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* KillItWithIce: Ice tends to be effective against regeneration. Especially effective against [[GreenThumb plant-based regeneration]], but against targets from the animal kingdom, the implication might be that frostbite or gangrene is keeping the cells dead. Even if it doesn't outright kill the target, being frozen solid is usually sufficient to render them incapable of acting, effectively defeating them as long as they are not thawed.

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* KillItWithIce: Ice tends to be effective against regeneration. Especially effective against [[GreenThumb plant-based regeneration]], but against targets from the animal kingdom, the implication might be that frostbite or gangrene is keeping the cells dead. [[HarmlessFreezing Even if it doesn't outright kill the target, target]], being frozen solid is usually sufficient to render them incapable of acting, effectively defeating them as long as they are not thawed.
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** The [[https://darkestdungeon.gamepedia.com/Hateful_Virago Hateful Virago]], the ultimate EliteMook of the Weald, can create [[https://darkestdungeon.gamepedia.com/Necrotic_Fungus Necrotic Fungi]] out of the corpses of her fallen allies. As long as at least one such Necrotic Fungus is on the field, you can’t use HP-restoring skills. The solution to this is to either eliminate the Hateful Virago first, make sure to kill the other enemies in a way that won’t leave a corpse, or eliminate any corpse left by a fallen foe ''immediately''.

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** The [[https://darkestdungeon.gamepedia.com/Hateful_Virago Hateful Virago]], the ultimate EliteMook of the Weald, can create [[https://darkestdungeon.gamepedia.com/Necrotic_Fungus Necrotic Fungi]] out of the corpses of her fallen allies. As long as at least one such Necrotic Fungus is on the field, you can’t use HP-restoring skills. The solution to this is to either eliminate the Hateful Virago first, make sure to kill the other enemies in a way that won’t leave a corpse, or eliminate any corpse left by a fallen foe ''immediately''.before the Virago can convert it, or failing that, attack and destroy the Fungus directly.

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** Exposure to constant sources of damage. If a regenerator is exposed to an environment that inflicts constant injury, like the vacuum of space or the depths of the ocean, they may require the full strength of their healing factor to survive. With their powers occupied trying to keep restoring the body as the environment destroys it, they will be unable to ever fully restore themselves or escape under their own power.



** Psychological assaults can be viable methods of attack. This can be from using [[PsychicPowers psychics]] to [[MindRape attack the psyche directly]], but more mundane methods of psychological warfare can be just as effective. In either case, these assaults on the target's mental and emotional state can weaken or even completely incapacitate the regenerator without leaving a scratch on their bodies. In more benign cases, the "attack" may be a simple as [[TalkingTheMonsterToDeath talking the regenerator into standing down]].

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** Psychological assaults can be viable methods of attack. This Methods of invoking this can be range from using the exotic, such as using [[PsychicPowers psychics]] to [[MindRape attack the psyche directly]], but more to the mundane methods of such as psychological warfare can be just as effective.tactics like disinformation or emotional manipulation. In either case, these assaults on the target's mental and emotional state can weaken or even completely incapacitate the regenerator without leaving a scratch on their bodies. In more benign cases, the "attack" may be a simple as [[TalkingTheMonsterToDeath talking the regenerator into standing down]].down willingly]].
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* In ''VideoGame/{{Bonfire}}'', certain abilities (mostly [[KillItWithFire fire-based attacks]]) cause greater MaximumHPReduction than normal.
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* Identifying the source of the healing and [[ShootTheMedicFirst interfering with it or destroying it]].

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* Identifying the source of the healing and [[ShootTheMedicFirst interfering with it or destroying it]]. See also GeminiDestructionLaw.
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* ''VideoGame/{{Overwatch}}'': Ana's [[TrickBomb Biotic Grenade]] prevents enemies from healing temporarily, whether by HealingFactor or other healing sources.

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* ''VideoGame/{{Overwatch}}'': Ana's [[TrickBomb Biotic Grenade]] and Junkerqueen's [[BladeSpam Rampage]] prevents enemies from healing temporarily, whether by HealingFactor or other healing sources.
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** There are map effects that shut down types form of health recovery, such as by turning off regeneration or preventing [[LifeDrain leech]], or impede it by reducing the rate of life recovery.

