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[[quoteright:296:[[WebVideo/Lonelygirl15 https://static.tvtropes.org/pmwiki/pub/images/elizabethcough_4627.jpg]]]]
[[caption-width-right:296:[-[[BloodFromTheMouth The bloody handkerchief isn't a good sign.]]-] ]]

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[[quoteright:296:[[WebVideo/Lonelygirl15 %% Image selected per Image Pickin' thread: https://tvtropes.org/pmwiki/posts.php?discussion=1572231644005228100
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[[quoteright:149:[[ComicBook/Marvel1602
https://static.tvtropes.org/pmwiki/pub/images/elizabethcough_4627.jpg]]]]
[[caption-width-right:296:[-[[BloodFromTheMouth The bloody handkerchief isn't a good sign.]]-] ]]
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* ''Manga/KarakuriCircus'': Narumi has a bizarre form - he is nigh-incapable of breathing until he can make someone laugh. Too bad he's TheComicallySerious.
* Souji Okita makes quite a few appearances in fiction, complete with his famous sickness. In ''Bakumatsu Kikansetsu Irohanihoheto'' he is a frail looking spectre of a man, who sees a ghostly cat and wastes away while reminiscing with the hero and lamenting his sad fate. Then he dies.
* ''Manga/{{Gintama}}'' has few of these too. Most of them happen during serious fights (and usually only bad guy dies afterwards), but there's actual example too. Since killing off Okita Sougo (a character loosely based on Okita Souji) would've completely messed up the comedic nature of the series, mangaka twisted things a bit - instead of Sougo having tuberculosis, it was his sister Mitsuba who suffered from illness... and she lasts for about two episodes.
** Also Kouka (Umibozu's wife/Kagura and Kamui's mother), during her lingering illness due to being separated from the altana of the devastated Yato home world. The symptoms first appear when she coughs up blood on newborn Kagura.
* In ''VisualNovel/{{Clannad}}'', IllGirl Nagisa has an evidently non-lethal version of this. [[spoiler: Until she gives birth, which complicates things a bit.]]
** In ''After Story'', [[spoiler: One of the first signs that her and Tomoya's daughter Ushio inherited the already [[DeathByChildbirth deceased Nagisa]]'s illness is that she beings coughing profusely. It gets nastier for both father and daughter. [[{{Retcon}} And then better.]]]]

to:

* ''Manga/KarakuriCircus'': Narumi has a bizarre form - Creator/HayaoMiyazaki's mother had TB while he is nigh-incapable and his brothers were kids. She spent eight years of breathing his childhood in and out of sanatoriums until he can make someone laugh. Too bad he's TheComicallySerious.
she was cured in 1955. Since it was such a big part of his formative years, it left an impact on him and it's shown up in a couple of his works:
** Averted in ''Anime/MyNeighborTotoro''. It's never outright stated but Satsuki and Mei's mother clearly ''is'' in a clinic for tuberculosis but [[spoiler:gets cured and sent home (after a few scares) in the end. Itís based on his own childhood, after all]].
** Played straight in ''Anime/TheWindRises''. Jiroís [[spoiler: wife Naoki]] is already in advanced stages of the disease when they meet again as adults. He [[spoiler: marries her]] despite knowing how sick she is and she dies at the end from it.
* Souji Okita makes quite a few appearances in fiction, complete with his famous sickness. In ''Bakumatsu Kikansetsu Irohanihoheto'' he is a frail looking spectre of a man, who sees a ghostly cat and wastes away while reminiscing with the hero and lamenting his sad fate. Then he dies.
dies.
* ''Manga/{{Gintama}}'' has few of these too. Most of them happen during serious fights (and usually only bad guy dies afterwards), but there's actual example too. Since killing off Okita Sougo (a ''Manga/XxxHolic'' main character loosely based on Okita Souji) would've completely messed up Watanuki -- who is also the comedic nature ButtMonkey / TheWoobie of the series, mangaka twisted things show -- suffers from the dreaded blood-coughing after [[spoiler: befriending a bit - instead of Sougo having tuberculosis, it was lonely ghost whose presence sadly sucks out his sister Mitsuba who life energy even if she doesn't want him harm]] in a episode arc. He does survive because another character [[spoiler:kills the ghost with a spiritual arrow in order to save him]], but it is made clear that it would have killed him if the situation would have continued any longer.
* Hatsune Otonashi in ''Anime/AngelBeats'' suffers from this.
* In ''Webcomic/AxisPowersHetalia'', WordOfGod says that a pre-teen Holy Roman Empire
suffered from illness... this and she lasts for about two episodes.
** Also Kouka (Umibozu's wife/Kagura
BloodFromTheMouth. TeamMom Hungary is seen picking him up and Kamui's mother), during carrying him around [[BridalCarry in her lingering illness due to being separated from the altana of the devastated Yato home world. The symptoms first appear when she coughs up blood on newborn Kagura.
* In ''VisualNovel/{{Clannad}}'', IllGirl Nagisa has an evidently non-lethal version of this.
arms]] at least once. [[spoiler: Until she gives birth, which complicates things a bit.He died later, but is strongly implied to have sort-of being brought BackFromTheDead... as Germany.]]
** * In ''After Story'', ''Anime/BtX'', Hokuto suffers from radiation poisoning, and is stated to have few months of life left [[spoiler: One of the first signs He isn't planning to last that her and Tomoya's daughter Ushio inherited the already [[DeathByChildbirth deceased Nagisa]]'s illness is that she beings coughing profusely. It gets nastier for both father and daughter. [[{{Retcon}} And then better.]]]]long.]]



