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*** Because of how [[OneHitPointWonder The Lost]]'s health[[labelnote:*]]After every variation of his current or maximum health (that doesn't result in his death), he's immediately brought back to 0 heart container and 0.5 soul hearts, all other hearts being erased[[/labelnote]] works, [[GameBreaker he can use Magic Skin with absolutely no limits to get every single item in the entire game]].
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*** Because of how [[OneHitPointWonder The Lost]]'s health[[labelnote:*]]After every variation of his current or maximum health (that doesn't result in his death), he's immediately brought back to 0 heart container and 0.5 soul hearts, all other hearts being erased[[/labelnote]] works, [[GameBreaker he can use Magic Skin with absolutely no limits to get every single item in the entire game]]. This was heavily {{Nerf}}ed in ''Repentance'', with Magic Skin now being a one-time use item for The Lost.
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* DrugsAreBad: The [[MushroomSamba Black Mushroom]] is an active item with a recharge time of a few seconds that increases tears and stacks with itself, so theoretically, you'd want to use it as much as possible... except each use also [[InterfaceScrew increasingly distorts your screen]]. You have to clear rooms to make the distortion clear up, but if you're relying on the Black Mushroom for damage, [[Catch22Dilemma you probably have to use it every room]]. If you ''really'' spam it to hell and back, it's entirely possible to render a run UnintentionallyUnwinnable due to the screen being distorted to the point of unplayability.
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* DrugsAreBad: The [[MushroomSamba Black Mushroom]] Mushroom]][[note]]Wavy Cap in ''Repentance''[[/note]] is an active item with a recharge time of a few seconds that increases tears and stacks with itself, so theoretically, you'd want to use it as much as possible... except each use also [[InterfaceScrew increasingly distorts your screen]]. You have to clear rooms to make the distortion clear up, but if you're relying on the Black Mushroom for damage, [[Catch22Dilemma you probably have to use it every room]]. If you ''really'' spam it to hell and back, it's entirely possible to render a run UnintentionallyUnwinnable due to the screen being distorted to the point of unplayability.
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** To unlock the final chapter of the alternate route, [[spoiler:Corpse]], you need to [[spoiler:find and assemble all three pieces of a knife hidden throughout the Alternate Route, then use it on the fleshy door that appears after defeating Mom in the Mausoleum]]; however, if you have [[spoiler:Mom's Knife]], you can use that instead.
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** To unlock the final chapter of the alternate route, [[spoiler:Corpse]], you need to [[spoiler:find and assemble all three pieces of a knife hidden throughout the Alternate Route, then use it on the fleshy door that appears after defeating Mom in the Mausoleum]]; however, if you have [[spoiler:Mom's Knife]], you can use that instead. This was removed in ''Repentance'', though there are still other means of opening the door (Cracked Orb, Soul of Cain, etc.)
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Crosswicking new trope.
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* ''VideoGame/TheBindingOfIsaac'': The mod adds "Immortal Hearts." They function identically to Soul Hearts, but will regenerate at the end of the room if they don't get destroyed.
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** The UsefulNotes/OculusRift is a passive item. Here, it's [[PunnyName a dimensional rift with an eye inside of it]].
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** The UsefulNotes/OculusRift Platform/OculusRift is a passive item. Here, it's [[PunnyName a dimensional rift with an eye inside of it]].
