up to eleven."
69* In order to accommodate Nintendo's policies, ''Rebirth'' will be somewhat censored, including a [[http://i0.kym-cdn.com/photos/images/newsfeed/001/024/193/ea5.png fig leaf to cover nakedness]] and [[http://i0.kym-cdn.com/photos/images/newsfeed/001/024/194/fe6.png God being replaced with a dog.]] The censoring is an April Fool's joke, but the game did release on the Wii U and the New 3DS.
70** And under the main post, there's a bunch of strikethrough text that details the [[LongList many other changes]] that will be made.
71---> Note: other minor changes made to the 3ds and wiiU release are as follows: isaacs blood has been replaced with sweat. all instances of pills have been replaced with lollipops. all demon forms are now purple instead of black. you can now choose the gender identity of eden when you choose to play as them. maggy is now Hispanic. the womb has been replaced with a meat boy themed world. all instances of suicide now have text popups of local suicide hotlines. the letters R P A and E have been removed from the games code. isaacs mother is no longer overweight unless you choose the fat acceptance mode from the options menu, you can also replace mom with isaacs dad or isaacs dog from this menu. all references to isaacs sexuality being anything other than straight have been removed and he now carries a football. isaac is no longer shamed for dressing slutty. mulligans now wear police hats. any instance of abortion has been replaced with a funny cat video. the devil is no longer black. Isaac no longer eats dog food and spoiled milk, but healthy snacks of apples. the A button has been replaced with the “Trigger Button” a simple tap when triggered will close the game and removed it from your system. Isaac is now 18. racism no longer exists and finally all instances of my name have been removed from the game as well as any association with my blog, past games and this post.
72* The Adversary's design. For the record, The Adversary is the [[BackFromTheDead post-mortem]] version of the Dark One, and all of the other undead bosses have suffered some form of BodyHorror (Monstro II is missing most of his skin, the Carrion Queen is almost completely skeletal, etc). The Adversary? [[BandageMummy Covered in bandages]] and missing a horn. It almost looks comical.
73* When the achievements for ''Afterbirth'' were posted on Steam slightly before release, those with Real Platinum God saw that they no longer had 100% of achievements. Instead, they had 69%. Whether or not this is intentional is unknown, but likely.
74* Edmund asked Twitter what the antithesis of "Immaculate Conception" would be. The results... well, [[https://mobile.twitter.com/edmundmcmillen/status/561422400269471744 just read for yourself.]]
75* Two of the pills from ''Afterbirth'', named "One Makes You Larger" and "One Makes You Small", make you bigger and smaller, respectively. They also stack, so you can either end up with an Isaac who can barely even be seen he's so small, or an Isaac who takes up half of the screen with his size.
76* Ultra Greed's rotating sprites include several of his butt. This has reached the point of MemeticMutation and causes things like [[http://platinumgod.co.uk/ultra-butt this]] to pop up.
77* The Chaos item from ''Afterbirth''. After picking this item up, all further collectible items in the run will be drawn from random item pools, which can have... interesting effects. Such as an Angel showing up and offering you [[JokeItem Butter Bean]] or a Devil Room [[{{Irony}} offering the Halo]]. And then there's the [[http://hydra-media.cursecdn.com/bindingofisaacrebirth.gamepedia.com/e/e6/Chaos_App.png expression]] Isaac gets after picking up the item...
78* Upon finding Bum Friend, Dark Bum, and Key Bum in one run, a cutscene will trigger, showing the three [[FusionDance merging together]] to become Super Bum.
79* The Epilogue that plays after beating Mom for the first time starts off with her about to kill Isaac... then ''a Bible hits her on the head.''
80* The Aprils Fool challenge in ''Afterbirth+''. Nothing is what it looks like, every boss is the Bloat unless you randomly use Book of Revelations (every active item is Dead Sea Scrolls on steroids, so have fun if you get an infinite-use item like Guppy's Paw), and the reward is Maggy starting with a pill.
81** To make this even funnier, a Reddit user once suggested a challenge where every boss is The Bloat. When ''Afterbirth+'' came out ([[HilariousInHindsight and with it the Aprils Fool challenge]]), they were banned from /r/FUCKBLOAT (the official anti-Bloat subreddit) and forced to use [[MedalOfDishonor a unique "I Love The Bloat" flair]] on the main Isaac subreddit.
82-->'''Note From the Moderators''': [[YouBastard YOU DID THIS, NOW WE ALL HAVE TO SUFFER THROUGH THE CHALLENGE]]
83* The icon for the 1000000% achievement? A glittering stop sign with a gold background. The message? "[[CompletionMockery Just Stop!]]" The kicker? ''It's not even the highest completion percentage you can achieve.''
84* Delirium can shapeshift into other bosses, and if it rolls a boss with multiple health-based forms, its form will adapt to its current health. This means that if Delirium transforms into Brownie at low health, it ''[[EpicFail kills itself]]'' as the aforementioned boss splits into Dank Squirts when its health gets low, resulting in a hilarious anti-climax.