* In the ''Manga/BlackButler'' manga during the {{circus|OfFear}} arc Ciel is dragged off to the makeshift outdoor baths by his roommate. During this time it's winter and the water the circus performers are washing up with isn't heated (it's VictorianLondon, after all). After being soaked with the freezing water we later see Ciel coughing, eventually falling into an aggressive coughing fit that causes him to vomit. We find out that he [[spoiler: suffers from asthma, a disease he inherited from his mother. The cold had aggravated it.]] He gets better, though.



* ''Manga/{{Naruto}}'':
** Uchiha Itachi dies from one of these. Apparently, he had been keeping himself alive with all sorts of medicine so he could [[spoiler: be killed by Sasuke]]. Then we find out ''why''.
** There's also Kimimaro, who plays this completely straight, and Hayate who has a cough, but averts the death aspect by being sliced in half.
*** So far, Hayate's cough is the only actual sign of a disease we've seen in-universe. And we don't even actually know what it is.
** Hinata Hyuga nearly avoids this. She acquires exponential damage to her body's chakra system and heart from facing her cousin, Neji Hyuga, in the preliminaries. She is still feeling the affects of such a strain on her body that she breaks out in a violent coughing fit during the fight between Neji and Naruto a month later and subsequently passes out. Kiba Inuzuka finds an ANBU overlooking the final Chunin matches [[spoiler: It's really Kabuto Yakushi in disguise]] and has him heal her with his medical ninjutsu.
** Sai's "older brother" Shin also died from one of these [[spoiler: before Danzo could force them to fight to the death]].



* In ''Anime/BtX'', Hokuto suffers from radiation poisoning, and is stated to have few months of life left [[spoiler: He isn't planning to last that long.]]

to:

* Ayumi starts to do this in Episode 5 of ''Anime/{{Charlotte}}'', first over the phone while talking to Yu during their stakeout camping trip. Later when he's back home a few days later, she starts coughing again, and also mentions that she ran out of her pizza sauce. Double subverted, however, as while it turns out that her cough was merely a one-day cold, it does, in a very roundabout way, lead to her death. Yuu thinks she's still safe at home, but Ayumi, feeling all better, has decided to sneak out to school, where her yandere classmate's threatening her with a knife causes her to panic and accidentally trigger her special ability, Collapse. ''This'' kills her.
* In ''Anime/BtX'', Hokuto ''Manga/ChronoCrusade'', Joshua Christopher suffers from radiation poisoning, and is stated to have few months of life left this trope, until [[spoiler: He isn't planning to last he accepts Chrono's horn from Aion and becomes part of the antagonist organization, the Sinners.]].
* In ''VisualNovel/{{Clannad}}'', IllGirl Nagisa has an evidently non-lethal version of this. [[spoiler: Until she gives birth, which complicates things a bit.]]
** In ''After Story'', [[spoiler: One of the first signs
that long.]]her and Tomoya's daughter Ushio inherited the already [[DeathByChildbirth deceased Nagisa]]'s illness is that she beings coughing profusely. It gets nastier for both father and daughter. [[{{Retcon}} And then better.]]]]



