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* ''VideoGame/{{Rimworld}}'': The Pigskin race added in the ''Biotech'' DLC are explained in FlavorText to not be genetically modified humans like the other races, but in fact pigs which have been genetically modified with human DNA to become [[PigMan pig people]], giving them human-level intelligence, an upright posture, and tissues compatible with baseline humans (indeed, they were originally created by some long-disappeared government to act as organ farms).

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* ''Film/JohnnyMnemonic'' includes the cybernetically-enhanced uplifted dolphin Jones, as in the original William Gibson story.



* ''Film/JohnnyMnemonic'' includes the cybernetically-enhanced uplifted dolphin Jones, as in the original William Gibson story.
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* ''TabletopGame/WerewolfTheApocalypse'' has the Lupus, werewolves who started out as wolves rather then humans. While already unusually smart as wolves, once they shapeshift for the first time they permenantly jump to human intelligence. There are analogues in other Breeds too -- perphaps the biggest leap is the Ananasi, who can jump to human intelligence from being a ''spider''.
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* ''VideoGame/HeroesOfTheSeasons'': Nestlei was once an ordinary sheep, but gained humanlike intelligence after drinking from an enchanted river.
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* ''TabletopGame/EclipsePhase'' has uplifted apes of all kinds -- [[SapientCetaceans dolphins]], parrots, crows, octopi, orcas, whales, and pigs, all of which are entirely common player character backgrounds.:

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* ''TabletopGame/EclipsePhase'' has uplifted apes of all kinds -- kinds, plus [[SapientCetaceans dolphins]], parrots, crows, octopi, orcas, whales, and pigs, all of which are entirely common player character backgrounds.:
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* Creator/JohnScalzi's ''Literature/StarterVillain'' includes uplifted cats, dolphins, and humpback whales. The cats are management. The dolphins and [[spoiler: eventually the whales]] are unionized and strike for better work conditions in the villain's organization.

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* Creator/JohnScalzi's ''Literature/StarterVillain'' ''Literature/StarterVillain2023'' includes uplifted cats, dolphins, and humpback whales. The cats are management. The dolphins and [[spoiler: eventually the whales]] are unionized and strike for better work conditions in the villain's organization.
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*** Humans, dolphins, and chimpanzees avoid being "adopted" (aka enslaved and forcibly genetically altered) by the more-hostile Galactics [[ValuesDissonance only because humans had uplifted the dolphins and chimpanzees before first contact]]. Said Galactics then object to humans having started to also uplift dogs and gorillas.
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* ''Literature/ChildrenOfTime2015'': The prologue is about Doctor Kern starting an experiment intended to uplift monkeys on a terraformed world to full sapience within fifty generations. Unfortunately, a hardline faction against the "obsolescence of humanity" sabotages the project (at the same time as they start a war that ends up nearly annihilating the human race), resulting in all the monkeys being killed. However, the nanovirus intended to uplift the primates lands on the planet and finds hosts. While it was designed to avoid mammals and vertebrates to prevent the monkeys from having competition, it ends up finding fertile ground in invertebrate species, resulting in a world of GiantCreepyCrawlies. However, since the virus was never designed to work with them, its results are mixed; some insects end up merely giant, but not really that much more intelligent, others become intelligent enough to use as work animals, and the ants remain individually completely mindless but create a biological calculation engine that becomes the world's first superpower, complete with metallurgy and siege weapons, despite ''not actually being conscious''. The apex predators, at least on land, end up being a highly evolved form of jumping spider that slowly develop culture and technology comparable to human, if still completely alien.