85** While this was eventually patched out, there's another way to make a fool out of Delirium. Have Vade Retro, whittle it down to 50% HP, wait for it to transform into a ghost boss (Haunt, Forsaken, Rainmaker, Heretic, etc.), and use the item. Cut to death animation.
86* Sometimes, if you get particularly good items during a run (especially in the early floors), bosses go from mildly difficult to a complete joke. In fact, it's not uncommon for the following scenario to take place: the VersusCharacterSplash appears, showing the boss looking menacing compared to your crying character... and almost immediately after the fight begins, the boss reduced to a big red splat mark on the floor once you let'er rip. The AntiClimax potential can easily elicit a few chuckles, especially if it's one of the harder endgame bosses, which crosses over into [[SugarWiki/MomentOfAwesome Awesome]].
87** It's extra funny if one of your items is Ipecac or Number One. You literally [[VomitIndiscretionShot vomit]]/[[UrineTrouble pee]] on them to death!
88* On another note, due to the way synergies work, your tears change shape, color, and size. [[BreathWeapon Brim]][[BloodyMurder stone]] results in a good-sized blood beam fired from the mouth, as an example... but you get Number One, it turns yellow. Yes, your character goes from firing blood lasers to firing a [[WebVideo/RealTimeFandub SUPER LAZER PISS]]. [[{{Squick}} From the mouth, too.]]
89* Once Isaac dispatches the first three of the Ultra forms of TheFourHorsemenOfTheApocalypse in the TrueFinalBoss ([[CapcomSequelStagnation we promise. Honest!]]), Death has [[SurroundedByIdiots a very understandably frustrated]] FacePalm. It is quite amusing to see arguably the scariest of the four [[YouHaveGotToBeKiddingMe getting annoyed that his brethren just got killed by a naked child]].
90* An addition made in ''Repentance'' is Horse Pills — larger pills that grant exaggerated versions of the typical effects; good becomes great, bad becomes worse, and [[LargeHam the narrator is more hammy]]. This is applied to almost every pill in the game... including the already funny "I Found Pills", which causes Isaac's face to morph into a horse's grin while the narrator screams "I FOUND '''PILLS!'''" at the top of his lungs. This hammy narrator can also lead to lines like "EXPLOSIVE DIARRHEA!" and "QUESTIONY QUESTIONY QUESTIONY!"
91* During the second phase of the Dogma battle, there are preachers in the background rambling and ranting verses of the Bible and the way they say their lines in such [[CarefulWithThatAxe an over the top way]] that you can't help but laugh even in spite of Dogma being a KnightOfCerebus.
92--->'''BLASPHEMY AGAINST THE HOLY SPIIIIRIIIIIIIIT!'''
93* What do you get when you cross Loki and Hornfel and someone insane enough to stich them together? You get the Horny Boys, one of the funniest bosses made for ''Isaac'' yet.
94** Hornfel has always had a problem with getting motion sick when he goes too fast… so when Loki starts posing faster and faster to fire off larger volleys, [[VomitIndiscretionShot it ends predictably]]. The tell for this attack even has Hornfel [[ThisIsGonnaSuck realize exactly where the attack is going]] before Loki starts.
95** Also the fact that they only appear in Gehenna, of all places. You fight your way through a bloodstained Satanic temple filled with depraved cultists, only to come across one of the silliest bosses in the game.
96* The Reverse arcana Tarot Cards are an interesting lot, having effects that are either the opposite of the original card, or behave in the spirit of that opposite. Death Reversed turns two enemies in the room into charmed skeletons instead of acting like a SmartBomb, Temperance Reversed causes Isaac to eat five random pills instead of spawning a Blood Donation Machine, etc. But Tower Reversed has among the most outlandish interpretations of this; instead of dropping several bombs into the room and destroying most rocks and pots in it, the card causes ''reverse explosions'' that will ''create'' rocks and pots in a way that leaves the exits unobstructed.
97** Reversed High Priestess also deserves a mention. When you pick it up, the description is a brief [[OhCrap "Run."]]. Cue Isaac being barraged by an onslaught of Mom stomps for a solid minute.
98** Reversed Emperor sends you to a boss fight 2 floors after. If used in the ??? floor, it will spawn '''[[WarmUpBoss MONSTRO]]''' instead, and you get Hush's completition marks [[AntiClimaxBoss by beating]] [[PostFinalBoss Monstro]], who at this point in the run should be a ZeroEffortBoss.
99* In the event that 700+ items isn't enough variety for the player, ''Repentance'' introduces "Glitch Items" that are found from TMTRAINER or have a chance to be in Secret and ERROR Rooms after beating Delirium with Tainted Eden. They can do ''anything,'' to the point of some downright absurd effects, [[https://old.reddit.com/r/bindingofisaac/comments/mj0xv9/the_binding_of_isaac_repentance_delete_this/ such as replacing fireplaces with End Chests]] and [[https://www.youtube.com/watch?v=AproWfov93E allowing the run to be ended in 3 seconds.]] The DELETE THIS challenge has the player start the run with TMTRAINER and go all the way to ???, ensuring a chaotic run.
