History PermanentlyMissableContent / RolePlayingGame

*** Even back in FES, it's easy to forget to confirm that you've taken Elizabeth (or Theodore in Portable) out on a date to obtain key items to fuse certain Personas before the quest's deadline.

** The Rainbow Weapons are the most powerful weapons of the game, and you need to do several steps in order to tame them, such as recruiting Zappa (who hints at these weapons earlier) and talking to Nikki in the S.S Zelbees, after which, if you don't do them, those opportunities are gone, meaning it's impossible to fight all of the 6 Dragons as the Black Dragon can't be fought and the Master Hammer, which you'll need in order to forge these weapons, can't be brought.

** The Rainbow Weapons are the most powerful weapons of the game, and you need to do several steps in order to tame them: recruiting Zappa (who hints at these weapons earlier), talking to Nikki in the S.S Zelbees, after which, if you don't do them, those opportunities are gone, meaning it's impossible to fight the 6 Dragons as the Black Dragon can't be fought and the Master Hammer, which you'll need in order to forge these weapons, can't be brought.

** Say yes to Kid when she first offers to join? Well, you just lost Leena. Answer one or both of the questions she asked earlier wrong? Well, you just lost her best tech.

** ''VideoGame/FinalFantasyIVTheAfterYears'' takes this [[SerialEscalation to the next level]]. Didn't get the needed parts to repair the airship in Rydia's Tale, including two that are dropped by [[GuideDangIt specific enemies which only appear in one deserted room during a specific lunar cycle]] with the same drop rate as the [[ThatOneSidequest PinkTail]]? Sorry, [[spoiler:Calca and Brina will have to be scrapped for replacement parts]]. Lost a battle and didn't reload your save when playing as any of the Eblan Four or picked the wrong dialogue option as Gekkou? Sorry, that ninja is KilledOffForReal. Don't have a party of [[spoiler:Cecil, Ceodore and Rosa]] when [[spoiler: Golbez makes his HeroicSacrifice?]] Sorry, [[KilledOffForReal you can't save him]]. Also, in the final chapter it's possible to permanently kill [[spoiler:brainwashed Shiva and Ramuh]] if you hit them while they're calming down, which is easy to do by accident if you have an action queued up right when the dialogue that tells you to stop attacking them pops up.

*** Many, many materia are missable if you don't pick them up at the first opportunity or miss the wrong sidequest. This includes Comet, Ultima, Morph, W-Item, one of the Enemy Skill Materia, Added Effect, MP Turbo, Steal as Well, MP Absorb, Elemental, Ifrit, Ramuh, Bahamut, Neo Bahamut, Leviathan, and Luck Plus.

*** If Aeris is equipped with any unique items before [[spoiler:her death]], you'll lose them permanently for the rest of the game.

** ROM hacks of Final Fantasy VI:

** In the expansion, if you happen to have kept the Flail, you can also acquire two more heads for said butler to attach, completing the flail, and as you add each head it grows in power, dealing more damage and providing better abilities. Theoretically. The catch? When the final head is added, the Flail begins granting Free Action while it's equipped. That would be fine, except that free action prevents all changes to your movement speed, good or bad. While you're immune to the (by now rather weak) movement-stopping spells like Web and Entangle, you're also "immune" to spells like Haste, and the Boots of Speed. Since both of these are especially useful for melee fighters, who are most likely to be using the flail...Suffice it to say that many experienced players avoid applying the final upgrade, considering the Flail more useful with one head missing. Sadly, once you perform the upgrade (without knowing what the "improved" flail will give) there's no way to downgrade it again other than editing your inventory with an external program or reverting to an earlier save. Since Free Action is a relatively uncommon effect, it's not immediately obvious to many players that they've effectively received a debuff, so they may overwrite their previous saves before realising the problem.

** If you bring a full team to help break Imoen out of Spellhold, and Yoshimo isn't one of them, odds are good you're going to end up leaving one of them in the depths of the Asylum maze without any meaningful way to get them back until the expansion.

** The first game ''VideoGame/GoldenSun1'' doesn't have anything that is technically missable during the game, but once the final credits roll and the file is completed, they cannot play that file anymore. However the sequel, ''VideoGame/GoldenSunTheLostAge'', has extra content, including a bonus dungeon, that is locked unless the player picked up all Djinn and optional items in the first game and then transferred their save file.