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* CompletionMockery: getting OneHundredPercentCompletion with both {{Expansion Pack}}s installed [[spoiler:unlocks the 1000000% achievement, represented by a picture of a stop sign and the description "Just Stop!"]]


* OurZombiesAreDifferent: Most of the enemies in the game behave like zombies and seem to be undead of some sort, and they all come in different shapes and sizes, many of them with various [BodyHorror horrific]] appearances. In addition, some bosses have posthumous forms making them a more borderline case of this trope.

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* OurZombiesAreDifferent: Most of the enemies in the game behave like zombies and seem to be undead of some sort, and they all come in different shapes and sizes, many of them with various [BodyHorror [[BodyHorror horrific]] appearances. In addition, some bosses have posthumous forms making them a more borderline case of this trope.


* OurZombiesAreDifferent: Most of the enemies in the game behave like zombies and seem to be undead of some sort, and they all come in different shapes and sizes, many of them with various [BodyHorror horrific]] appearances. In addition, some bosses have posthumous forms making them a more borderline case of this trope.



* PottyFailure: The item "Lemon Mishap" allows you to lay down a puddle of pee that damages enemies, and the item "Number One" replaces your tears with a rapid-fire stream of urine. Also, certain pills will give you bad gas or literally explosive diarrhea. There's also the boss monster Peep, who uses urine as his main weapon.

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* PottyFailure: The item "Lemon Mishap" allows you to lay down a puddle of pee that damages enemies, and the item "Number One" replaces your tears with a rapid-fire stream of urine. Also, certain pills will give you bad gas or literally explosive diarrhea. There's also the boss monster Peep, who uses urine as his main weapon.weapon, and Mega Fatty, who can attack you by farting out diarrhea or small turds.


** Certain bosses have pink champion versions which feature two of the boss, but each only has half health of the original.
** The "Double Trouble!" mechanic can randomly pair two bosses together, usually two of the same boss but occasionally different ones. This includes pink champion bosses, which means both versions will be doubled.

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** Certain bosses have pink champion versions which feature two of the boss, but each only has half the health of the original.
** The "Double Trouble!" mechanic can randomly pair two bosses together, usually two of the same boss but occasionally different ones. This includes pink champion bosses, which means both versions will be doubled.


* DualBoss:
** Certain bosses have pink champion versions which feature two of the boss, but each only has half health of the original.
** The "Double Trouble!" mechanic can randomly pair two bosses together, usually two of the same boss but occasionally different ones. This includes pink champion bosses, which means both versions will be doubled.



* {{Feelies}}: The ''Nintendo Switch'' boxed release includes a fully illustrated instruction manual, which parodies the original ''Legend of Zelda'' game manual, as well as some stickers featuring some of the game's character's and enemies.

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* {{Feelies}}: The ''Nintendo Switch'' boxed release includes a fully illustrated instruction manual, which parodies the original ''Legend of Zelda'' game manual, as well as some stickers featuring some of the game's character's characters and enemies.


The story follows [[MeaningfulName Isaac, a young boy]] who finds himself in possibly the worst situation imaginable. After his [[TheFundamentalist fanatical Christian]] mother, Magdalene O. Moriah, begins [[HearingVoices hearing the voice]] of {{God}}, she removes all of his worldly possessions and [[NakedOnArrival strips him naked]], confines him to his bedroom, and unhesitatingly accepts a commission to kill him in sacrifice to prove her devotion. Isaac discovers her intentions and manages to escape into [[DungeonCrawling the basement]], where, still naked, he goes on the run as he fights off nightmares both physical and mental (using [[AbnormalAmmo his own tears]], no less), discovers memories of his own past, and ultimately confronts [[BigBad Mom]] in an effort to survive.