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** There are map effects that shut down types form of health recovery, such as by turning off regeneration or preventing [[LifeDrain leech]], or impede it by reducing the rate of life recovery.
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* ''VideoGame/PathOfExile:''
** There are map effects that shut down types form of health recovery, such as by turning off regeneration or preventing [[LifeDrain leech]], or impede it by reducing the rate of life recovery.
** Players have a number of options to reduce or prevent enemy regeneration, such as the [[KillItWithIce frost bomb]] anti-regeneration debuff. However, it's more typical to simply deal enough damage to power through any recovery.
** [[EldritchAbomination The Maven]] emits slowly spinning beams of light that prevent all forms of health recovery for a full 10 seconds on contact. Incredibly dangerous for all builds, and a near-certain death sentence for builds using skills such as righteous fire, which deals massive self-damage that's typically overcome through high regeneration. On the higher difficulty setting one her more directed attacks also inflicts this debuff.
** In Affliction League the [[{{Superboss}} Incarnation of Agony]] has an aura that prevents all health recovery ''and'' inflicts stacking damage of all types over time. Unlike the Maven, whose effects are highly telegraphed and thus avoidable, the Incarnation automatically applies the debuff to anyone nearby, making it an almost impossible fight for close-range builds.
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** Beerus can permanently annihilate anything with his Hakai (energy of destruction), [[DeaderThanDead erasing the target from existence]]. Every other universe's God of Destruction has the same ability. If the target's [[KiManipulation ki]] is strong enough, they can block the Hakai from actually touching them, but once it ''does'' impact their body no amount of regeneration can reverse the effect. Not the Dragon Balls can restore someone killed by Hakai energy as there won't be a soul left to revive.

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** Beerus can permanently annihilate anything with his Hakai (energy of destruction), [[DeaderThanDead erasing the target from existence]]. Every other universe's God of Destruction has the same ability. If the target's [[KiManipulation ki]] is strong enough, they can block the Hakai from actually touching them, but once it ''does'' impact their body no amount of regeneration can reverse the effect. Not even the Dragon Balls can restore someone killed by Hakai energy as there won't be a soul left to revive.
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* ''Film/GodzillaMinusOne'': Having seen Godzilla's Healing Factor, Noda creates a plan to kill Godzilla by sinking it deep in the ocean where water pressure would kill it and, should that fail, immediately raise it to the surface for decompression to kill it. Noda notes that because Godzilla is a mysterious creature he cannot guarantee his plan will kill it. [[spoiler:And while the plan goes off along with Shikishima flying a plane armed with a bomb into Godzilla's mouth and detonating, Godzilla is shown to be healing as its corpse sinks in the ocean.]]

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* ''Film/GodzillaMinusOne'': Having seen Godzilla's Healing Factor, HealingFactor, Noda creates a plan to kill Godzilla by sinking it deep in the ocean where water pressure would kill it and, should that fail, immediately raise it to the surface for decompression to kill it. Noda notes that because Godzilla is a mysterious creature he cannot guarantee his plan will kill it. [[spoiler:And while the plan goes off along with Shikishima flying a plane armed with a bomb into Godzilla's mouth and detonating, Godzilla is shown to be healing as its corpse sinks in the ocean.]]
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* ''Film/GodzillaMinusOne'': Having seen Godzilla's Healing Factor, Noda creates a plan to kill Godzilla by sinking it deep in the ocean where water pressure would kill it and, should that fail, immediately raise it to the surface for decompression to kill it. Noda notes that because Godzilla is a mysterious creature he cannot guarantee his plan will kill it. [[spoiler:And while the plan goes off along with Shikishima flying a plane armed with a bomb into Godzilla's mouth and detonating, Godzilla is shown to be healing as its corpse sinks in the ocean.]]
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* In ''Manga/DemonSlayerKimetsuNoYaiba'', there's the Nichirin Blades, the signature weapons of the Demon Slayer Corps. Demons in this setting are supernatural creatures with healing abilities so potent that they recover from almost any injury quickly. One of the only things that can kill them is [[WeakenedByTheLight sunlight]], forcing them to be active only at night or indoors. Nichirin blades are weapons made of special ore that mimics the properties of sunlight. A Nichirin weapon won't shut down a demon's regeneration entirely, but it can kill a demon if it [[OffWithHisHead cuts their head off]]. This is the only thing that lets the [[CharlesAtlasSuperpower highly trained, but still human]] Demon Slayers have fighting chance against their inhumanly powerful opponents. Later in the series a new tier of power is introduced to make the Nichirin Blades even deadlier, [[spoiler:the Crimson Blade state. In this state, the most powerful Demon Slayers can heat their swords at will to disrupt demonic regeneration no matter where the weapon cuts them. This is enough to seriously harm even the strongest demons in the plot.]]