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* ''Literature/ChildrenOfTime2015'': The prologue is about Doctor Kern starting an experiment intended to uplift monkeys on a terraformed world to full sapience within fifty generations. Unfortunately, a hardline faction against the "obsolescence of humanity" sabotages the project (at the same time as they start a war that ends up nearly annihilating the human race), resulting in all the monkeys being killed. However, the nanovirus intended to uplift the primates lands on the planet and finds hosts. While it was designed to avoid mammals and vertebrates to prevent the monkeys from having competition, it ends up finding fertile ground in invertebrate species, resulting in a world of GiantCreepyCrawlies.BigCreepyCrawlies. However, since the virus was never designed to work with them, its results are mixed; some insects end up merely giant, but not really that much more intelligent, others become intelligent enough to use as work animals, and the ants remain individually completely mindless but create a biological calculation engine that becomes the world's first superpower, complete with metallurgy and siege weapons, despite ''not actually being conscious''. The apex predators, at least on land, end up being a highly evolved form of jumping spider that slowly develop culture and technology comparable to human, if still completely alien.
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* ''Literature/ChildrenOfTime2015'': The prologue is about Doctor Kern starting an experiment intended to uplift monkeys on a terraformed world to full sapience within fifty generations. Unfortunately, a hardline faction against the "obsolescence of humanity" sabotages the project (at the same time as they start a war that ends up nearly annihilating the human race), resulting in all the monkeys being killed. However, the nanovirus intended to uplift the primates lands on the planet and finds hosts. While it was designed to avoid mammals and vertebrates to prevent the monkeys from having competition, it ends up finding fertile ground in invertebrate species, resulting in a world of GiantCreepyCrawlies. However, since the virus was never designed to work with them, its results are mixed; some inects end up merely giant, but not really that much more intelligent, others become intelligent enough to use as work animals, and the ants remain individually completely mindless but create a biological calculation engine that becomes the world's first superpower, complete with metallurgy and siege weapons, despite ''not actually being conscious''. The apex predators, at least on land, end up being a highly evolved form of jumping spider that slowly develop culture and technology comparable to human, if still completely alien.

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* ''Literature/ChildrenOfTime2015'': The prologue is about Doctor Kern starting an experiment intended to uplift monkeys on a terraformed world to full sapience within fifty generations. Unfortunately, a hardline faction against the "obsolescence of humanity" sabotages the project (at the same time as they start a war that ends up nearly annihilating the human race), resulting in all the monkeys being killed. However, the nanovirus intended to uplift the primates lands on the planet and finds hosts. While it was designed to avoid mammals and vertebrates to prevent the monkeys from having competition, it ends up finding fertile ground in invertebrate species, resulting in a world of GiantCreepyCrawlies. However, since the virus was never designed to work with them, its results are mixed; some inects insects end up merely giant, but not really that much more intelligent, others become intelligent enough to use as work animals, and the ants remain individually completely mindless but create a biological calculation engine that becomes the world's first superpower, complete with metallurgy and siege weapons, despite ''not actually being conscious''. The apex predators, at least on land, end up being a highly evolved form of jumping spider that slowly develop culture and technology comparable to human, if still completely alien.
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* ''Literature/ChildrenOfTime2015'': The prologue is about Doctor Kern starting an experiment intended to uplift monkeys on a terraformed world to full sapience within fifty generations. Unfortunately, a hardline faction against the "obsolescence of humanity" sabotages the project (at the same time as they start a war that ends up nearly annihilating the human race), resulting in all the monkeys being killed. However, the nanovirus intended to uplift the primates lands on the planet and finds hosts. While it was designed to avoid mammals and vertebraes to prevent the monkeys from having competition, it ends up finding fertile ground in invertebrae species, resulting in a world of GiantCreepyCrawlies. However, since the virus was never designed to work with them, its results are mixed; some inects end up merely giant, but not really that much more intelligent, others become intelligent enough to use as work animals, and the ants remain individually completely mindless but create a biological calculation engine that becomes the world's first superpower, complete with metallurgy and siege weapons, despite ''not actually being conscious''. The apex predators, at least on land, end up being a highly evolved form of jumping spider that slowly develop culture and technology comparable to human, if still completely alien.