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The story follows [[MeaningfulName Isaac, a young boy]] who finds himself in possibly the worst situation imaginable. After his [[TheFundamentalist fanatical Christian]] mother, Magdalene O. Moriah, mother begins [[HearingVoices hearing the voice]] of {{God}}, she removes all of his worldly possessions and [[NakedOnArrival strips him naked]], confines him to his bedroom, and unhesitatingly accepts a commission to kill him in sacrifice to prove her devotion. Isaac discovers her intentions and manages to escape into [[DungeonCrawling the basement]], where, still naked, he goes on the run as he fights off nightmares both physical and mental (using [[AbnormalAmmo his own tears]], no less), discovers memories of his own past, and ultimately confronts [[BigBad Mom]] in an effort to survive.


The story follows [[MeaningfulName Isaac, a young boy]] who finds himself in possibly the worst situation imaginable. After his [[TheFundamentalist fanatical Christian]] mother begins [[HearingVoices hearing the voice]] of {{God}}, she removes all of his worldly possessions and [[NakedOnArrival strips him naked]], confines him to his bedroom, and unhesitatingly accepts a commission to kill him in sacrifice to prove her devotion. Isaac discovers her intentions and manages to escape into [[DungeonCrawling the basement]], where, still naked, he goes on the run as he fights off nightmares both physical and mental (using [[AbnormalAmmo his own tears]], no less), discovers memories of his own past, and ultimately confronts [[BigBad Mom]] in an effort to survive.

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The story follows [[MeaningfulName Isaac, a young boy]] who finds himself in possibly the worst situation imaginable. After his [[TheFundamentalist fanatical Christian]] mother mother, Magdalene O. Moriah, begins [[HearingVoices hearing the voice]] of {{God}}, she removes all of his worldly possessions and [[NakedOnArrival strips him naked]], confines him to his bedroom, and unhesitatingly accepts a commission to kill him in sacrifice to prove her devotion. Isaac discovers her intentions and manages to escape into [[DungeonCrawling the basement]], where, still naked, he goes on the run as he fights off nightmares both physical and mental (using [[AbnormalAmmo his own tears]], no less), discovers memories of his own past, and ultimately confronts [[BigBad Mom]] in an effort to survive.



* In ''Afterbirth+'', [[spoiler:it is revealed that the very final boss and true villain of the story is [[EldritchAbomination Deliruim]], a giant melting skull that is the physical manifestation of Isaac's SanitySlippage and DyingDream, and is the one creating all the monsters/nightmares that Isaac has been fighting, including Mom and Satan]].

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* In ''Afterbirth+'', [[spoiler:it is revealed that the very final boss and true villain of the story is [[EldritchAbomination Deliruim]], Delirium]], a giant melting skull that is the physical manifestation of Isaac's SanitySlippage and DyingDream, and is the one creating all the monsters/nightmares that Isaac has been fighting, including Mom and Satan]].


The story follows [[MeaningfulName Isaac, a young boy]] who finds himself in possibly the worst situation imaginable. After his [[TheFundamentalist fanatical Christian]] mother begins [[HearingVoices hearing the voice]] of {{God}}, she removes all of his worldly possessions and [[NakedOnArrival strips him naked]], confines him to his bedroom, and unhesitatingly accepts a commission to kill him in sacrifice to prove her devotion. Isaac discovers her intentions and manages to escape into [[DungeonCrawling the basement]], where, still naked, he goes on the run as he fights off nightmares both physical and mental (using [[AbnormalAmmo his own tears]], no less), discovers memories of his own past, and ultimately confronts her in an effort to survive.

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The story follows [[MeaningfulName Isaac, a young boy]] who finds himself in possibly the worst situation imaginable. After his [[TheFundamentalist fanatical Christian]] mother begins [[HearingVoices hearing the voice]] of {{God}}, she removes all of his worldly possessions and [[NakedOnArrival strips him naked]], confines him to his bedroom, and unhesitatingly accepts a commission to kill him in sacrifice to prove her devotion. Isaac discovers her intentions and manages to escape into [[DungeonCrawling the basement]], where, still naked, he goes on the run as he fights off nightmares both physical and mental (using [[AbnormalAmmo his own tears]], no less), discovers memories of his own past, and ultimately confronts her [[BigBad Mom]] in an effort to survive.



* BigBad: Who it is is really, really, really convoluted. Is it God, ordering Mom to kill Isaac? Is it Mom, who's just imagining things? Is it some combination of the two?