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* In ''Manga/DemonSlayerKimetsuNoYaiba'', there's the Nichirin Blades, the signature weapons of the Demon Slayer Corps. Demons in this setting are supernatural creatures with healing abilities so potent that they recover from almost any injury quickly. One of the only things that can kill them is [[WeakenedByTheLight sunlight]], forcing them to be active only at night or indoors. Nichirin blades are weapons made of special ore that mimics the properties of sunlight. A sunlight designed specifically to cut through all but the toughest demons. Wounds from Nichirin weapon won't shut down weapons don't completely stop a demon's regeneration entirely, regeneration, but it can the weapons will kill a demon demons if it they're used to [[OffWithHisHead cuts cut their head heads off]]. This is the only thing that lets the [[CharlesAtlasSuperpower highly trained, but still human]] Demon Slayers have fighting chance against their inhumanly powerful opponents. Later in the series a new tier of power is introduced to make the Nichirin Blades even deadlier, [[spoiler:the Crimson Blade state. In this state, the most powerful Demon Slayers can heat their swords at will to disrupt demonic regeneration no matter where the weapon cuts them. This is enough to seriously harm even the strongest demons in the plot.]]



** Beerus can permanently annihilate anything with his Hakai (energy of destruction), [[DeaderThanDead erasing the target from existence]]. Every other universe's God of Destruction has the same ability. If the target's [[KiManipulation ki]] is strong enough, they can block the Hakai from actually touching them, but once it ''does'' impact their body no amount of regeneration can reverse the effect.

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** Beerus can permanently annihilate anything with his Hakai (energy of destruction), [[DeaderThanDead erasing the target from existence]]. Every other universe's God of Destruction has the same ability. If the target's [[KiManipulation ki]] is strong enough, they can block the Hakai from actually touching them, but once it ''does'' impact their body no amount of regeneration can reverse the effect. Not the Dragon Balls can restore someone killed by Hakai energy as there won't be a soul left to revive.
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Consolidating the "win without wounding" methods.


** Particularly strong restraint devices can be sufficient for regenerators with limited additional power. It doesn't matter if the opponent can regrow an arm if both their current ones clapped in iron cuffs or encased in concrete.
** Inducing unconsciousness through chemical, physical, or mystical means can render a regenerator helpless without the need of any lasting injury. In some cases, it can be a viable method of long term containment to force the target into an induced coma for the foreseeable future.

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** Particularly strong Strong restraint devices can be sufficient for regenerators with limited additional power. It doesn't matter if the opponent can regrow an arm if both their current ones clapped in iron cuffs or encased in concrete.
** Inducing unconsciousness through chemical, physical, or mystical means can render a regenerator helpless without the need of any lasting injury. In some cases, it inducing a coma can be a viable method of long term containment to force the target into an induced coma for the foreseeable future.a regenerating enemy.



* Psychological assaults can be viable methods of attack. This can be from using [[PsychicPowers psychics]] to [[MindRape attack the psyche directly]], but more mundane methods like target's senses or overall mental state can be just as effective. In either case, these mental and emotional assaults can either serve to weaken or incapacitate the regenerator without leaving a scratch on their bodies. In more benign cases, the "attack" may be a simple as [[TalkingTheMonsterToDeath talking the regenerator into standing down]].

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* ** Psychological assaults can be viable methods of attack. This can be from using [[PsychicPowers psychics]] to [[MindRape attack the psyche directly]], but more mundane methods like target's senses or overall mental state of psychological warfare can be just as effective. In either case, these assaults on the target's mental and emotional assaults state can either serve to weaken or even completely incapacitate the regenerator without leaving a scratch on their bodies. In more benign cases, the "attack" may be a simple as [[TalkingTheMonsterToDeath talking the regenerator into standing down]].

