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* On ''WesternAnimation/AvatarTheLastAirbender'', Toph's seismic sense functions as a LivingLieDetector by picking up the stress-induced changes in breath and heartbeat that occur when someone lies. The only person this doesn't work on is the quasi-[[TheSociopath sociopathic]] Princess Azula, who [[ConsummateLiar lies without a second thought]]:

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* On ''WesternAnimation/AvatarTheLastAirbender'', Toph's seismic sense functions as a LivingLieDetector by picking up the stress-induced changes in breath and heartbeat that occur when someone lies. The only person this doesn't work on is the quasi-[[TheSociopath nigh-[[TheSociopath sociopathic]] Princess Azula, who [[ConsummateLiar lies without a second thought]]:


* On ''WesternAnimation/AvatarTheLastAirbender'', Toph's seismic sense functions as a LivingLieDetector by picking up the stress-induced changes in breath and heartbeat that occur when someone lies. The only person this doesn't work on is Azula, a [[TheSociopath sociopath]] who [[ConsummateLiar lies without a second thought]]:

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* On ''WesternAnimation/AvatarTheLastAirbender'', Toph's seismic sense functions as a LivingLieDetector by picking up the stress-induced changes in breath and heartbeat that occur when someone lies. The only person this doesn't work on is the quasi-[[TheSociopath sociopathic]] Princess Azula, a [[TheSociopath sociopath]] who [[ConsummateLiar lies without a second thought]]:


* Subverted in the ''WesternAnimation/AtomicBetty'' episode "Dr. Cerebral and the Stupefactor Ray". The eponymous villain develops a weapon that can destroy intelligence. [[DeadpanSnarker X-5]] keeps making jokes about how "dumb" Sparky. When Sparky is hit with the ray... it actually turns him brain dead.

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* Subverted in the ''WesternAnimation/AtomicBetty'' episode "Dr. Cerebral and the Stupefactor Ray". The eponymous villain develops a weapon that can destroy intelligence. [[DeadpanSnarker X-5]] keeps making jokes about how "dumb" Sparky.Sparky is. When Sparky is hit with the ray... it actually turns him brain dead.


* Completely inverted in ''WesternAnimation/BatmanTheBraveAndTheBold'', when Joker gains the powers of [[RealityWarper Batmite]]. After torturing Batman the entire episode, Batman tricks him into trying to drive Batman insane by entering his mind. Turns out [[spoiler:Batman is so sane even the reality warping powers Joker now has are completely useless in there, and Batman ultimately uses it to show Joker his worst nightmare: a world where Batman doesn't exist and, consequently, the Joker is a no-name average joe.]]

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* Completely inverted in ''WesternAnimation/BatmanTheBraveAndTheBold'', when Joker gains the powers of [[RealityWarper Batmite]]. After torturing Batman the entire episode, Batman tricks him into trying to drive Batman insane by entering his mind. Turns out [[spoiler:Batman is so sane even the reality warping powers Joker now has are completely useless in there, and Batman ultimately uses it to show Joker his worst nightmare: a world where Batman doesn't exist and, consequently, the Joker is a no-name average joe.joe... and a perfectly sane one at that.]]

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* ''LightNovel/UndefeatedBahamutChronicle'': Those who fuse with Sacred Eclipse slowly lose their sanity, lose their conscience, and gain the desire to eat humans. This is shown when the originally unconfident [[spoiler:Queen Raffi Atismata]] calmly kills her political enemies and tortures her once beloved niece. In contrast, Hayes Vi Arcadia didn't change much after fusing with Sacred Eclipse, since she was already a genocidal and sadistic lunatic before the fusion.

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* In ''VideoGame/FireEmblemPathOfRadiance'', touching Lehran's Medallion (the titular Fire Emblem) causes anyone with a hint of chaos in them to go completely berserk. On Hard Mode, the FinalBoss Ashard touches the Medallion to go OneWingedAngel, and is still able to speak and act normally afterwards. The implication is that Ashnard can't go insane because he already was. (He's not called the [[TheCaligula Mad King]]) for nothing.


* ''WesternAnimation/JusticeLeague'': Ace, a girl with telepathic powers, turns people brain-dead with insanity just by looking at them. Joker is able to [[FalseFriend "befriend"]] her because he's too crazy for it to affect him, and puts her on TV to drive as many people possible insane. [[spoiler:However, he held onto Ace's control headband, so he at least suspected that Ace would be powerful enough to affect him. [[TheDogBitesBack Upon discovering this]] Ace deliberately focuses her power on him [[SubvertedTrope and proves that suspicion right]]. [[DoubleSubversion However]], Joker [[WesternAnimation/BatmanBeyondReturnOfTheJoker would eventually recover]], proving that [[DownplayedTrope he was very resistant even if he wasn't immune]].]]