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* BigBad: Who The frequent updates and use of {{True Final Boss}}es make it rather convoluted to tell, but in order:
** The original game has Magdalene O. Moriah, AKA [[AbusiveParents Mom]], who tries to sacrifice her son [[PlayerCharacter Issac]] believing she hears the voice of God commanding her to, and serves as the FinalBoss. It
is ambiguous as to whether she is really, really, really convoluted. Is it God, ordering Mom simply delusional or GodIsEvil and the GreaterScopeVillain. [[spoiler:Though either way, ''Afterbirth+'' reveals her to kill Isaac? Is it Mom, who's just imagining things? Is it some combination be [[AllJustADream a nightmare version]] of Isaac's real mother.]]
** In ''Wrath
of the two?Lamb'' and ''Rebirth'', [[spoiler:the real antagonist is implied to be {{Satan}}, who was using Isaac through his [[DealWithTheDevil deals]] before turning on him and is implied to have been the true source of the voice, [[TheManBehindTheMan manipulating Mom into killing Isaac]]. Though ''Afterbirth+'' reveals that he too was a delusion]].
* In ''Afterbirth+'', [[spoiler:it is revealed that the very final boss and true villain of the story is [[EldritchAbomination Deliruim]], a giant melting skull that is the physical manifestation of Isaac's SanitySlippage and DyingDream, and is the one creating all the monsters/nightmares that Isaac has been fighting, including Mom and Satan]].


* ''Afterbirth'', the remake's first expansion, released on October 30th of 2015. Not only does it come with the usual stuff (such as new items, bosses, and a new character), but it also features [[MultiMookMelee Greed Mode]] and even more alternative areas. Some of this new content are ideas [[OfficialFanSubmittedContent suggested by the community]]; this includes items, challenges, and other features.

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* ''Afterbirth'', the remake's first expansion, released on October 30th of 2015. Not only does it come with the usual stuff (such as new items, bosses, and a new character), but it also features [[MultiMookMelee Greed Mode]] and even more alternative areas. Some of this new content are ideas [[OfficialFanSubmittedContent suggested by the community]]; community; this includes items, challenges, and other features.



** The [[VideoGame/MeatBoy Dr. Fetus]] powerup. Good luck trying to kill [[DemonicSpiders hosts]] with it. The Ipecac Syrup, added in the expansion, [[UpToEleven is even more Awesome But Impractical]] -- it launches the same green spit bombs as the green enemies do. It can blow open doors and poisons enemies, but on the other hand, it travels in an arc that can make it very difficult to work with, especially on faster enemies. It also explodes when traveling over a rock, [[DepthPerplexion even when it's visibly meters above it]], so it ''will'' blow up in your face. Of course, just like Brimstone, mastery of such items can make them DifficultButAwesome.

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** The [[VideoGame/MeatBoy Dr. Fetus]] powerup. Good luck trying to kill [[DemonicSpiders hosts]] hosts with it. The Ipecac Syrup, added in the expansion, [[UpToEleven is even more Awesome But Impractical]] -- it launches the same green spit bombs as the green enemies do. It can blow open doors and poisons enemies, but on the other hand, it travels in an arc that can make it very difficult to work with, especially on faster enemies. It also explodes when traveling over a rock, [[DepthPerplexion even when it's visibly meters above it]], so it ''will'' blow up in your face. Of course, just like Brimstone, mastery of such items can make them DifficultButAwesome.



** [[Franchise/{{Pokemon}} The MissingNo Item]]. [[spoiler:Have fun getting your items and stats completely randomized at the start of every floor.]]

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** [[Franchise/{{Pokemon}} [[VideoGame/{{PokemonRedAndBlue}} The MissingNo Item]]. [[spoiler:Have fun getting your items and stats completely randomized at the start of every floor.]]


* {{Foreshadowing}}: While they usually just feature Isaac getting humiliated in some way, one of Isaac's between-level nightmares shows him suffocating inside of a chest, [[spoiler:foreshadowing the Sheol ending and ???'s possible origins.]]