* In ''Manga/ChronoCrusade'', Joshua Christopher suffers from this trope, until [[spoiler: he accepts Chrono's horn from Aion and becomes part of the antagonist organization, the Sinners.]].
* Nemu in ''Manga/DaCapo'' coughs up CherryBlossoms and quickly deteriorates in health. Subverted in that she survives.

to:

* In ''Manga/ChronoCrusade'', Joshua Christopher suffers the ''Anime/CowboyBebop'' episode ''Jupter Jazz Part 2'', Gren starts coughing and bleeding from this trope, until [[spoiler: he accepts Chrono's horn from Aion the mouth as a result of internal injuries sustained in a fight with Vicious. Spike tries to summon medical aid, but Gren tells him not to bother, since he's dying anyway, and becomes part of asks Spike to instead tow his ship into orbit. He dies in the antagonist organization, cockpit and the Sinners.]].
ship crashes back to the planet's surface.
* Nemu in ''Manga/DaCapo'' ''VisualNovel/DaCapo'' coughs up CherryBlossoms and quickly deteriorates in health. Subverted in that she survives.survives.
* Subverted in ''Manga/DrStone'', where village high priestess Ruri has had a debilitating illness all her life (usually marked by severe coughing fits) and isn't expected to make it to age 20. In the end it turns out to be ordinary pneumonia, which ''would'' have been this trope in the science-less "Stone World", but TeenGenius Senku manages to create sulfonamide and Ruri makes a full recovery.
* In the manga ''Manga/{{Emerging}}'', a heavy cough that sometimes [[BloodFromTheMouth produces blood]] is one of the first signs that a character may have contracted the extremely deadly [[ThePlague mystery illness]] that is spreading across Tokyo.



* Takiko Ohkuda from ''Manga/FushigiYuugiGenbuKaiden'' continuously coughs during her journey. When she's back in the Real World, it's revealed that she [[spoiler: caught the consumption of her late mother, Yoshie]]. Then again, [[spoiler: it's already revealed by Miaka that she originally was {{mercy kill}}ed at the hands [[OffingTheOffspring of her father]].]]
* ''Manga/{{Gintama}}'' has few of these too. Most of them happen during serious fights (and usually only bad guy dies afterwards), but there's actual example too. Since killing off Okita Sougo (a character loosely based on Okita Souji) would've completely messed up the comedic nature of the series, mangaka twisted things a bit - instead of Sougo having tuberculosis, it was his sister Mitsuba who suffered from illness... and she lasts for about two episodes.
** Also Kouka (Umibozu's wife/Kagura and Kamui's mother), during her lingering illness due to being separated from the altana of the devastated Yato home world. The symptoms first appear when she coughs up blood on newborn Kagura.
* Somewhat subverted in ''Manga/GlassMask'', since Maya's mother, Haru ''does'' suffer from tuberculosis, but [[spoiler: actually dies after being hit by a car]].



* In ''Anime/MobileFighterGGundam'', the "elderly" (actually only 50) Master Asia is the greatest fighter in the world. [[MyKungFuIsStrongerThanYours His Kung Fu is stronger than everybody else's.]] He can effortlessly destroy HumongousMecha using just his bare hands, or by swinging [[NerfArm a piece of cloth]] at them. Basically the only one who's even worthy of ''thinking'' about fighting him is the main character... who happens to be his student. Yet when he turns against his boss, a weakling of a normal human, poor Master Asia is conveniently incapacitated by his Incurable Cough Of Death.
* Somewhat subverted in ''Manga/GlassMask'', since Maya's mother, Haru ''does'' suffer from tuberculosis, but [[spoiler: actually dies after being hit by a car]].
* Also, in the manga ''Manga/MobileSuitGundamSEEDAstray'', a master swordsmith and swordsman named Un'no is also able to fight against HumongousMecha on foot...though he uses a katana to do it, and "only" slices the barrels off their guns. His Incurable Cough Of Death actually is TB, which he dies from shortly after passing on his knowledge to Lowe Gear.

to:

* In ''Anime/MobileFighterGGundam'', the "elderly" (actually only 50) Master Asia is the greatest fighter in the world. [[MyKungFuIsStrongerThanYours His Kung Fu is stronger than everybody else's.]] He can effortlessly destroy HumongousMecha using just his bare hands, or by swinging [[NerfArm a piece of cloth]] at them. Basically the only one who's even worthy of ''thinking'' about fighting him is the main character... who happens to be his student. Yet when he turns against his boss, a weakling of a normal human, poor Master Asia is conveniently incapacitated by his Incurable Cough Of Death.
* Somewhat subverted in ''Manga/GlassMask'', since Maya's mother, Haru ''does'' suffer from tuberculosis, but [[spoiler: actually dies after being hit by a car]].
* Also, in
the manga ''Manga/MobileSuitGundamSEEDAstray'', a master swordsmith and swordsman named Un'no is also able to fight against HumongousMecha on foot...though he uses a katana to do it, and "only" slices the barrels off their guns. His Incurable Cough Of Death actually is TB, which he dies from shortly after passing on his knowledge to Lowe Gear.''VideoGame/HeartNoKuniNoAlice'' Nightmare has one.