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* ''WesternAnimation/JusticeLeague'': Ace, a girl with telepathic powers, turns people brain-dead with insanity just by looking at them. Joker is able to [[FalseFriend "befriend"]] her because he's too crazy for it to affect him, and puts her on TV to drive as many people possible insane. [[spoiler:However, he held onto Ace's control headband, so he at least suspected that Ace would be powerful enough to affect him. [[TheDogBitesBack Upon discovering this]] Ace [[ImmunityAttrition deliberately focuses her power on him him]] [[SubvertedTrope and proves that suspicion right]]. [[DoubleSubversion However]], Joker [[WesternAnimation/BatmanBeyondReturnOfTheJoker would eventually recover]], proving that [[DownplayedTrope he was very resistant even if he wasn't immune]].]]



* Completely inverted in ''WesternAnimation/BatmanTheBraveAndTheBold'', when Joker gains the powers of [[RealityWarper Batmite]]. After torturing Batman the entire episode, Batman tricks him into trying to drive Batman insane by entering his mind. Turns out [[spoiler:Batman is so sane even the reality warping powers Joker now has are completely useless in there, and Batman ultimately uses it to show Joker his worst nightmare - a world where Batman doesn't exist and, consequently, the Joker is a no-name average joe.]]

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* Completely inverted in ''WesternAnimation/BatmanTheBraveAndTheBold'', when Joker gains the powers of [[RealityWarper Batmite]]. After torturing Batman the entire episode, Batman tricks him into trying to drive Batman insane by entering his mind. Turns out [[spoiler:Batman is so sane even the reality warping powers Joker now has are completely useless in there, and Batman ultimately uses it to show Joker his worst nightmare - nightmare: a world where Batman doesn't exist and, consequently, the Joker is a no-name average joe.]]


* The Maniacs and Dementeds in ''Videogame/HeroesOfMightAndMagicAshan/Might and Magic: Heroes VI'' are two castes of demon who were created as servants to the Demon Lord of Madness. They are completely immune to mind-affecting spells because their thought process is too alien for any other race to comprehend.

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* The Maniacs and Dementeds in ''Videogame/HeroesOfMightAndMagicAshan/Might ''[[Videogame/HeroesOfMightAndMagicAshan Might and Magic: Heroes VI'' VI]]'' are two castes of demon who were created as servants to the Demon Lord of Madness. They are completely immune to mind-affecting spells because their thought process is too alien for any other race to comprehend.

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** In ''ComicBook/{{Venomverse}}'', Venompool is able to [[spoiler: maintain his self-control even after being consumed by one of the Poisons through his "special brand of crazy"]]. As a result he can [[spoiler: act as a spy within the Poison's forces, and eventually, a trojan horse for the resistance, though even he isn't sure how long he can hold out]].


** Also, in DC and ComicBook/TheMask crossovers, both Joker and SelfDemonstrating/{{Lobo}} put on the titular mask, and it didn't affect their personalities much at all. Eventually Joker became much more destructive, and when Batman pointed out that this wasn't funny (by Joker's standards, anyway), Joker realized he was right and promptly took the mask off.

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** Also, in DC and ComicBook/TheMask crossovers, both Joker and SelfDemonstrating/{{Lobo}} put on the titular mask, and it didn't affect their personalities much at all. Eventually Joker became much more destructive, and when Batman pointed out that this wasn't funny (by Joker's standards, anyway), Joker realized he was right and promptly took the mask off.off, showing that the mask actually did unlock inhibitions--it was making him pull stunts and commit crimes that he normally wouldn't think were "funny".

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* The Maniacs and Dementeds in ''Videogame/HeroesOfMightAndMagicAshan/Might and Magic: Heroes VI'' are two castes of demon who were created as servants to the Demon Lord of Madness. They are completely immune to mind-affecting spells because their thought process is too alien for any other race to comprehend.

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**His ArchEnemy, TheMaster (AxCrazy and PsychoticManchild extraordinaire), apparently owns a copy of the Necronomicon.

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** In a story with the Teen Titans, Raven engulfs Joker in her cloak in order to MindRape him by flooding his mind with visions of horrors that could scare anyone out of their minds into a comatose state. However, Raven then ejects him in shocked horror because not only was Joker not scared of the horror world he was thrown into, he actually thought it was ''funny''.

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* The Thriller Bark arc in ''Manga/OnePiece'' features Perona, who can manipulate the Negative Ghosts, which have the ability to break the will and spirit of anyone they phase through. Luffy, Zoro, Sanji, and Franky were victims of this, becoming so stricken with grief and despair to the point they just want to lie there and die. However, Usopp was completely immune to the effects since he's naturally a negative person. When Perona tried to overdose him with ghosts, the ''ghosts'' were the ones who fell into despair.


* A variation appears in ''WesternAnimation/StevenUniverse''. [[spoiler: Blue Diamond]] has the ability to project her own despair onto any other gems nearby, incapacitating them through shear misery. [[spoiler: Lapis Lazuli]], however, is able to NoSell it due to the simple fact she's been in despair for most of her existence.

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* A variation appears in ''WesternAnimation/StevenUniverse''. [[spoiler: Blue Diamond]] has the ability to [[EmotionBomb project her own despair onto any other gems nearby, nearby]], incapacitating them through shear misery. [[DespairEventHorizon sheer misery]]. [[spoiler: Lapis Lazuli]], however, is able to NoSell it due to the simple fact she's been in [[TraumaCongaLine despair for most of her existence.existence]].

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