100** Even the "item get" sounds for glitch items are completely randomized, including its pitch, which can result in anything from Satan's voice clips in a high pitch to even a slow-mo version of ''[[CrossesTheLineTwice Mom and]]'' ''[[https://www.youtube.com/watch?v=Gm9k7bakIw8&t=85s Dad arguing]]''
101* The trailer for ''Repentance'' is basically Awesome all the way, but in one instance, as it flaunts the game having MORE ENEMIES, MORE ITEMS, MORE ROOMS, MORE ACHIEVEMENTS, it suddenly drops ''MORE POOP''! Given that this update added Dross, Giant Poop, Charming Poop, and [[DungFu Tainted ???]], it certainly wasn't lying.
102* Suplex!, an active item gotten by defeating Delirium with Jacob and Esau, allows you to, well, [[ExactlyWhatItSaysOnTheTin suplex enemies]]. The hilarious part is when you realize there is no limit to it. Isaac (or any of the other characters) can give a SuplexFinisher to himself, his dead body, {{Satan}}, his mom, and ''himself as a fetus''.
103** Taken up to eleven should Tainted Samson use Suplex during his BerserkerRage. He slams things into the ground so hard that they EXPLODE!
104* Tainted Jacob's gimmick is that [[StalkedByTheBell after a given amount of time passes, the wretched spirit of Esau will rise from Hell]] and begin relentlessly chasing Jacob, hellbent on killing him. It's a tense and difficult mechanic to play around, but before a patch rendered him invulnerable to all forms of damage, you could also foil Esau ''permanently'' by... [[CessationOfExistence throwing an eraser at him.]] He didn't even get DraggedOffToHell by Big Horn like he did before the rework — he just vanished in a pink puff of smoke.
105* Tainted Jacob is based on the Biblical story of Jacob fleeing after taking Esau's birthright. So what happens when he gets the Birthright item? It summons ''[[FromBadToWorse another]]'' [[PoisonMushroom shadowy Dark Esau]]; in other words, grabbing it just pissed Esau off even more.
106-->'''Birthright Description:''' It's not yours.
107* Several of the new planetarium items embody {{pun}}s based on what they do in relation to what sign they represent. These range from the painfully obvious to the hilariously subtle.
108** Terra: "Born to rock" turns Isaac into a RockMonster and his tears into high damage boulders that can break things. The pun is so obvious it is guaranteed not to rock anyone's world view.
109** Uranus: "Ice Tears" turns Isaac into AnIcePerson and his tears can freeze enemies into statues for an instant kill on regular enemies if a threshold is passed. While it's mainly a reference to Uranus being extremely cold (with an average surface temperature of -353 degrees Fahrenheit), it also paves the way for a hilarious (if not [[ObligatoryJoke obvious]]) joke: [[UranusIsShowing Icy Uranus]].
110** Jupiter: "You're a gas giant" makes Isaac hilariously obese and causes him to leave [[{{Fartillery}} poisonous farts]] everywhere he walks. The planet Jupiter is a gas giant, so it turns Isaac into a different kind of gas giant.
111** Mars: "Double tap dash" turns Isaac into the boss War (based on the Biblical horseman). For some theological crossed wires, Mars is the god of war in Roman mythology.
112* On November 4th 2022, in order to promote a special G-Fuel flavor based on the game, a special daily challenge was made which gives Isaac a G-Fuel Item at the start of each floor. What does it do? Well, it gives Isaac an increasingly absurd combination of Base game items and First Person Shooter weapons, including [[ShotgunsAreJustBetter Shotguns]], [[MoreDakka Machine Guns]], and even ''rocket launchers''. No, not the Dr. Fetus + Rocket Jar synergy, an '''actual rocket launcher'''. Also, the more G-Fuels you get, the faster the gameplay becomes, the higher your speed stat becomes (even [[ReadingsAreOffTheScale bypassing the normal 2.0 limit]]), and the more often [[StuffBlowingUp everything explodes]]. Oh, and over time, as you pick up more G-Fuels, the narrator's voice grows progressively louder, until it gets to the point when the narrator just yells, "[[LargeHam G-FUELLLLLLLLLL!]]" whenever you pick up a G-Fuel.
113** What's better? The fact that a G-Fuel Run can be played at any time using the seed: GFVE LLLL
114** Additionally, the challenge run in particular was set up that Baby Plum was one of the first bosses encountered. Defeat Baby Plum, and her defeat animation plays out as normal... until a CGI ''missile strike'' comes in and [[ThereIsNoKillLikeOverkill blows her to high heaven.]] Even funnier? After the challenge came and went, there's still a ''very'' small chance for that to happen.

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