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* ''Franchise/{{Pokemon}}'': The move Heal Block prevents the target Pokémon from healing, whether by its own moves, abilities, terrain, or items (for the last one, only Generation V and onward). Pokémon with the ability Liquid Ooze will also cause opponents that attempt to use [[LifeDrain draining]] moves on them to take damage instead of regenerating health. Toxic is a move that commonly shuts down tanky Pokémon as the poison damage increases each turn making it impossible to out-heal.

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* ''Franchise/{{Pokemon}}'': The ''Franchise/{{Pokemon}}'':
** Toxic is a
move Heal Block prevents the target that commonly shuts down tanky Pokémon from healing, whether by its own moves, abilities, terrain, or items (for as the last one, only Generation V and onward). poison damage increases each turn making it impossible to out-heal.
**
Pokémon with the ability Liquid Ooze will also cause opponents that attempt to use [[LifeDrain draining]] moves on them to take damage instead of regenerating health. Toxic is a health.
** The
move that commonly shuts down tanky Heal Block prevents the target Pokémon as from healing, whether by its own moves, abilities, terrain, or items (for the poison damage increases each turn making it impossible last one, only Generation V and onward).
** The move Psychic Noise prevents target Pokémon from healing, whether by its own moves, abilities, terrain, or items, for two turns in addition
to out-heal.damaging them.
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[[folder:Visual Novel]]
* The Mystic Eyes of Death Perception from ''VisualNovel/{{Tsukihime}}'' and ''Literature/TheGardenOfSinners'', while most famed for being able to kill things DeaderThanDead, another side effect of their ability is that anything sliced alongside their lines, assuming they don't die instantly, will be cut apart such that no form of healing or regeneration can repair. One character was able to recover from being diced into pieces, but had to do this by essentially completely recreating their body from scratch.
[[/folder]]
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* [[RingOut Relocation]]. Moving the opponent so far from the battlefield

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* [[RingOut Relocation]]. Moving the opponent so far from the battlefield

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** [[RingOut Removing the opponent from the battlefield]] may be sufficient to end their threat, at least for the moment. The exact method may vary, but as long as they are forced out of the area of interest and unable or unwilling to follow, they may be considered "defeated".




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* [[RingOut Relocation]]. Moving the opponent so far from the battlefield
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* The beginning of ''[[Film/Hercules1958 Hercules Unchained]]'' has a fight against Antaeus, who recovers from all injury whenever he touches the ground. Unlike the original Greek myth, Hercules defeats Antaeus by throwing him into the sea.

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* The beginning of ''[[Film/Hercules1958 Hercules Unchained]]'' has a fight against Antaeus, who recovers from all injury whenever he touches the ground. Unlike the original Greek myth, Hercules Heracles defeats Antaeus by throwing him into the sea.



** One of Hercules' tasks was to kill the hydra, which regrows any heads that were cut off. He succeeded when his nephew Iolaus started to cauterize the severed stumps with his torch before they could grow back. In some versions of the myth, one of the hydra's heads had CompleteImmortality, so Hercules simply buried that head under a large rock after destroying the rest of it.

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** One of Hercules' Heracles' tasks was to kill the hydra, which regrows any heads that were cut off. He succeeded when his nephew Iolaus started to cauterize the severed stumps with his torch before they could grow back. In some versions of the myth, one of the hydra's heads had CompleteImmortality, so Hercules Heracles simply buried that head under a large rock after destroying the rest of it.
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* ''TabletopGame/YuGiOh'' has several cards that either prevent [[HitPoint Life Point]] gaining or turn it into damage (most famously Bad Reaction to Simochi and Darklord Reficule). This is usually only a moderate annoyance ([[CriticalExistenceFailure "the only Life Point that matters is the last"]], after all), but against decks that run on gaining LP (like Aroma decks), it can utterly ''ruin'' their day.