* ''Manga/KarakuriCircus'': Narumi has a bizarre form - he is nigh-incapable of breathing until he can make someone laugh. Too bad he's TheComicallySerious.



* Aslan Battour from ''Manga/KazeToKiNoUta'' suffers from tuberculosis in the backstory. [[spoiler:He's already dead in the main storyline.]]



* In the ''Manga/BlackButler'' manga during the {{circus|OfFear}} arc Ciel is dragged off to the makeshift outdoor baths by his roommate. During this time it's winter and the water the circus performers are washing up with isn't heated (it's VictorianLondon, after all). After being soaked with the freezing water we later see Ciel coughing, eventually falling into an aggressive coughing fit that causes him to vomit. We find out that he [[spoiler: suffers from asthma, a disease he inherited from his mother. The cold had aggravated it.]] He gets better, though.



* Creator/HayaoMiyazakiís mother had TB while he and his brothers were kids. She spent eight years of his childhood in and out of sanatoriums until she was cured in 1955. Since it was such a big part of his formative years, it left an impact on him and itís shown up in a couple of his works:
** Averted in ''Anime/MyNeighborTotoro''. Itís never outright stated but Satsuki and Mei's mother clearly ''is'' in a clinic for tuberculosis but [[spoiler:gets cured and sent home (after a few scares) in the end. Itís based on his own childhood, after all]].
** Played straight in ''Anime/TheWindRises''. Jiroís [[spoiler: wife Naoki]] is already in advanced stages of the disease when they meet again as adults. He [[spoiler: marries her]] despite knowing how sick she is and she dies at the end from it.

to:

* Creator/HayaoMiyazakiís mother had TB while he and his brothers were kids. She spent eight years of his childhood in and out of sanatoriums until she was cured in 1955. Since it was such a big part of his formative years, it left an impact on him and itís shown up in a couple of his works:
** Averted in ''Anime/MyNeighborTotoro''. Itís never outright stated but Satsuki and Mei's mother clearly ''is'' in a clinic for tuberculosis but [[spoiler:gets cured and sent home (after a few scares)
In ''Anime/MobileFighterGGundam'', the "elderly" (actually only 50) Master Asia is the greatest fighter in the end. Itís based world. [[MyKungFuIsStrongerThanYours His Kung Fu is stronger than everybody else's.]] He can effortlessly destroy HumongousMecha using just his bare hands, or by swinging [[NerfArm a piece of cloth]] at them. Basically the only one who's even worthy of ''thinking'' about fighting him is the main character... who happens to be his student. Yet when he turns against his boss, a weakling of a normal human, poor Master Asia is conveniently incapacitated by his Incurable Cough Of Death.
* Also, in the manga ''Manga/MobileSuitGundamSEEDAstray'', a master swordsmith and swordsman named Un'no is also able to fight against HumongousMecha on foot...though he uses a katana to do it, and "only" slices the barrels off their guns. His Incurable Cough Of Death actually is TB, which he dies from shortly after passing
on his own childhood, after all]].
** Played straight in ''Anime/TheWindRises''. Jiroís [[spoiler: wife Naoki]] is already in advanced stages of the disease when they meet again as adults. He [[spoiler: marries her]] despite knowing how sick she is and she dies at the end from it.
knowledge to Lowe Gear.



* ''Manga/NagasareteAirantou'': Ikuto is trying to make a wooden object that involves water and then he starts sneezing. Few pages later Suzu runs into Michiru saying that she's in a hurry for some ice for Ikuto. Eager to help with his cold she quickly finds a way to fly with her ice powers, but keeps falling and hitting stuff all over the island looking for him. When she finds him he's still sneezing but [[spoiler:he was just allergic to the sawdust while trying to build a refrigerator.]]
* ''Manga/{{Naruto}}'':
** Uchiha Itachi dies from one of these. Apparently, he had been keeping himself alive with all sorts of medicine so he could [[spoiler: be killed by Sasuke]]. Then we find out ''why''.
** There's also Kimimaro, who plays this completely straight, and Hayate who has a cough, but averts the death aspect by being sliced in half.
*** So far, Hayate's cough is the only actual sign of a disease we've seen in-universe. And we don't even actually know what it is.
** Hinata Hyuga nearly avoids this. She acquires exponential damage to her body's chakra system and heart from facing her cousin, Neji Hyuga, in the preliminaries. She is still feeling the affects of such a strain on her body that she breaks out in a violent coughing fit during the fight between Neji and Naruto a month later and subsequently passes out. Kiba Inuzuka finds an ANBU overlooking the final Chunin matches [[spoiler: It's really Kabuto Yakushi in disguise]] and has him heal her with his medical ninjutsu.
** Sai's "older brother" Shin also died from one of these [[spoiler: before Danzo could force them to fight to the death]].



