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* In a normal immune system reaction, cytokines signal T cells and macrophages to attack an infection and produce more cytokines in a controlled manner. In a cytokine storm, that control fails and your immune system goes berserk, producing and signalling more and more cells, causing damage to healthy tissue in the process. It can kill otherwise healthy individuals, which is believed to be why such people died in the 1918 Spanish flu pandemic.

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* In a normal immune system reaction, cytokines signal T cells and macrophages to attack an infection and produce more cytokines in a controlled manner. In a cytokine storm, that control fails and your immune system goes berserk, producing and signalling more and more cells, causing damage to healthy tissue in the process. It can kill otherwise healthy individuals, which is believed to be why such people died in [[UsefulNotes/TheSpanishFlu the 1918 Spanish flu pandemic.pandemic]].


* The titular SuperPrototype of ''Anime/MobileSuitGundam00'' initially suffered from a design fault in that it couldn't go [[SuperMode Trans-Am]] for more than a few seconds or its GN Drives will belch smoke and shut down with "Error S0557". It was eventually corrected by real-time fine-tuning of the drives from the [[MechaExpansionPack 0-Raiser]] - and ''[[BoringInvincibleHero how]]''.

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* The titular SuperPrototype of ''Anime/MobileSuitGundam00'' initially suffered from a design fault in that it couldn't go [[SuperMode Trans-Am]] for more than a few seconds or its GN Drives will belch smoke and shut down with "Error S0557". It was eventually corrected by real-time fine-tuning of the drives from the [[MechaExpansionPack 0-Raiser]] - and ''[[BoringInvincibleHero ''[[InvincibleHero how]]''.

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* In the ''Literature/{{Discworld}}'' as visited by Creator/AAPessimal, the standard witch's broomstick is a sedate thing likened to an old Morris Minor caron our world - it will do the job reliably and consistently at an unremarkable speed. Then the WrenchWench mentality arrived[[note]]Two flight-minded Witches out of Far Überwald who REALLY wanted to know how to make them go faster, higher and further. And above all, ''faster''[[/note]], along with the {{Magitek}} of ground-based engineers and broomstick designers with interesting ideas. The Air Watch, backed by the goodwill of Vetinari and the unlimited development cash provided by Sam Vimes, attracts Witches of the right mind-set backed by ground Tekniks. Accidents happen. An early error when a broom was overloaded with more thaumic potential than the staff and bristles could hold led - very briefly - to a fast, powerful, aircraft. And then an incandescent fireball over Ankh-Morpork. Pilot Dorothy Culpclapper is now remembered on the memorial plaque.

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* A minor example in ''Webcomic/{{Misfile}}''; James has challenged Ash to an endurance car race, going down the same stretch of road over and over until the person behind passes or the person in front pulls entirely out of sight. Ash plays it smart when it's his turn behind, keeping his distance so he can watch what James is doing and focus on driving well himself, only attempting to pass when he sees a real opening. James, on the other hand, lets his emotions get the best of him while behind, staying as close as possible and attempting to pass at every opportunity. This puts more stress on the car, wearing down his breaks and giving Ash a subtle but constantly growing advantage as the race goes on, until Ash is able to take advantage and pass James.


** There's also the Smoke Knights' "Movit" potions. Movit #6 is the most potent one that your average schmuck can safely use; even Smoke Knights, whose training includes conditioning to be able to utilize the potions, tread carefully with the higher numbers. Zola (spoiler warning: not a Smoke Knight) somehow managed to steal a vial of Movit #11, the most potent one period; it gives her a massive energy boost, but Violetta explicitly says that it'll kill her in short order as her body burns up from within. Later on, rather than outright poisoning Zola, Violetta chooses to inject her with ''more'' Movit #11 - which at that point is more lethal to her than any poison.

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** There's also the Smoke Knights' "Movit" potions. Movit #6 is the most potent one that your average schmuck can safely use; even Smoke Knights, whose training includes conditioning to be able to utilize the potions, tread carefully with the higher numbers. Zola (spoiler warning: not formally a Smoke Knight) Knight, but all family members have some level of the training) somehow managed to steal a vial of Movit #11, the most potent one period; it gives her a massive energy boost, but Violetta explicitly says that it'll kill her in short order as her body burns up from within. Later on, rather than outright poisoning Zola, Violetta chooses to inject her with ''more'' Movit #11 - which at that point is more lethal to her than any poison.

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* ''ComicBook/WonderWoman1987'': Dr. Lazarus' HardLight AI system has yet to be perfected and the hard light constructs can explode on contact. Once things go quite wrong and his system is being used to create supervillains without his knowledge these explosions are significantly more powerful than the one which wrecked his first laboratory.

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* In ''Fanfic/IncompatibleSystem'', the Quarians, when cornered by Batarian ships, overcharge their main gun to the point of slagging it. It destroys one enemy and cripples another, allowing them to run.