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* ''TabletopGame/YuGiOh'' has several cards that either prevent [[HitPoint Life Point]] gaining or turn it into damage (most famously Bad Reaction to Simochi and Darklord Reficule). This is usually only a moderate annoyance ([[CriticalExistenceFailure "the only Life Point that matters is the last"]], after all), but against decks that run on gaining LP (like Aroma decks), it can utterly ''ruin'' their day. There are also numerous cards that heal your opponent, either as a cost or as their effect entire, designed to be used with one of these cards - healing the opponent to death is actually a viable strategy.
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** The Time Lords have Stasers, weapons that are the standard armament of the Chancellery Guard on Gallifrey. While not stated in the show, Time Lords shot with these weapons don't regenerate (the Lord President in The Deadly Assassin, for example).
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* ''TabletopGame/FabulaUltima'':
** The Commander class has a skill, King's Castle, which can be used to prevent all combatants from recovering HP and MP until the start of the Commander's next turn.
** The Symbolist class's Symbol of Despair is a downplayed version of this, halving the HP and MP that a creature marked with the symbol recovers from all healing effects.
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** Sustained attacks over an extended period can render healing a [[ImmunityDisability liability]]. Even if the opponent can physically recover from this, enduring the agony repeated lethal wounds without the ability to die can be enough to convince most opponents to surrender just to make the pain stop. The [[ToThePain threat alone]] can intimidate a healer into submission, making it an effective, if [[ColdBloodedTorture ruthless]] tactic for those with the stamina and/or resources to invoke it.

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** Sustained attacks over an extended period can render healing a [[ImmunityDisability liability]]. period. Even if the opponent can physically recover from this, this assault, [[ImmortalityHurts enduring the agony repeated lethal wounds without the ability to die die]] can be enough to convince most opponents to surrender just to make the pain stop. The [[ToThePain threat alone]] can intimidate a healer into submission, making it an effective, if [[ColdBloodedTorture ruthless]] ruthless]], tactic for those with the stamina and/or resources to invoke it.
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** Sustained attacks over an extended period can render healing a [[ImmunityDisability liability]. Even if the opponent can physically recover from this, enduring the agony repeated lethal wounds without the ability to die can be enough to convince most opponents to surrender just to make the pain stop. The [[ToThePain threat alone]] can intimidate a healer into submission, making it an effective, if [[ColdBloodedTorture ruthless]] tactic for those with the stamina and/or resources to invoke it.

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** Sustained attacks over an extended period can render healing a [[ImmunityDisability liability].liability]]. Even if the opponent can physically recover from this, enduring the agony repeated lethal wounds without the ability to die can be enough to convince most opponents to surrender just to make the pain stop. The [[ToThePain threat alone]] can intimidate a healer into submission, making it an effective, if [[ColdBloodedTorture ruthless]] tactic for those with the stamina and/or resources to invoke it.
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** Sustained attacks over an extended period can render healing a [[ImmunityDisability liability]. Even if the opponent can physically recover from this, enduring the agony repeated lethal wounds without the ability to die can be enough to convince most opponents to surrender just to make the pain stop. The [[ToThePain threat alone]] can intimidate a healer into submission, making it an effective, if [[ColdBloodedTorture ruthless]] tactic for those with the stamina and/or resources to invoke it.
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** [[spoiler:Gojo vs. Makima]]: [[spoiler:Makima can transfer fatal injuries to others and come back good as new, but she needs some biomass to come back from. Gojo uses Hollow Purple to reduce her to nothingness, leaving nothing to come back.]]
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** [[spoiler:Cole [=MacGrath=] vs. Alex Mercer]]: [[spoiler:Alex can regenerate on a molecular level, but Cole can drain his bioelectricity to weaken him and his electric attacks are powerful enough to disintegrate people on an atomic level, reducing Alex to nothing.]]

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** [[spoiler:Cole [=MacGrath=] vs. Alex Mercer]]: [[spoiler:Alex can regenerate on a molecular level, level and keep coming back as long as he has biomass to spare, but Cole can drain his bioelectricity to weaken him and his electric attacks are powerful enough to both destroy cities and disintegrate people on an atomic level, overcoming Alex's durability and reducing Alex him to nothing.nothing to regenerate ''from''.]]
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** [[spoiler:Cole [=MacGrath=] vs. Alex Mercer]]: [[spoiler:Alex can regenerate on a molecular level, but Cole can drain his bioelectricity to weaken him and his electric attacks are powerful enough to disintegrate people in an atomic level, reducing Alex to nothing.]]

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** [[spoiler:Cole [=MacGrath=] vs. Alex Mercer]]: [[spoiler:Alex can regenerate on a molecular level, but Cole can drain his bioelectricity to weaken him and his electric attacks are powerful enough to disintegrate people in on an atomic level, reducing Alex to nothing.]]

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