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* ''Literature/ChildrenOfTime2015'': ''Literature/ChildrenOfTime2015'': The prologue is about Doctor Kern starting an experiment intended to uplift monkeys on a terraformed world to full sapience within fifty generations. generations. Unfortunately, a hardline faction against the "obsolescence of humanity" sabotages the project (at the same time as they start a war that ends up nearly annihilating the human race), resulting in all the monkeys being killed. killed. However, the nanovirus intended to uplift the primates lands on the planet and finds hosts. hosts. While it was designed to avoid mammals and vertebraes vertebrates to prevent the monkeys from having competition, it ends up finding fertile ground in invertebrae invertebrate species, resulting in a world of GiantCreepyCrawlies. GiantCreepyCrawlies. However, since the virus was never designed to work with them, its results are mixed; some inects end up merely giant, but not really that much more intelligent, others become intelligent enough to use as work animals, and the ants remain individually completely mindless but create a biological calculation engine that becomes the world's first superpower, complete with metallurgy and siege weapons, despite ''not actually being conscious''. conscious''. The apex predators, at least on land, end up being a highly evolved form of jumping spider that slowly develop culture and technology comparable to human, if still completely alien.
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None

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* ''Literature/ChildrenOfTime2015'': The prologue is about Doctor Kern starting an experiment intended to uplift monkeys on a terraformed world to full sapience within fifty generations. Unfortunately, a hardline faction against the "obsolescence of humanity" sabotages the project (at the same time as they start a war that ends up nearly annihilating the human race), resulting in all the monkeys being killed. However, the nanovirus intended to uplift the primates lands on the planet and finds hosts. While it was designed to avoid mammals and vertebraes to prevent the monkeys from having competition, it ends up finding fertile ground in invertebrae species, resulting in a world of GiantCreepyCrawlies. However, since the virus was never designed to work with them, its results are mixed; some inects end up merely giant, but not really that much more intelligent, others become intelligent enough to use as work animals, and the ants remain individually completely mindless but create a biological calculation engine that becomes the world's first superpower, complete with metallurgy and siege weapons, despite ''not actually being conscious''. The apex predators, at least on land, end up being a highly evolved form of jumping spider that slowly develop culture and technology comparable to human, if still completely alien.
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* ''Literature/TheWarWithNoName'' series by Creator/RobertRepino: The Change caused animals to become more intelligent and anthropomorphic, giving them the ability to talk, understand human speech… and hold a lethal grudge against their owners for being their long-time oppressors.

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* ''Literature/TheWarWithNoName'' ''Literature/WarWithNoName'' series by Creator/RobertRepino: The Change caused animals to become more intelligent and anthropomorphic, giving them the ability to talk, understand human speech… and hold a lethal grudge against their owners for being their long-time oppressors.
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* ''Literature/TheWarWithNoName'' series by Creator/RobertRepino: The Change caused animals to become more intelligent, giving them the ability to talk, understand human speech… and hold a lethal grudge against them for being their long-time oppressors.

to:

* ''Literature/TheWarWithNoName'' series by Creator/RobertRepino: The Change caused animals to become more intelligent, intelligent and anthropomorphic, giving them the ability to talk, understand human speech… and hold a lethal grudge against them their owners for being their long-time oppressors.
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None

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* ''Literature/TheWarWithNoName'' series by Creator/RobertRepino: The Change caused animals to become more intelligent, giving them the ability to talk, understand human speech… and hold a lethal grudge against them for being their long-time oppressors.
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* Bond from ''Manga/SpyXFamily'' is a dog who was experimented on as part of a secret government project to create hyper-intelligent dogs for covert operations. While he can't speak, he can understand human speech and complex instructions, picking up on things before even humans can. He also has the power [[{{Seers}} to see the future]]; while his visions aren't set in stone, he's smart enough to try avoiding any unpleasant futures he sees. [[DownplayedTrope That said]], he still usually defaults to thinking like a dog, and his ability to understand the complexities of human society is limited at best despite his general understanding of human language.