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* {{Foreshadowing}}: {{Foreshadowing}}:
**
While they usually just feature Isaac getting humiliated in some way, one of Isaac's between-level nightmares shows him suffocating inside of a chest, [[spoiler:foreshadowing the Sheol ending and ???'s possible origins.]]
** The description for the Suicide King card is "A true ending?" and the card itself kills you. [[spoiler:The later endings of the game make it clear that Isaac suffocates himself in his toy chest; in other words, the "true ending" of the game is Isaac's suicide.
]]



* GainaxEnding: At first. All endings after the "Epilogue" except the tenth, Endings 1-9, are little more than item/character/achievement unlocks with no plot-relevance, and make no sense within the story. However, Ending 10 is a huge WhamEpisode, revealing that [[spoiler:Isaac has been DeadAllAlong, as he actually suffocated to death in the Chest as seen in one of the vignettes]], and Endings 11, 12, and 13 then explain the events leading up to that point, wrapping up the story.
** Rebirth's Ending 16 shows what happens to Isaac inside the chest. [[DownerEnding It isn't pretty.]] [[NightmareFuel Quite the opposite, really.]]

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* GainaxEnding: At first. All endings after the "Epilogue" except the tenth, Endings 1-9, are little more than item/character/achievement unlocks with no plot-relevance, and make no sense within the story. However, Ending 10 is a huge WhamEpisode, revealing that [[spoiler:Isaac has been DeadAllAlong, as he actually suffocated to death in the Chest as seen in one of the vignettes]], and Endings 11, 12, and 13 then explain the events leading up to that point, wrapping up the story.
**
story. Rebirth's Ending 16 shows what happens to Isaac inside the chest. [[DownerEnding It isn't pretty.]] [[NightmareFuel Quite the opposite, really.]]


** The reward for beating [[spoiler:[[BonusBoss Mega Satan]]]]] and/or completing all bosses on Hard Mode on a character? A different selectable skin for co-op babies. [[spoiler: Except for [[OneHitPointWonder The Lost]], who unlocks the extremely powerful Godhead if you manage to clear all Hard Mode marks with him]].


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* AndYourRewardIsClothes: The reward for beating [[spoiler:[[BonusBoss Mega Satan]]]] and/or completing all marks (defeat every major boss plus the Boss Rush) on Hard Mode on a character? A different selectable skin for co-op babies. [[spoiler: Except for [[OneHitPointWonder The Lost]], who unlocks the extremely powerful Godhead if you manage to clear all Hard Mode marks with him]].

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** The reward for beating [[spoiler:[[BonusBoss Mega Satan]]]]] and/or completing all bosses on Hard Mode on a character? A different selectable skin for co-op babies. [[spoiler: Except for [[OneHitPointWonder The Lost]], who unlocks the extremely powerful Godhead if you manage to clear all Hard Mode marks with him]].


** Lerry Jr. and the Hollow can also split if you destroy a segment in the middle of their body.



* SegmentedSerpent Larry Jr. and the Hollow are made of multiple segments, each of which can be individually damaged. They can split into multiple entities if a segment is broken and there are two or more remaining segments on either side.



* SelfImposedChallenge: Pretty much the only reason why anyone would pick up the nine lives item (which reduces your hearts to only one and resets them to one every time you die) willingly outside of HundredPercentCompletion, the challenge of the same name, or [[spoiler:turning one of the characters into Guppy.]]

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* SelfImposedChallenge: SelfImposedChallenge:
**
Pretty much the only reason why anyone would pick up the nine lives item (which reduces your hearts to only one and resets them to one every time you die) willingly outside of HundredPercentCompletion, the challenge of the same name, or [[spoiler:turning one of the characters into Guppy.]]



* ToiletHumor

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* ToiletHumorToiletHumor: There are quite a few items related to urine and feces, piles of poop are ubiquitous throughout the game, and several enemies are living embodiments of the same.

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** Averted if you manage to get your hands on a Placebo/Blank Card, which let you reuse your pills and cards on a short cooldown, at the cost of your active item slot.

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** Lerry Jr. and the Hollow can also split if you destroy a segment in the middle of their body.

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