* ''VideoGame/SeikenDensetsu3'' has items for most spells to account for all the possible party setups. No group need go without healing, stat-ups or elemental weapons.

* Dis-X (where X is the condition) in ''ShinMegamiTensei'' games.

* "Chakra" or "Soul" items in different ShinMegamiTensei games.

* Revival Beads Revival Gems, and Balm of Life in ShinMegamiTensei games.

* "X Rocks" "X Gems", and sometimes "X Magatama" each cast a specific spell in ''ShinMegamiTensei'' games.

** In the earlier ''VideoGame/{{SaGa|RPG}}'' games, those items are a bit more common. In ''VideoGame/{{Romancing SaGa 2}}'', the only known item that can restore LifePoints can be bought from a witch for 10,000 (the money {{Cap}}). In ''VideoGame/{{Romancing SaGa 3}}'' these items are mostly [[RandomlyDrops item drops]].

** In the earlier ''[[Franchise/SaGaRPG SaGa]]'' games, those items are a bit more common. In ''VideoGame/{{Romancing SaGa 2}}'', the only known item that can restore LifePoints can be bought from a witch for 10,000 (the money {{Cap}}). In ''VideoGame/{{Romancing SaGa 3}}'' these items are mostly [[RandomlyDrops item drops]].

** In the earlier ''VideoGame/{{SaGa}}'' games, those items are a bit more common. In ''VideoGame/{{Romancing SaGa 2}}'', the only known item that can restore LifePoints can be bought from a witch for 10,000 (the money {{Cap}}). In ''VideoGame/{{Romancing SaGa 3}}'' these items are mostly [[RandomlyDrops item drops]].

* ''Franchise/TheElderScrolls'' goes as far to allow the player to make their own in the form of enchanted weapons and potions.

* ''Franchise/TheElderScrolls'' series tends to have diverse items; although potions are most often of the restoring kind, it's possible to create potions and enchanted items with (almost) ''any'' effect, provided you can find 2 (often rare and expensive) materials with the same effect (and such a pairing may have a negative effect appear twice, applying it to the potion), down to summoning an InfinityPlusOneSword from {{Hammerspace}}.
** Or increasing your intelligence (and thus ability to make potions) then drinking it and making another and so on, until your potions are {{Game Breaker}}s.
*** This is capped in ''[[VideoGame/TheElderScrollsIVOblivion Oblivion]]'', so you can't get something completely gamebreaking... just mostly. Unfortunately a couple of effects (Vampirism, and the Conjuration school spells) are gone from the alchemy lists in Oblivion.

** Or increasing your intelligence (and thus ability to make potions) then drinking it and makeing another and so on, until your potions are {{Game Breaker}}s.
*** This is capped in ''[[VideoGame/TheElderScrollsIVOblivion Oblivion]]'', so you can't get something completly gamebreaking... just mostly. Unfortunatly a couple effects (Vampirism, and the Conjuration school spells) are gone from the alchemy lists in Oblivion.

* Yggdrasil leaves from the ''Franchise/DragonQuest'' series. You can usually get them for free late into the game, but you can only carry one at a time unless you find one in a treasure chest.

* The ''DragonQuest'' series has plenty of these.

* ''VideoGame/Darkest Dungeon'' has Bandages, Antivenom and Laudanum to cure Bleed, Blight and Horror respectively.

* Holy water in ''VideoGame/Darkest Dungeon'' buffs resistances to bleed, blight, stuns and debuffs for three turns. The Blood serves to buff up heroes with the Crimson Curse, in different ways depending on how bad the curse is acting up.

** The Golden Mushrooms in ''MarioAndLuigiSuperstarSaga'', and the Star Candies in ''MarioAndLuigiBowsersInsideStory''.

* Peppers in ''MarioAndLuigiSuperstarSaga'' -- the Red ones boost power, and the Green ones boost defense.
** ''MarioAndLuigiPartnersInTime'' adds the Blue Pepper, which boosts Speed.

* X-Items from ''{{Pokemon}}''.

* The ''TalesSeries'' has fruit-flavored Gels/Gummy. Orange and Pine heals 30% and 60% TP.

* The ''TalesSeries'' has Melange Gels, which heal 30% of both HP and TP, and Miracle Gels, which heal 60% HP and TP. Also, Elixirs heal both to full.

* Life Bottles from the ''TalesSeries''

* As well as ''VideoGame/GoldenSun'' and the ''TalesSeries''.

* Every object in ''PhantomBrave''. Not just weapons, but loaves of bread, vases, rocks, trees, fish, clumps of grass, crates, and more. Otherwise, the game pretty much averts this trope with no inventory items at all.

* Refreshing Herbs from ''[[VideoGame/MarioAndLuigi Mario & Luigi]]'', and Tasty Tonics from ''PaperMario''.

*** HP Drains, Ice Storms, Thunder Bolts, Earth Quakes, and POW Blocks in ''PaperMarioTheThousandYearDoor''.