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* Bond from ''Manga/SpyXFamily'' ''Manga/SPYxFAMILY'' is a dog who was experimented on as part of a secret government project to create hyper-intelligent dogs for covert operations. While he can't speak, he can understand human speech and complex instructions, picking up on things before even humans can. He also has the power [[{{Seers}} to see the future]]; while his visions aren't set in stone, he's smart enough to try avoiding any unpleasant futures he sees. [[DownplayedTrope That said]], he still usually defaults to thinking like a dog, and his ability to understand the complexities of human society is limited at best despite his general understanding of human language.
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* A '''bacteria''' that has ascended to human-level intelligence is a one-shot foe in ''Fanfic/VoyagesOfTheWildSeaHorse'', with the transformation being justified through a combination of CannibalismSuperpower and the use of a [[HumanShifting Human-Human Zoan]] type of [[PowerUpFood Devil Fruit]].
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-->'''Olimar:''' Wait, so he was so disgusting that your brain ''evolved'' just so it could process the horrors it was witnessing?\\

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-->'''Olimar:''' Wait, so he was so disgusting that your brain ''evolved'' just so it could process the horrors it was witnessing?\\
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* ''Literature/KittyCatKillSat'': Lily, interestingly, did this to ''herself''. She was an ordinary, though immortal, house cat and the last survivor on the station. She spent decades slooowly learning human language, and eventually reached the point where she could tell a biolab she had found to make her smarter.
-->'''Lily:''' The first dose made me very sick, and I decided to never do it again. The second dose made me very sick, and I decided to never do it again. The third dose made me very sick, and one day later, it was like I'd woken up for the very first time.
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* Parodied and played for laughs in [[https://youtu.be/OHvc4CaHOy8?feature=shared this]] ''Franchise/{{Pikmin}}'' animation by WebAnimation/DoobusGoobus, where a Bulborb mentions that he went from a mindless Pikmin-eating animal to a TalkingAnimal with morals after [[EveryoneHasStandards being horrified from watching how Louie eats Pikmin]].

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* Parodied and played for laughs in [[https://youtu.be/OHvc4CaHOy8?feature=shared this]] ''Franchise/{{Pikmin}}'' ''VideoGame/{{Pikmin}}'' animation by WebAnimation/DoobusGoobus, where a Bulborb mentions that he went from a mindless Pikmin-eating animal to a TalkingAnimal with morals after [[EveryoneHasStandards being horrified from watching how Louie eats Pikmin]].
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* Parodied and played for laughs in [[https://youtu.be/OHvc4CaHOy8?feature=shared this]] ''Franchise/{{Pikmin}}'' animation by WebAnimation/DoobusGoobus, where a Bulborb mentions that he went from a mindless Pikmin-eating animal to a TalkingAnimal with morals after [[EveryoneHasStandards being horrified from watching how Louie eats Pikmin]].
-->'''Olimar:''' Wait, so he was so disgusting that your brain ''evolved'' just so it could process the horrors it was witnessing?\\
'''Bulborb:''' Yes, and now I can comprehend my nightmares, which I've had ever since seeing them, so ''fuck'' you, Louie!
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* ''Film/JohnnyMnemonic'' includes the cybernetically-enhanced uplifted dolphin Jones, as in the original William Gibson story.


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* ''Johnny Mnemonic'', part of Creator/WilliamGibson's Literature/SprawlTrilogy, includes a cybernetically uplifted dolphin named Jones, who was part of a United States Navy project to hack mines and other underwater military hardware. After leaving the military, he works in an amusement park and moonlights in data recovery.
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* Creator/JohnScalzi's ''Literature/StarterVillain'' includes uplifted cats, dolphins, and humpback whales. The cats are management. The dolphins and [[spoiler: eventually the whales]] are unionized and strike for better work conditions in the villain's organization.
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* {{Discussed}} in ''Fanfic/{{Medicated}}''. After Anne reverts into a {{human|sThroughAlienEyes}} for the first time, Hop Pop assumes that she gained her sapience from being a frog for most of her life, and she'll lose it eventually. Turns out that's not the case. Much later, [[spoiler:it turns out that Marcy believes this as well. She tells Anne and Sasha that Andrias is invading Earth to uplift humans. Since Anne has spent months on Earth and taught the entire resistance the truth about humans, they don't buy it.]]
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** The ComicBook/GreenLantern Adam is from a species that "gives birth" to itself when they die. He was nonsapient due to being unable to learn (as all knowledge he did pick up would be lost when he died), but when the Green Lantern Corps found him they learned Green Lantern rings can store a person's memories. After a few generations, Adam became sapient due to his ring teaching him what his previous generations had learned.

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