* We know that since ''Manga/RoseOfVersailles'' is a tragic shojo anime, that there's little chance that Lady Oscar will make it to the end of the series alive, but when she starts coughing up blood, that pretty much cinches it. Although, unusually, [[spoiler:she doesn't actually die from the cough (though she ''is'' informed that it's terminal) but in a far more suitably dramatic manner while storming the Bastille and being shot to death.]]
** Also, both [[spoiler: the Dauphin [[TooGoodForThisSinfulEarth Louis Joseph]] ]] and Marie Antoinette had tuberculosis (a particularly painful osseous tuberculosis for [[spoiler: Louis Joseph]]), althrough only [[spoiler: the Dauphin]] died of it.
* In one episode of ''Anime/RuneSoldierLouie'', Louie helps a little girl to find a rare flower for her grandmother, who has an unspecified sickness, that mostly consists of a bad cough.



* We know that since ''Manga/RoseOfVersailles'' is a tragic shojo anime, that there's little chance that Lady Oscar will make it to the end of the series alive, but when she starts coughing up blood, that pretty much cinches it. Although, unusually, [[spoiler:she doesn't actually die from the cough (though she ''is'' informed that it's terminal) but in a far more suitably dramatic manner while storming the Bastille and being shot to death.]]
** Also, both [[spoiler: the Dauphin [[TooGoodForThisSinfulEarth Louis Joseph]] ]] and Marie Antoinette had tuberculosis (a particularly painful osseous tuberculosis for [[spoiler: Louis Joseph]]), althrough only [[spoiler: the Dauphin]] died of it.
* In one episode of ''Anime/RuneSoldier'', Louie helps a little girl to find a rare flower for her grandmother, who has an unspecified sickness, that mostly consists of a bad cough.



* Subverted in ''Manga/{{Superior}}'' when Angelica mistakes Umberto's cough as a sign of a deadly illness (not helped by him asking for a specific medicine during a coughing fit). It was actually a pollen allergy.