** In "The Red Queen's Race", to send something back in time, someone overclocks a ''nuclear power station'', making it a bunch of scrap.
** The Mule from ''Literature/{{Foundation}}'' stated he had the ability to force a human brain to work at top capacity, effectively, as he stated, a state of permanent hunch. One known case resulted in a superweapon (an imperfect one), another allowed a man to replicate (in part) a genius mathematician's lifetime work. Death in a few weeks was the usual side effect.
** ''Pebble in the Sky'' (a novel in the same 'verse, but centuries before the Foundation novels) features a permanent and technologically induced similar state to that caused by the Mule's ability, and implies that it is essentially an {{Overdrive}} situation: you think faster and clearer, and might even develop telepathic powers, but wear and tear increases. Do this for a couple of weeks, maybe some months at most, and the wear and tear is pronounced enough to make metaphorical 'engine failure' a statistical near-certainty.

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** In "The Red Queen's Race", to "Literature/TheRedQueensRace": To send something back in time, someone overclocks a ''nuclear power station'', making it a bunch of scrap.
** The "Literature/TheMule": Part of the EmotionControl powers that the Mule from ''Literature/{{Foundation}}'' stated he had has allows him to cause intuition and creativity to skyrocket, at the ability expense of their lives]]. He describes human brains as normally operating at 20% efficiency (essentially [[NinetyPercentOfYourBrain failing to use 80%]]), and he can use his power to force a human brain all of it to work at top capacity, effectively, as he stated, a state ''non-stop'' without any chance of permanent hunch. One known case resulted rest for weeks on end. He puts Ebling Mis in a superweapon (an imperfect one), another allowed a man this state, allowing him to replicate (in part) most of a genius mathematician's lifetime work. Death life's work in only a few weeks was weeks, at the usual side effect.
** ''Pebble in the Sky'' (a novel in
cost of killing him within the same 'verse, but centuries before the Foundation novels) features a timeframe.
** ''Literature/PebbleInTheSky'': A
permanent and technologically induced similar state to [[NinetyPercentOfYourBrain mental state]] that caused by the Mule's ability, and implies that it is implied to essentially an {{Overdrive}} situation: you think faster and clearer, and might even develop telepathic powers, but wear and tear increases. Do this for a couple of weeks, maybe some months at most, and the wear and tear is pronounced enough to make metaphorical 'engine failure' a statistical near-certainty.


*** Dialing a 9 symbol address to reach the Destiny billions of lightyears away in ''Series/StargateUniverse'' requires overclocking the stargate using a planet with a naquida core. It's such a power release that any instability causes an EarthShatteringKaboom. Destiny was dialed twice and subsequently the galaxy now has two fewer planets.
** Similarly, [=ZPMs=], the Ancient's preferred power source in their late days, contain absurd amounts of energy. An episode of Atlantis has The Trust "plant a bomb" in the city in order to remove it as a possible means for the Wraith to ever reach the Milky Way. The "bomb" in question was actually the city's ZPM, they had simply disabled the city's safeguards which moderate its energy flow. Without them drawing too much energy from the ZPM (as in dialing the stargate, or raising the city's shield) would cause an uncontrolled release of energy that would be close to the time Rodney blew up 3/5 of a solar system.

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*** Dialing a 9 symbol address to reach the Destiny ''Destiny'' billions of lightyears away in ''Series/StargateUniverse'' requires overclocking the stargate Stargate using a planet with a naquida core. It's such a power release that any instability causes an EarthShatteringKaboom. Destiny ''Destiny'' was dialed twice and subsequently the galaxy now has two fewer planets.
planets. The third (heavily populated) planet with a naquida core is understandably unwilling to dial Destiny, and is not reassured by Rodney's claim that they have found a way to dial ''Destiny'' without blowing up the planet.
** Similarly, [=ZPMs=], the Ancient's preferred power source in their late days, contain absurd amounts of energy. An episode of Atlantis has The Trust "plant a bomb" in the city in order to remove it as a possible means for the Wraith to ever reach the Milky Way. The "bomb" in question was actually the city's ZPM, they had simply disabled the city's safeguards which moderate its energy flow. Without them drawing too much energy from the ZPM (as in dialing the stargate, Stargate, or raising the city's shield) would cause an uncontrolled release of energy that would be close to the time Rodney blew up 3/5 of a solar system.


* In VisualNovel/FateStayNight a Servant can overload their Noble Phantasm with prana and transform it into a Broken Phantasm, causing them to take a massive power hike in exchange for being lost. Given that most Servants only have between one to three Noble Phantasms ([[PublicDomainArtifact which are artifacts such as Excalibur]]), and Noble Phantasms represent the solidified history of each Servant the very idea is unthinkable. When Archer uses a Broken Phantasm against Berserker early on in the ''Unlimited Blade Works'' route, his Master Rin has a minor freakout because he seemingly destroyed one of his Noble Phantasms seemingly on a whim. He does this again when fighting Caster, using another Noble Phantasm very similar to the one he used against Berserker. [[spoiler:As it turns out, Archer's true ability is [[SpontaneousWeaponCreation projection magic]], which allows him to replicate other Noble Phantasms infinitely - this means that he can use Broken Phantasms as much as he wants with no loss to him, something very terrifying if other Servants knew about this.]]