** Subverted in ''VideoGame/WildArms5'', by the ''same character'', but in a [[TheCameo cameo]] [[ContinuityNod appearance]]. Although she still has the cough, the player can go on an obnoxiously long IrrelevantSidequest to cure her and give her a happier ending. Ironically, the thing you use is the same cure-all that had no effect on her in ''VideoGame/{{Wild ARMs 4}}''.
* ''Manga/XxxHolic'' main character Watanuki -- who is also the ButtMonkey / TheWoobie of the show -- suffers from the dreaded blood-coughing after [[spoiler: befriending a lonely ghost whose presence sadly sucks out his life energy even if she doesn't want him harm]] in a episode arc. He does survive because another character [[spoiler:kills the ghost with a spiritual arrow in order to save him]], but it is made clear that it would have killed him if the situation would have continued any longer.
* In the manga ''Manga/{{Emerging}}'', a heavy cough that sometimes [[BloodFromTheMouth produces blood]] is one of the first signs that a character may have contracted the extremely deadly [[ThePlague mystery illness]] that is spreading across Tokyo.
* Takiko Ohkuda from ''Manga/FushigiYuugiGenbuKaiden'' continuously coughs during her journey. When she's back in the Real World, it's revealed that she [[spoiler: caught the consumption of her late mother, Yoshie]]. Then again, [[spoiler: it's already revealed by Miaka that she originally was {{mercy kill}}ed at the hands [[OffingTheOffspring of her father]].]]
* In the manga ''VideoGame/HeartNoKuniNoAlice'' Nightmare has one.
* Hatsune Otonashi in ''Anime/AngelBeats'' suffers from this.
* Aslan Battour from ''Manga/KazeToKiNoUta'' suffers from tuberculosis in the backstory. [[spoiler:He's already dead in the main storyline.]]
* In ''Webcomic/AxisPowersHetalia'', WordOfGod says that a pre-teen Holy Roman Empire suffered from this and BloodFromTheMouth. TeamMom Hungary is seen picking him up and carrying him around [[BridalCarry in her arms]] at least once. [[spoiler: He died later, but is strongly implied to have sort-of being brought BackFromTheDead... as Germany.]]
* Ayumi starts to do this in Episode 5 of ''Anime/{{Charlotte}}'', first over the phone while talking to Yu during their stakeout camping trip. Later when he's back home a few days later, she starts coughing again, and also mentions that she ran out of her pizza sauce. Double subverted, however, as while it turns out that her cough was merely a one-day cold, it does, in a very roundabout way, lead to her death. Yuu thinks she's still safe at home, but Ayumi, feeling all better, has decided to sneak out to school, where her yandere classmate's threatening her with a knife causes her to panic and accidentally trigger her special ability, Collapse. ''This'' kills her.
* Subverted in ''Manga/{{Superior}}'' when Angelica mistakes Umberto's cough as a sign of a deadly illness (not helped by him asking for a specific medicine during a coughing fit). It was actually a pollen allergy.
* Subverted in ''Manga/DrStone'', where village high priestess Ruri has had a debilitating illness all her life (usually marked by severe coughing fits) and isn't expected to make it to age 20. In the end it turns out to be ordinary pneumonia, which ''would'' have been this trope in the science-less "Stone World", but TeenGenius Senku manages to create sulfonamide and Ruri makes a full recovery.
* In the ''Anime/CowboyBebop'' episode ''Jupter Jazz Part 2'', Gren starts coughing and bleeding from the mouth as a result of internal injuries sustained in a fight with Vicious. Spike tries to summon medical aid, but Gren tells him not to bother, since he's dying anyway, and asks Spike to instead tow his ship into orbit. He dies in the cockpit and the ship crashes back to the planet's surface.
* ''Manga/NagasareteAirantou'': Ikuto is trying to make a wooden object that involves water and then he starts sneezing. Few pages later Suzu runs into Michiru saying that she's in a hurry for some ice for Ikuto. Eager to help with his cold she quickly finds a way to fly with her ice powers, but keeps falling and hitting stuff all over the island looking for him. When she finds him he's still sneezing but [[spoiler:he was just allergic to the sawdust while trying to build a refrigerator.]]

to:

** Subverted in ''VideoGame/WildArms5'', by the ''same character'', but in a [[TheCameo cameo]] [[ContinuityNod appearance]]. Although she still has the cough, the player can go on an obnoxiously long IrrelevantSidequest to cure her and give her a happier ending. Ironically, the thing you use is the same cure-all that had no effect on her in ''VideoGame/{{Wild ARMs 4}}''.
* ''Manga/XxxHolic'' main character Watanuki -- who is also the ButtMonkey / TheWoobie of the show -- suffers from the dreaded blood-coughing after [[spoiler: befriending a lonely ghost whose presence sadly sucks out his life energy even if she doesn't want him harm]] in a episode arc. He does survive because another character [[spoiler:kills the ghost with a spiritual arrow in order to save him]], but it is made clear that it would have killed him if the situation would have continued any longer.
* In the manga ''Manga/{{Emerging}}'', a heavy cough that sometimes [[BloodFromTheMouth produces blood]] is one of the first signs that a character may have contracted the extremely deadly [[ThePlague mystery illness]] that is spreading across Tokyo.
* Takiko Ohkuda from ''Manga/FushigiYuugiGenbuKaiden'' continuously coughs during her journey. When she's back in the Real World, it's revealed that she [[spoiler: caught the consumption of her late mother, Yoshie]]. Then again, [[spoiler: it's already revealed by Miaka that she originally was {{mercy kill}}ed at the hands [[OffingTheOffspring of her father]].]]
* In the manga ''VideoGame/HeartNoKuniNoAlice'' Nightmare has one.
* Hatsune Otonashi in ''Anime/AngelBeats'' suffers from this.
* Aslan Battour from ''Manga/KazeToKiNoUta'' suffers from tuberculosis in the backstory. [[spoiler:He's already dead in the main storyline.]]
* In ''Webcomic/AxisPowersHetalia'', WordOfGod says that a pre-teen Holy Roman Empire suffered from this and BloodFromTheMouth. TeamMom Hungary is seen picking him up and carrying him around [[BridalCarry in her arms]] at least once. [[spoiler: He died later, but is strongly implied to have sort-of being brought BackFromTheDead... as Germany.]]
* Ayumi starts to do this in Episode 5 of ''Anime/{{Charlotte}}'', first over the phone while talking to Yu during their stakeout camping trip. Later when he's back home a few days later, she starts coughing again, and also mentions that she ran out of her pizza sauce. Double subverted, however, as while it turns out that her cough was merely a one-day cold, it does, in a very roundabout way, lead to her death. Yuu thinks she's still safe at home, but Ayumi, feeling all better, has decided to sneak out to school, where her yandere classmate's threatening her with a knife causes her to panic and accidentally trigger her special ability, Collapse. ''This'' kills her.
* Subverted in ''Manga/{{Superior}}'' when Angelica mistakes Umberto's cough as a sign of a deadly illness (not helped by him asking for a specific medicine during a coughing fit). It was actually a pollen allergy.
* Subverted in ''Manga/DrStone'', where village high priestess Ruri has had a debilitating illness all her life (usually marked by severe coughing fits) and isn't expected to make it to age 20. In the end it turns out to be ordinary pneumonia, which ''would'' have been this trope in the science-less "Stone World", but TeenGenius Senku manages to create sulfonamide and Ruri makes a full recovery.
* In the ''Anime/CowboyBebop'' episode ''Jupter Jazz Part 2'', Gren starts coughing and bleeding from the mouth as a result of internal injuries sustained in a fight with Vicious. Spike tries to summon medical aid, but Gren tells him not to bother, since he's dying anyway, and asks Spike to instead tow his ship into orbit. He dies in the cockpit and the ship crashes back to the planet's surface.
* ''Manga/NagasareteAirantou'': Ikuto is trying to make a wooden object that involves water and then he starts sneezing. Few pages later Suzu runs into Michiru saying that she's in a hurry for some ice for Ikuto. Eager to help with his cold she quickly finds a way to fly with her ice powers, but keeps falling and hitting stuff all over the island looking for him. When she finds him he's still sneezing but [[spoiler:he was just allergic to the sawdust while trying to build a refrigerator.]]
''VideoGame/WildArms4''.

Added DiffLines:

* In [[BizarroEpisode the episode written by a computer]] of ''WebVideo/HardlyWorking'', we are told that Grant "will pass away underneath the couch exactly one year from today". Grant chooses to represent this by coughing unhealthily.


* In Film/BriansSong, the first big sign that something more than a little weight loss is happening is Brian Piccolo hacking and wheezing on the sidline complaining of hay fever and allergies. A fairly realistic example of this trope since he's actually got a tumor in his lung.

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* In Film/BriansSong, ''Film/BriansSong'', the first big sign that something more than a little weight loss is happening is Brian Piccolo hacking and wheezing on the sidline complaining of hay fever and allergies. A fairly realistic example of this trope since he's actually got a tumor in his lung.


* Film/CaptainAmericaTheWinterSoldier: Agent Peggy Carter starts coughing during her discussion with Steve in hospital. This is heavily implied to be related to her illness, except that further context indicates her illness is Alzheimer's disease - not exactly a respiratory ailment.

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* Film/CaptainAmericaTheWinterSoldier: ''Film/CaptainAmericaTheWinterSoldier'': Agent Peggy Carter starts coughing during her discussion with Steve in hospital. This is heavily implied to be related to her illness, except that further context indicates her illness is Alzheimer's disease - not exactly a respiratory ailment.


** [[spoiler:Anna develops a cough after falling into a chemical dump and lying unconscious without a gas mask before Artyom finds her. It doesn't get better in the dusty desert air of the Caspian and she eventually reveals that the doctor in Yamantau told her the lung damage will kill her in a few months. Finding a treatment becomes the next main onjective.]]

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** [[spoiler:Anna develops a cough after falling into a chemical dump and lying unconscious without a gas mask before Artyom finds her. It doesn't get better in the dusty desert air of the Caspian and she eventually reveals that the doctor in Yamantau told her the lung damage will kill her in a few months. Finding a treatment becomes the next main onjective.objective.]]


* A semi-common trope in fanfiction in general is '[[https://fanlore.org/wiki/Hanahaki_Disease Hanahaki disease]]', which has at its focus people coughing up flower petals as a result of unrequited love. Eventually the petals will fill the victim's lungs or throat so much they choke to death. The only cure is for the love to be reciprocated or surgery to remove the flowers, but that also removes the love the victim has for their love interest (and in some cases the ability to love altogether). Notably, most victims refuse the surgery, preferring to die rather than lose their feelings (and in many cases are rewarded with reciprocation).