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* In VisualNovel/FateStayNight ''Franchise/FateSeries'', a Servant can overload their Noble Phantasm with prana and transform it into a Broken Phantasm, causing them to take a massive power hike in exchange for being lost. Given that most Servants only have between one to three Noble Phantasms ([[PublicDomainArtifact which are artifacts such as Excalibur]]), and Noble Phantasms represent the solidified history of each Servant the very idea is unthinkable. When unthinkable.
** In ''VisualNovel/FateStayNight'', when
Archer uses a Broken Phantasm against Berserker early on in the ''Unlimited Blade Works'' route, his Master Rin has a minor freakout because he seemingly destroyed one of his Noble Phantasms seemingly on a whim. He does this again when fighting Caster, using another Noble Phantasm very similar to the one he used against Berserker. [[spoiler:As it turns out, Archer's true ability is [[SpontaneousWeaponCreation projection Projection magic]], which allows him to replicate other Noble Phantasms infinitely - this means that he can use Broken Phantasms as much as he wants with no loss to him, something very terrifying if other Servants knew about this.]]


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** In ''VideoGame/FateGrandOrder'', the Rider-class Servant Mandricado has this with his Noble Phantasm ''Serment de Durandal''. He can imbue any weapon he gets a hold of with the power of the legendary sword Durandal, even if that "weapon" is just a wooden stick...but he can't copy Durandal's (unbreakable) durability. As a result, any weapon he uses inevitably ends up ''exploding'' from overuse, forcing him to get a new one.


** The Mazda rotary engines, well known for their weird Wankel design where EverythingIsBetterWithSpinning, is capable of reaching ridiculously high revolution speeds for its size, approaching motorcycle engines that are a fraction of its size. The [=13B=] engine mounted in the Mazda RX-8 is capable of reaching well above 9000 RPM, but the engineers had to limit it to 9000 to prevent it from causing the clutch plate from explosively disintegrating, shredding the driver and passenger's feet with metal shrapnel in the process. Modifying the ECU can get around this restriction, but carries the high risk of explosive failure if using the standard clutch.

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** The Mazda rotary engines, well known for their weird Wankel design where EverythingIsBetterWithSpinning, with SpectacularSpinning, is capable of reaching ridiculously high revolution speeds for its size, approaching motorcycle engines that are a fraction of its size. The [=13B=] engine mounted in the Mazda RX-8 is capable of reaching well above 9000 RPM, but the engineers had to limit it to 9000 to prevent it from causing the clutch plate from explosively disintegrating, shredding the driver and passenger's feet with metal shrapnel in the process. Modifying the ECU can get around this restriction, but carries the high risk of explosive failure if using the standard clutch.

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* It's repeatedly mentioned throughout ''FanFic/PrincessOfTheBlacks'' that Jen's connection to the Earth gives her an almost infinite supply of magical energy, but that if she draws more than the most infinitesimal fraction of that power at once, it will vaporize her. [[spoiler: In the final battle against Voldemort, Jen (who is fatally wounded anyway), throws her connection open all the way, and in the moment before the energy surge kills her, dumps it all into a blast that vaporizes Voldemort as well.]]


Sometimes "normal" OverDrive is not enough. Almost any piece of AppliedPhlebotinum can be made to work a little harder, at the cost of an increased risk ([[FinaglesLaw or certainty]]) that it will eventually explode. A NecessaryDrawback to show why it shouldn't be used this way very often.

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Sometimes "normal" OverDrive {{Overdrive}} is not enough. Almost any piece of AppliedPhlebotinum can be made to work a little harder, at the cost of an increased risk ([[FinaglesLaw or certainty]]) that it will eventually explode. A NecessaryDrawback to show why it shouldn't be used this way very often.


[[folder:Live Action TV]]

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[[folder:Live Action [[folder:Live-Action TV]]


** In the direct sequel, ''Endgame'', [[spoiler: Thanos uses the damaged gauntlet to destroy the Infinity Gems off-screen, which, combined with the terrible wound Thor gave him at the end of ''Infinity War'', almost killed him. The gauntlet became fused to his arm and has lost all the gold shine it once had, and Thanos is visibly struggling to breathe quite often.]]

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** In the direct sequel, ''Endgame'', [[spoiler: Thanos ''[[Film/AvengersEndgame Endgame]]'', [[spoiler:Thanos uses the damaged gauntlet to destroy the Infinity Gems Stones off-screen, which, combined with the terrible wound Thor gave him at the end of ''Infinity War'', almost killed him. The gauntlet became fused to his arm and has lost all the gold shine it once had, and Thanos is visibly struggling to breathe quite often.]]
*** Later in ''Endgame'', [[spoiler:both Hulk and Iron Man use the Stones with a new gauntlet, and suffer in a similar fashion to Thanos. Hulk's arm becomes crippled from their power, and Iron Man [[TheHeroDies doesn't survive their use]].
]]



* Mentioned rather nastily in Crreator/LoisMcMasterBujold's ''Literature/ShardsOfHonor''.

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* Mentioned rather nastily in Crreator/LoisMcMasterBujold's Creator/LoisMcMasterBujold's ''Literature/ShardsOfHonor''.

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