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* A semi-common trope in fanfiction in general is '[[https://fanlore.org/wiki/Hanahaki_Disease Hanahaki disease]]', 'HanahakiDisease', which has at its focus people coughing up flower petals as a result of unrequited love. Eventually the petals will fill the victim's lungs or throat so much they choke to death. The only cure is for the love to be reciprocated or surgery to remove the flowers, but that also removes the love the victim has for their love interest (and in some cases the ability to love altogether). Notably, most victims refuse the surgery, preferring to die rather than lose their feelings (and in many cases are rewarded with reciprocation).


* French playwright and actor Molière, who suffered from tuberculosis, is famous for having collapsed into a coughing fit while performing in the last play he wrote, ironically titled ''The Hypochondriac'' (''La Malade imaginaire''). Despite coughing up blood, he insisted on finishing the performance. Afterward he had another fit of coughing and hemorrhaging before being taken home, where he died a few hours later.

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* French playwright and actor Molière, who suffered from tuberculosis, is famous for having collapsed into a coughing fit while performing in the last play he wrote, ironically titled ''The Hypochondriac'' (''La ''[[Theatre/TheImaginaryInvalid The Hypochondriac]]'' (''Le Malade imaginaire''). Despite coughing up blood, he insisted on finishing the performance. Afterward he had another fit of coughing and hemorrhaging before being taken home, where he died a few hours later.

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* ''Manga/NagasareteAirantou'': Ikuto is trying to make a wooden object that involves water and then he starts sneezing. Few pages later Suzu runs into Michiru saying that she's in a hurry for some ice for Ikuto. Eager to help with his cold she quickly finds a way to fly with her ice powers, but keeps falling and hitting stuff all over the island looking for him. When she finds him he's still sneezing but [[spoiler:he was just allergic to the sawdust while trying to build a refrigerator.]]


* In WebVideo/{{UALA}}, Hero's mom died in a Flash Back from this.



* In WebVideo/{{UALA}}, Hero's mom died in a Flash Back from this.

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* In WebVideo/{{UALA}}, Hero's mom died in a Flash Back from this.

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* ''[[https://archiveofourown.org/works/2848895/chapters/6388262 Fuges]]'' is a fanfic of ''The Simpsons'' that tries to explain Edna's death. She had a persistent cough but thought nothing of it. It turned out to be terminal lung cancer.


* In ''Franchise/GreenLantern's ComicBook/SinestroCorpsWar'', Guy Gardner coughs in mid-battle, indicating that he's infected by the sentient bio-virus Despotellis. He soldiers on and fights, until eventually collapsing, before the Corps medic injects him with Leezle Pon, a sentient smallpox virus... who's also a GreenLantern. Two viruses enter, one leaves victorious.

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* In ''Franchise/GreenLantern's ComicBook/SinestroCorpsWar'', Guy Gardner coughs in mid-battle, indicating that he's infected by the sentient bio-virus Despotellis. He soldiers on and fights, until eventually collapsing, before the Corps medic injects him with Leezle Pon, a sentient smallpox virus... who's also a GreenLantern.ComicBook/GreenLantern. Two viruses enter, one leaves victorious.


* Averted in ''Anime/MyNeighborTotoro'', where Satsuki and Mei's mother clearly ''is'' in a clinic for tuberculosis but [[spoiler:gets cured and sent home (after a few scares) in the end]].

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* Creator/HayaoMiyazakiís mother had TB while he and his brothers were kids. She spent eight years of his childhood in and out of sanatoriums until she was cured in 1955. Since it was such a big part of his formative years, it left an impact on him and itís shown up in a couple of his works:
**
Averted in ''Anime/MyNeighborTotoro'', where ''Anime/MyNeighborTotoro''. Itís never outright stated but Satsuki and Mei's mother clearly ''is'' in a clinic for tuberculosis but [[spoiler:gets cured and sent home (after a few scares) in the end]].end. Itís based on his own childhood, after all]].
** Played straight in ''Anime/TheWindRises''. Jiroís [[spoiler: wife Naoki]] is already in advanced stages of the disease when they meet again as adults. He [[spoiler: marries her]] despite knowing how sick she is and she dies at the end from it.

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* In ''VideoGame/MetroExodus'', tuberculosis is one the main killers in post-apocalyptic Russia.
** [[spoiler:Anna develops a cough after falling into a chemical dump and lying unconscious without a gas mask before Artyom finds her. It doesn't get better in the dusty desert air of the Caspian and she eventually reveals that the doctor in Yamantau told her the lung damage will kill her in a few months. Finding a treatment becomes the next main onjective.]]

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